WO2005032504A1 - Cosmetic preparation containing high molecular antioxidant component - Google Patents

Cosmetic preparation containing high molecular antioxidant component Download PDF

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Publication number
WO2005032504A1
WO2005032504A1 PCT/CZ2004/000063 CZ2004000063W WO2005032504A1 WO 2005032504 A1 WO2005032504 A1 WO 2005032504A1 CZ 2004000063 W CZ2004000063 W CZ 2004000063W WO 2005032504 A1 WO2005032504 A1 WO 2005032504A1
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preparation
concentration range
total weight
salts
acid
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PCT/CZ2004/000063
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French (fr)
Inventor
Stanislav Pavek
Melita Vodenicarova
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Cpn Spol. S.R.O.
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Publication of WO2005032504A1 publication Critical patent/WO2005032504A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers

Definitions

  • the present invention relates to a cosmetic preparation containing an antioxidant hydrophilic component.
  • the main and entire part of this component is a high molecular tamarind antioxidant with a molecular weight from 3xl0 3 to 5xl0 5 g.moi "1 .
  • the antioxidants and antiradicals can protect intercellular lipids, cell membranes, low molecular compounds, such as amino acids with thiol group and glutathione, and further macromolecules, such as proteins and glycosamin glycanes against direct oxidation.
  • Reactive forms of oxygen affect the lipids, which results, in the final phase, in reactive aldehydes that can irreversibly modify soluble and insoluble proteins, with adverse effect upon their function.
  • Such modification leading to cross-linking of the structural proteins of the dermis results in the loss of elasticity and the occurrence of wrinkles, as well as in damaging the cell integrity or exhausting the protective antioxidants that are naturally present in biological tissues.
  • a part of cosmetic carrier emulsions are lipids and also emulsifiers containing lipid segments in their molecules, which makes them easily prone to chemical conversions induced by reaction with oxygen. Many natural substances contain non saturated bonds between carbon atoms which are susceptible to peroxidation.
  • the change of chemical structure of components during the storage and use of cosmetic preparations usually leads to a decrease of dermal tolerance of these products , .and even to poor emulsion stability due to changed properties of the emulsifier and to changed polarity of the lipid components.
  • the current cosmetic preparations contain preferably at least one component with antioxidant or antiradical effect.
  • these substances can be hydrophilic or lipophilic.
  • the choice of optimum antioxidant does not depend just upon the solubility in a certain carrier, but it is also affected by other properties, such as undesirable interactions with a carrier, stability in a final product during storage, skin penetration ability after a topical application of the preparation, possibly the production of cytotoxic or immunosuppressive products of a reaction with free radicals, with or without combined action with ultraviolet light.
  • lipophilic antioxidants in current cosmetic preparations is very popular.
  • the reason is relatively good stability, high compatibility with emulsion systems and a good compatibility with non-emulsion ones, good skin tolerance and their ability to penetrate in deeper epidermal layers.
  • the disadvantage is their sensitivity to oxygen leading, together with high penetrability, to a reduction of antioxidant concentration in the skin surface within a short time after the application, and even to a fast antioxidant exhaustion, such as under the combined effect with ultraviolet light. Then the skin surface has no protection against an attack of reactive compounds from the environment.
  • Another disadvantage can reside in lower solubility within an environment supporting the creation of most hydrophilic reactive forms of hydrogen, and also the insufficiently investigated properties of products resulting from antioxidant reactions with radicals under the combined effect of ultraviolet light.
  • Hydrophilic antioxidants have not been broadly used in current cosmetic preparations because of their low stability after treatment with liquid systems.
  • the main favoured group uses various carrier forms and derivatives of ascorbic acid which can, however, interact with emulsion and gel systems and, moreover, they can cause changes of physical parameters of a final product during storage.
  • a large group consists of antioxidants of phenolic character isolated from plant extracts, such as flavonoids, oligomeric proanthocyanides and their esters. However, these substances are intensively coloured and their use in commercially acceptable preparations is very limited.
  • Their further disadvantage is their pro-oxidative effect in some biological systems, simile to the derivatives of ascorbic acid..
  • antioxidant cosmetic components also enzymes can be used, such as superoxide dismutase and catalyse, but this brings problems related to their stabilisation during the storage of final products.
  • Current preparations for decorative, sunbathing, baby products, and daily cosmetics have preferably some ingredients that are not water soluble, such as inorganic compounds of transition metals playing decorative or UN-protective functions. A topical application of such preparation leads to an accumulation of inorganic pigments in the skin surface, possibly just in a few upper layers of strata cornea.
  • transition metals tend to catalyse in water environment and, in the presence of oxidising substances or UV rays, they create free radicals.
  • a very reactive hydroxyl radical is generated that impacts numbers of biologically important compounds and structures, initiating the production of cytotoxic secondary products.
  • Topic application of cosmetic preparations containing currently used antioxidants in combination with pigments based upon inorganic compounds of transition metals is therefore connected with a fast decrease of antioxidant concentration in the skin surface as a result of a reaction with air oxygen, with reactive forms of oxygen, .and also due to its ability to penetrate into deeper cell strata.
  • polysaccharide is not specified as an antioxidant, but as a polysaccharide with a higher resistance against cleavage by a hydroxyl radical leading to the decrease of it's molecular weight, whereas the therapeutic or cosmetic properties are close to the non modified polysaccharide.
  • many pl.ant extracts contain groups of components with various chemical structures and antioxidant effect. The presence of low molecular antioxidant substances in the Tamarindus indica species .are described in US patents No. 6 294 190 and 5 762 936.
  • Subject -matter of the invention The disadvantages of cosmetic preparations mentioned above containing antioxidant components, especially in a combination with pigments on the base of inorganic compounds of transition metals are eliminated to a great extent by the invention using a high molecular antioxidant produced by alkaline extraction of the coat of seeds of Tamarindus indica species.
  • Literature describes low molecular, and even oligomeric substances extracted from tamarind seed coats by various organic solvents.
  • an extraction method with a suitable solvent containing water as the main component with alkaline pH allows to reach an extraction of a complex with molecular weight from 3xl0 3 to 5xl0 5 g.mol "1 , consisting of sub-molecular formations that are responsible for the anti-oxidant effect .and .are bonded with a polysaccharide of the xylane type.
  • Components with molecular weight less than 3xl0 3 g.mol "1 are removed from the extracted complex by a suitable method.
  • Using high molecular antioxidant isolated from the coats of tamarind seeds as a component for cosmetic preparations is beneficial in comparison with current antioxidants in use down to the present, because of it's longer retention in the skin surface.
  • this antioxidant is soluble in the skin surface environment where also a hydroxyl radical is generated by the catalysis of transition metals ions, this invention offers the benefit of fast and durable deactivation of hydroxyl radicals, especially if applying preparations containing inorganic pigments.
  • hydroxyl radicals being generated by interaction of ultraviolet light with the watery environment of the epidermis
  • the use of high molecular tamarind antioxidant is preferable also in all preparations used for the treatment of skin exposed to daylight. Its use is advantageous also for preparing a cosmetic carrier, since it does not disturb emulsion or gel structures created by emulsifiers or by gelling agents, respectively.
  • a cosmetic preparation according to the invention contains a high-molecular tamarind antioxidant produced by alkaline extraction of tamarind seeds coats, separately or in a combination with at least one hydrophilic or lipophilic antioxidant, a stable, cosmetically acceptable and dermatologically safe carrier.
  • the preparation can preferably contain at least one hydration component and also pigments on the base of inorganic compounds of transition metals with decorative or UN-protective functions.
  • a topical application of the preparation being envisaged for protecting the skin against ultraviolet light the preparation can preferably contain at least one organic UV filter, at least one component with anti-inflammatory effect and a component with immunity-modulating effect.
  • a cosmetic preparation according to the invention contains a high molecular tamarind antioxidant with molecular weight 3xl0 3 az 5xl0 5 g.mol "1 within the concentration range from 0,001 to v 5 % (dry matter) of the total weight of the preparation.
