WO2004062717A1 - Procédé et mécanisme pour distributeur de médicaments - Google Patents

Procédé et mécanisme pour distributeur de médicaments Download PDF

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Publication number
WO2004062717A1
WO2004062717A1 PCT/FI2004/000015 FI2004000015W WO2004062717A1 WO 2004062717 A1 WO2004062717 A1 WO 2004062717A1 FI 2004000015 W FI2004000015 W FI 2004000015W WO 2004062717 A1 WO2004062717 A1 WO 2004062717A1
Authority
WO
WIPO (PCT)
Prior art keywords
medicine
dispenser
functional element
transformation
locking part
Prior art date
Application number
PCT/FI2004/000015
Other languages
English (en)
Inventor
Juha Laiho
Vesa Junkkarinen
Seppo Arento
Kari Hakulinen
Original Assignee
Perlos Oyj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perlos Oyj filed Critical Perlos Oyj
Publication of WO2004062717A1 publication Critical patent/WO2004062717A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers

Definitions

  • the invention relates to a method for controlling the operation of a medicine dispenser.
  • the invention further relates to a mechanism for controlling the operation of a medicine dispenser, the mechanism comprising a locking part having a first position, in which a medicine dose can be dispensed with an actuator, and a second position, in which the medicine dispensing is prevented, the locking part being arranged to shift from the first position to the second position after the dispenser has dispensed a given amount of medicinal substance.
  • the invention further relates to a medicine dispenser comprising a locking part having a first position, in which a medicine dose can be dispensed by using an actuator, and a second position, in which the medicine dispensing is prevented, the locking part being arranged to shift from the first position to the second position after the dispenser has dispensed a given amount of medicinal substance.
  • Medicine dispensers enable a patient himself or herself or assisted by a nurse to dispense a given, predetermined sized volume of medicine subcutaneously, into the blood vascular system, via the respiratory ducts, onto mucous membranes or onto the skin.
  • the medicine may be e.g. in the form of a powder, aerosol, liquid, solid compact dose, or a combination thereof.
  • the above-mentioned medicine dispensers include e.g. inhalators, intravenous dosing apparatuses and syringes.
  • the medicine is generally arranged in a medicine container provided in an inhalator.
  • the medicine container includes a pre-dosaged medicine dose which, together with the breathing air, is transferred to the system of the user of the inhalator; in such a case, the inhalator comprises several separate medicine containers containing medicine, arranged in a magazine-like form in several separate small medicine containers.
  • dispensing means are used for dispensing a given amount of medicine from a medicine container to a particular chamber provided an inhalator, from which chamber the medicine becomes mixed with the breathing air.
  • the inhalator is provided with means for removing the medicine from the medicine container and for arranging the medicine to be mixed with the flow of air passing through the inhalator.
  • An inhalator may be disposable, which means that it becomes waste once the medicine therein has run out, or it may be refilled with the medicine.
  • An object of the present invention is to provide a novel and improved method, a mechanism implementing the method and a medicine dispenser so as to enable the above-mentioned problems to be avoided.
  • the method for controlling the operation of a medicine dispenser of the invention is characterized by using an actuator of the medicine dispenser for discharging a medicine dose such that a locking part of the dispenser moves from a first position to a second, locked, position in which position the use of the actuator does not permit medicine dispensing,
  • the mechanism of the invention for implementing the method for controlling a dispenser is characterized in that the mechanism further comprises a functional element, which includes memory material having a rest state and an excited state, in which states said element differs in shape, and that a transformation of the memory material is arranged to shift the locking part from the first position to the second position and vice versa.
  • the medicine dispenser of the invention is characterized in that the medicine dispenser further comprises a functional element that includes memory material having a rest state and an excited state, in which states said element differs in shape, and that the transformation of the memory material is arranged to shift the locking part from the first position to the second position and vice versa.
  • An advantage of the invention is that with simple solutions and in a cost-effective manner, the invention prevents medicine from being dispensed too frequently.
  • Figure 1a is a schematic side view showing a medicine dispenser of the invention
  • Figure 1b is a schematic side view showing the medicine dispenser of Figure 1a
  • Figures 2a to 2d are partially sectioned, schematic side views showing a second locking mechanism of the invention
  • Figures 3a and 3b are partially sectioned top views showing a third medicine dispenser of the invention.
  • Figures 4a to 4d are partially sectioned views showing a fourth locking mechanism of the invention.
  • FIGS 1a and 1b schematically show a medicine dispenser of the invention and the operation of a locking mechanism thereof.
  • the outlines of a medicine dispenser 1 hereinafter a dispenser 1 , are shown in dot-and- dash lines in the figure.
  • the components of the dispenser 1 are manufactured preferably mainly of polymer materials by moulding or injection moulding or by us- ing another similar method.
  • the dispenser 1 may comprise several medicine containers, each comprising one dispensable medicine dose.
