WO2004029031A2 - Therapeutic piperazine compounds - Google Patents

Therapeutic piperazine compounds Download PDF

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Publication number
WO2004029031A2
WO2004029031A2 PCT/US2003/030185 US0330185W WO2004029031A2 WO 2004029031 A2 WO2004029031 A2 WO 2004029031A2 US 0330185 W US0330185 W US 0330185W WO 2004029031 A2 WO2004029031 A2 WO 2004029031A2
Authority
WO
WIPO (PCT)
Prior art keywords
compound
halo
phenyl
alkyl
substituted
Prior art date
Application number
PCT/US2003/030185
Other languages
English (en)
French (fr)
Other versions
WO2004029031A3 (en
Inventor
Qun Sun
Xiaoming Zhou
Original Assignee
Euro-Celtque, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2500113A priority Critical patent/CA2500113C/en
Priority to JP2004539882A priority patent/JP4560610B2/ja
Priority to DE60312544T priority patent/DE60312544T2/de
Priority to EP03754883A priority patent/EP1562936B1/en
Priority to SI200330815T priority patent/SI1562936T1/sl
Priority to NZ539205A priority patent/NZ539205A/en
Priority to MXPA05003302A priority patent/MXPA05003302A/es
Priority to BR0314699-5A priority patent/BR0314699A/pt
Application filed by Euro-Celtque, S.A. filed Critical Euro-Celtque, S.A.
Priority to DK03754883T priority patent/DK1562936T3/da
Priority to AU2003272685A priority patent/AU2003272685A1/en
Publication of WO2004029031A2 publication Critical patent/WO2004029031A2/en
Publication of WO2004029031A3 publication Critical patent/WO2004029031A3/en
Priority to HK06102046A priority patent/HK1083216A1/xx
Priority to CY20071100730T priority patent/CY1106634T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
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    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
PCT/US2003/030185 2002-09-24 2003-09-24 Therapeutic piperazine compounds WO2004029031A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
MXPA05003302A MXPA05003302A (es) 2002-09-24 2003-09-24 Compuestos de piperazina terapeuticos.
DE60312544T DE60312544T2 (de) 2002-09-24 2003-09-24 Therapeutische piperazin verbindungen.
EP03754883A EP1562936B1 (en) 2002-09-24 2003-09-24 Therapeutic piperazine compounds
SI200330815T SI1562936T1 (sl) 2002-09-24 2003-09-24 Terapevtske piperazinske spojine
NZ539205A NZ539205A (en) 2002-09-24 2003-09-24 Therapeutic piperazine compounds
CA2500113A CA2500113C (en) 2002-09-24 2003-09-24 Therapeutic piperazine compounds
BR0314699-5A BR0314699A (pt) 2002-09-24 2003-09-24 Composto, composição e métodos para o tratamento da dor e para inibição da função vr1 em uma célula
JP2004539882A JP4560610B2 (ja) 2002-09-24 2003-09-24 治療的ピペラジン化合物
DK03754883T DK1562936T3 (da) 2002-09-24 2003-09-24 Terapeutiske piperazinforbindelser
AU2003272685A AU2003272685A1 (en) 2002-09-24 2003-09-24 Therapeutic piperazine compounds
HK06102046A HK1083216A1 (en) 2002-09-24 2006-02-16 Terapeutic piperazine compounds
CY20071100730T CY1106634T1 (el) 2002-09-24 2007-06-04 Θεραπευτικα παραγωγα της πιπεραζινης

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41284702P 2002-09-24 2002-09-24
US60/412,847 2002-09-24

Publications (2)

Publication Number Publication Date
WO2004029031A2 true WO2004029031A2 (en) 2004-04-08
WO2004029031A3 WO2004029031A3 (en) 2004-08-05

Family

ID=32043195

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/030185 WO2004029031A2 (en) 2002-09-24 2003-09-24 Therapeutic piperazine compounds

Country Status (20)

