WO2004101494B1 - Inhibiteurs de la calpaine - Google Patents

Inhibiteurs de la calpaine

Info

Publication number
WO2004101494B1
WO2004101494B1 PCT/ES2004/070034 ES2004070034W WO2004101494B1 WO 2004101494 B1 WO2004101494 B1 WO 2004101494B1 ES 2004070034 W ES2004070034 W ES 2004070034W WO 2004101494 B1 WO2004101494 B1 WO 2004101494B1
Authority
WO
WIPO (PCT)
Prior art keywords
phenyl
biphenyl
amino
group
aryl
Prior art date
Application number
PCT/ES2004/070034
Other languages
English (en)
Spanish (es)
Other versions
WO2004101494A1 (fr
Inventor
Garcia Bernardo Herradon
Cano Esperanza Benito
Lopez Antonio Chana
Morales Enrique Mann
Aguado Ana Montero
Original Assignee
Consejo Superior Investigacion
Garcia Bernardo Herradon
Cano Esperanza Benito
Lopez Antonio Chana
Morales Enrique Mann
Aguado Ana Montero
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior Investigacion, Garcia Bernardo Herradon, Cano Esperanza Benito, Lopez Antonio Chana, Morales Enrique Mann, Aguado Ana Montero filed Critical Consejo Superior Investigacion
Publication of WO2004101494A1 publication Critical patent/WO2004101494A1/fr
Publication of WO2004101494B1 publication Critical patent/WO2004101494B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne des composés ayant une structure de peptide-biphényle hybride, ainsi que des composés associés présentant une activité comme inhibiteurs de la calpaine. Un composé de la présente invention est un biphényle 2,2'-disubstitué, les substituants en position 2 et 2' du squelette biphényle étant des chaînes contenant des structures associées aux aminoacides, des peptides et des amides, pouvant être identiques ou différents. La présente invention concerne également tous les isomères conformationnels (atropisomères) dudit composé représenté par la formule générale (I). Les composés représentés par la formule générale (I) sont destinés au traitement préventif ou thérapeutique d'une maladie dégénérative.
PCT/ES2004/070034 2003-05-14 2004-05-11 Inhibiteurs de la calpaine WO2004101494A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200301125A ES2219187B1 (es) 2003-05-14 2003-05-14 Inhibidores de calpaina.
ESP200301125 2003-05-14

Publications (2)

Publication Number Publication Date
WO2004101494A1 WO2004101494A1 (fr) 2004-11-25
WO2004101494B1 true WO2004101494B1 (fr) 2005-01-06

Family

ID=33443029

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2004/070034 WO2004101494A1 (fr) 2003-05-14 2004-05-11 Inhibiteurs de la calpaine

Country Status (2)

Country Link
ES (1) ES2219187B1 (fr)
WO (1) WO2004101494A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2243131B1 (es) 2004-05-07 2007-02-01 Consejo Sup. Investig. Cientificas Tiamidas derivadas de bifenilo como inhibidores de calpaina.
ES2255848B1 (es) 2004-12-16 2007-07-01 Consejo Superior Investig. Cientificas Derivados de isoquinolina como inhibidores de calpaina.
CN115745830B (zh) * 2022-11-14 2024-03-29 武汉大学人民医院（湖北省人民医院） 联萘二甲酸衍生物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0840614A1 (fr) * 1995-06-13 1998-05-13 Sanofi Winthrop, Inc. Inhibiteurs de la calpaine destines au traitement de maladies neurodegeneratives
RU2190599C2 (ru) * 1996-12-11 2002-10-10 Басф Акциенгезельшафт Новые кетобензамиды

Also Published As

Publication number Publication date
ES2219187A1 (es) 2004-11-16
ES2219187B1 (es) 2006-02-16
WO2004101494A1 (fr) 2004-11-25

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