WO2005040332A3 - Verfahren und bioreaktor zum kultivieren und stimulieren von dreidimensionalen, vitalen und mechanisch widerstandsfähigen zelltransplantaten - Google Patents

Verfahren und bioreaktor zum kultivieren und stimulieren von dreidimensionalen, vitalen und mechanisch widerstandsfähigen zelltransplantaten Download PDF

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Publication number
WO2005040332A3
WO2005040332A3 PCT/EP2004/011788 EP2004011788W WO2005040332A3 WO 2005040332 A3 WO2005040332 A3 WO 2005040332A3 EP 2004011788 W EP2004011788 W EP 2004011788W WO 2005040332 A3 WO2005040332 A3 WO 2005040332A3
Authority
WO
WIPO (PCT)
Prior art keywords
bioreactor
cultivation
stimulation
mechanically
resistant cell
Prior art date
Application number
PCT/EP2004/011788
Other languages
English (en)
French (fr)
Other versions
WO2005040332A2 (de
Inventor
Ronny Schulz
Augustinus Bader
Original Assignee
Univ Leipzig
Ronny Schulz
Augustinus Bader
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leipzig, Ronny Schulz, Augustinus Bader filed Critical Univ Leipzig
Priority to US10/576,618 priority Critical patent/US20070026517A1/en
Priority to CA002543374A priority patent/CA2543374A1/en
Priority to JP2006536026A priority patent/JP2007508830A/ja
Priority to EP04790613A priority patent/EP1675939A2/de
Publication of WO2005040332A2 publication Critical patent/WO2005040332A2/de
Publication of WO2005040332A3 publication Critical patent/WO2005040332A3/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Mechanical Engineering (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

Der Bioreaktor (1) besteht aus einem Grundkörper, der mit einem Reaktorverschluss (21) druckdicht und steril verbunden ist und mindestens einen Reaktorraum bildet, in dem eine Ablagefläche für ein Transplantat (11) sowie ein Mini-Aktuator (14) implementiert sind. Weiterhin ist der Bioreaktor (1) mit wenigstens zwei Schlauchkupplungsanschlüssen (19) für die Mediumzufuhr und Mediumabfuhr bzw. zur Begasung versehen ist.
PCT/EP2004/011788 2003-10-21 2004-10-19 Verfahren und bioreaktor zum kultivieren und stimulieren von dreidimensionalen, vitalen und mechanisch widerstandsfähigen zelltransplantaten WO2005040332A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/576,618 US20070026517A1 (en) 2004-10-19 2004-10-19 Method and bioreactor for the cultivation and stimulation of three-dimensional, vitally and mechanically reistant cell transplants
CA002543374A CA2543374A1 (en) 2003-10-21 2004-10-19 Method and bioreactor for the cultivation and stimulation of three-dimensional vital and mechanically-resistant cell transplants
JP2006536026A JP2007508830A (ja) 2003-10-21 2004-10-19 三次元、生体及び機械的抵抗性を有する細胞移植体の培養と刺激のための方法とバイオ反応装置
EP04790613A EP1675939A2 (de) 2003-10-21 2004-10-19 Verfahren und bioreaktor zum kultivieren und stimulieren von dreidimensionalen, vitalen und mechanisch widerstandsf higen zel ltransplantaten

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10349484.7 2003-10-21
DE2003149484 DE10349484A1 (de) 2003-10-21 2003-10-21 Verfahren und Bioreaktor zum Kultivieren und Stimulieren von dreidimensionalen, vitalen und mechanisch widerstandsfähigen Zelltransplantaten

Publications (2)

Publication Number Publication Date
WO2005040332A2 WO2005040332A2 (de) 2005-05-06
WO2005040332A3 true WO2005040332A3 (de) 2005-06-30

Family

ID=34484964

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/011788 WO2005040332A2 (de) 2003-10-21 2004-10-19 Verfahren und bioreaktor zum kultivieren und stimulieren von dreidimensionalen, vitalen und mechanisch widerstandsfähigen zelltransplantaten

Country Status (7)

Country Link
EP (1) EP1675939A2 (de)
JP (1) JP2007508830A (de)
CN (1) CN1898375A (de)
CA (1) CA2543374A1 (de)
DE (1) DE10349484A1 (de)
RU (1) RU2370534C2 (de)
WO (1) WO2005040332A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2814472C1 (ru) * 2022-11-29 2024-02-29 Общество с ограниченной ответственностью "РЕГЕНТРОН" Биореактор для тканевой инженерии с аэрозольным способом подачи культуральной питательной среды