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US (4) US7157462B2 (US07737148-20100615-C00064.png)
EP (2) EP1810970B8 (US07737148-20100615-C00064.png)
JP (1) JP4560610B2 (US07737148-20100615-C00064.png)
KR (1) KR20050052514A (US07737148-20100615-C00064.png)
CN (1) CN100393713C (US07737148-20100615-C00064.png)
AT (2) ATE467627T1 (US07737148-20100615-C00064.png)
AU (1) AU2003272685A1 (US07737148-20100615-C00064.png)
BR (1) BR0314699A (US07737148-20100615-C00064.png)
CA (1) CA2500113C (US07737148-20100615-C00064.png)
CY (1) CY1106634T1 (US07737148-20100615-C00064.png)
DE (2) DE60332562D1 (US07737148-20100615-C00064.png)
DK (1) DK1562936T3 (US07737148-20100615-C00064.png)
ES (1) ES2285170T3 (US07737148-20100615-C00064.png)
HK (1) HK1083216A1 (US07737148-20100615-C00064.png)
MX (1) MXPA05003302A (US07737148-20100615-C00064.png)
NZ (1) NZ539205A (US07737148-20100615-C00064.png)
PT (1) PT1562936E (US07737148-20100615-C00064.png)
SI (1) SI1562936T1 (US07737148-20100615-C00064.png)
WO (1) WO2004029031A2 (US07737148-20100615-C00064.png)
ZA (1) ZA200502326B (US07737148-20100615-C00064.png)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012287A1 (en) * 2003-08-01 2005-02-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
WO2007095050A2 (en) * 2006-02-09 2007-08-23 Incyte Corporation N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase
US7776861B2 (en) 2003-07-24 2010-08-17 Purdue Pharma L.P. Therapeutic agents useful for treating pain
US7834035B2 (en) 2003-11-06 2010-11-16 Addex Pharma Sa Allosteric modulators of metabotropic glutamate receptors
US8034953B2 (en) 2005-05-10 2011-10-11 Incyte Corporation Modulators of indoleamine 2,3-dioxygenase and methods of using the same
US8088803B2 (en) 2008-07-08 2012-01-03 Incyte Corporation 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
WO2012158844A1 (en) 2011-05-17 2012-11-22 Shionogi & Co., Ltd. Heterocyclic compounds
US8377976B2 (en) 2006-09-19 2013-02-19 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
US8431575B2 (en) 2010-02-18 2013-04-30 Transtech Pharma, Inc. Phenyl-heteroaryl derivatives and methods of use thereof
US8450351B2 (en) 2005-12-20 2013-05-28 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
US8507541B2 (en) 2006-09-19 2013-08-13 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
US8557872B2 (en) 2008-01-28 2013-10-15 Amorepacific Corporation Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
US8691855B2 (en) 2008-07-02 2014-04-08 Amorepacific Corporation Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist and pharmaceutical compositions containing the same
US9017722B2 (en) 2001-01-29 2015-04-28 Intermune, Inc. Pharmaceutical composition containing as an active ingredient 5-methyl-1-phenyl-2-(1H)-pyridone
US9321755B2 (en) 2013-11-08 2016-04-26 Incyte Corporation Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
US10188637B2 (en) 2016-03-29 2019-01-29 Hoffmann-La Roche Inc. Granulate formulation of 5-methyl-1-phenyl-2-(1H)-pyridone and method of making the same
WO2022229615A1 (en) 2021-04-26 2022-11-03 Pathios Therapeutics Limited Compounds
DE102022104759A1 (de) 2022-02-28 2023-08-31 SCi Kontor GmbH Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7157462B2 (en) * 2002-09-24 2007-01-02 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US7582635B2 (en) 2002-12-24 2009-09-01 Purdue Pharma, L.P. Therapeutic agents useful for treating pain
UA84710C2 (ru) * 2003-07-24 2008-11-25 Евро-Селтик С.А. Пиперидиновые производные, фармацевтическая композиция, которая их содержит, и способ лечения
EP2012790A4 (en) * 2006-04-19 2009-07-01 Smith Jill P TREATMENT OF INFLAMMATORY AND ULCEROUS DISEASES OF THE COLON USING OPIOID ANTAGONISTS
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
US20080153845A1 (en) * 2006-10-27 2008-06-26 Redpoint Bio Corporation Trpv1 antagonists and uses thereof
CA2833209C (en) * 2007-04-27 2016-06-28 Purdue Pharma L.P. Piperidine and piperazine compounds as trpv1 antagonists
WO2009052377A1 (en) * 2007-10-18 2009-04-23 Harry Fisch Treatment of migraine headaches using antiestrogens
US8921373B2 (en) 2010-06-22 2014-12-30 Shionogi & Co., Ltd. Compounds having TRPV1 antagonistic activity and uses thereof
UA113288C2 (xx) 2011-06-22 2017-01-10 Trpv1 антагоністи, що містять дигідроксизамісник, і їх застосування
US11443441B2 (en) 2017-02-24 2022-09-13 Brainlab Ag Deep inspiration breath-hold setup using x-ray imaging