  • This high molecular tamarind antioxidant is advantageously produced by alkaline extraction of seeds coats of Tamarindus indica' species)
  • a cosmetic preparation according to the invention contains preferably at least one further hydrophilic or lipophilic antioxidant within the concentration range from 0,001 to 15 % of the total weight of the preparation and a stable, cosmetically acceptable and dermatologically safe carrier: '
  • ⁇ -carotene ⁇ -carotene, ⁇ -carotene, ⁇ -carotene, ⁇ -carotene, lutein, xantophyll, zeaxanthine, violaxanthine, cryptoxanthine, fukoxanthine, antheraxanthine, lycopene, didehydrolycopene and tetradehydrolycopene carotenoides in the concentration range from 0,001 to 5 % of the total weight of the preparation, more preferably from 0,01 to 0,1 % of the total weight of the preparation or superoxide dismutase, catalyse, ubiquinone-50 (coenzyme Q10), in the concentration range from 0,001 to 2 % of the total weight of the preparation, more preferably from 0,01 to 0,1 % of the total weight of the preparation.
  • - hyaluronic acid with molecular weight from 5x10 to 1x10 g.mol " or salts thereof with alkali metals and or alkaline-earth metals in the concentration range from 5xl0 "4 to 1,5 %, more preferably from 0,005 to 0,1 % of the total weight of the preparation.
  • - hyaluronic acid with molecular weight from 280 g.mol "1 to 5xl0 3 g.mol "1 or salts thereof with alkali metals and or alkaline-earth metals in the concentration range from 5xl0 "4 to 5 %, more preferably from 0,01 to 0,5 % of the total weight of the preparation.
  • panthenol glycerine, urea, pyrrolidoncarboxylic acid and alkali salts thereof, milk acid and alkali salts thereof, niacinamide and trehalose in the concentration range from 0,05 to 10 %, more preferably from 0,01 to 4 % of the total weight of the preparation.
  • - titanic oxide zinc oxide, ferric oxide, ferrous-ferric oxide and their crystalline modifications, in the concentration range from 0,001 to 15%, more preferably from 0,01 to 3% of the total weight of the preparation.
  • - micronised forms of titanic oxide, zinc oxide, ferric oxide, ferrous-ferric oxide and their crystalline modifications in the concentration range from 0,001 to 15%, more preferably from 0,01 to 3% of the total weight of the preparation.
  • - encapsulated forms of zinc oxide, ferric oxide, ferrous-ferric oxide and their crystalline modifications in the concentration range from 0,01 to 25%, more preferably from 0,1 to 10% of the total weight of the preparation.
  • the preparation further contains at least one organic UV filter from the group comprising 4-aminobenzoic acid, ethoxylated ethyl-4-aminobenzoate, 2-ethylhexyl-4-dimethyl.aminobenzoate, homomenthyl salicylate, 2-ethylhexyl salicylate, isopentyl-4-methoxycinnamate, 2-ethylhexyl-4-methoxycinn.amate, 2- -ethylhexyl-2-cyano-3,3-diphenylacrylate, oxybenzon, 2-hydroxy-4-methoxybenzofenone-5- -sulfonic acid and salts thereof, 2-phenylbenzimidazole-5-sulfonic acid .and salts thereof, N,N,N- -trimethyl-4-(2-oxoborn-3-ylidenmethyl) anilineium methyl sulfate, alpha-(2-ox
  • R (CH 2 ) m -(CHOH)-(CH 2 ) n R 2 (V), where Ri a R 2 are hydrogen atoms or OH group, m,n are integral numbers from 0 to 17, the sum of m+n does not exceed 21 in the concentration range from 0,01 to 25 %, more preferably from 0,1 to 5 % of the total weight of the preparation;
  • VH Another preferable embodiment of the invention is a preparation further containing at least one component with immunity-modulating effect from the group consisting of ⁇ j 7 1
  • a preferable preparation according to the invention has the form of cosmetic face creme of the type of oil in water or water in oil with low or medium viscosity, hydrophylic or lipophilic gel, one phase solution or a preparation for aerosol application, and preferably further in the form of a solid emulsion peg or a solid preparation produced by moulding the starting components.
  • the high-molecular antioxidant of the invention used in cosmetic preparations is a polysaccharide produced by alkaline extraction of seed coats of Tamarindus indica species.
  • the coats are separated from seeds before the extraction, they are left to swell up and then the extraction is carried out in a suitable solvent, main part of which is water of alkaline pH.
  • a suitable solvent main part of which is water of alkaline pH.
  • Hyaluronic acid of the invention is a polysaccharide of the general formula ( ⁇ -D- -glucuronic acid-[l 3]- ⁇ -N-acetyl-D-glucosamine-[l 4]) n , where n is an integral number from 1 to 8 000.
  • Carboxymethylglucane of the invention is a polysaccharide produced by partial carboxymethylation ⁇ -(l 3),(1 6) of glucane. The linear chain of this slightly branched polysaccharide is created by a ⁇ -D-glucopyranosyle unit connected by (1 3) bond.
  • Mono- saccharide side chains are connected with the linear chain by (1 6) bond and are created by ⁇ - -D-glucopyranosyle unit.
  • the molecular weight of the carboxymethylglucane can be in the range of 5xl0 3 to lxlO 7 g.mol "1 .
  • schizophyllane for the purpose of the invention a polysacharide is understood that is isolated from the medium after cultivation of Schizophyllum commune.
  • the linear chain of this slightly branched polysaccharide is created by ⁇ -D-glucopyranosyle units connected by (1 3) bond.
  • the monosaccharide side chains are connected with the linear chain by (1 6) bond and are created by ⁇ -D-glucopyranosyle unit.
  • This primary polysaccharide allows to prepare schizophyllane with lower molecular weight by bond cleavage inside the linear chain under given reaction condition.
  • the factor leading to fragmentation can be higher temperature, hydrolysis in acid, neutral or alkaline environment, oxidative digestion with following reduction by radiation treatment, ultra-sound or enzyme digesting (1 3)- ⁇ -glycosidic bond.
  • Molecular weight of schizophyllane can be in the range of 5x10 3 to lxlO 7 g.mol "1 .
  • Xyloglucane of the invention can be a polysaccharide isolated from Tamarindus indica seeds.
  • the linear chain of this slightly branched polysaccharide is created by ⁇ -D- -glucopyranosyle unit connected by (1 4) bond.
  • One and disaccharide side chains are connected to this linear chain by (1 6) bond.
  • the molecular weight of xyloglucane can be in the range of 5x10 3 to lxl 0 6 g.mol '1 .
  • Glucomannan of the invention is a polysaccharide isolated from cell weight of Candida utilis or from the medium for its cultivation.
  • the main chain of this slightly branched polysaccharide is created by ⁇ -D-mannopyranosyle units connected by (1 6) bond.
  • the short side mannooligosaccharide chains (1-5 units) are connected to the linear chain by (1 2)- ⁇ - -glycosidic bond, units are connected with each other by (1 2)- ⁇ -and occasionally by (1 3)- ⁇ - -glycosidic bond. Some side chains are finished by nonreducting ⁇ -D-glucopyranosyl unit connected by (1 2) bond.
  • the molecular weight of the glucomannane can be in the range of 5xl0 3 to 2xl0 5 g.mol "1 .
  • the cosmetic preparation according to the invention is currently applicable as a preparation of decorative, sunbathing, baby and daily cosmetics for the treatment of the whole body, or for the treatment of the skin of the face, neck, low neck, hands and feet. Examples of the invention
  • Example 1 Hot melted mix of of 2g of ethoxylated (2 EO) stearylalcohol, 3 g of ethoxylated (21 EO) stearylalcohol, 3 g of cetylalcohol, 0,5 g of polydimethylsiloxane, 2 g of isopropylpalmitate, 3 g of cyclopentasiloxane, 0,1 g of ⁇ -bisabolol, 1 g of tocoferylacetate, 2 g of stearine, 3 g of hydrogenated polyisobutene, 2,5 g dioctylcarbonate and 2 g of micronizated titanic oxide were added to water phase of 0,5 g of panthenole and 2 g of glycerine were dissolved in 62,35 g of water.
  • 2 ethoxylated (2 EO) stearylalcohol 3 g of ethoxylated (21 EO) stearyl
  • Example 2 0,2 g of allantoin, 0,5 g panthenol and dispergated 0,3 g carboxyvinyl polymer were dissolved in 52,85 g of water. Hot melted mix of 2 g of PVP/eikosen copolymer, 2 g of ethoxylated (21 EO) stearylalcohol, 1 g of cetylalcohol, 2 g of glycerylmonostearate, 6 g of octylmethoxycinnamate, 2,5 g of butylmethoxy dibenzoylmethane, 5 g of izopropyl izostearate,
  • 3 g of isopropylmyristate, 4g of isostearylisostearate, 1 g of stearine, 0,2 g of g ⁇ -bisabolole, 1 g of tocoferylacetate, 0,02 g tocopherole, 0,5 g caroten oil and 4 g of paraffine oil was emulgated with the water phase of 7 g of trehalose dihydrate, 2 g of glycerine, 0,2 g of allantoin, 0,5 g of panthenol dissolved in 59,85 g of water and dispergated in 0,2 g of carboxyvinylated polymer.
  • Example 4 Hot melted mix of of 2g of ethoxylated (2 EO) stearyl alcohol, 3 g of ethoxylated (21 EO) stearyl alcohol, 3 g of izostearyl izostearate, 2 g of stearine, 0,5 g of tocoferyl acetate, 3 g of hydrogenated polyisobutene were added to 0,5 g of panthenole, 0,1 g of sodium pyrrolidon carboxylate and 2 g of glycerine dissolved in 65,65 g of water.
  • 2 ethoxylated (2 EO) stearyl alcohol 3 g of ethoxylated (21 EO) stearyl alcohol, 3 g of izostearyl izostearate, 2 g of stearine, 0,5 g of tocoferyl acetate, 3 g of hydrogenated polyisobutene were added to 0,5 g of panthenole, 0,1 g
  • This emulsion was further enriched by 0,5 g of solution of methyl-, butyl,- ethyl and propyl parabene in fenoxyethanol and 0,2 g of perfume.
  • the solution of 0,2 g of glucomannane, 0,5 g of schizophyllane, 0,02 g of sodium hyaluronate with molecular weight l,3xl0 6 g.mol "1 , 0,03 g of sodium hyaluronate with molecular weight 2xl0 5 g.mol "1 and 0,05 g of high molecular tamarind antioxidant in 10 g of water were added.
  • the product can be used as a cosmetic preparation for current treatment as a body milk. Described examples of embodiment serve for illustration only, without limiting or exhausting possible options within the scope of the invention.

