WO2004094671A3 - Procedes et produits pour identifier et evaluer des ligands des tlr - Google Patents

Procedes et produits pour identifier et evaluer des ligands des tlr Download PDF

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Publication number
WO2004094671A3
WO2004094671A3 PCT/US2004/012788 US2004012788W WO2004094671A3 WO 2004094671 A3 WO2004094671 A3 WO 2004094671A3 US 2004012788 W US2004012788 W US 2004012788W WO 2004094671 A3 WO2004094671 A3 WO 2004094671A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
assessment
products
identification
tlr ligands
Prior art date
Application number
PCT/US2004/012788
Other languages
English (en)
Other versions
WO2004094671A9 (fr
WO2004094671A2 (fr
Inventor
Joerg Vollmer
Marion Jurk
Grayson B Lipford
Christian Schetter
Alexandra Forsbach
Arthur M Krieg
Original Assignee
Coley Pharm Gmbh
Coley Pharm Group Inc
Joerg Vollmer
Marion Jurk
Grayson B Lipford
Christian Schetter
Alexandra Forsbach
Arthur M Krieg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coley Pharm Gmbh, Coley Pharm Group Inc, Joerg Vollmer, Marion Jurk, Grayson B Lipford, Christian Schetter, Alexandra Forsbach, Arthur M Krieg filed Critical Coley Pharm Gmbh
Priority to EP04760178A priority Critical patent/EP1631687A2/fr
Publication of WO2004094671A2 publication Critical patent/WO2004094671A2/fr
Publication of WO2004094671A9 publication Critical patent/WO2004094671A9/fr
Publication of WO2004094671A3 publication Critical patent/WO2004094671A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne de nouvelles compositions et de nouveaux procédés de criblage pour identifier et différencier des composés immunomodulateurs candidats. L'invention concerne en outre des procédés pour évaluer l'activité biologique d'une composition contenant un ligand connu des TLR, ces procédés pouvant être mis en oeuvre pour évaluer la qualité de divers lots de compositions d'essai, notamment des produits pharmaceutiques à usage clinique, et effectuer une sélection.
PCT/US2004/012788 2003-04-22 2004-04-22 Procedes et produits pour identifier et evaluer des ligands des tlr WO2004094671A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04760178A EP1631687A2 (fr) 2003-04-22 2004-04-22 Procedes et produits pour identifier et evaluer des ligands des tlr

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US46458603P 2003-04-22 2003-04-22
US46458803P 2003-04-22 2003-04-22
US60/464,586 2003-04-22
US60/464,588 2003-04-22

Publications (3)

Publication Number Publication Date
WO2004094671A2 WO2004094671A2 (fr) 2004-11-04
WO2004094671A9 WO2004094671A9 (fr) 2005-01-27
WO2004094671A3 true WO2004094671A3 (fr) 2005-09-22

Family

ID=33313485

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/012788 WO2004094671A2 (fr) 2003-04-22 2004-04-22 Procedes et produits pour identifier et evaluer des ligands des tlr

Country Status (2)

Country Link
EP (1) EP1631687A2 (fr)
WO (1) WO2004094671A2 (fr)

Families Citing this family (35)