  • the medicine is arranged in one single medicine container from which only a given amount of the medicine is retrieved for a medicine dose, in other words the medicine container is filled with enough medicine to constitute more than one medicine dose. It is to be noted that no medicine container is shown in the figures.
  • the shape of the dispenser 1 shown in Figures 1a, 1b is basically axially symmetrical, a middle axis 9 constituting the symmetry axis.
  • the dispenser 1 comprises an actuator 2 having the shape of a circular cylinder and arranged in the dispenser 1 so as to turn around the middle axis 9.
  • the actuator 2 is to be turned a given rotational angle in the direction of arrow A, with respect to a frame part 3 of the dispenser.
  • the actuator 2 is provided with a locking part 4 comprising a lock part 5 and a functional element 6 attached thereto.
  • the lock part 5 is a cylindrical, hollow form part whose one end is closed; naturally, it may also be a different one.
  • the functional element 6 is formed from a metal wire wound into a shape resembling a coil spring.
  • the wire comprises memory material which changes its shape reversibly, transforming in a controlled manner when its energy state changes, i.e. when it shifts from a rest state to an excited state or vice versa. In both the rest state and the excited state, the memory material has a certain shape the memory material tries to adopt while shifting to the particular state.
  • a change in the energy state is caused by a change in temperature, but it may also be caused by a change in an electric field or a change in a magnetic field.
  • the memory material consists e.g. of Nitinol, i.e. an alloy consisting of an approximately half-and-half mixture of nickel and titanium, or another memory alloy, such as Cu-Zn-AI or Cu-AI-Ni.
  • the operation of the memory metal is based on the fact that the crystal structure of the metal changes. In the change of structure, the atoms of the crystal structure rearrange themselves since a particular order in a particular temperature has the lowest energy, and the structure always aims at an energy minimum. A temperature or a temperature range within which a change takes place is called a transition temperature.
  • the frame part 3 is provided with a lock part counterpart 7, here a recess whose diameter is slightly longer than that of the lock part 5 and whose depth is substantially smaller than the height of the lock part.
  • the counterpart 7 is arranged such that when the actuator 2 is turned in order to dispense, the lock part 5 glides at the counterpart 7.
  • the dispenser 1 further comprises electric contacts 8' and 8" coupled to a power source 10.
  • the power source 10 is a disposable battery or a rechargeable battery known per se.
  • the electric contacts 8' and 8" are arranged such that when the actuator 2 is turned in order to dispense, the functional element 6, at some stage of the turning movement, couples the electric contacts 8' and 8" electrically to each other so as to form a closed circuit.
  • electric current travels via the functional element 6, and its 6 temperature rises substantially due to the electric resistance generated by the element 6.
  • the temperature of the functional element 6 thus rises above the transition temperature so that the memory material shifts to the excited state. In the present embodiment, such excitation becomes apparent such that the functional element 6 tries to increase its length.
  • the elongating functional element 6 pushes the lock part 5 into the counterpart 7.
  • the lock part 5 in the counterpart 7 prevents the actuator 2 from being turned in order to redispense the medicine.
  • the user may take the dispensed medicine, but the locking part 4 prevents the actuator 2 from being turned immediately again in order to dispense another dose.
  • the functional element 6 When the functional element 6 has been turned with respect to the electronic contacts 8', 8" such that the circuit opens, it starts to cool down. After the temperature has dropped below the transition temperature, the excitation state of the memory material trips and the lock part 5 ascends and comes off from the counterpart 7 so that the dispenser 1 may again be used for dispensing the medicine.
  • the time elapsed prior to the excitation state tripping i.e. the delay, depends on the properties of the memory material itself, mainly on the transition temperature, and the rate of change of the temperature thereof. In the same environmental conditions, a lower transition temperature yields a longer delay than a higher transition temperature.
  • the locking time may be e.g. 5 to 30 minutes.
  • FIGS 2a to 2d are partially sectioned, schematic side views showing a second locking mechanism of the invention.
  • a dispenser is made to dispense medicine by first moving an actuator 2 in the direction of arrow A.
  • the actuator 2 is provided with a projection-like operating switch 11 to make the actuator 2 easier to use.
  • the mechanism further comprises a dispensing part 12 arranged to be in contact with the actuator, however, such that the particular components are allowed to glide with respect to each other.
  • the dispensing part 12 is further arranged to be in a gliding contact with a frame part 3; gliding surfaces between the dispensing part 12 and the actuator 2 as well as the dispensing part 12 and the frame part 3 are parallel, so the dispensing part 12 is allowed to move between the actuator 2 and the frame part 3 in the direction of arrows A and R.
  • a movement of the dispensing part 12 extending sufficiently far in the direction of arrow A implements dispensing so that medicine can be discharged from the dispenser into the system.