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Abstract

The present invention relates to a cosmetic preparation containing a hydrophobic high molecular tamarind antioxidant component with molecular weight from 3x103 to 5x105 g.mo1-1 in the concentration range from 0,001 to 5% of dry matter of the total weight of the preparation.

Description

Cosmetic Preparation Containing High Molecular Antioxidant Component
Field of Invention The present invention relates to a cosmetic preparation containing an antioxidant hydrophilic component. The main and entire part of this component is a high molecular tamarind antioxidant with a molecular weight from 3xl03 to 5xl05 g.moi"1.
Back-πx>und of the invention Substances having antioxidant and antiradical effects have two functions in current cosmetic prep,arations. Commercial considerations lead to emphasising in particular their function of active component in a cosmetic preparation. This resides in their capability of local reducing of the active oxygen form in the immediate surrounding of the application to the skin, protecting against the oxidation of tissue components and their modification by secondary products of lipid oxidation. A not less important, although not so strongly highlighted, function of the antioxidants is their protective effect upon the components of the preparation in question that are sensitive to oxidation by air oxygen, which offers the benefit of higher stability of the product and it's longer shelf live. After the application to the skin the antioxidants and antiradicals can protect intercellular lipids, cell membranes, low molecular compounds, such as amino acids with thiol group and glutathione, and further macromolecules, such as proteins and glycosamin glycanes against direct oxidation. Reactive forms of oxygen affect the lipids, which results, in the final phase, in reactive aldehydes that can irreversibly modify soluble and insoluble proteins, with adverse effect upon their function. Such modification leading to cross-linking of the structural proteins of the dermis results in the loss of elasticity and the occurrence of wrinkles, as well as in damaging the cell integrity or exhausting the protective antioxidants that are naturally present in biological tissues. The use of antioxid.ants for the protection of the components of the final preparation that are sensitive to oxidation by air oxygen is important for ensuring long storage stability, as well as the utility characteristics of the product. A part of cosmetic carrier emulsions are lipids and also emulsifiers containing lipid segments in their molecules, which makes them easily prone to chemical conversions induced by reaction with oxygen. Many natural substances contain non saturated bonds between carbon atoms which are susceptible to peroxidation. The change of chemical structure of components during the storage and use of cosmetic preparations usually leads to a decrease of dermal tolerance of these products , .and even to poor emulsion stability due to changed properties of the emulsifier and to changed polarity of the lipid components. For reducing the said interactions the current cosmetic preparations contain preferably at least one component with antioxidant or antiradical effect. According to the chemical structure and solubility in various phases of cosmetic carriers these substances can be hydrophilic or lipophilic. The choice of optimum antioxidant does not depend just upon the solubility in a certain carrier, but it is also affected by other properties, such as undesirable interactions with a carrier, stability in a final product during storage, skin penetration ability after a topical application of the preparation, possibly the production of cytotoxic or immunosuppressive products of a reaction with free radicals, with or without combined action with ultraviolet light. The use of lipophilic antioxidants in current cosmetic preparations is very popular. The reason is relatively good stability, high compatibility with emulsion systems and a good compatibility with non-emulsion ones, good skin tolerance and their ability to penetrate in deeper epidermal layers. The disadvantage is their sensitivity to oxygen leading, together with high penetrability, to a reduction of antioxidant concentration in the skin surface within a short time after the application, and even to a fast antioxidant exhaustion, such as under the combined effect with ultraviolet light. Then the skin surface has no protection against an attack of reactive compounds from the environment. Another disadvantage can reside in lower solubility within an environment supporting the creation of most hydrophilic reactive forms of hydrogen, and also the insufficiently investigated properties of products resulting from antioxidant reactions with radicals under the combined effect of ultraviolet light. Hydrophilic antioxidants have not been broadly used in current cosmetic preparations because of their low stability after treatment with liquid systems. The main favoured group uses various carrier forms and derivatives of ascorbic acid which can, however, interact with emulsion and gel systems and, moreover, they can cause changes of physical parameters of a final product during storage. A large group consists of antioxidants of phenolic character isolated from plant extracts, such as flavonoids, oligomeric proanthocyanides and their esters. However, these substances are intensively coloured and their use in commercially acceptable preparations is very limited. Their further disadvantage is their pro-oxidative effect in some biological systems, simile to the derivatives of ascorbic acid.. Sensitivity to oxygen and penetrability lead to time limited skin surface protection after topic application, the same as in lipophilic antioxidants. In the function of antioxidant cosmetic components also enzymes can be used, such as superoxide dismutase and catalyse, but this brings problems related to their stabilisation during the storage of final products. Current preparations for decorative, sunbathing, baby products, and daily cosmetics have preferably some ingredients that are not water soluble, such as inorganic compounds of transition metals playing decorative or UN-protective functions. A topical application of such preparation leads to an accumulation of inorganic pigments in the skin surface, possibly just in a few upper layers of strata cornea. According to literature the oxides and ions of transition metals tend to catalyse in water environment and, in the presence of oxidising substances or UV rays, they create free radicals. Thus a very reactive hydroxyl radical is generated that impacts numbers of biologically important compounds and structures, initiating the production of cytotoxic secondary products. Topic application of cosmetic preparations containing currently used antioxidants in combination with pigments based upon inorganic compounds of transition metals is therefore connected with a fast decrease of antioxidant concentration in the skin surface as a result of a reaction with air oxygen, with reactive forms of oxygen, .and also due to its ability to penetrate into deeper cell strata. In the contrary, the concentration of insoluble chemically stable pigment in the skin surface does not decrease and, accordingly, hydroxyl radicals are generated throughout the whole period during which the factors causing oxidative stress .are effective. The existing technology allows the formulation of preparations containing antioxid.ants which, however, do not protect sufficiently the upper epidermal layers if they are applied to the skin at the same time as pigments based upon compounds of transition metals. The choice of an optimum combination of antioxidants with sufficiently long retention in the skin surface is a key issue for solving the task. A direction of further possible development is illustrated by US patent No. 5 612 321 describing a polysaccharide whose main chain has a bond to at least one group with antioxidant effect. Here the polysaccharide is not specified as an antioxidant, but as a polysaccharide with a higher resistance against cleavage by a hydroxyl radical leading to the decrease of it's molecular weight, whereas the therapeutic or cosmetic properties are close to the non modified polysaccharide. Further it is known from literature that many pl.ant extracts contain groups of components with various chemical structures and antioxidant effect. The presence of low molecular antioxidant substances in the Tamarindus indica species .are described in US patents No. 6 294 190 and 5 762 936. Subject -matter of the invention The disadvantages of cosmetic preparations mentioned above containing antioxidant components, especially in a combination with pigments on the base of inorganic compounds of transition metals are eliminated to a great extent by the invention using a high molecular antioxidant produced by alkaline extraction of the coat of seeds of Tamarindus indica species. Literature describes low molecular, and even oligomeric substances extracted from tamarind seed coats by various organic solvents. Using an extraction method with a suitable solvent containing water as the main component with alkaline pH allows to reach an extraction of a complex with molecular weight from 3xl03 to 5xl05 g.mol"1, consisting of sub-molecular formations that are responsible for the anti-oxidant effect .and .are bonded with a polysaccharide of the xylane type. Components with molecular weight less than 3xl03 g.mol"1 are removed from the extracted