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000052001A1 (en) * 1999-03-03 2000-09-08 Samjin Pharmaceutical Co., Ltd. Piperazine derivatives and process for the preparation thereof

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439606A (en) 1982-05-06 1984-03-27 American Cyanamid Company Antiatherosclerotic 1-piperazinecarbonyl compounds
US4450272A (en) 1982-05-06 1984-05-22 American Cyanamid Company Antiatherosclerotic 1-piperazine-thicarboxamides
US5316759A (en) 1986-03-17 1994-05-31 Robert J. Schaap Agonist-antagonist combination to reduce the use of nicotine and other drugs
DE3822792C2 (de) 1987-07-11 1997-11-27 Sandoz Ag Neue Verwendung von 5HT¶3¶-Antagonisten
US5198459A (en) 1987-07-11 1993-03-30 Sandoz Ltd. Use of 5HT-3 antagonists in preventing or reducing dependency on dependency-inducing agents
US5075341A (en) 1989-12-01 1991-12-24 The Mclean Hospital Corporation Treatment for cocaine abuse
US6204284B1 (en) 1991-12-20 2001-03-20 American Cyanamid Company Use of 1-(substitutedphenyl)-3-azabicyclo[3.1.0]hexanes for the treatment of chemical dependencies
US5232934A (en) 1992-07-17 1993-08-03 Warner-Lambert Co. Method for the treatment of psychomotor stimulant addiction
DE4234295A1 (de) 1992-10-12 1994-04-14 Thomae Gmbh Dr K Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5321012A (en) 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
GB9306578D0 (en) 1993-03-30 1993-05-26 Merck Sharp & Dohme Therapeutic agents
GB9308725D0 (en) 1993-04-27 1993-06-09 Wyeth John & Brother Ltd Piperazine derivatives
US5461047A (en) 1993-06-16 1995-10-24 G. D. Searle & Co. 2-,3-,4-,5-,6-,7-,8-,9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use
US5464788A (en) 1994-03-24 1995-11-07 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
FR2722788B1 (fr) 1994-07-20 1996-10-04 Pf Medicament Nouvelles piperazides derivees d'aryl piperazine, leurs procedes de preparation, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant
US5556837A (en) 1994-08-01 1996-09-17 Regeneron Pharmaceuticals Inc. Methods for treating addictive disorders
US5762925A (en) 1994-11-03 1998-06-09 Sagen; Jacqueline Preventing opiate tolerance by cellular implantation
PL183865B1 (pl) 1995-01-11 2002-07-31 Samjin Pharmaceutical Co Nowe pochodne piperazyny i środek farmaceutyczny
PL325341A1 (en) 1996-06-29 1998-07-20 Samjin Pharmaceutical Co Derivatives od piperazine and method of obtaining them
JP2003524574A (ja) 1997-08-05 2003-08-19 ノボ ノルディスク アクティーゼルスカブ ２，５−及び３，５−二置換アニリン誘導体、その調製及び使用
EP1067123B1 (en) 1998-03-31 2011-01-19 Kyowa Hakko Kirin Co., Ltd. Nitrogenous heterocyclic compounds
US6329395B1 (en) 1998-06-08 2001-12-11 Schering Corporation Neuropeptide Y5 receptor antagonists
AU754529B2 (en) 1998-09-22 2002-11-21 Yamanouchi Pharmaceutical Co., Ltd. Cyanophenyl derivatives
US6109269A (en) 1999-04-30 2000-08-29 Medtronic, Inc. Method of treating addiction by brain infusion
EP1313477A4 (en) 2000-07-15 2004-03-03 Smithkline Beecham Corp COMPILATIONS AND METHODS
US6723730B2 (en) * 2000-07-20 2004-04-20 Neurogen Corporation Capsaicin receptor ligands
ATE393141T1 (de) 2000-08-21 2008-05-15 Pacific Corp Neue thiourea-derivate und pharmazeutische zusammensetzungen die diese enthalten
JP2004506714A (ja) 2000-08-21 2004-03-04 パシフィック　コーポレーション 新規チオ尿素化合物及びこれを含有する薬学的組成物
PE20030417A1 (es) 2001-09-13 2003-08-06 Smithkline Beecham Plc Derivados de urea como antagonistas del receptor vainilloide
KR20040085151A (ko) 2002-01-17 2004-10-07 뉴로젠 코포레이션 캡사이신 조절자로서의 치환된 퀴나졸린-4-일 아민 유사체
ES2316777T3 (es) 2002-02-15 2009-04-16 Glaxo Group Limited Moduladores de receptores vainilloides.
US20030158188A1 (en) 2002-02-20 2003-08-21 Chih-Hung Lee Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7074805B2 (en) 2002-02-20 2006-07-11 Abbott Laboratories Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
EA200500114A1 (ru) * 2002-06-28 2005-06-30 Еуро-Селтик, С. А. Терапевтические агенты, используемые для лечения боли
US7157462B2 (en) * 2002-09-24 2007-01-02 Euro-Celtique S.A. Therapeutic agents useful for treating pain
UA84710C2 (ru) * 2003-07-24 2008-11-25 Евро-Селтик С.А. Пиперидиновые производные, фармацевтическая композиция, которая их содержит, и способ лечения
CN101935315A (zh) * 2003-07-24 2011-01-05 欧洲凯尔蒂克公司 用于治疗或预防疼痛的杂芳基-四氢哌啶基化合物
EA200601249A1 (ru) * 2003-12-30 2007-02-27 Еуро-Селтик С. А. Пиперазины, пригодные для лечения боли

