Classifications

• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P27/00—Drugs for disorders of the senses
  • A61P27/02—Ophthalmic agents
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/0005—Other compounding ingredients characterised by their effect
  • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/02—Inorganic compounds ; Elemental compounds
  • C11D3/04—Water-soluble compounds
  • C11D3/06—Phosphates, including polyphosphates
• • C—CHEMISTRY; METALLURGY
  • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
  • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
  • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
  • C11D3/16—Organic compounds
  • C11D3/34—Organic compounds containing sulfur
  • C11D3/349—Organic compounds containing sulfur additionally containing nitrogen atoms, e.g. nitro, nitroso, amino, imino, nitrilo, nitrile groups containing compounds or their derivatives or thio urea

Definitions

• Taurine also significantly suppressed the decrease in the transepithelial electrical resistance, a measure of cell membrane integrity, caused by sodium laurate in rat large-intestinal tissue in the aforementioned study. More recently, a study of cell survival during a 450 mOsm/kg hypertonic medium challenge was conducted on human corneal epithelial cells (Shioda et al., IOVS, September 2002, Vol. 43, No. 9, pp. 2916-2922). This study showed that additional medium supplementation with 1 mM taurine (0.0125 w/v%) significantly increased cell survival. The authors concluded that the results reflected an antioxidant or membrane stabilization effect of taurine. This study did not disclose, hint, suggest or otherwise direct anyone skilled in the art to the instant teachings or that taurine could provide a protective benefit during contact lens wear.
• compositions and associated methods taught by the '383 Patent may comprise at least two agents selected from the group consisting of a heme oxygenase inducer, a membrane-permeable anti- acidosis buffer and an osmoprotectant.
• the '383 Patent discloses by inference, if not expressly, the possibility that taurine is an osmoprotectant.
• Shinohara, et al., in U.S. Pat. No. 5,998,488 disclose a method for inhibiting antimicrobial preservative from adsorbing to contact lens, comprising a cationic preservative, a cyclodextrin, ethylenediaminetetraacetic acid, boric acid or borax, and optionally taurine or another agent.
• this reference does not disclose any mechanism or possible role played by taurine in the described method.
• Tsuzuki et al., in U. S. Pat. No. 6,121,327, disclose a contact lens disinfecting solution which does not include protease, and which contains in an aqueous medium, an organic nitrogen disinfectant and 0.01-5 w/v% of at least one polyol, and further contains bis(2-hydroxyethyl) iminotris(hydroxymethyl)methane.
• at least one buffer is added to effectively maintain the pH of the contact lens disinfecting solution within the desired range for assuring safety to the eyes.
• Tsuzuki discloses only that taurine and its derivatives may be used as a buffer, among many others listed.
• the inclusion of one or more other components in the present compositions is effective in providing additional beneficial properties to the compositions, and preferably provide further lens wearer/user comfort and acceptability benefits.
• the present compositions have a multitude of applications, for example, as disinfecting, cleaning, soaking, wetting, rewetting, rinsing, storing, in-the-eye cleaning, and conditioning compositions, for contact lens care, while providing substantial lens wearer/user comfort and acceptability.
• the present compositions necessarily increase user compliance, that is promote regular and consistent contact lens care, and, ultimately, lead to or facilitate better ocular health.
• multi-purpose solutions for contact lens care comprise taurine, an aqueous liquid medium; an antimicrobial component in an amount effective to disinfect a contact lens contacted with the solution; a surfactant in an amount effective in cleaning a contact lens contacted with the solution; a phosphate buffer component in an amount effective in maintaining the pH of the solution within a physiologically acceptable range; a viscosity inducing component present in an effective amount; and a tonicity component in an amount effective in providing the desired tonicity to the solution.
• the antimicrobial component may be any suitable, preferably ophthalmically acceptable, material effective to disinfect a contact lens contacted with the present solutions or alternatively adequately preserve a solution such as a contact lens rewetting solution.
• the antimicrobial component is selected from biguanides, biguanides polymers, salts thereof and mixtures thereof, and is present in an amount in the range of about 0.1 ppm to about 3 ppm or less than 5 ppm (w/v).
• the antimicrobial component may be a monomeric quaternary ammonium or biguanide compound such as chlorhexidine digluconate, chlorhexidine diacetate, benzethonium chloride and myristamidopropyldimethylamine.
• the antimicrobial component may also be a polymeric quaternary ammonium compound such as Polyquad.RTM. (polyquatemium-1) or poly [oxyethylene (dimethyliminio) ethylene- (dimethyliminio) ethylene dichloride] (sold under the trademark WSCP by Buckman Laboratories, Inc.).
• the preferred relatively reduced concentration of the antimicrobial component has been found to be very effective, in the present compositions, in disinfecting contact lenses contacted with the compositions, while at the same time promoting lens wearer/user comfort and acceptability.
• surfactant component which is effective in cleaning contact lenses may be employed.
• the surfactant component preferably is non ionic and, more preferably, is selected from poly(oxyethylene) - poly(oxypropylene) block copolymers and mixtures thereof.
• the present compositions preferably include an effective amount of a chelating component.
• a chelating component Any suitable, preferably ophthalmically acceptable, chelating component may be included in the present compositions, although ethylenediaminetetraacetic acid (EDTA), salts thereof and mixtures thereof are particularly effective.
• the present compositions include chelating components in effective amounts less than about 0.05% (w/v) and still more preferably 0.02°s (w/v) or less. Such reduced amounts of chelating component in the present compositions remain effective in providing the desired chelating and/or sequestering functions while, at the same time, are better tolerated in the eye, thereby reducing the risk of user discomfort and or ocular irritation.
• a chlorine dioxide precursor in included in the present compositions it generally is present in an effective preservative or contact lens disinfecting amount.
• Such effective preservative or disinfecting concentrations usually are in the range of about 0.002 to about 0.06% (w/v) of the present compositions.
• Such chlorine dioxide precursors may be used in combination with other antimicrobial components, such as biguanides, biguanide polymers, salts thereof and mixtures thereof.
• compositions usually have an osmolality of at least about 200 mOsmol/kg and are buffered to maintain the pH within an acceptable physiological range, for example, a range of about 6 to about 10.
• compositions usually further comprise effective amounts of one or more additional components, such as a detergent or surfactant component; a viscosity inducing or thickening component; a chelating or sequestering component; a tonicity component; and the like and mixtures thereof.
• additional component or components may be selected from materials which are known to be useful in contact lens care compositions and are included in amounts effective to provide the desired effect or benefit.
• an additional component is included, it is generally compatible under typical use and storage conditions with the other components of the composition.
• the aforesaid additional component or components are substantially stable in the presence of the antimicrobial and buffer components described herein.
• Ethylenediaminetetraacetic acid (EDTA) and its alkali metal salts are preferred, with disodium salt of EDTA, also known as disodium edetate, being particularly preferred.
• the chelating component preferably is present in an effective amount, for example, in a range of about 0.01% and about 1% (w/v) of the solution.
• Table 2 summarizes the incidence of itching among the four test groups.
• the solutions according to example 2 and 3 may be used, for example, to clean contact lenses.
• approximately three (3) ml of this solution is introduced into a lens vial containing a lipid, oily deposit laden, hydrophilic or soft contact lens.
• the contact lens is maintained in this solution at room temperature for at least about four (4) hours.
• This treatment is effective to disinfect the contact lens.
• a substantial portion of the deposits previously present on the lens has been removed. This demonstrates that this solution has substantial passive contact lens cleaning ability. Passive cleaning refers to the cleaning which occurs during soaking of a contact lens, without mechanical or enzymatic enhancement.
• the solutions according to examples 4-7 may be used, for example, to wet or rewet contact lenses.
• a hydrophilic contact lens is ready for wear.
• one or two drops of one of the solutions of Examples 4-5 is placed on the lens immediately prior to placing the lens in the lens wearer's eye. The wearing of this lens is comfortable and safe.
• a lens wearer wearing a contact lens may apply one or two drops of one of the solutions of Examples 4-5 in the eye wearing the lens. This effects a re-wetting of the lens and provides for comfortable and safe lens wear.