complex by a suitable method. Using high molecular antioxidant isolated from the coats of tamarind seeds as a component for cosmetic preparations is beneficial in comparison with current antioxidants in use down to the present, because of it's longer retention in the skin surface. Since this antioxidant is soluble in the skin surface environment where also a hydroxyl radical is generated by the catalysis of transition metals ions, this invention offers the benefit of fast and durable deactivation of hydroxyl radicals, especially if applying preparations containing inorganic pigments. Also hydroxyl radicals being generated by interaction of ultraviolet light with the watery environment of the epidermis, the use of high molecular tamarind antioxidant is preferable also in all preparations used for the treatment of skin exposed to daylight. Its use is advantageous also for preparing a cosmetic carrier, since it does not disturb emulsion or gel structures created by emulsifiers or by gelling agents, respectively. In the presence of ions of transition metals it does not show any pro-oxidative impact, but it has a chelating effect upon these ions. Because its high molecular weight it penetrates the skin very slowly after its application, as compared with common antioxidants, the sub-molecular formations responsible for anti-oxidation effects being eliminated from the main chains of xylane type by the influence of the enzymatic system of the skin. For protecting all layers of the epidermis certain combinations of a high molecular antioxidant with lipophilic low molecular antioxidants are preferable. A cosmetic preparation according to the invention contains a high-molecular tamarind antioxidant produced by alkaline extraction of tamarind seeds coats, separately or in a combination with at least one hydrophilic or lipophilic antioxidant, a stable, cosmetically acceptable and dermatologically safe carrier. The preparation can preferably contain at least one hydration component and also pigments on the base of inorganic compounds of transition metals with decorative or UN-protective functions. A topical application of the preparation being envisaged for protecting the skin against ultraviolet light, the preparation can preferably contain at least one organic UV filter, at least one component with anti-inflammatory effect and a component with immunity-modulating effect. A cosmetic preparation according to the invention contains a high molecular tamarind antioxidant with molecular weight 3xl03 az 5xl05 g.mol"1 within the concentration range from 0,001 tov 5 % (dry matter) of the total weight of the preparation. This high molecular tamarind antioxidant is advantageously produced by alkaline extraction of seeds coats of Tamarindus indica' species) A cosmetic preparation according to the invention contains preferably at least one further hydrophilic or lipophilic antioxidant within the concentration range from 0,001 to 15 % of the total weight of the preparation and a stable, cosmetically acceptable and dermatologically safe carrier: '
Further hydrophilic or lipophilic antioxidants are advantageously selected from the group containing
- tocopherol (α, β, γ, δ isomers) and ita s esters of acids with general formulas H(CH2)n(CHR)COOH (I) a CH3(CH2)m CH=CH(CH2)n COOH (II), where R is hydrogen atom or OH group, m,n are integral numbers from 0 to 22 where m+n sum is maximally 22 in the concentration range from 0,005 to 15 % of the total weight of the preparation, more preferably from 0,01 to 1 % of the total weight of the preparation;
- ascorbic acid, it's esters with phosphoric acid and also sodium, potassium, lithium and magnesium salts, further ester with pyrrolidoncarboxylic acid and esters of acids with general formulas H(CH2)n(CHR)COOH (HI) a CH3(CH2)mCH=CH(CH2)nCOOH (IV), where R is a hydrogen atom or OH group, m,n are integral numbers from 0 to 20, whereas the m+n sum is not more th.an 21 in the concentration range from 0,005 to 5 % of the total weight of the preparation, more preferably from 0,1 to 1 % of the total weight of the preparation;
- α-carotene, β-carotene, γ-carotene, δ-carotene, lutein, xantophyll, zeaxanthine, violaxanthine, cryptoxanthine, fukoxanthine, antheraxanthine, lycopene, didehydrolycopene and tetradehydrolycopene carotenoides in the concentration range from 0,001 to 5 % of the total weight of the preparation, more preferably from 0,01 to 0,1 % of the total weight of the preparation or superoxide dismutase, catalyse, ubiquinone-50 (coenzyme Q10), in the concentration range from 0,001 to 2 % of the total weight of the preparation, more preferably from 0,01 to 0,1 % of the total weight of the preparation.
In another embodiment of the invention the preparation further contains at least one hydration component from the group comprising
- hyaluronic acid with molecular weight from 5x10 to 1x10 g.mol" or salts thereof with alkali metals and or alkaline-earth metals in the concentration range from 5xl0"4 to 1,5 %, more preferably from 0,005 to 0,1 % of the total weight of the preparation.
- hyaluronic acid with molecular weight from 280 g.mol"1 to 5xl03 g.mol"1 or salts thereof with alkali metals and or alkaline-earth metals in the concentration range from 5xl0"4 to 5 %, more preferably from 0,01 to 0,5 % of the total weight of the preparation.
- panthenol, glycerine, urea, pyrrolidoncarboxylic acid and alkali salts thereof, milk acid and alkali salts thereof, niacinamide and trehalose in the concentration range from 0,05 to 10 %, more preferably from 0,01 to 4 % of the total weight of the preparation.
In another embodiment of the invention the preparation further contains at least one of the pigments on the base of inorganic compounds of alkaline-earth metals from the group comprising
- titanic oxide, zinc oxide, ferric oxide, ferrous-ferric oxide and their crystalline modifications, in the concentration range from 0,001 to 15%, more preferably from 0,01 to 3% of the total weight of the preparation.
- micronised forms of titanic oxide, zinc oxide, ferric oxide, ferrous-ferric oxide and their crystalline modifications, in the concentration range from 0,001 to 15%, more preferably from 0,01 to 3% of the total weight of the preparation. - encapsulated forms of zinc oxide, ferric oxide, ferrous-ferric oxide and their crystalline modifications, in the concentration range from 0,01 to 25%, more preferably from 0,1 to 10% of the total weight of the preparation.
- modified forms of zinc oxide, ferric oxide, ferrous-ferric oxide and their crystalline modifications, which means either organic or inorganic treatment of vehicles surface in the concentration range from 0,001 to 15%, more preferably from 0,01 to 3% of the total weight of the preparation.
According to another preferable embodiment of the invention the preparation further contains at least one organic UV filter from the group comprising 4-aminobenzoic acid, ethoxylated ethyl-4-aminobenzoate, 2-ethylhexyl-4-dimethyl.aminobenzoate, homomenthyl salicylate, 2-ethylhexyl salicylate, isopentyl-4-methoxycinnamate, 2-ethylhexyl-4-methoxycinn.amate, 2- -ethylhexyl-2-cyano-3,3-diphenylacrylate, oxybenzon, 2-hydroxy-4-methoxybenzofenone-5- -sulfonic acid and salts thereof, 2-phenylbenzimidazole-5-sulfonic acid .and salts thereof, N,N,N- -trimethyl-4-(2-oxoborn-3-ylidenmethyl) anilineium methyl sulfate, alpha-(2-oxoborn-3-yliden) -toluen-4-sulfonic acid and salts thereof, 3-(4'-methylbenzyliden)-d-l-camphor, 3- -benzylidencamphor, 1 -(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane- 1 ,3-dione, 2,4,6- -trianiline-(p-carbo-2'-ethylhexyl-r-oxo)-l,3,5-triazin,3,3'-(l,4-phenylenedimethylene)-bis(7,7- -dimethyl-2-oxo-bicyclo-[2.2.1]-hept-l-ylmethanesulfonic) acid and salts thereof, polymeric N- -{(2 and 4)-[(2-oxoborn-3-ylidene) methyl] benzyl} acrylamide, menthyl anthranilate, 2-(2H- -benzotri£izole-2-yl)-methyl-6-(2-methyl-3-(l ,3,3,3-tetramethyl- 1 -(trimethylsilyl)- -disyloxanyle)propyl)phenol, 4,4'-[[6-[[4-
-[[(1. l-dimethylethyl)amino]carbonyl]phenyl]amino] 1 ,2,3-triaxin-2,4-diyl]dimono]bis- bis-(ethylhexyl)benzoate, benzyliden malonate polysiloxan, 2,2'-methylene-bis-(6-(2H- -benzotriazole-2-yl)-4-(l ,1 ,3,3-tetramethylbutyl)phenol, 2,2'-(l ,4-phenylen)bis-lH-
-benzimidazol-4,6-disulfonic acid (monosodium salt) and 2,4-bis{[4-(2-ethylhexyloxy)-2- -hydroxy]-phenyl}-6-(4-methoxyphenyl)-l,3,5)-triazine in the concentration range from 0,05 to 20 %, more preferably from 0,2 to 10 % of the total weight of the preparation.
Another preferable embodiment of the invention is a preparation which further comprises at least one component with anti-inflammatory effect from a group containing
- α-bisabolol, alantoin, lyophilized extract of aloe vera, panthenol, betulin, sodium glycyrrhizinate, potassium glycyrrhizinate, ammonium glycyrrhizinate in the concentration range from 0,005 to 5 %, more preferably from 0,01 to 2 % of the total weight of the preparation; botulinic acid, alkaline salts thereof and salts of alkaline-earth metals, boswellic acid, alkaline salts thereof and salts of alkaline-earth metals, rosemaric acid, alkaline salts thereof and salts of alkaline-earth metals in the concentration range from 0,005 to 5 %, more preferably from 0,01 to 1 % of the total weight of the preparation; polynonsaturated fat acids, as linoleic (18:2n6), α-linolenic (18:3n3), γ-linolenic (18:3n6), octadekanetetraenic (18:4n3), dihomo-γ-linolenic (20:3n6), eikos.antetraenic (20:4n3), arachidonic (20:4n6), eikosanpentaenic (20:5n3) acids and esters thereof with alcohols of the general formula