  • the actuator After dispensing, the actuator returns to the initial position shown in Figure 2a, transferred in direction R by a force element, such as a return spring, arranged in the dispenser; in order to simplify the representation, no force element is shown in the figures.
  • the dispenser includes a locking part 4 comprising a functional element 6 and a lock part 5 attached thereto; the functional element and the lock part are arranged to move together with the dispensing part 12 whereas a counterpart 7 is arranged in the actuator 2.
  • the functional element 6 applied herein is manufactured such that its length is greater below the transition temperature than at temperatures higher than this. Consequently, when the functional element 6 is excited, its length decreases.
  • the movement of the dispensing part 12 implements or enables a procedure in dependence on the operation principle and structure of the dispenser; for example, it makes a puncture through a pre- dosed medicine capsule, or dispenses medicine from a non-predosed medicine container, or opens a valve of a propellant gas container or, in a powder inhalator, opens an air duct leading to a mixing space for medicine and air.
  • the rate at which the temperature decreases may be slowed down and the time during which medicine is prevented from being dispensed may be increased by providing the locking part 4 with a thermal insulation material element 11 around the functional element 6.
  • FIG. 3a is a partially sectioned top view showing a third medicine dispenser of the invention in a first excitation state
  • Figure 3b is a partially sectioned top view showing the same in a second excitation state
  • a medicine dispenser 1 comprises a first frame part 13a having the shape of a circular cylinder, and a second frame part 13b arranged coaxially inside the first frame part.
  • the frame parts 13a, 13b are allowed to move with respect to each other along gliding surfaces 20.
  • the frame parts 13a, 13b are interconnected through a return spring 18 which, at its one end, is attached to a middle axis 19 nonrotatably attached with respect to the first frame part 13a and which, at its other end, is attached to the second frame part 13b.
  • the return spring 18 tries to turn the second frame part 13b with respect to the first frame part 13a in a turning direction opposite to turning direction T shown in the figure.
  • any other force element capable of providing the necessary turning movement may also be used.
  • a locking part 4 comprising a lock part 5 and a functional element 6.
  • the functional element 6 is manufactured of a reversably transforming, wire-shaped memory material wound into a shape resembling a coil spring. In a rest state, the functional element 6 is substantially shorter than in an excited state, which means that the lock part 5 is allowed to move in a gliding groove 17.
  • the gliding groove 17 is provided in connection with a gliding surface 20 on the side of the first frame part 13a such that its inner circle abuts on a gliding surface of the second frame part.
  • the dispenser 1 comprises a power source 10 and a first and a second capacitor 22a, 22b, each being coupled to the power source 10.
  • the electric system of the dispenser 1 comprises an activation switch 21 , which has two operating states: in the first one it allows electric current to travel from the power source 10 to the capacitors 22a, 22b, and in the second one it opens the circuit such that the capacitors 22a, 22b do not charge.
  • the power source charges the capacitors 22a, 22b to the full whereas in the second state, the circuit of the power source and the capacitor is open and no charging occurs.
  • the lock part 5 presses against the activation switch 21 placed at one end of the gliding groove 17, and the functional element 6 is in the rest state.
  • the activation switch 21 is in the first state, i.e. the power source 10 then charges the capacitors 22a, 22b to the full.
  • the first capacitor 22a is further coupled to a first electric contact 8' by a first electric conductor 14 and to the functional element 6 by a second electric conductor 15; similarly, the second capacitor 22b is coupled to a second electric contact 8" and to the functional element 6.
  • the electric contacts 8', 8" are arranged in the gliding groove 17 such that while gliding in the gliding groove 17, the lock part 5 manufactured of an electrically conducting material comes into contact with the electric contacts.
  • a first medicine dose is produced by turning the second frame part 13b with respect to the first frame part 13a an angle ai in turning direction T.
  • the switch shifts to the second state in which the circuit between the capacitors 22a, 22b and the power source 10 is open and the power source is incapable of charging the capacitors.
  • the lock part 5 glides along the gliding groove 17 and the first electric contact 8' arranged therein.
  • the first capacitor 22a then discharges via the circuit closed by the first electric contact 8' and heats the functional element 6 such that its temperature rises above the transition temperature of the particular material. Therefore, the functional element 6 tries to increase its length.
  • the locking part 4 turns at a first counterpart 7a so that the functional element pushes the lock part inside the first counterpart 7a, locking the frame parts 13a, 13b to this position.
  • the first medicine dose may now be dispensed.
  • the functional element 6 cools down it becomes shorter, so the lock part 5 withdraws gradually from the first counterpart 7a.
  • the first counterpart 7a is formed such that in turning direction T at the mouth of the back surface, there is a sloped surface 16, and only part of the back surface is substantially perpendicular to the turning movement T.
  • the perpendicular part 23 prevents the turning from continuing forward when the lock part 5 resides inside this part.
