WO2004069102A1 - Hüftgfelenkprothese mit einem in den oberschenkelknochen einzusetzenden schaft - Google Patents

Hüftgfelenkprothese mit einem in den oberschenkelknochen einzusetzenden schaft Download PDF

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Publication number
WO2004069102A1
WO2004069102A1 PCT/EP2003/005292 EP0305292W WO2004069102A1 WO 2004069102 A1 WO2004069102 A1 WO 2004069102A1 EP 0305292 W EP0305292 W EP 0305292W WO 2004069102 A1 WO2004069102 A1 WO 2004069102A1
Authority
WO
WIPO (PCT)
Prior art keywords
prosthesis
bone
trochanteric
shaft
hip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2003/005292
Other languages
German (de)
English (en)
French (fr)
Inventor
Helmut D. Link
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Waldemar Link GmbH and Co KG
Original Assignee
Waldemar Link GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Waldemar Link GmbH and Co KG filed Critical Waldemar Link GmbH and Co KG
Priority to EP03815690A priority Critical patent/EP1592369B1/de
Priority to AU2003232803A priority patent/AU2003232803B2/en
Priority to AT03815690T priority patent/ATE435627T1/de
Priority to BR0318096-4A priority patent/BR0318096A/pt
Priority to JP2004567744A priority patent/JP4347813B2/ja
Priority to DE50311696T priority patent/DE50311696D1/de
Priority to CA2515065A priority patent/CA2515065C/en
Publication of WO2004069102A1 publication Critical patent/WO2004069102A1/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30721—Accessories
    • A61F2/30739—Devices connected to the proximal part of an endoprosthetic femoral shaft for reinforcing or replacing the trochanters, e.g. the greater trochanter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/16—Instruments for performing osteoclasis; Drills or chisels for bones; Trepans
    • A61B17/1659—Surgical rasps, files, planes, or scrapers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
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    • A—HUMAN NECESSITIES
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
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    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30317—The prosthesis having different structural features at different locations within the same prosthesis
    • A61F2002/30322—The prosthesis having different structural features at different locations within the same prosthesis differing in surface structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30433—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using additional screws, bolts, dowels, rivets or washers e.g. connecting screws
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
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    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30604—Special structural features of bone or joint prostheses not otherwise provided for modular
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A—HUMAN NECESSITIES
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    • A61F2/3609—Femoral heads or necks; Connections of endoprosthetic heads or necks to endoprosthetic femoral shafts
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2/3609—Femoral heads or necks; Connections of endoprosthetic heads or necks to endoprosthetic femoral shafts
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    • A61F2250/0026—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in surface structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00976—Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF