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US7935675B1 (en) 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US20030026782A1 (en) 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
DK1077722T3 (da) 1998-05-22 2006-11-27 Ottawa Health Research Inst Fremgangsmåder og produkter til induktion af mukosaimmunitet
ATE464907T1 (de) 1999-02-17 2010-05-15 Csl Ltd Immunogene komplexe und methoden in bezug auf diese
SK287400B6 (sk) 1999-09-25 2010-08-09 University Of Iowa Research Foundation Prostriedok s obsahom imunostimulačnej nukleovej kyseliny a jeho použitie na stimuláciu imunitnej reakcie
US6949520B1 (en) 1999-09-27 2005-09-27 Coley Pharmaceutical Group, Inc. Methods related to immunostimulatory nucleic acid-induced interferon
DK1366077T3 (da) 2000-09-15 2011-09-12 Coley Pharm Gmbh Fremgangsmåde til screening i store mængder af CpG-baserede immunoagonister/-antagonister
EA007232B1 (ru) 2001-08-17 2006-08-25 Коли Фармасьютикал Гмбх Иммуностимулирующие олигонуклеотиды, содержащие комбинацию мотивов и обладающие повышенной активностью
ES2734652T3 (es) 2002-04-04 2019-12-11 Zoetis Belgium S A Oligorribonucleótidos inmunoestimulantes que contienen G y U
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
CN1678188B (zh) * 2002-07-03 2012-10-10 科勒制药集团有限公司 调节免疫反应的核酸成份
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
AR040996A1 (es) 2002-08-19 2005-04-27 Coley Pharm Group Inc Acidos nucleicos inmunoestimuladores
EP1556077A2 (fr) 2002-10-29 2005-07-27 Coley Pharmaceutical Group, Ltd Techniques et produits relatifs au traitement et a la prevention de l'infection par le virus de l'hepatite c
JP2006512927A (ja) 2002-12-11 2006-04-20 コーリー ファーマシューティカル グループ，インコーポレイテッド ５’ｃｐｇ核酸およびその使用方法
WO2005042018A2 (fr) * 2003-10-30 2005-05-12 Coley Pharmaceutical Gmbh Analogues d'oligonucleotides de classe c presentant des proprietes immunostimulatrices accrues
MY159370A (en) 2004-10-20 2016-12-30 Coley Pharm Group Inc Semi-soft-class immunostimulatory oligonucleotides
WO2006054129A1 (fr) 2004-11-19 2006-05-26 Institut Gustave Roussy Traitement ameliore du cancer par arn double brin
JP2010503608A (ja) * 2005-09-16 2010-02-04 コーリー ファーマシューティカル ゲーエムベーハー ホスホジエステルバックボーンを有する免疫刺激性一本鎖リボ核酸
US8426375B2 (en) 2005-10-12 2013-04-23 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US8383598B2 (en) 2005-10-12 2013-02-26 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
US8399423B2 (en) 2005-10-12 2013-03-19 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
ES2542989T3 (es) * 2005-10-12 2015-08-13 Idera Pharmaceuticals, Inc. Compuestos oligonucleótidos inmuno reguladores (IRO) para modular la respuesta inmune basada en receptor semejante a Toll
BRPI0618857B1 (pt) 2005-11-25 2022-07-19 Zoetis Belgium S.A Oligonucleotídeo de rna isolado, e método para regular negativamente células reguladoras cd4+ imunossupressoras
KR101251707B1 (ko) 2006-09-27 2013-04-11 콜리 파마슈티칼 게엠베하 면역 자극 활성이 증강된 소수성 Ｔ 유사체를 함유하는 ＣｐＧ 올리고뉴클레오티드 유사체
US8377898B2 (en) 2006-10-12 2013-02-19 Idera Pharmaceuticals, Inc. Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
CA2722589A1 (fr) 2008-04-25 2009-10-29 Innate Pharma Compositions agonistes de tlr3 ameliorees
MX2011003625A (es) 2008-10-06 2011-05-31 Idera Pharmaceuticals Inc Uso de inhibidores de receptores tipo toll en la prevencion y tratamiento de hipercolesterolemia e hiperlipidemia y enfermedades relacionadas con esto.
CN103492878B (zh) 2011-04-08 2015-11-25 罗盖特兄弟公司 用于检测含葡萄糖聚合物溶液中污染物的方法
WO2018112407A1 (fr) 2016-12-15 2018-06-21 Duke University Anticorps et méthodes d'appauvrissement de cellules régulatrices b10 et leur utilisation en combinaison avec des inhibiteurs de points de contrôle de l'immunité
US20220170042A1 (en) * 2020-11-27 2022-06-02 Wyvern Pharmaceuticals Inc. Compositions and methods for regulating production of a precursor protein
WO2022229302A1 (fr) 2021-04-28 2022-11-03 Enyo Pharma Potentialisation forte d'effets d'agonistes de tlr3 à l'aide d'agonistes de fxr en tant que traitement combiné