  • the lock part 5 After about five minutes, the lock part 5 has withdrawn from inside the perpendicular part 23 of the first counterpart 7a.
  • the lock part 5 may now be turned forward in turning direction T of an angle a 2 , although the lock part 5 has not completely withdrawn from the first counterpart 7a.
  • the sloped surface 16 forces the functional element 6 to compress so that the lock part 5 turns forward along the gliding groove 17 in direction T.
  • the lock part 5 glides over the second electric contact 8" so that the second capacitor 22" discharges and the functional element 6 reheats.
  • no power source 10 no capacitors 22a, 22b and no necessary conductors are shown in Figure 3b.
  • the dispenser 1 may be used for first dispensing the first medicine dose and, not until five minutes have elapsed from this at the earliest, the second medicine dose.
  • the second medicine dose may be the same size as the first medicine dose or it may differ in size therefrom.
  • the depth of the second counterpart 7b has been dimensioned such that it takes the lock part 5 about 30 minutes to withdraw therefrom. During this time it is impossible to dispense a next medicine dose by using the dispenser 1.
  • the return spring 18 turns the second frame part 13b in a direction opposite with respect to turning direction T until the lock part 5 turns against the activation switch 21 placed at one end of the gliding groove 17.
  • the activation switch then shifts to its first state and the power source 10 recharges the capacitors 22a, 22b to the full.
  • the capacitors 22a, 22b may also be charged by using a power source external to the medicine dispenser arranged e.g. in a desktop holder for the medicine dispenser.
  • FIGS 4a to 4d are partially sectioned views showing a fourth locking mechanism of the invention.
  • a locking part 4 comprises a lock part 5 attached to a first part 13a of a medicine dispenser by means of a support element 29.
  • the lock part 5, supported by the support element 29, is allowed to move closer to the first part 13a than in the position shown in Figure 4a. This may be implemented e.g. by providing the first part 13a with a groove or a channel to receive the support element 29.
  • a coil spring 24 is arranged between the lock part 5 and the first frame part 13a.
  • the coil spring may be compressed from its state shown in Figure 4a so that the lock part 5 moves closer to the first frame part 13a.
  • the locking mechanism further comprises a functional element 6, which serves as a counterpart of the lock part 5 and which is attached to the second frame part 13b of the medicine dispenser.
  • the functional element 6 is manufactured of a magnetostrictive material which undergoes a transformation when the magnetic field affecting the material changes.
  • the mechanism 4 further comprises a return spring 25, which tries to keep the first frame part 13a in the position shown on Figure 4a with respect to the second frame part 13b.
  • the first frame part 13a When dispensing the medicine, the first frame part 13a is to be moved in the manner shown by arrow A with respect to the second frame part 13b. Simultaneously, the sloped upper surface of the lock part 5 and the sloped lower surface of the functional element 6 force the lock part 5 closer to the first frame part 13a such that the lock part 5 passes the functional element 6.
  • the coil spring 24 forces the lock part behind the functional element 6 so that despite the spring force of the return spring 25 affecting the first frame part 13a, the first frame part 13a is not allowed to return to the position shown in Figure 4a with respect to the second frame part 13b.
  • the mechanism is thus in the state shown in Figure 4b. This state enables one medicine dose to be dispensed.
  • the mechanism In order to dispense the next medicine dose, the mechanism has to be returned to the state shown in Figure 4a. This is carried out by bringing the medicine dispenser 1 into a medicine dispenser holder 26 shown in Figure 4c.
  • the holder 26 comprises means 27 for generating a magnetic field 28.
  • the magnetic field 28 affects the functional element 6 of the locking part 4 such that the element changes its shape in the manner shown in Figure 4d.
  • the functional element 6 withdraws from the front of the lock part 5 so that the return spring 25 pushes the first frame part 13a in the direction of arrow R into the state shown in Figure 4a. Selecting the materials and design of the functional element 6 as well as changing the properties of the magnetic field 28 enable the return time to be adjusted.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un procédé pour commander le fonctionnement d'un distributeur de médicaments, un mécanisme pour commander le fonctionnement d'un distributeur de médicaments et un distributeur de médicaments. Ce distributeur de médicaments (1) est pourvu d'un actionneur (2) qui sert à débiter une dose de médicament, de sorte qu'un élément de fermeture (4) du distributeur passe d'une première position à une deuxième position fermée, dans laquelle l'utilisation de l'actionneur (2) ne permet pas la distribution de médicament. L'élément de fermeture (4) peut se remettre en première position au bout d'un certain laps de temps, position dans laquelle la distribution de médicament est possible. Le laps de temps est déterminé par un élément fonctionnel (6) comportant un état de repos et un état d'excitation, une variation de l'élément (6) provoquant le déplacement du dispositif de fermeture de la première position en deuxième position et vice versa.
PCT/FI2004/000015 2003-01-13 2004-01-12 Procédé et mécanisme pour distributeur de médicaments WO2004062717A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20030044A FI116451B (fi) 2003-01-13 2003-01-13 Lääkeannostelijan toiminnan ohjausmenetelmä ja mekanismi sen toteuttamiseksi
FI20030044 2003-01-13

