WO2005013951A3 - Compositions pharmaceutiques et methodes permettant de prevenir le cancer du sein et de l'ovaire - Google Patents
Compositions pharmaceutiques et methodes permettant de prevenir le cancer du sein et de l'ovaire Download PDFInfo
- Publication number
- WO2005013951A3 WO2005013951A3 PCT/PL2004/000063 PL2004000063W WO2005013951A3 WO 2005013951 A3 WO2005013951 A3 WO 2005013951A3 PL 2004000063 W PL2004000063 W PL 2004000063W WO 2005013951 A3 WO2005013951 A3 WO 2005013951A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pharmaceutical compositions
- ovarian cancer
- preventing breast
- selenium
- breast
- Prior art date
Links
- 206010006187 Breast cancer Diseases 0.000 title abstract 2
- 208000026310 Breast neoplasm Diseases 0.000 title abstract 2
- 206010061535 Ovarian neoplasm Diseases 0.000 title abstract 2
- 210000000481 breast Anatomy 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 206010033128 Ovarian cancer Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229910052711 selenium Inorganic materials 0.000 abstract 2
- 239000011669 selenium Substances 0.000 abstract 2
- FDKWRPBBCBCIGA-REOHCLBHSA-N (2r)-2-azaniumyl-3-$l^{1}-selanylpropanoate Chemical compound [Se]C[C@H](N)C(O)=O FDKWRPBBCBCIGA-REOHCLBHSA-N 0.000 abstract 1
- 102000036365 BRCA1 Human genes 0.000 abstract 1
- 108700020463 BRCA1 Proteins 0.000 abstract 1
- 101150072950 BRCA1 gene Proteins 0.000 abstract 1
- FDKWRPBBCBCIGA-UWTATZPHSA-N D-Selenocysteine Natural products [Se]C[C@@H](N)C(O)=O FDKWRPBBCBCIGA-UWTATZPHSA-N 0.000 abstract 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 abstract 1
- RJFAYQIBOAGBLC-BYPYZUCNSA-N Selenium-L-methionine Chemical compound C[Se]CC[C@H](N)C(O)=O RJFAYQIBOAGBLC-BYPYZUCNSA-N 0.000 abstract 1
- RJFAYQIBOAGBLC-UHFFFAOYSA-N Selenomethionine Natural products C[Se]CCC(N)C(O)=O RJFAYQIBOAGBLC-UHFFFAOYSA-N 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- UEQANLFPOFICBH-UHFFFAOYSA-N methylseleninic acid Chemical compound C[Se](O)=O UEQANLFPOFICBH-UHFFFAOYSA-N 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- QYHFIVBSNOWOCQ-UHFFFAOYSA-N selenic acid Chemical compound O[Se](O)(=O)=O QYHFIVBSNOWOCQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003748 selenium group Chemical group *[Se]* 0.000 abstract 1
- ZKZBPNGNEQAJSX-UHFFFAOYSA-N selenocysteine Natural products [SeH]CC(N)C(O)=O ZKZBPNGNEQAJSX-UHFFFAOYSA-N 0.000 abstract 1
- 229940055619 selenocysteine Drugs 0.000 abstract 1
- 235000016491 selenocysteine Nutrition 0.000 abstract 1
- 229960002718 selenomethionine Drugs 0.000 abstract 1
- -1 selenomethylcysteine Chemical compound 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA200600386A EA200600386A1 (ru) | 2003-08-11 | 2004-08-10 | Фармацевтические композиции и способы предотвращения рака молочной железы и яичников |
EP04775169A EP1660060A2 (fr) | 2003-08-11 | 2004-08-10 | Compositions pharmaceutiques et methodes permettant de prevenir le cancer du sein et de l'ovaire |
CA002535506A CA2535506A1 (fr) | 2003-08-11 | 2004-08-10 | Compositions pharmaceutiques et methodes permettant de prevenir le cancer du sein et de l'ovaire |
AU2004263070A AU2004263070A1 (en) | 2003-08-11 | 2004-08-10 | Pharmaceutical compositions for preventing breast and ovarian cancer |
JP2006523155A JP2007502270A (ja) | 2003-08-11 | 2004-08-10 | 乳癌および卵巣癌の予防のための医薬組成物および方法 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PLP.361597 | 2003-08-11 | ||
PL361597A PL214402B1 (pl) | 2003-08-11 | 2003-08-11 | Zastosowanie selenu albo jego zwiazku do otrzymywania srodka do obnizania odziedziczonego ryzyka zachorowania na raka piersi lub jajnika |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005013951A2 WO2005013951A2 (fr) | 2005-02-17 |
WO2005013951A3 true WO2005013951A3 (fr) | 2005-09-15 |
Family
ID=34132453