R,(CH2)m-(CHOH)-(CH2)nR2 (V), where Ri a R2 are hydrogen atoms or OH group, m,n are integral numbers from 0 to 17, the sum of m+n does not exceed 21 in the concentration range from 0,01 to 25 %, more preferably from 0,1 to 5 % of the total weight of the preparation;
phyto sterols and their polyethoxylates derivatives of the general formulas VI and VII below, where R is isoalkyl or isoalkenyl group with 8-10 carbon atoms, where n is integral number from 0 to 50, especially campesterol, β-sitosterol, stigmasterol, cholesterol, Δ-5- -avenasterol, Δ-7-avenasterol, brassicasterol, spinasterol and fukosterol in the concentration range from 0,01 to 20 %, more preferably from 0,5 to 5 % of the total weight of the preparation;
Figure imgf000009_0001
(VI) (VH) Another preferable embodiment of the invention is a preparation further containing at least one component with immunity-modulating effect from the group consisting of ■j 7 1
- carboxymethylglucane with molecular weight from 5x10 to 1x10 g.mol" in salt forms of alkaline metals and alkaline-earth metals in the concentration range from 0,0005 to 5 %, more preferably from 0,01 to 0,3 % of the total weight of the preparation;
- schizophyllane with molecular weight from 5x10 to 1x10 g.mol" in the concentration range from 0,0005 to 5 %, more preferably from 0,005 to 0,3 % of the total weight of the preparation;
- xyloglucanes with molecular weight from 5x10 to 5x10 g.mol" in the concentration range from 0,0005 do 5 %, more preferably from 0,005 to 0,2 % of the total weight of the preparation; or
- glucomannane with molecular weight from 5xl03 to 2xl05 g.mol"1 ' in the concentration range from 0,001 to 5%, more preferably 0,01 to 0,3 %, of the total weight of the preparation. A preferable preparation according to the invention has the form of cosmetic face creme of the type of oil in water or water in oil with low or medium viscosity, hydrophylic or lipophilic gel, one phase solution or a preparation for aerosol application, and preferably further in the form of a solid emulsion peg or a solid preparation produced by moulding the starting components. The high-molecular antioxidant of the invention used in cosmetic preparations is a polysaccharide produced by alkaline extraction of seed coats of Tamarindus indica species. The coats are separated from seeds before the extraction, they are left to swell up and then the extraction is carried out in a suitable solvent, main part of which is water of alkaline pH. During the technological operations consisting of extract purification, stabilization, pH adjustment and drying, a complex is isolated having molecular weight from 3xl03 to 5x105 g.mol"1 and being created by sub-molecular aggregates that are bonded to a polysaccharide of a xylane type and are responsible for the antioxidant effect. Hyaluronic acid of the invention is a polysaccharide of the general formula (β-D- -glucuronic acid-[l 3]-β-N-acetyl-D-glucosamine-[l 4])n, where n is an integral number from 1 to 8 000. Carboxymethylglucane of the invention is a polysaccharide produced by partial carboxymethylation β-(l 3),(1 6) of glucane. The linear chain of this slightly branched polysaccharide is created by a β-D-glucopyranosyle unit connected by (1 3) bond. Mono- saccharide side chains are connected with the linear chain by (1 6) bond and are created by β- -D-glucopyranosyle unit. The molecular weight of the carboxymethylglucane can be in the range of 5xl03 to lxlO7 g.mol"1. As schizophyllane for the purpose of the invention a polysacharide is understood that is isolated from the medium after cultivation of Schizophyllum commune. The linear chain of this slightly branched polysaccharide is created by β-D-glucopyranosyle units connected by (1 3) bond. The monosaccharide side chains are connected with the linear chain by (1 6) bond and are created by β-D-glucopyranosyle unit. This primary polysaccharide allows to prepare schizophyllane with lower molecular weight by bond cleavage inside the linear chain under given reaction condition. The factor leading to fragmentation can be higher temperature, hydrolysis in acid, neutral or alkaline environment, oxidative digestion with following reduction by radiation treatment, ultra-sound or enzyme digesting (1 3)-β-glycosidic bond. Molecular weight of schizophyllane can be in the range of 5x103 to lxlO7 g.mol"1. Xyloglucane of the invention can be a polysaccharide isolated from Tamarindus indica seeds. The linear chain of this slightly branched polysaccharide is created by β-D- -glucopyranosyle unit connected by (1 4) bond. One and disaccharide side chains are connected to this linear chain by (1 6) bond. The molecular weight of xyloglucane can be in the range of 5x103 to lxl 06 g.mol'1. Glucomannan of the invention is a polysaccharide isolated from cell weight of Candida utilis or from the medium for its cultivation. The main chain of this slightly branched polysaccharide is created by α-D-mannopyranosyle units connected by (1 6) bond. The short side mannooligosaccharide chains (1-5 units) are connected to the linear chain by (1 2)-α- -glycosidic bond, units are connected with each other by (1 2)-α-and occasionally by (1 3)-α- -glycosidic bond. Some side chains are finished by nonreducting α-D-glucopyranosyl unit connected by (1 2) bond. The molecular weight of the glucomannane can be in the range of 5xl03 to 2xl05 g.mol"1. The cosmetic preparation according to the invention is currently applicable as a preparation of decorative, sunbathing, baby and daily cosmetics for the treatment of the whole body, or for the treatment of the skin of the face, neck, low neck, hands and feet. Examples of the invention
Example 1 Hot melted mix of of 2g of ethoxylated (2 EO) stearylalcohol, 3 g of ethoxylated (21 EO) stearylalcohol, 3 g of cetylalcohol, 0,5 g of polydimethylsiloxane, 2 g of isopropylpalmitate, 3 g of cyclopentasiloxane, 0,1 g of α-bisabolol, 1 g of tocoferylacetate, 2 g of stearine, 3 g of hydrogenated polyisobutene, 2,5 g dioctylcarbonate and 2 g of micronizated titanic oxide were added to water phase of 0,5 g of panthenole and 2 g of glycerine were dissolved in 62,35 g of water. To this emulsion 0,5 g of solution of methyl-, butyl,- ethyl and propylparabene and 0,2 g of perfume was added. Finally, a mixed solution of 0,18 g of lyophilizated extract of aloe vera,
0,1 g of schizophyllane, 0,02 g of sodium hyaluronate of molecular weight l,3xl06 g.mol"1 and
0,05 g of high molecular tamarind antioxidant in 10 g of water was added.. The product can be used as creamy cosmetic preparation for daily use without organic UV filters.
Example 2 0,2 g of allantoin, 0,5 g panthenol and dispergated 0,3 g carboxyvinyl polymer were dissolved in 52,85 g of water. Hot melted mix of 2 g of PVP/eikosen copolymer, 2 g of ethoxylated (21 EO) stearylalcohol, 1 g of cetylalcohol, 2 g of glycerylmonostearate, 6 g of octylmethoxycinnamate, 2,5 g of butylmethoxy dibenzoylmethane, 5 g of izopropyl izostearate,
5 g of izostearyl izostearate, 0,5 g of polydimethyl siloxane, 0,5 g of tocoferyl acetate, 0,02 g of ascorbyl palmitate, 0,1 g of bisabolole .and 3 g of micronizated titanic oxide were emulgated with the water phase. 5 g of 40% solution of phenyl benzimid azolsulfate acid ammonium salt, 0,5 g of solution of methyl-, butyl,- ethyl and propyl parabene in fenoxyethanole and 0,2 g of perfume were added to the emulsion and finally a solution of 0,13 g xyloglucane, 0,2 g of schizophyllane and 0,1 g of a high molecular tamarind antioxidant in 10 g of water was added. The product can be used as a cosmetic preparation for sunbathing protection.
Example 3 Hot melted mix of 3 g of ethoxylated (4 EO) tricetylstearylphosphate, 2 g of cetylalcohol,
3 g of isopropylmyristate, 4g of isostearylisostearate, 1 g of stearine, 0,2 g of g α-bisabolole, 1 g of tocoferylacetate, 0,02 g tocopherole, 0,5 g caroten oil and 4 g of paraffine oil was emulgated with the water phase of 7 g of trehalose dihydrate, 2 g of glycerine, 0,2 g of allantoin, 0,5 g of panthenol dissolved in 59,85 g of water and dispergated in 0,2 g of carboxyvinylated polymer. 0,5 g of solution of methyl-, butyl,- ethyl and propyl parabene in fenoxy ethanol and 0,2 g of perfume were added to the emulsion. Finally a mixed solution of 0,2 g of lyophilizated extract of aloe vera, 0,18 g of carboxymethyl-β- (l-3)-gluc. ne, 0,4 g of superoxide dismutase (activity 45000-55000 PlU/ml) and 0,5 g of high molecular tamarind antioxidant in 10 g of water were added. The product can be used as a cosmetic preparation for treating the skin after a sunbath.
Example 4 Hot melted mix of of 2g of ethoxylated (2 EO) stearyl alcohol, 3 g of ethoxylated (21 EO) stearyl alcohol, 3 g of izostearyl izostearate, 2 g of stearine, 0,5 g of tocoferyl acetate, 3 g of hydrogenated polyisobutene were added to 0,5 g of panthenole, 0,1 g of sodium pyrrolidon carboxylate and 2 g of glycerine dissolved in 65,65 g of water. This emulsion was further enriched by 0,5 g of solution of methyl-, butyl,- ethyl and propyl parabene in fenoxyethanol and 0,2 g of perfume. Finally the solution of 0,2 g of glucomannane, 0,5 g of schizophyllane, 0,02 g of sodium hyaluronate with molecular weight l,3xl06 g.mol"1 , 0,03 g of sodium hyaluronate with molecular weight 2xl05 g.mol"1 and 0,05 g of high molecular tamarind antioxidant in 10 g of water were added. The product can be used as a cosmetic preparation for current treatment as a body milk. Described examples of embodiment serve for illustration only, without limiting or exhausting possible options within the scope of the invention.