Publications (1)

Publication Number Publication Date
WO2004062717A1 true WO2004062717A1 (fr) 2004-07-29

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ID=8565310

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Application Number Title Priority Date Filing Date
PCT/FI2004/000015 WO2004062717A1 (fr) 2003-01-13 2004-01-12 Procédé et mécanisme pour distributeur de médicaments

Country Status (2)

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FI (1) FI116451B (fr)
WO (1) WO2004062717A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006095194A1 (fr) * 2005-03-11 2006-09-14 Sosei R & D Ltd. Distributeur pour la distribution de medicaments
WO2010114504A1 (fr) * 2009-03-30 2010-10-07 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Inhalateur de poudre sèche et mécanisme de verrouillage
JP2012500695A (ja) * 2008-08-29 2012-01-12 ノボ・ノルデイスク・エー／エス 時間遅延インジケータを備える医療用注射器
US9314573B2 (en) 2004-10-21 2016-04-19 Novo Nordisk A/S Injection device with means for signalling the time since the last injection
US9731103B1 (en) 2017-01-13 2017-08-15 Berkshire Biomedical, LLC Computerized oral prescription administration devices and associated systems and methods
US10441509B2 (en) 2018-03-16 2019-10-15 Berkshire Biomedical, LLC Computerized oral prescription administration with refillable medication dispensing devices and associated systems and methods
US10729860B1 (en) 2019-05-22 2020-08-04 Berkshire Biomedical, LLC Computerized oral prescription administration for securely dispensing a medication and associated systems and methods
US10792226B2 (en) 2017-06-07 2020-10-06 Berkshire Biomedical, LLC Refill and dosage management devices and associated systems and methods for use with computerized oral prescription administration devices