Definitions

  • the cancellous bone tissue in the metaphysis of the femur has a complicated structure made up of trabeculae that connect the parts of the bone under pressure and tension on the femoral neck, the large trochanter, the small trochanter and the diaphysis to transmit pressure and tension. In total, they form continuous traction and pressure trajectories (color atlases of medicine, Vol. 7: Movement apparatus I. Verlag Thieme, Stuttgart, 1992).
  • the primary traction trajectories in particular which connect the femoral neck to the opposite, intertrochanteric surface area of the bone, are largely interrupted. If they are then no longer involved in the power transmission, they recede.
  • the invention has for its object to provide a prosthesis that more closely integrates the trochanteric region of the metaphysis of the femur when using a hip joint prosthesis in the power flow.
  • the solution according to the invention consists in the features of the claims.
  • osteoinductive substances are to be understood as stimulating undifferentiated pluripotent stem cells for reshaping in bone cells (Albrechtsson, Johansson: Osteoinduction, Osteoconstruction and Osseointegration; In: Gunzburg ed .: The use ob bone substitutes in Spine Surgery; Springer - Denissen, H. et al .: Ceramic hydroxyapatite Implants for the Release of bisphosphonates; in: Bone and Mineral 1994, pp. 123-134. - Yoshinari, M.
  • the coating can be of any type.
  • it can be a porous metal layer.
  • Coatings which are inherently osteoconductive as such and which consist, for example, of calcium phosphate or hydroxylapatite are particularly advantageous.
  • the effect of the invention is that very quickly after the operation, bone cells develop in the immediate vicinity and in connection with the surface of the prosthesis. This ensures that a gap or a connective tissue intermediate layer does not initially form as a result of relative movements between the bone surface and the bone, which impairs or makes impossible the subsequent intimate bond.
  • the invention is based on the finding that even in those cases in which a close connection between the surface of the prosthesis and the bone substance had already been achieved according to the optical impression, there was actually a separating, if microscopic, thin intermediate layer.
  • a faster bone accumulation and bone insertion in the pores and recesses takes place on the trochanteric surface of the prosthesis, so that the trochanteric bone area quickly receives a permanent connection to the prosthesis and as a result is involved in the transmission of force.
  • the measure according to the invention is normally only intended for the trochanteric area of the prosthesis. Although within the scope of the invention it should not be ruled out to use osteoinductively modified surfaces in other areas of the prosthesis, this is generally not desirable because the detachment of the prosthesis from the bone in the event of a reoperation can be hindered because of its intimate connection.
  • the part of the surface of the trochanteric prosthesis part containing the osteoinductive substance expediently has pores or undercuts with respect to the lateral direction, so that the bone substance formed as a result of the osteoinduction can anchor itself not only by adhesion to the surface but also by positive locking.
  • the trochanteric surface of the prosthesis is that which is intended to lie within the trochanteric area of the femur after normal implantation.
  • the trochanteric part of the bone is the part hatched in FIG. 1. If you go from the intersection between the
  • the trochanteric area lies laterally from the tangent drawn by this intersection to the upper edge of the femoral head and laterally from the part of the femoral neck midline that continues this tangent.
  • the trochanteric surface of the prosthesis is the part of its surface which is intended to be in the trochanteric part of the knot to lie. This part of the surface can also be easily determined on the prosthesis that has not yet been implanted, because it is known how it is to be implanted and what position it will normally assume in the bone.
  • the cancellous bone is sometimes less dense than near the bone cortex. Therefore, the parts of the trochanteric, osteoinductively equipped surface parts of the prosthesis that are turned ventrally and dorsally are preferably at a certain distance from the median plane of the bone. Therefore, the part of the prosthesis that forms these surface portions should not be too thin in the AP direction. Its thickness and thus the distance between the surface portions mentioned is expediently more than 6 and further advantageously more than 9 mm to about 15 mm.
  • the growth of fresh bone cells on the surface of the prosthesis can be promoted by a press fit of the relevant area parts. It is therefore expedient to design the surfaces in question and their counter surfaces in a wedge shape in the direction in which the prosthesis is inserted into the bone, and the rasp associated with the prosthesis, which is used to form the receiving space for the prosthesis socket to provide tighter cross-sectional dimensions, so that when the prosthesis shaft is inserted into the space prepared by the rasp, the relevant parts of the surface displace bone material.
  • FIG. 1 shows a longitudinal section through the proximal section of the thigh bone in the plane which contains the longitudinal axis of the handle holder
  • FIG. 2 shows a cross section along the section line II-II of FIGS. 1 and
  • FIG. 3 shows a section through the prosthesis according to section line III-III of FIG. 1.
  • the outer outline of the bone is shown in solid lines in FIG. 1.
  • the inner boundary line of the compact bone cortex 1 is sketched with solid lines insofar as its thickness is considerable. This is the case in the area of the diaphysis 2.
  • the bone cortex is predominantly so thin that it was only indicated by a line.
  • the metaphysis 3 and partly also the upper part of the diaphysis is filled with cancellous bone substance, not shown.
  • trochanteric area 4 which is shown with hatching, is assigned to the larger trochanter.
  • the former is the center line of the femoral neck 5 and the femoral head 6.
  • the latter is the tangent to the femoral head 6 from point S, in which the line H and the central axis M of the proximal diaphysis intersect in the plane of the drawing.
  • the trochanteric part of the bone also includes the bone parts located in front of and behind the plane of the drawing in the area of the hatched area 4.
  • the prosthesis to be inserted into the bones is indicated by dashed lines in FIG. 1 and by solid lines in FIGS. 2 and 3. It consists of a head 10, a neck 11 and a shaft 12, from which a projection 13 projects into the trochanteric region 4 of the bone.
  • the projection 13 is provided with bores 14 which form surface areas which look towards the ventrals. These are undercut with respect to the lateral direction 17. Bone substance that grows into these holes grips behind the undercut surfaces and thereby contributes to the transmission of tensile forces from the prosthesis to the trochanteric bone area.
  • the projection and the undercut surfaces can also be formed in a different, known manner.
  • the projection can be sheet-shaped or bow-shaped.
  • trochanteric parts or trochanteric surface of the prosthesis. This particularly includes the projection 13.
  • a type of prosthesis is shown, the shaft 12 of which is designed and implanted such that it is firmly anchored in the diapyse 2 of the bone.
  • This type of anchoring leads to great relief of the trochanteric bone area. Therefore, the use of the invention is particularly advantageous for this type of prosthesis.
  • it can also be used with other types of prosthesis that are anchored to a significant extent in the metaphysis and / or are secured by means of a Support the collar (not shown) on the resection surface 15 of the bone.
  • the surface of the shaft 12 or parts thereof can be designed or equipped in a known manner so that the connection to the bone is favored.
  • a coating can be provided that is porous and / or consists of calcium phosphate or hydroxyapatite.
  • Such a layer can also be provided in whole or in part in the trochanteric area of the prosthesis.
  • an area 16 is indicated which is provided with a coating.
  • this coating contains an osteoinductive substance.
  • the osteoinductive coating in the corresponding areas 16 leads to intensive bone growth in direct contact with the prosthesis surface and also in any undercut areas. Therefore, the forces exerted on the prosthesis can be effectively transmitted from its surface to the trochanteric region 4 of the bone. As a result, he is involved in the flow of force and bone breakdown is prevented.
  • Figure 2 illustrates that the protrusion 13 has a considerable thickness in the antero-posterior direction. Its anterior and posterior surface portions 16 are therefore removed from the central area, in which the cancellous bone substance is poor in some cases, and are located in an area closer and denser to the bone cortex. This will reduce the likelihood of a good connection between the bone surface and the bone substance further enlarged.
  • Fig. 3 illustrates the cross-sectional shape of the projection 13 in the cutting direction III-III, which also corresponds approximately to the direction of insertion. If the hollow shape, which has been prepared for the prosthesis by means of a rasp, is somewhat narrower than the shape of the prosthesis, inserting this wedge shape into the bone displaces the bone substance and thereby increases the pressure exerted by the bone substance on the surface of the prosthesis connected. This also promotes a rapidly growing and intimate bond between the surface of the prosthesis and the bone.
  • the projection 13 is therefore designed to be detachable from the shaft 12.
  • it can be connected to and removed from the shaft 12 by means of screws 18 or other connecting means along a connecting joint 17, which is indicated by dashed lines in FIGS. 1 and 2, before the shaft is removed from the bone.
  • the protrusion can then be more easily removed from the bone surrounding it and fused with it.