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/PL2004/000063 WO2005013951A2 (fr) | 2003-08-11 | 2004-08-10 | Compositions pharmaceutiques et methodes permettant de prevenir le cancer du sein et de l'ovaire |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1660060A2 (fr) |
JP (1) | JP2007502270A (fr) |
KR (1) | KR20060066719A (fr) |
CN (1) | CN1835740A (fr) |
AU (1) | AU2004263070A1 (fr) |
CA (1) | CA2535506A1 (fr) |
EA (1) | EA200600386A1 (fr) |
PL (1) | PL214402B1 (fr) |
WO (1) | WO2005013951A2 (fr) |
ZA (1) | ZA200602081B (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080081039A1 (en) * | 2004-09-21 | 2008-04-03 | Velacor Therapeutics Pty. Ltd. | Inorganic Selenium For Treatment Of Cancer |
US20110117545A1 (en) * | 2007-03-26 | 2011-05-19 | Decode Genetics Ehf | Genetic variants on chr2 and chr16 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment |
CN100548311C (zh) * | 2007-06-13 | 2009-10-14 | 中国科学技术大学 | 硒代硫酸钠在制备临床补硒和治疗癌症药物中的应用及快速制备方法 |
WO2009043106A1 (fr) * | 2007-10-03 | 2009-04-09 | Velacor Therapeutics Pty Ltd | Sélénium inorganique et angiogenèse |
EP2313529A2 (fr) * | 2008-03-13 | 2011-04-27 | Pomorska Akademia Medyczna | Procédé visant à déterminer une prédisposition réduite au cancer, à partir du profil génétique |
KR101026291B1 (ko) * | 2008-06-30 | 2011-03-31 | 주식회사 태강 | SeO2 doped W-Mo-Li 화합물을 함유한 항암제 조성물 |
GB0916010D0 (en) * | 2009-09-11 | 2009-10-28 | Isis Innovation | JMJD2 demethylase inhibitors |
WO2012067525A1 (fr) | 2010-11-18 | 2012-05-24 | Pomorski Uniwersytet Medyczny | Génotypes et niveau de sélénium utilisés en tant que marqueurs du risque de cancer du sein/ovaire chez des sujets porteurs d'une mutation du gène brca1 |
AU2012237327B2 (en) | 2011-04-01 | 2016-10-20 | Iasomai Ab | New combination comprising N-acetyl-L-cysteine and its use |
CN114533753A (zh) | 2013-03-15 | 2022-05-27 | 全技术公司 | 含硒组合物及其治疗和预防与线粒体功能障碍有关的疾病或病症的应用 |
MX2016011897A (es) * | 2014-03-14 | 2017-04-27 | Alltech Inc | Composiciones de compuestos selenoorganicos y metodos de uso de los mismos. |
PL442921A1 (pl) * | 2022-11-23 | 2024-05-27 | Read-Gene Spółka Akcyjna | Obniżanie ryzyka zgonów u kobiet z dziedziczną predyspozycją do raka piersi |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999064018A1 (fr) * | 1998-06-09 | 1999-12-16 | Biosyn Arzneimittel Gmbh | Combinaison de composes contenant du selenium avec des agents cytostatiques |
-
2003
- 2003-08-11 PL PL361597A patent/PL214402B1/pl unknown
-
2004
- 2004-08-10 EP EP04775169A patent/EP1660060A2/fr not_active Withdrawn
- 2004-08-10 WO PCT/PL2004/000063 patent/WO2005013951A2/fr active Application Filing
- 2004-08-10 CA CA002535506A patent/CA2535506A1/fr not_active Abandoned
- 2004-08-10 EA EA200600386A patent/EA200600386A1/ru unknown
- 2004-08-10 KR KR1020067002810A patent/KR20060066719A/ko not_active Application Discontinuation
- 2004-08-10 CN CNA2004800231246A patent/CN1835740A/zh active Pending
- 2004-08-10 AU AU2004263070A patent/AU2004263070A1/en not_active Abandoned
- 2004-08-10 JP JP2006523155A patent/JP2007502270A/ja not_active Withdrawn
-
2006
- 2006-03-10 ZA ZA200602081A patent/ZA200602081B/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999064018A1 (fr) * | 1998-06-09 | 1999-12-16 | Biosyn Arzneimittel Gmbh | Combinaison de composes contenant du selenium avec des agents cytostatiques |
Non-Patent Citations (16)
Title |
---|
CAFFREY P B ET AL: "SELENITE CYTOTOXICITY IN DRUG RESISTANT AND NONRESISTANT HUMAN OVARIAN TUMOR CELLS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 52, no. 17, 1 September 1992 (1992-09-01), pages 4812 - 4816, XP008041713, ISSN: 0008-5472 * |
CAFFREY P B ET AL: "SENSITIVITY OF MELPHALAN-RESISTANT TUMORS TO SELENITE IN VIVO", CANCER LETTERS, NEW YORK, NY, US, vol. 121, no. 2, 1997, pages 177 - 180, XP008041650, ISSN: 0304-3835 * |
