WO2005033261A3 - Verfahren und versorgungseinheit zur überwachung von veränderungen und zuständen in reaktionskammern - Google Patents

Verfahren und versorgungseinheit zur überwachung von veränderungen und zuständen in reaktionskammern Download PDF

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Publication number
WO2005033261A3
WO2005033261A3 PCT/EP2004/052405 EP2004052405W WO2005033261A3 WO 2005033261 A3 WO2005033261 A3 WO 2005033261A3 EP 2004052405 W EP2004052405 W EP 2004052405W WO 2005033261 A3 WO2005033261 A3 WO 2005033261A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
states
supply unit
reaction chambers
monitoring changes
Prior art date
Application number
PCT/EP2004/052405
Other languages
English (en)
French (fr)
Other versions
WO2005033261B1 (de
WO2005033261A2 (de
Inventor
Ralf Ehret
Axel Kob
Elke Thedinga
Heiko Holst
Original Assignee
Bionas Gmbh
Ralf Ehret
Axel Kob
Elke Thedinga
Heiko Holst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bionas Gmbh, Ralf Ehret, Axel Kob, Elke Thedinga, Heiko Holst filed Critical Bionas Gmbh
Priority to JP2006530271A priority Critical patent/JP2007507335A/ja
Priority to US10/574,338 priority patent/US20070037285A1/en
Priority to EP04791117A priority patent/EP1667795A2/de
Publication of WO2005033261A2 publication Critical patent/WO2005033261A2/de
Publication of WO2005033261A3 publication Critical patent/WO2005033261A3/de
Publication of WO2005033261B1 publication Critical patent/WO2005033261B1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/048—Function or devices integrated in the closure enabling gas exchange, e.g. vents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

Die Erfindung bezieht sich auf ein Verfahren zur Überwachung von Veränderungen und Zuständen in Reaktionskammern und eine Versorgungseinheit, welche bei Untersuchungen an Zellkulturen für die Einbringung eines flüssigen Kulturmediums benötigt wird. Aufgabe der Erfindung ist es, eine luftblasenfreie Messung in Reaktionskammern zur Überwachung von Veränderungen und Zuständen in Reaktionskammern zu ermöglichen. Auf eine Entgasung soll ganz verzichtet werden. Erfindungsgemäss wird ein Fluid aus einem Vorratsbehälter über ein Schlauch- und/oder Rohrsystem abgezogen oder abgepumpt und zu einer Versorgungseinheit transportiert. Das Fluid tropft oder fliesst über einen Einlasskanal (6) in einen Tropfraum. Oberhalb eines Kopfes (7) und eines Reaktionsraums (2) bildet das Fluid einen Vorrat (3). Die Höhe (4) der Fluidgrenze und somit das Vorratsvolumen wird mit Hilfe eines Absaugkanals (5) bestimmt.
PCT/EP2004/052405 2003-10-03 2004-10-01 Verfahren und versorgungseinheit zur überwachung von veränderungen und zuständen in reaktionskammern WO2005033261A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2006530271A JP2007507335A (ja) 2003-10-03 2004-10-01 反応チャンバ内の変化および状態を監視する方法および管理ユニット
US10/574,338 US20070037285A1 (en) 2003-10-03 2004-10-01 Method and supply unit for monitoring changes and states in reaction chambers
EP04791117A EP1667795A2 (de) 2003-10-03 2004-10-01 Verfahren und versorgungseinheit zur berwachung von veränderungen und zuständen in reaktionskammern

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10346451A DE10346451B4 (de) 2003-10-03 2003-10-03 Verfahren zur Überwachung von Veränderungen und Zuständen in Reaktionskammern
DEDE10346451.4 2003-10-03

Publications (3)

Publication Number Publication Date
WO2005033261A2 WO2005033261A2 (de) 2005-04-14
WO2005033261A3 true WO2005033261A3 (de) 2005-05-26
WO2005033261B1 WO2005033261B1 (de) 2005-07-14

Family

ID=34399314

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/052405 WO2005033261A2 (de) 2003-10-03 2004-10-01 Verfahren und versorgungseinheit zur überwachung von veränderungen und zuständen in reaktionskammern

Country Status (5)

Country Link
US (1) US20070037285A1 (de)
EP (1) EP1667795A2 (de)
JP (1) JP2007507335A (de)
DE (1) DE10346451B4 (de)
WO (1) WO2005033261A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7276351B2 (en) 2003-09-10 2007-10-02 Seahorse Bioscience Method and device for measuring multiple physiological properties of cells
US8658349B2 (en) 2006-07-13 2014-02-25 Seahorse Bioscience Cell analysis apparatus and method
US8202702B2 (en) * 2008-10-14 2012-06-19 Seahorse Bioscience Method and device for measuring extracellular acidification and oxygen consumption rate with higher precision
DE102009036695B3 (de) * 2009-08-07 2011-04-07 Hp Medizintechnik Gmbh Einsatz für ein Well in einer Multiwellplatte und dessen Verwendung
WO2014078379A2 (en) 2012-11-13 2014-05-22 Seahorse Bioscience Apparatus and methods for three-dimensional tissue measurements based on controlled media flow
CN116809131A (zh) 2014-06-02 2023-09-29 安捷伦科技有限公司 用于分析生物样本的单列微板系统和载体
US10883978B2 (en) * 2017-01-31 2021-01-05 Agilent Technologies, Inc. Method and device for calibration of biological flux

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6336783A (ja) * 1986-07-31 1988-02-17 Ishikawa Seisakusho:Kk 多孔性素材を用いる化学反応方法及び装置
DE19920811A1 (de) * 1999-05-06 2000-11-16 Micronas Intermetall Gmbh Vorrichtung zur Durchführung von Untersuchungen an Zellkulturen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS615774A (ja) * 1984-06-19 1986-01-11 Kyowa Hakko Kogyo Co Ltd 発酵槽から発酵液の無菌採取装置
US6017483A (en) * 1997-07-18 2000-01-25 Becton Dickinson And Company Receptacle with a fused coating on an interior surface and an injection molding process for forming the article
DE10019862A1 (de) * 2000-04-18 2001-11-08 Cell Lining Ges Fuer Zellkulti Verfahren und Vorrichtung zur Automatisierung des Medienwechsels in Zellkulturen
WO2002072423A1 (en) * 2001-03-09 2002-09-19 Biomicro Systems, Inc. Microplate lid
WO2003008531A1 (de) * 2001-07-16 2003-01-30 Theodor Lauboeck Verfahren und vorrichtung zur bereitung eines mit mikroorganismen befrachteten fluides, mikroorganismen enthaltender stoff sowie verfahren zur veränderung der wachstumsbedingungen von pflanzen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6336783A (ja) * 1986-07-31 1988-02-17 Ishikawa Seisakusho:Kk 多孔性素材を用いる化学反応方法及び装置
DE19920811A1 (de) * 1999-05-06 2000-11-16 Micronas Intermetall Gmbh Vorrichtung zur Durchführung von Untersuchungen an Zellkulturen

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 012, no. 248 (C - 511) 13 July 1988 (1988-07-13) *

Also Published As

Publication number Publication date
EP1667795A2 (de) 2006-06-14
US20070037285A1 (en) 2007-02-15
DE10346451A1 (de) 2005-05-12
DE10346451B4 (de) 2007-08-02
JP2007507335A (ja) 2007-03-29
WO2005033261B1 (de) 2005-07-14
WO2005033261A2 (de) 2005-04-14

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