Claims

C L A I M S
1. Cosmetic preparation characterized in that it contains a high molecular tamarind antioxidant with molecular weight from 3xl03 to 5xl05 g.mol"1 in the concentration range from 0,001 to 5% of dry matter of the total weight of the preparation.
2. Cosmetic preparation of claim 1 characterized in that the high molecular tamarind antioxidant is produced by alkaline extraction of Tamarindus indica species seeds coats.
3. Cosmetic preparation of claims 1 and 2 characterized in that it further contains at least one other hydrophilic or lipophilic antioxidant in the concentration range from 0,001 to 15% of dry matter of the total weight of the preparation.
4. Cosmetic preparation of claim 3 characterized in that the further hydrophilic or lipophilic antioxidant is from the group containing
- tocopherol (α, β, γ, δ isomers) and it's esters of acids of general formulas I and II H(CH2)n(CHR)COOH (I) a CH3(CH2)m CH=CH(CH2)n COOH (II), where R is hydrogen atom or OH group, m,n are integral numbers from 0 to 22 where the sum of m+n is not more than 22 in the concentration range from 0,005 to 15 % of the total weight of the preparation;
- ascorbic acid, its esters with phosphoric acid and also sodium, potassium, lithium and magnesium salts, further ester with pyrrolidon carboxylic acid and esters of acids of general formulas III and IV H(CH2)n(CHR)COOH (HI) a CH3(CH2)mCH=CH(CH2)nCOOH (IV),
where R is hydrogen atom or OH group, m,n are integral numbers from 0 to 20 where the sum of m+n sum is not more than 21 in the concentration range from 0,005 to 5 % of the total weight of the preparation; - α-carotene, β-carotene, γ-carotene, δ-carotene, lutein, xantophyll, zeaxanthine, violaxanthine, cryptoxanthine, fukoxanthine, antheraxanthine, lycopene, didehydrolycopene, tetradehydro lycopene caroteneoids in the concentration range from 0,001 to 5 % of the total weight of the preparation or superoxidedismutase, catalyse, ubichinon-50 (coenzyme Q10), in the concentration range from 0,001 to 2 % of the total weight of the preparation.
5. Cosmetic preparation according to claim 4 characterised in that the concentration range of tocopherol and its esters is from 0,01 to 1 % of the total weight of the preparation, concentration range of ascorbic acid and its derivatives is from 0,1 to 1 % of the total weight of the preparation, concentration range of carotenoids is from 0,01 to 1 % of the total weight of the preparation and the concentration range of superoxide dismutase, catalyse, ubiquinone-50 (coenzyme Q10) is from 0^01 to 0,1 % of the total weight of the preparation.
6. Cosmetic preparation according to any of claims 1 to 5 characterised in that it further contains at least one hydrating substance from the group comprising
- hyaluronic acid with molecular weight from 5xl03 to lxlO7 g.mol"1 or salts thereof with alkali metals and or alkaline-earth metals in the concentration range from 5xl0"4 to 1,5 % of the total weight of the preparation;
- hyaluronic acid with molecular weight from 280 g.mol"1 to 5xl03 g.mol"1 or salts thereof with alkali metals and or alkaline-earth metals in the concentration range from 5X10"4 to 5 % of the total weight of the preparation; or
- panthenol, glycerine, urea, pyrrolidon carboxylic acid and salts thereof with alkali metals, milk acid and salts thereof with alkali metals, niacinamide and trehalose in the concentration range from 0,05 to 10 % of the total weight of the preparation.
7. Cosmetic preparation according to claim 6 characterised in that the concentration range of hyaluronic acid with molecular weight 5xl03 to lxlO7 g.mol"1 and salts thereof with alkali metals and alkali-earth metals is in the range from 0,005 to 0,1 % of the total weight of the preparation, the concentration range of hyaluronic acid with molecular weight from 280 g.mol"1 to 5x10 g.mol' and salts thereof with alkali metals and alkali-earth metals is in the range from 0,01 to 0,5 % of the total weight of the preparation, the concentration range of panthenol, glycerine, urea, pyrrolidon, carboxyl acid and alkali salts thereof, milk acid and alkali salts thereof, niacinamide and trehalose is in the range from 0,01 to 4 % of the total weight of the preparation.
8. Cosmetic preparation according to any of claims 1 to 7 characterised in that it further contains at least one pigment on the base of inorganic compounds of alkali-earth metals that is selected from the group comprising
- titanic oxide, zinc oxide, ferric oxide, ferrous-ferric oxide and their crystalline modifications, in the concentration range from 0,001 to 15% of the total weight of the preparation.
- micronised forms of zinc oxide, ferric oxide, ferrous-ferric oxide and their crystalline modifications, in the concentration range from 0,001 to 15% of the total weight of the preparation.
- encapsulated forms of zinc oxide, ferric oxide, ferrous-ferric oxide and their crystalline modifications, in the concentration range from 0,01 to 25% of the total weight of the preparation; or
- modified forms of zinc oxide, ferric oxide, ferrous-ferric oxide and their crystalline modifications, which means either organic or inorganic treatment of particle surface in the concentration range from 0,001 to 15% of the total weight of the preparation.
9. Cosmetic preparation according to claim 8 characterised in that the concentration range of titanic oxide, zinc oxide, ferric oxide, ferrous-ferric oxide and their crystalline modifications is from 0,01 to 3% of the total weight of the preparation, the concentration range of micronised forms of titanic oxide, zinc oxide, ferric oxide, ferrous-ferric oxide and their crystalline modifications is from 0,01 to 3% of the total weight of the preparation, concentration range of encapsulated forms of oxide titanic oxide, zinc oxide, ferric oxide, ferrous-ferric oxide and their crystalline modifications is from 0,1 to 10% of the total weight of the preparation, concentration range of modified forms of titanic oxide, zinc oxide, ferric oxide, ferrous-ferric oxide and their crystalline modifications residing in organic or inorganic treatment of surface particles is from 0,01 to 3% of the total weight of the preparation.
10. Cosmetic preparation according to any of claims 1 to 9 characterised in that it further contains at least one of the organic UV filters from the group comprising 4-aminobenzoic acid, ethoxylated ethyl-4-aminobenzoate, 2-ethylhexyl-4-dimethylaminobenzoate, homomenthyl salicylate, 2-ethylhexyl salicylate, isopentyl-4-methoxycinnamate, 2-ethylhexyl- 4-methoxycinnamate, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, oxybenzone, 2-hydroxy-4- -methoxybenzofenone-5-sulfonic acid and salts thereof, 2-phenylbenzimidazole-5-sulfonic acid and salts thereof, N,N,N-trimethyl-4-(2-oxoborn-3-ylidenmethyl) anilineium methyl sulfate, alpha-(2-oxoborn-3-yliden) toluen-4-sulfonic acid and salts thereof, 3-(4'-methylbenzyliden)-d-l- -camphor, 3-benzylidencamphor, l-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-l ,3-dione, 2,4,6-trianiline-(p-carbo-2'-ethylhexyl-r-oxo)-l,3,5-triazin,3,3'-(l,4-phenylenedimethylene)- -bis(7,7-dimethyl-2-oxo-bicyclo-[2.2.1]-hept-l-ylmethanesulfonic) acid and salts thereof, polymeric N-{(2 and 4)-[(2-oxoborn-3-ylidene) methyl] benzyl} acrylamide, menthyl anthranilate, 2-(2H-benzotriazole-2-yl)-methyl-6-(2-methyl-3-(l ,3,3,3-tetramethyl- 1 -
