WO2004083823A1 - マイクロチップならびに試料抽出方法、試料分離方法、試料分析方法、および試料回収方法 - Google Patents

マイクロチップならびに試料抽出方法、試料分離方法、試料分析方法、および試料回収方法 Download PDF

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Publication number
WO2004083823A1
WO2004083823A1 PCT/JP2004/003751 JP2004003751W WO2004083823A1 WO 2004083823 A1 WO2004083823 A1 WO 2004083823A1 JP 2004003751 W JP2004003751 W JP 2004003751W WO 2004083823 A1 WO2004083823 A1 WO 2004083823A1
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WIPO (PCT)
Prior art keywords
sample
microchip
recovering
sampling
weir
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Application number
PCT/JP2004/003751
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English (en)
French (fr)
Inventor
Toru Sano
Masakazu Baba
Kazuhiro Iida
Hisao Kawaura
Noriyuki Iguchi
Wataru Hattori
Hiroko Someya
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Nec Corporation
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Publication date
Application filed by Nec Corporation filed Critical Nec Corporation
Priority to JP2005503761A priority Critical patent/JP4356694B2/ja
Priority to US10/549,284 priority patent/US20060177350A1/en
Publication of WO2004083823A1 publication Critical patent/WO2004083823A1/ja

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D57/00—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C
    • B01D57/02—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C by electrophoresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0454—Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental & Geological Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

試料導入部（１０７）に、試料−担体複合体（１１９）を導入し、試料−担体複合体（１１９）を移動させ、堰き止め部（１１１）に堆積させる。所定量の試料−担体複合体（１１９）を堰き止め部（１１１）に堆積させた段階で、堰き止め部（１１１）を加熱する。所定の温度まで昇温し、試料−担体複合体（１１９）を試料（１２１）と担体（１２３）とに分解させる。そして、試料導入部（１０７）と試料回収部（１０９）との間に電圧を印加し、柱状体（１１５）間を通過させて試料（１２１）を第二の流路（１０６）中に移動させ、所定の分離、分析または回収操作を行う。
PCT/JP2004/003751 2003-03-19 2004-03-19 マイクロチップならびに試料抽出方法、試料分離方法、試料分析方法、および試料回収方法 WO2004083823A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2005503761A JP4356694B2 (ja) 2003-03-19 2004-03-19 マイクロチップならびに試料抽出方法、試料分離方法、試料分析方法、および試料回収方法
US10/549,284 US20060177350A1 (en) 2003-03-19 2004-03-19 Microchip, sampling method, sample separating method, sample analyzing method, and sample recovering method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003076401 2003-03-19
JP2003-076401 2003-03-19

Publications (1)

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WO2004083823A1 true WO2004083823A1 (ja) 2004-09-30

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Country Status (4)

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US (1) US20060177350A1 (ja)
JP (1) JP4356694B2 (ja)
CN (1) CN1761865A (ja)
WO (1) WO2004083823A1 (ja)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006234559A (ja) * 2005-02-24 2006-09-07 Mitsui Eng & Shipbuild Co Ltd フローサイトメータ
WO2007074756A1 (ja) * 2005-12-26 2007-07-05 Institute Of Microchemical Technology 免疫分析マイクロチップ、免疫分析用キット及び免疫分析方法
WO2007142061A1 (ja) * 2006-06-06 2007-12-13 Konica Minolta Medical & Graphic, Inc. マイクロチップ検査装置
EP1797955A3 (en) * 2005-11-28 2007-12-26 Seiko Epson Corporation Microfluidic system, sample analysis device, and target substance measurement method
JP2008275412A (ja) * 2007-04-27 2008-11-13 Hitachi High-Technologies Corp 試料分析システム及び試料搬送方法
JP2014173934A (ja) * 2013-03-07 2014-09-22 Toshiba Corp 半導体マイクロ分析チップ及びその製造方法
JP2018506264A (ja) * 2014-11-26 2018-03-08 インターナショナル・ビジネス・マシーンズ・コーポレーションＩｎｔｅｒｎａｔｉｏｎａｌ Ｂｕｓｉｎｅｓｓ Ｍａｃｈｉｎｅｓ Ｃｏｒｐｏｒａｔｉｏｎ ピラー・アレイ構造を使用してエンティティを分別する装置、流体装置を提供する方法、およびナノピラー・アレイを形成する方法
JP2020536255A (ja) * 2017-10-02 2020-12-10 ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ ｏｆ ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ ｏｆ Ｃａｌｉｆｏｒｎｉａ 標的分子をナノポアに送達するシステム及び方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008126064A2 (en) * 2007-04-17 2008-10-23 Nxp B.V. A fluid separation structure and a method of manufacturing a fluid separation structure
JP5559967B2 (ja) * 2007-04-27 2014-07-23 独立行政法人産業技術総合研究所 電気泳動チップ、電気泳動装置およびキャピラリー電気泳動法による試料の分析方法
CN101663578B (zh) * 2007-04-27 2013-11-13 爱科来株式会社 电泳芯片和电泳装置
EP2144057B1 (en) * 2007-04-27 2019-04-10 ARKRAY, Inc. Method for analyzing a sample containing glycosylated hemoglobin and glucose
US8862048B2 (en) * 2009-09-11 2014-10-14 Geo-Broadcast Solutions, Llc Equipment, system and methodologies for segmentation of listening area into sub-areas enabling delivery of localized auxiliary information
JP5877512B2 (ja) * 2011-03-31 2016-03-08 国立大学法人 岡山大学 運動性良好な精子採取装置
US20160187274A1 (en) * 2013-07-31 2016-06-30 Empire Technology Development Llc Dynamic chemical sensors
EP3325955A1 (en) * 2015-07-22 2018-05-30 Honeywell International Inc. Separate compression of wetting and contact sections
JP6964590B2 (ja) * 2015-12-30 2021-11-10 バークレー ライツ，インコーポレイテッド 光学的に駆動される対流及び変位のマイクロ流体デバイス、そのキット及び方法
JP7343875B2 (ja) 2017-02-28 2023-09-13 ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア マルチモード干渉導波路を用いるオプトフルイディックアナライト検出システム
CN108897192B (zh) * 2018-04-19 2022-04-05 中科院广州化学有限公司南雄材料生产基地 一种巯基-烯纳米压印光刻胶及其使用方法
CN114126762B (zh) 2019-04-30 2023-01-03 伯克利之光生命科技公司 用于包封和测定细胞的方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53130424A (en) * 1977-03-04 1978-11-14 Pharmacia Diagnostics Ab Method for doing test and anlysis method comprising biologically specific compatible reaction and reagent used in said method
JPH06222060A (ja) * 1993-01-27 1994-08-12 Canon Inc フローセル
WO2001069230A2 (en) * 2000-03-10 2001-09-20 Applera Corporation Methods and apparatus for the location and concentration of polar analytes using an alternating electric field
JP2002502597A (ja) * 1998-02-05 2002-01-29 アクレイラ バイオサイエンシズ，インコーポレイティド 統合ミクロ流体装置
JP2004042012A (ja) * 2001-10-26 2004-02-12 Nec Corp 分離装置、分析システム、分離方法および分離装置の製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US6403367B1 (en) * 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US6159749A (en) * 1998-07-21 2000-12-12 Beckman Coulter, Inc. Highly sensitive bead-based multi-analyte assay system using optical tweezers
US6491872B1 (en) * 1999-09-17 2002-12-10 The United States Of America As Represented By The Secretary Of The Army Method and system for detecting and recording submicron sized particles
US6783647B2 (en) * 2001-10-19 2004-08-31 Ut-Battelle, Llc Microfluidic systems and methods of transport and lysis of cells and analysis of cell lysate