DAS, B. ET AL: "Regulation of growth and polyamine metabolism in MCF-7 human breast adenocarcinoma cells by selenium", INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES , 61(4), 213-218 CODEN: IJSIDW; ISSN: 0250-474X, 1999, XP008041662 * |
DONG, YAN ET AL: "Identification of molecular targets associated with selenium-induced growth inhibition in human breast cells using cDNA microarrays", CANCER RESEARCH , 62(3), 708-714 CODEN: CNREA8; ISSN: 0008-5472, 2002, XP008041640 * |
IP C ET AL: "MAMMARY CANCER PREVENTION BY REGULAR GARLIC AND SELENIUM-ENRICHED GARLIC", NUTRITION AND CANCER, LONDON, GB, vol. 17, no. 3, 1992, pages 279 - 286, XP002920430, ISSN: 0163-5581 * |
IP C ET AL: "SELENIUM-ENRICHED GARLIC INHIBITS THE EARLY STAGE BUT NOT THE LATE STAGE OF MAMMARY CARCINOGENESIS", CARCINOGENESIS, IRL PRESS, LONDON, GB, vol. 17, no. 9, 1996, pages 1979 - 1982, XP008041663, ISSN: 0143-3334 * |
IP, CLEMENT: "Anticarcinogenic effect of selenium in the dimethylbenz(a)anthracene- induced mammary tumor model in rats", JAOCS, J. AM. OIL CHEM. SOC. , 61(12), 1881-7 CODEN: JJASDH, 1984, XP008042181 * |
KAECK, MARK ET AL: "Differential induction of growth arrest inducible genes by selenium compounds", BIOCHEMICAL PHARMACOLOGY , 53(7), 921-926 CODEN: BCPCA6; ISSN: 0006-2952, 1997, XP002315942 * |
KOWALSKA E ET AL: "Increased rates of chromosome breakage in BRCA1 carriers are reduced by oral selenium supplementation", EJC SUPPLEMENTS, vol. 2, no. 3, March 2004 (2004-03-01), & EUROPEAN BREAST CANCER SCREENING GROUP MEETING - BREAST CANCER SCREENING IN EUROPE - CURRENT STATUS; MARCH 16-20, 2004, pages 186, XP008041608, ISSN: 1359-6349 * |
MEDINA, D. ET AL: "Se-methylselenocysteine: A new compound for chemoprevention of breast cancer", NUTRITION AND CANCER , 40(1), 12-17 CODEN: NUCADQ; ISSN: 0163-5581, 2001, XP008041658 * |
REDMAN, CLAIRE ET AL: "Inhibitory effect of selenomethionine on the growth of three selected human tumor cell lines", CANCER LETTERS (SHANNON, IRELAND) , 125(1,2), 103-110 CODEN: CALEDQ; ISSN: 0304-3835, 1998, XP008041649 * |
RONAI, ZE'EV ET AL: "Effects of organic and inorganic selenium compounds on rat mammary tumor cells", INTERNATIONAL JOURNAL OF CANCER , 63(3), 428-34 CODEN: IJCNAW; ISSN: 0020-7136, 1995, XP008041677 * |
SIEJA, KRZYSZTOF: "Selenium (Se) deficiency in women with ovarian cancer undergoing chemotherapy and the influence of supplementation with this micro-element on biochemical parameters", PHARMAZIE , 53(7), 473-476 CODEN: PHARAT; ISSN: 0031-7144, 1998, XP008041722 * |
SINHA, R. ET AL: "Effects of methylselenocysteine on PKC activity, cdk2 phosphorylation and gadd gene expression in synchronized mouse mammary epithelial tumor cells", CANCER LETTERS (SHANNON, IRELAND) , 146(2), 135-145 CODEN: CALEDQ; ISSN: 0304-3835, 1999, XP008041646 * |
YEO, JUN-KYU ET AL: "Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells", CANCER LETTERS (SHANNON, IRELAND) , 182(1), 83-92 CODEN: CALEDQ; ISSN: 0304-3835, 2002, XP008041642 * |
YUAN R ET AL: "Co-ordinate alterations in the expression of BRCA1, BRCA2, p300, and Rad51 in response to genotoxic and other stresses in human prostate cancer cells", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, no. 41, March 2000 (2000-03-01), & 91ST ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH.; SAN FRANCISCO, CALIFORNIA, USA; APRIL 01-05, 2000, pages 743, XP001182998, ISSN: 0197-016X * |
Also Published As
Publication number | Publication date |
---|---|
CN1835740A (zh) | 2006-09-20 |
PL361597A1 (en) | 2005-02-21 |
CA2535506A1 (fr) | 2005-02-17 |
ZA200602081B (en) | 2007-05-30 |
JP2007502270A (ja) | 2007-02-08 |
AU2004263070A1 (en) | 2005-02-17 |
EA200600386A1 (ru) | 2006-12-29 |
EP1660060A2 (fr) | 2006-05-31 |
PL214402B1 (pl) | 2013-07-31 |
KR20060066719A (ko) | 2006-06-16 |
WO2005013951A2 (fr) | 2005-02-17 |
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