-(trimethylsilyl)-disyloxanyle)propyl)phenol, 4,4'-[[6-[[4-[[(l .1-dimethylethyl) amino]carbonyl] phenyl] amino]l,2,3-triaxin-2,4-diyl]dimono]bis-bis-(ethylhexyl)benzoate, benzyliden malonate polysiloxan, 2,2'-methylene-bis-(6-(2H-benzotriazole-2-yl)-4-(l,l,3,3-tetramethylbutyl)phenol, 2,2'-(l,4-phenylen)bis-lH-benzimidazol-4,6-disulfonic acid (monosodium salt) and 2,4-bis{[4- -(2-ethylhexyloxy)-2-hydroxy]-phenyl} -6-(4-methoxyphenyl)-l ,3,5)-triazine in the concentration range from 0,05 to 20 % of the total weight of the preparation.
11. Cosmetic preparation according to claim 10 characterised in that the concentration range
Of each applied organic filter of claim 8 is from 0,2 to 10% of the total weight of the preparation.
12. Cosmetic preparation according to claim 10 characterised in that it further contains at least one component with anti-inflammatory effect from the group consisting of
- α-bisabolole, allantoine, lyophilized extract of aloe vera, panthenol, betuline, sodium glycyrrhizinate, potassium and ammonium glycyrrhizinate in the concentration range from 0,005 to 5 % of the total weight of the preparation;
- betulinic acid, alkaline salts thereof and salts of alkaline-earth metals, boswellic acid, boswellic acid, alkaline salts thereof and salts of alkaline-earth metals, rosemaric acid, alkaline salts thereof and salts of alkaline-earth metals in the concentration range from 0,005 to 5 % of the total weight of the preparation;
- polynonsaturated fat acids, as linoleic (18:2n6), α-linolenic (18:3n3), γ-linolenic (18:3n6), octadekanetetraenic (18:4n3), dihomo-γ-linolenic (20:3n6), eikosantetraenic (20:4n3), arachidonic (20:4n6), eikosanpentaenic (20:5n3) acids and esters therof with alcohols of the general formula R,(CH2)m-(CHOH)-(CH2)nR2 (V), where Ri a R2 are hydrogen atoms or OH group, m,n are integral numbers from 0 to 17, the sum of m+n does not exceed 21 in the concentration range from 0,01 to 25 % of the total weight of the preparation; or phytosterols and their polyethoxylated derivatives of the general formulas VI and VII
Figure imgf000018_0001
(Ni), (VII),
where R is isoalkyl or isoalkenyl group with 8-10 carbon atoms, where n is an integral number from 0 to 50, especially campesterol, β-sitosterol, stigmasterol, cholesterol, Δ-
-5-avenasterol, Δ-7-avenasterol, brassicasterol, spinasterol and fucosterol in the concentration range from 0,01 to 20 % of the total weight of the preparation.
13. Cosmetic preparation according to claim 12 characterised in that the concentration range of α-bisabolole, allantoine, lyophilized extract of aloe vera, panthenole, betuline, sodium glycyrrhizinate, potassium and ammonium glycyrrhizinates in the concentration range from 0,01 to 2 % of the total weight of the preparation, the concentration range of betulinic acid, alkaline salts thereof and salts of alkaline-earth metals, boswellic acid and alkaline salts thereof and salts of alkaline-earth metals, rosemaric acid, alkaline salts thereof and salts of alkaline-earth metals, in the concentration range from 0,01 to 1 % of the total weight of the preparation; the concentration range of polynonsaturated fat acids, as linoleic (18:2n6), α-linolenic (18:3n3), γ- -linolenic (18:3n6), octadekanetetraenic (18:4n3), dihomo-γ-linolenic (20:3n6), eikosantetraenic (20:4n3), arachidonic (20:4n6), eikosanpentaenic (20:5n3) acids and esters thereof with alcohols of the general formula V Rι(CH2)m-(CHOH)-(CH2)nR2 (V), is from 0,1 to 5% of the total weight of the preparation and the concentration range of phytosterols and their polyethoxylated derivatives of the general formulas VI and VII defined in claim 12, as campesterol, β-sitosterol, stigmasterol, cholesterol, Δ-5-avenasterol, Δ-7- -avenasterol, brassicasterol, spinasterol and fucosterol in the concentration range from 0,5 to 5 % of the total weight of the preparation.
14. Cosmetic preparation according to any of claims 1 to 13 characterised in that it further contains at least one component with immunity-modulating effect from the group consisting of carboxymethyl glucane with molecuhr weight from 5xl03 to lxl 07 g.mol'1 in salt forms of alkaline metals and alkaline-earth metals in the concentration range from 0,0005 to 5 % of the total weight of the preparation; • ^ 7 1 schizophyllane with molecular weight from 5x10 to 1x10 g.mol" in the concentration range from 0,0005 to 5 % of the total weight of the preparation; or
- xyloglucane s with molecular weight from 5xl03 to 5xl06 g.mol"1 in the concentration range from 0,0005 do 5 % of the total weight of the preparation; or gglluukkoommaannnnaannee wwiitthh mmoolleeccuullaarr wweeiigghhtt frfroomm 55xx1100 ttoo 22xx1100 g.mol" in the concentration range from 0,001 to 5 % of the total weight of the preparation.
15. Cosmetic preparation according to claim 14 characterised in that the concentration range of carboxymethylglucane with molecular weight 5xl03 aέ lxlO7 g.mol"1 in salt forms of alkaline metals and alkaline-earth metals is from 0,01 to 0,3 % of the total weight of the preparation, the 7 1 concentration range of schizophillane with molecular weight 5x10 az 1x10 g.mol" is from 0,005 to 0,3 % of the total weight of the preparation, the concentration range of xyloglucane with molecular weight 5xl03 az 5xl06 g.mol"1 is from 0,005 to 0,2 % of the total weight of the preparation and the concentration range of glucomannane with molecular weight 5x10 az 2x10 g.mol"1 is from 0,01 to 0,3 % of the total weight of the preparation.
16. Cosmetic preparation according to any of claims 1 to 15 characterized in that it contains a stable, cosmetically acceptable and dermatologically safe carrier.
17. Cosmetic preparation according to any of claims 1 to 16 characterised in that it is in a form of cosmetic creme of oil in water or water in oil type from medium to high viscosity.
18. Cosmetic preparation according to any of claims 1 to 16 characterised in that it is in a form of cosmetic milk of oil in water or water in oil type from low to medium viscosity.
19. Cosmetic preparation according to any of claims 1 to 16 characterised in that it is in the form of hydrophilic or lipophilic gel, one phase solution or a preparation for aerosol application.
20. Cosmetic preparation according to any of claims 1 to 16 characterised in that it is in the form of a solid emulsion peg or a solid preparation produced by compacting all components.
PCT/CZ2004/000063 2003-10-08 2004-10-08 Cosmetic preparation containing high molecular antioxidant component WO2005032504A1 (en)