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• Chemical & Material Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Engineering & Computer Science (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Organic Chemistry (AREA)
• Oil, Petroleum & Natural Gas (AREA)
• Wood Science & Technology (AREA)
• Health & Medical Sciences (AREA)
• Inorganic Chemistry (AREA)
• Bioinformatics & Cheminformatics (AREA)
• General Health & Medical Sciences (AREA)
• General Chemical & Material Sciences (AREA)
• Medicinal Chemistry (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Pharmacology & Pharmacy (AREA)
• Animal Behavior & Ethology (AREA)
• Ophthalmology & Optometry (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Medicinal Preparation (AREA)
• Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
• Eyeglasses (AREA)
• Apparatus For Disinfection Or Sterilisation (AREA)

Priority Applications (5)

Applications Claiming Priority (2)

Publications (1)

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Cited By (2)

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• 2002
  • 2002-12-23 US US10/328,641 patent/US20040120916A1/en not_active Abandoned
• 2003
  • 2003-12-23 CA CA002511550A patent/CA2511550A1/en not_active Abandoned
  • 2003-12-23 AU AU2003299907A patent/AU2003299907A1/en not_active Abandoned
  • 2003-12-23 JP JP2004562561A patent/JP2006511577A/ja active Pending
  • 2003-12-23 WO PCT/US2003/041279 patent/WO2004058930A1/en not_active Ceased
  • 2003-12-23 EP EP03800180A patent/EP1576080A1/en not_active Withdrawn
  • 2003-12-23 BR BR0317688-6A patent/BR0317688A/pt not_active IP Right Cessation
  • 2003-12-23 CN CNA2003801096410A patent/CN1748024A/zh active Pending

Patent Citations (2)

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