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078639A1 (fr) * 1999-06-21 2000-12-28 Bespak Plc Ameliorations relatives a un appareil de distribution
US20020000225A1 (en) * 2000-06-02 2002-01-03 Carlos Schuler Lockout mechanism for aerosol drug delivery devices
WO2002034318A2 (fr) * 2000-10-20 2002-05-02 Glaxo Group Limited Inhalateur
US20020189612A1 (en) * 1999-12-11 2002-12-19 Rand Paul Kenneth Medicament dispenser

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078639A1 (fr) * 1999-06-21 2000-12-28 Bespak Plc Ameliorations relatives a un appareil de distribution
US20020189612A1 (en) * 1999-12-11 2002-12-19 Rand Paul Kenneth Medicament dispenser
US20020000225A1 (en) * 2000-06-02 2002-01-03 Carlos Schuler Lockout mechanism for aerosol drug delivery devices
WO2002034318A2 (fr) * 2000-10-20 2002-05-02 Glaxo Group Limited Inhalateur

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9314573B2 (en) 2004-10-21 2016-04-19 Novo Nordisk A/S Injection device with means for signalling the time since the last injection
WO2006095194A1 (fr) * 2005-03-11 2006-09-14 Sosei R & D Ltd. Distributeur pour la distribution de medicaments
JP2008543353A (ja) * 2005-03-11 2008-12-04 ソーセイ アールアンドディ リミテッド 薬剤を供給するためのディスペンサ
US8210403B2 (en) 2005-03-11 2012-07-03 Sosei R&D Ltd. Dispenser for delivering medicament
JP2012500695A (ja) * 2008-08-29 2012-01-12 ノボ・ノルデイスク・エー／エス 時間遅延インジケータを備える医療用注射器
US8894611B2 (en) 2008-08-29 2014-11-25 Novo Nordisk A/S Medical injection device with time delay indicator
EP2239002A1 (fr) * 2009-03-30 2010-10-13 Sanovel Ilac Sanayi ve Ticaret A.S. Inhalateur de poudre sèche et mécanisme de verrouillage
EA021162B1 (ru) * 2009-03-30 2015-04-30 Арвен Айлак Санайи Ве Тиджарет А.С. Ингалятор для ингаляции сухого порошка и механизм блокировки
WO2010114504A1 (fr) * 2009-03-30 2010-10-07 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Inhalateur de poudre sèche et mécanisme de verrouillage
US10188840B2 (en) 2017-01-13 2019-01-29 Berkshire Biomedical, LLC Computerized oral prescription administration devices and associated systems and methods
US9981116B1 (en) 2017-01-13 2018-05-29 Berkshire Biomedical, LLC Computerized oral prescription administration devices and associated systems and methods
US9731103B1 (en) 2017-01-13 2017-08-15 Berkshire Biomedical, LLC Computerized oral prescription administration devices and associated systems and methods
US11097085B2 (en) 2017-01-13 2021-08-24 Berkshire Biomedical, LLC Computerized oral prescription administration devices and associated systems and methods
US12076517B2 (en) 2017-01-13 2024-09-03 Berkshire Biomedical Corporation Computerized oral prescription administration devices and associated systems and methods
US10792226B2 (en) 2017-06-07 2020-10-06 Berkshire Biomedical, LLC Refill and dosage management devices and associated systems and methods for use with computerized oral prescription administration devices
US10441509B2 (en) 2018-03-16 2019-10-15 Berkshire Biomedical, LLC Computerized oral prescription administration with refillable medication dispensing devices and associated systems and methods
US11412983B2 (en) 2018-03-16 2022-08-16 Berkshire Biomedical Corporation Computerized oral prescription administration with refillable medication dispensing devices and associated systems and methods
US10729860B1 (en) 2019-05-22 2020-08-04 Berkshire Biomedical, LLC Computerized oral prescription administration for securely dispensing a medication and associated systems and methods
US12048804B2 (en) 2019-05-22 2024-07-30 Berkshire Biomedical Corporation Computerized oral prescription administration for securely dispensing medication and associated systems and methods

Also Published As

Publication number Publication date
FI20030044A (fi) 2004-07-14
FI116451B (fi) 2005-11-30
FI20030044A0 (fi) 2003-01-13

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