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CZPUV14681-03 2003-10-08

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006077433A1 (en) * 2005-01-21 2006-07-27 Promar As Sunscreen compositions comprising carotenoids
EP1834630A1 (en) * 2006-03-01 2007-09-19 Beiersdorf AG Cosmetic or dermatological preparations containing glycyrrhetin and/or glycyrrhizin and 2.4-Bis-{[4-(2-ethyl-hexyloxy)-)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazin
US8518949B2 (en) 2005-03-03 2013-08-27 Alfa Wassermann S.P.A. Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations
EP2008643A4 (en) * 2006-03-10 2015-07-29 Nisshin Oillio Group Ltd Gel composition and pack cosmetic using the same
RU2562580C2 (en) * 2010-05-24 2015-09-10 Индена С.П.А. Seed polysaccharide applicable in treating inflammatory diseases
WO2017129838A1 (en) * 2016-01-29 2017-08-03 Rnb, S.L. Composition for solar protection and repairing of the skin by means of protective complexes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0815857A1 (en) * 1995-12-26 1998-01-07 Suntory Limited Antiobestic agent containing procyanidin as the active ingredient
US5762936A (en) * 1996-09-04 1998-06-09 Biotics Research Corporation Antioxidant derived from lentil and its preparation and uses
JPH1112155A (en) * 1997-06-18 1999-01-19 Shiseido Co Ltd Cosmetic

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0815857A1 (en) * 1995-12-26 1998-01-07 Suntory Limited Antiobestic agent containing procyanidin as the active ingredient
US6294190B1 (en) * 1995-12-26 2001-09-25 Suntory Limited Antiobestic agent containing procyanidin as the active ingredient
US5762936A (en) * 1996-09-04 1998-06-09 Biotics Research Corporation Antioxidant derived from lentil and its preparation and uses
JPH1112155A (en) * 1997-06-18 1999-01-19 Shiseido Co Ltd Cosmetic

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 04 30 April 1999 (1999-04-30) *
TAKANORI TSUDA ET AL: "ANTIOXIDATIVE COMPONENTS ISOLATED FROM THE SEED OF TAMARIND (TAMARINDUS INDICA L.)", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, no. 12, 1 December 1994 (1994-12-01), pages 2671 - 2674, XP000480151, ISSN: 0021-8561 *
TSUDA T ET AL: "SUPERCRITICAL CARBON DIOXIDE EXTRACTION OF ANTIOXIDATIVE COMPONENTSFROM TAMARIND (TAMARINDUS INDICA L.) SEED COAT", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 43, no. 11, 1 November 1995 (1995-11-01), pages 2803 - 2806, XP000537900, ISSN: 0021-8561 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006077433A1 (en) * 2005-01-21 2006-07-27 Promar As Sunscreen compositions comprising carotenoids
US8834855B2 (en) 2005-01-21 2014-09-16 Promar As Sunscreen compositions comprising carotenoids
US8518949B2 (en) 2005-03-03 2013-08-27 Alfa Wassermann S.P.A. Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations
EP1834630A1 (en) * 2006-03-01 2007-09-19 Beiersdorf AG Cosmetic or dermatological preparations containing glycyrrhetin and/or glycyrrhizin and 2.4-Bis-{[4-(2-ethyl-hexyloxy)-)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazin
EP2008643A4 (en) * 2006-03-10 2015-07-29 Nisshin Oillio Group Ltd Gel composition and pack cosmetic using the same
RU2562580C2 (en) * 2010-05-24 2015-09-10 Индена С.П.А. Seed polysaccharide applicable in treating inflammatory diseases
WO2017129838A1 (en) * 2016-01-29 2017-08-03 Rnb, S.L. Composition for solar protection and repairing of the skin by means of protective complexes

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