Landscapes

  • Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Surgery (AREA)
  • Dentistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
PCT/EP2003/005292 2003-02-10 2003-05-20 Hüftgfelenkprothese mit einem in den oberschenkelknochen einzusetzenden schaft Ceased WO2004069102A1 (de)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP03815690A EP1592369B1 (de) 2003-02-10 2003-05-20 Hüftgelenkprothese mit einem in den oberschenkelknochen ein zusetzenden schaft
AU2003232803A AU2003232803B2 (en) 2003-02-10 2003-05-20 Hip joint prosthesis comprising a shaft to be inserted into the femur
AT03815690T ATE435627T1 (de) 2003-02-10 2003-05-20 Hüftgelenkprothese mit einem in den oberschenkelknochen ein zusetzenden schaft
BR0318096-4A BR0318096A (pt) 2003-02-10 2003-05-20 Prótese de junta de quadril com uma haste a ser inserida no fêmur
JP2004567744A JP4347813B2 (ja) 2003-02-10 2003-05-20 大腿骨に挿入される幹部を備える股関節用義足
DE50311696T DE50311696D1 (de) 2003-02-10 2003-05-20 Hüftgelenkprothese mit einem in den oberschenkelknochen ein zusetzenden schaft
CA2515065A CA2515065C (en) 2003-02-10 2003-05-20 Hip-joint prosthesis comprising a shaft to be inserted into the femur

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/361,007 2003-02-10
US10/361,007 US20040158329A1 (en) 2003-02-10 2003-02-10 Hip joint prosthesis with shaft inserted into femur

Publications (1)

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WO2004069102A1 true WO2004069102A1 (de) 2004-08-19

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US (2) US20040158329A1 (enExample)
EP (1) EP1592369B1 (enExample)
JP (1) JP4347813B2 (enExample)
KR (1) KR101045407B1 (enExample)
CN (1) CN100571656C (enExample)
AT (1) ATE435627T1 (enExample)
AU (1) AU2003232803B2 (enExample)
BR (1) BR0318096A (enExample)
CA (1) CA2515065C (enExample)
DE (1) DE50311696D1 (enExample)
ES (1) ES2328808T3 (enExample)
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US8071574B2 (en) * 2005-02-22 2011-12-06 John Dennis Bobyn Implant improving local bone formation
US8066775B2 (en) * 2009-06-12 2011-11-29 Branovacki George Joint implant
US8882740B2 (en) * 2009-12-23 2014-11-11 Stryker Trauma Gmbh Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone
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EP0093230B1 (de) 1982-05-03 1986-05-28 Waldemar Link (GmbH & Co.) Knochenimplantat, insbesondere femorale Hüftgelenkprothese
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1623685A1 (de) * 2004-08-06 2006-02-08 WALDEMAR LINK GmbH & Co. KG Hüftgelenkprothese mit einem in den Oberschenkelknochen einzusetzenden Schaft
US7947084B2 (en) 2004-08-06 2011-05-24 Waldemar Link Gmbh & Co. Kg Hip joint prosthesis with a shaft to be inserted into the femur
US8641772B2 (en) 2004-08-06 2014-02-04 Waldemar Link Gmbh & Co. Kg Hip-joint prosthesis with a shaft to be inserted into the femur

Also Published As

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JP4347813B2 (ja) 2009-10-21
JP2006513753A (ja) 2006-04-27
CA2515065C (en) 2011-07-12
KR20050095647A (ko) 2005-09-29
CA2515065A1 (en) 2004-08-19
ATE435627T1 (de) 2009-07-15
BR0318096A (pt) 2005-12-20
US20050246033A1 (en) 2005-11-03
AU2003232803A1 (en) 2004-08-30
ES2328808T3 (es) 2009-11-18
CN1741774A (zh) 2006-03-01
AU2003232803B2 (en) 2010-02-25
EP1592369B1 (de) 2009-07-08
DE50311696D1 (de) 2009-08-20
EP1592369A1 (de) 2005-11-09
CN100571656C (zh) 2009-12-23
US20040158329A1 (en) 2004-08-12
KR101045407B1 (ko) 2011-06-30

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