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DE102005049905A1 (de) * 2005-10-17 2007-04-19 Medizinische Hochschule Hannover Verfahren und Vorrichtung zur Herstellung eines Gelenkersatzes
JP5433129B2 (ja) 2006-07-10 2014-03-05 パーパス株式会社 細胞又は組織の培養方法
JP4981374B2 (ja) 2006-07-10 2012-07-18 パーパス株式会社 細胞又は組織の培養装置及び培養方法
ITMI20071945A1 (it) * 2007-10-09 2009-04-10 Milano Politecnico Bioreattore per la generazione e la stimolazione meccanica complessa di tessuto biologico ingegnerizzato.
EP2288688A2 (de) * 2008-03-25 2011-03-02 Novatissue Gmbh Perfundierbarer bioreaktor zur herstellung von menschlichen oder tierischen geweben
DE102008015633B4 (de) * 2008-03-25 2010-07-01 Nova Tissue Gmbh Perfundierbarer Bioreaktor zur Herstellung und/oder Kultivierung eines menschlichen oder tierischen Blutgefäßes und/oder eines menschlichen oder tierischen Gewebes
AT506826B1 (de) * 2008-05-23 2010-03-15 Greiner Bio One Gmbh Bioreaktor und verfahren zum kultivieren von zellen und geweben
DE102008050424B4 (de) 2008-10-08 2010-11-25 Universität Leipzig Verfahren und Vorrichtung zur homogenen Verteilung einer zellulären Suspension in porösem Trägermaterial für die Herstellung von vitalem biologischem Ersatzgewebe
EP2184347A3 (de) 2008-11-06 2011-05-18 Georg N. Duda Neue Komponenten und neues Bioreaktorsystem für die Kultur und mechanische Stimulation von biologischem Material
ITMI20090388A1 (it) * 2009-03-13 2010-09-14 Istituto Ortopedico Galeazzi S P A Bioreattore per la coltura di cellule o tessuti biologici, relativo metodo e sis tema multistazione
DE102009050498B4 (de) 2009-10-23 2015-08-06 Universität Leipzig Perfundierbarer Bioreaktor zur Herstellung von menschlichen und tierischen Geweben
RU2012132445A (ru) 2009-12-29 2014-02-10 У.Р. Грейс Энд Ко.-Конн. Композиции для образования пленок, имеющих желательную степень матирования, и способы их получения и применения
DE102010026369B4 (de) 2010-07-07 2015-07-30 Zellwerk Gmbh Verfahren und Druck-Drehbett-Bioreaktor zur dynamischen Expansion und/oder Differenzierung von Stammzellen oder primären Zellen humanen und tierischen Ursprungs
WO2012118304A2 (ko) * 2011-02-28 2012-09-07 주식회사 코리아본뱅크 동종 연조직 이식체 배양 장치
KR101313769B1 (ko) 2011-02-28 2013-10-01 주식회사 셀루메드 동종 연조직 이식체 배양 장치
RU2482180C2 (ru) * 2011-07-14 2013-05-20 Алексей Вячеславович Ковалев Биореактор для выращивания тканеинженерных конструкций
CN103930066A (zh) * 2011-09-12 2014-07-16 奥加诺沃公司 用于工程化的可植入组织和器官的平台及其制备方法
DE102012101078A1 (de) * 2012-02-09 2013-10-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Stimulationszelle und Verfahren zur in vitro Stimulation von Zellen oder Geweben
EP2909303B1 (de) * 2012-10-18 2020-04-15 Yongxin Zhang Bioreaktorsystem und verfahren für alternative zellkulturen zwischen statik und dynamik
ITFI20130220A1 (it) * 2013-09-20 2015-03-21 Azienda Ospedaliero Universitaria P Isana Apparato e processo per la preparazione di una protesi tissutale biomimetica della membrana timpanica
ITUB20160272A1 (it) * 2016-01-22 2017-07-22 Univ Degli Studi Di Palermo Bioreattore a perfusione autosufficiente monouso per crescite cellulari 3D
RU2612904C1 (ru) * 2016-04-15 2017-03-13 Евгений Александрович Тоневицкий Способ и микрофлюидный чип для культивирования клеток или клеточной модели
FR3081168B1 (fr) * 2018-05-21 2022-03-11 Univ Bordeaux Systeme de culture cellulaire en bioreacteur
DE102018122745B3 (de) * 2018-09-17 2019-12-19 Naturin Viscofan Gmbh Vorrichtung zur Medienzufuhr oder -abfuhr, Kulturgefäß mit einer solchen Vorrichtung und Verfahren zur Kultivierung von mikrobiologischen Systemen unter Verwendung eines solchen Kulturgefäßes
RU190863U1 (ru) * 2019-02-15 2019-07-15 Федеральное государственное бюджетное учреждение "Российский ордена Трудового Красного Знамени научно-исследовательский институт травматологии и ортопедии имени Р.Р. Вредена" Министерства здравоохранения Российской Федерации (ФГБУ "РНИИТО им. Р.Р. Вредена" Минздрава России) Устройство для совмещения клеточной культуры и биодеградируемого носителя
CN111705034A (zh) * 2020-06-30 2020-09-25 山东省医药生物技术研究中心（山东省病毒研究所） 一种高效促进软骨细胞增殖的方法
CN111996120A (zh) * 2020-09-25 2020-11-27 南通纺织丝绸产业技术研究院 一种带有微电流刺激功能的细胞培养装置
AT523906B1 (de) * 2020-10-02 2022-01-15 Inncellys Gmbh Inkubationskammer