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WO1998050547A2 (fr) * 1997-05-07 1998-11-12 Schering Corporation Recepteur proteique humain du type toll, reactifs connexes et techniques afferentes
WO1999020756A2 (fr) * 1997-10-17 1999-04-29 Genentech, Inc. Homologues toll humains
WO2000067023A1 (fr) * 1999-04-29 2000-11-09 Coley Pharmaceutical Gmbh Criblage de modificateurs fonctionnels de l'adn immunostimulant
WO2001055386A1 (fr) * 2000-01-25 2001-08-02 Glaxosmithkline Recepteur de type toll
WO2002022809A2 (fr) * 2000-09-15 2002-03-21 Coley Pharmaceutical Gmbh Procede de criblage a haut rendement d'immuno-agoniste/antagoniste base sur cpg
WO2002085933A1 (fr) * 2001-04-20 2002-10-31 The Institute For Systems Biology Ligands de recepteur de type 5 et procedes d'utilisation
US20030032090A1 (en) * 1997-05-07 2003-02-13 Schering Corporation, A New Jersey Corporation Human receptor proteins; related reagents and methods
WO2003031573A2 (fr) * 2001-10-05 2003-04-17 Coley Pharmaceutical Gmbh Agonistes et antagonistes de signalisation du recepteur 3 de type toll

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998050547A2 (fr) * 1997-05-07 1998-11-12 Schering Corporation Recepteur proteique humain du type toll, reactifs connexes et techniques afferentes
US20030032090A1 (en) * 1997-05-07 2003-02-13 Schering Corporation, A New Jersey Corporation Human receptor proteins; related reagents and methods
WO1999020756A2 (fr) * 1997-10-17 1999-04-29 Genentech, Inc. Homologues toll humains
WO2000067023A1 (fr) * 1999-04-29 2000-11-09 Coley Pharmaceutical Gmbh Criblage de modificateurs fonctionnels de l'adn immunostimulant
WO2001055386A1 (fr) * 2000-01-25 2001-08-02 Glaxosmithkline Recepteur de type toll
WO2002022809A2 (fr) * 2000-09-15 2002-03-21 Coley Pharmaceutical Gmbh Procede de criblage a haut rendement d'immuno-agoniste/antagoniste base sur cpg
WO2002085933A1 (fr) * 2001-04-20 2002-10-31 The Institute For Systems Biology Ligands de recepteur de type 5 et procedes d'utilisation
WO2003031573A2 (fr) * 2001-10-05 2003-04-17 Coley Pharmaceutical Gmbh Agonistes et antagonistes de signalisation du recepteur 3 de type toll

Non-Patent Citations (7)

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Title
HEMMI H ET AL: "SMALL ANTI-VIRAL COMPOUNDS ACTIVATE IMMUNE CELLLS VIA THE TLR7 MYD88-DEPENDENT SIGNALING PATHWAY", NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP,, GB, vol. 3, no. 2, February 2002 (2002-02-01), pages 196 - 200, XP009000917, ISSN: 1529-2908 *
JURK M ET AL: "HUMAN TLR7 OR TLR8 INDEPENDENTLY CONFER RESPONSIVENESS TO THE ANTIVIRAL COMPOUND R-848", NATURE IMMUNOLOGY, NATURE PUBLISHING GROUP,, GB, vol. 3, no. 6, June 2002 (2002-06-01), pages 499, XP009000821, ISSN: 1529-2908 *
ROTHENFUSSER SIMON ET AL: "Recent advances in immunostimulatory CpG oligonucleotides.", CURRENT OPINION IN MOLECULAR THERAPEUTICS. APR 2003, vol. 5, no. 2, April 2003 (2003-04-01), pages 98 - 106, XP009037365, ISSN: 1464-8431 *
See also references of EP1631687A2 *
VERTHELYI D ET AL: "Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 15 FEB 2001, vol. 166, no. 4, 15 February 2001 (2001-02-15), pages 2372 - 2377, XP002299044, ISSN: 0022-1767 *
VOLLMER J ET AL: "IMMUNOPHARMACOLOGY OF CPG OLIGODEOXYNUCLEOTIDE AND RIBAVIRIN", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 48, no. 6, June 2004 (2004-06-01), pages 2314 - 2317, XP009032686, ISSN: 0066-4804 *
YOSHIOKA T ET AL: "Bacterial lipopolysaccharide induces transforming growth factor beta and hepatocyte growth factor through toll-like receptor 2 in cultured human colon cancer cells.", THE JOURNAL OF INTERNATIONAL MEDICAL RESEARCH. 2001 SEP-OCT, vol. 29, no. 5, September 2001 (2001-09-01), pages 409 - 420, XP009037464, ISSN: 0300-0605 *

Also Published As

Publication number Publication date
WO2004094671A9 (fr) 2005-01-27
EP1631687A2 (fr) 2006-03-08
WO2004094671A2 (fr) 2004-11-04

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