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000052001A1 (en) * 1999-03-03 2000-09-08 Samjin Pharmaceutical Co., Ltd. Piperazine derivatives and process for the preparation thereof

Cited By (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9017722B2 (en) 2001-01-29 2015-04-28 Intermune, Inc. Pharmaceutical composition containing as an active ingredient 5-methyl-1-phenyl-2-(1H)-pyridone
US9561217B2 (en) 2001-01-29 2017-02-07 Intermune, Inc. Pharmaceutical composition containing as an active ingredient 5-methyl-1-phenyl-2-(1H)-pyridone
US8178560B2 (en) 2003-07-24 2012-05-15 Purdue Pharma L.P. Therapeutic agents useful for treating pain
US9301953B2 (en) 2003-07-24 2016-04-05 Purdue Pharma L.P. Therapeutic agents useful for treating pain
US7776861B2 (en) 2003-07-24 2010-08-17 Purdue Pharma L.P. Therapeutic agents useful for treating pain
US8637548B2 (en) 2003-07-24 2014-01-28 Purdue Pharma L.P. Therapeutic agents useful for treating pain
EP1942106A1 (en) * 2003-08-01 2008-07-09 Euro-Celtique S.A. Therapeutic agents useful for treating pain
AU2004261666B2 (en) * 2003-08-01 2009-06-18 Euro-Celtique S.A. Therapeutic agents useful for treating pain
WO2005012287A1 (en) * 2003-08-01 2005-02-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US7834035B2 (en) 2003-11-06 2010-11-16 Addex Pharma Sa Allosteric modulators of metabotropic glutamate receptors
US8030331B2 (en) 2003-11-06 2011-10-04 Addex Pharma Sa Allosteric modulators of metabotropic glutamate receptors
US8163775B2 (en) 2003-11-06 2012-04-24 Addex Pharma Sa Allosteric modulators of metabotropic glutamate receptors
US8372870B2 (en) 2005-05-10 2013-02-12 Incyte Corporation Modulators of indoleamine 2,3-dioxygenase and methods of using the same for treating cancer
US8034953B2 (en) 2005-05-10 2011-10-11 Incyte Corporation Modulators of indoleamine 2,3-dioxygenase and methods of using the same
US8846726B2 (en) 2005-05-10 2014-09-30 Incyte Corporation Modulators of indoleamine 2,3-dioxygenase and methods of using the same
US11192868B2 (en) 2005-05-10 2021-12-07 Incyte Corporation Modulators of indoleamine 2,3-dioxygenase and methods of using the same
US10208002B2 (en) 2005-05-10 2019-02-19 Incyte Corporation Modulators of indoleamine 2,3-dioxygenase and methods of using the same
US8951536B2 (en) 2005-12-20 2015-02-10 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
US8450351B2 (en) 2005-12-20 2013-05-28 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
WO2007095050A2 (en) * 2006-02-09 2007-08-23 Incyte Corporation N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase
WO2007095050A3 (en) * 2006-02-09 2007-11-15 Incyte Corp N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase