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Publication number Priority date Publication date Assignee Title
WO1996039992A1 (en) * 1995-06-07 1996-12-19 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing replacement cartilage tissue constructs
DE19808055A1 (de) * 1998-02-27 1999-09-02 Adamietz Verfahren und Apparatur zur Herstellung von dreidimensionalen Gewebezellkulturen
US20010043918A1 (en) * 2000-05-05 2001-11-22 Masini Michael A. In vitro mechanical loading of musculoskeletal tissues
WO2002048317A2 (de) * 2000-12-12 2002-06-20 Bauer Joerg Verfahren und vorrichtung zur herstellung von biologischem gewebe in einer wachstumskammer
WO2003029398A1 (fr) * 2001-08-30 2003-04-10 Takagi Industrial Co., Ltd. Incubateur pour cellules et structures

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DE4306661C2 (de) * 1993-03-03 1995-04-20 Michael Dipl Biol Sittinger Verfahren zum Herstellen eines Implantates aus Zellkulturen
DE19962456A1 (de) * 1999-12-22 2001-07-12 Biotechnologie Ges Mittelhesse Verfahren und Apparatur zur Herstellung, Untersuchung und mechanischen Stimulation dreidimensionaler Gewebezellkulturen
DE10201259A1 (de) * 2002-01-15 2003-08-28 Augustinus Bader Vorrichtung zum Züchten oder Kultivieren von Zellen in einem dosenartigen Behälter

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
WO1996039992A1 (en) * 1995-06-07 1996-12-19 Advanced Tissue Sciences, Inc. Apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing replacement cartilage tissue constructs
DE19808055A1 (de) * 1998-02-27 1999-09-02 Adamietz Verfahren und Apparatur zur Herstellung von dreidimensionalen Gewebezellkulturen
US20010043918A1 (en) * 2000-05-05 2001-11-22 Masini Michael A. In vitro mechanical loading of musculoskeletal tissues
WO2002048317A2 (de) * 2000-12-12 2002-06-20 Bauer Joerg Verfahren und vorrichtung zur herstellung von biologischem gewebe in einer wachstumskammer
WO2003029398A1 (fr) * 2001-08-30 2003-04-10 Takagi Industrial Co., Ltd. Incubateur pour cellules et structures

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2814472C1 (ru) * 2022-11-29 2024-02-29 Общество с ограниченной ответственностью "РЕГЕНТРОН" Биореактор для тканевой инженерии с аэрозольным способом подачи культуральной питательной среды

Also Published As

Publication number Publication date
RU2006117360A (ru) 2007-11-27
JP2007508830A (ja) 2007-04-12
CN1898375A (zh) 2007-01-17
CA2543374A1 (en) 2005-05-06
DE10349484A1 (de) 2005-05-25
WO2005040332A2 (de) 2005-05-06
RU2370534C2 (ru) 2009-10-20
EP1675939A2 (de) 2006-07-05

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