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53130424A (en) * 1977-03-04 1978-11-14 Pharmacia Diagnostics Ab Method for doing test and anlysis method comprising biologically specific compatible reaction and reagent used in said method
JPH06222060A (ja) * 1993-01-27 1994-08-12 Canon Inc フローセル
JP2002502597A (ja) * 1998-02-05 2002-01-29 アクレイラ バイオサイエンシズ，インコーポレイティド 統合ミクロ流体装置
WO2001069230A2 (en) * 2000-03-10 2001-09-20 Applera Corporation Methods and apparatus for the location and concentration of polar analytes using an alternating electric field
JP2004042012A (ja) * 2001-10-26 2004-02-12 Nec Corp 分離装置、分析システム、分離方法および分離装置の製造方法

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006234559A (ja) * 2005-02-24 2006-09-07 Mitsui Eng & Shipbuild Co Ltd フローサイトメータ
EP1797955A3 (en) * 2005-11-28 2007-12-26 Seiko Epson Corporation Microfluidic system, sample analysis device, and target substance measurement method
US7863054B2 (en) 2005-11-28 2011-01-04 Seiko Epson Corporation Microfluidic system, sample analysis device, and target substance detection/measurement method
JP4717081B2 (ja) * 2005-12-26 2011-07-06 マイクロ化学技研株式会社 免疫分析マイクロチップ、免疫分析用キット及び免疫分析方法
WO2007074756A1 (ja) * 2005-12-26 2007-07-05 Institute Of Microchemical Technology 免疫分析マイクロチップ、免疫分析用キット及び免疫分析方法
CN101389961B (zh) * 2005-12-26 2013-07-10 微化学技术有限公司 免疫分析微芯片、免疫分析用试剂盒及免疫分析方法
US8802449B2 (en) 2005-12-26 2014-08-12 Institute Of Microchemical Technology Microchips, kits, and methods for immunoassays
WO2007142061A1 (ja) * 2006-06-06 2007-12-13 Konica Minolta Medical & Graphic, Inc. マイクロチップ検査装置
JP2008275412A (ja) * 2007-04-27 2008-11-13 Hitachi High-Technologies Corp 試料分析システム及び試料搬送方法
JP2014173934A (ja) * 2013-03-07 2014-09-22 Toshiba Corp 半導体マイクロ分析チップ及びその製造方法
JP2018506264A (ja) * 2014-11-26 2018-03-08 インターナショナル・ビジネス・マシーンズ・コーポレーションＩｎｔｅｒｎａｔｉｏｎａｌ Ｂｕｓｉｎｅｓｓ Ｍａｃｈｉｎｅｓ Ｃｏｒｐｏｒａｔｉｏｎ ピラー・アレイ構造を使用してエンティティを分別する装置、流体装置を提供する方法、およびナノピラー・アレイを形成する方法
JP2020536255A (ja) * 2017-10-02 2020-12-10 ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ ｏｆ ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ ｏｆ Ｃａｌｉｆｏｒｎｉａ 標的分子をナノポアに送達するシステム及び方法
JP2023022107A (ja) * 2017-10-02 2023-02-14 ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア 標的分子をナノポアに送達するシステム及び方法
JP7234224B2 (ja) 2017-10-02 2023-03-07 ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア 標的分子をナノポアに送達するシステム及び方法
JP7454030B2 (ja) 2017-10-02 2024-03-21 ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア 標的分子をナノポアに送達するシステム及び方法

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CN1761865A (zh) 2006-04-19
JP4356694B2 (ja) 2009-11-04
US20060177350A1 (en) 2006-08-10
JPWO2004083823A1 (ja) 2006-06-22

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