US8507541B2 (en) 2006-09-19 2013-08-13 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
US8377976B2 (en) 2006-09-19 2013-02-19 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
US8557872B2 (en) 2008-01-28 2013-10-15 Amorepacific Corporation Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
US8691855B2 (en) 2008-07-02 2014-04-08 Amorepacific Corporation Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist and pharmaceutical compositions containing the same
US8822511B2 (en) 2008-07-08 2014-09-02 Incyte Corporation 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
US8993605B2 (en) 2008-07-08 2015-03-31 Incyte Corporation 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
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US9320732B2 (en) 2008-07-08 2016-04-26 Incyte Corporation 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
US8088803B2 (en) 2008-07-08 2012-01-03 Incyte Corporation 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
US9789094B2 (en) 2008-07-08 2017-10-17 Incyte Holdings Corporation 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
US10653677B2 (en) 2008-07-08 2020-05-19 Incyte Holdings Corporation 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
US10034864B2 (en) 2008-07-08 2018-07-31 Incyte Holdings Corporation 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
US10369137B2 (en) 2008-07-08 2019-08-06 Incyte Corporation 1,2,5-Oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
US8741900B2 (en) 2010-02-18 2014-06-03 Transtech Pharma, Llc Phenyl-heteroaryl derivatives and methods of use thereof
US9045461B2 (en) 2010-02-18 2015-06-02 Transtech Pharma, Llc Phenyl-heteroaryl derivatives and methods of use thereof
US8431575B2 (en) 2010-02-18 2013-04-30 Transtech Pharma, Inc. Phenyl-heteroaryl derivatives and methods of use thereof
US9156830B2 (en) 2011-05-17 2015-10-13 Shionogi & Co., Ltd. Heterocyclic compounds
WO2012158844A1 (en) 2011-05-17 2012-11-22 Shionogi & Co., Ltd. Heterocyclic compounds
US10280157B2 (en) 2013-11-08 2019-05-07 Incyte Corporation Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
US9873688B2 (en) 2013-11-08 2018-01-23 Incyte Holdings Corporation Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
US9321755B2 (en) 2013-11-08 2016-04-26 Incyte Corporation Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
US10188637B2 (en) 2016-03-29 2019-01-29 Hoffmann-La Roche Inc. Granulate formulation of 5-methyl-1-phenyl-2-(1H)-pyridone and method of making the same
WO2022229615A1 (en) 2021-04-26 2022-11-03 Pathios Therapeutics Limited Compounds
DE102022104759A1 (de) 2022-02-28 2023-08-31 SCi Kontor GmbH Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen

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