WO2004022542A3 - Substituted 1,2,3,4-tetrahydroquinoline derivatives - Google Patents
Substituted 1,2,3,4-tetrahydroquinoline derivatives Download PDFInfo
- Publication number
- WO2004022542A3 WO2004022542A3 PCT/EP2003/008889 EP0308889W WO2004022542A3 WO 2004022542 A3 WO2004022542 A3 WO 2004022542A3 EP 0308889 W EP0308889 W EP 0308889W WO 2004022542 A3 WO2004022542 A3 WO 2004022542A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- substituted
- tetrahydroquinoline derivatives
- tetrahydroquinoline
- derivatives
- medicaments
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003258598A AU2003258598A1 (en) | 2002-08-12 | 2003-08-11 | Substituted 1,2,3,4-tetrahydroquinoline derivatives |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10236910.0 | 2002-08-12 | ||
DE2002136910 DE10236910A1 (en) | 2002-08-12 | 2002-08-12 | Substituted 1,2,3,4-tetrahydroquinoline derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004022542A2 WO2004022542A2 (en) | 2004-03-18 |
WO2004022542A3 true WO2004022542A3 (en) | 2004-06-03 |
Family
ID=31501737
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2003/008889 WO2004022542A2 (en) | 2002-08-12 | 2003-08-11 | Substituted 1,2,3,4-tetrahydroquinoline derivatives |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2003258598A1 (en) |
DE (1) | DE10236910A1 (en) |
WO (1) | WO2004022542A2 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2033959T3 (en) * | 2003-12-20 | 2011-07-25 | Merck Patent Gmbh | Tetrahydropyranoquinoline derivatives |
DE102004020908A1 (en) * | 2004-04-28 | 2005-11-17 | Grünenthal GmbH | Substituted 5,6,7,8-tetrahydropyrido [4,3-d] pyrimidin-2-yl and 5,6,7,8-tetrahydroquinazolin-2-yl compounds |
DE102005027169A1 (en) * | 2005-06-13 | 2006-12-14 | Merck Patent Gmbh | tetrahydroquinoline |
WO2008109007A1 (en) * | 2007-03-02 | 2008-09-12 | Cara Therapeutics, Inc. | Bridged phenanthridines |
US8546427B2 (en) * | 2010-10-20 | 2013-10-01 | Hoffmann-La Roche Inc. | Tetrahydroquinoline derivatives |
WO2014053315A1 (en) * | 2012-10-02 | 2014-04-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Tetrahydroquinoline derivatives and their use as epac inhibitors |
CN110372589B (en) * | 2019-08-13 | 2020-12-25 | 聊城大学 | Preparation method of 4- (4-tert-butylphenyl) -2-phenyl-1, 2,3, 4-tetrahydroquinoline-8-methyl formate |
TW202241852A (en) | 2020-12-25 | 2022-11-01 | 日商東麗股份有限公司 | Tetrahydroquinoline derivatives and medical use thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5017584A (en) * | 1984-12-20 | 1991-05-21 | Sterling Drug Inc. | Antidepressant 2-(4,5-dihydro-1H-imidazolyl)-dihydro-1H-indoles, -1,2,3,4-tetrahydroquinolines and -1H-indoles, and methods of use thereas |
US5461063A (en) * | 1992-08-10 | 1995-10-24 | Merck Sharp & Dohme Limited | Azabicyclic compounds |
WO1998027093A1 (en) * | 1996-12-18 | 1998-06-25 | Eli Lilly And Company | Combinatorial process for preparing hydrofuroquinoline libraries |
WO1998034115A1 (en) * | 1997-02-04 | 1998-08-06 | Trega Biosciences, Inc. | 4-substituted-quinoline derivatives and 4-substitute-quinoline combinatorial libraries |
WO1998034111A1 (en) * | 1997-02-04 | 1998-08-06 | Trega Biosciences, Inc. | Tricyclic tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries |
WO2001058875A2 (en) * | 2000-02-07 | 2001-08-16 | Grünenthal GmbH | Substituted 1,2,3,4- tetrahydroquinoline-2-carboxylic acid derivatives |
WO2003015715A2 (en) * | 2001-08-20 | 2003-02-27 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives as antithrombotic agents |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4125270A1 (en) * | 1991-07-31 | 1993-02-04 | Bayer Ag | QUINOLINE-2-YL-METHOXYBENZYLHYDROXYHARNSTOFFE |
AP876A (en) * | 1995-09-29 | 2000-09-27 | Glaxo Wellcome Spa | Tetrahydroquinolines as NMDA antagonists. |
-
2002
- 2002-08-12 DE DE2002136910 patent/DE10236910A1/en not_active Withdrawn
-
2003
- 2003-08-11 AU AU2003258598A patent/AU2003258598A1/en not_active Abandoned
- 2003-08-11 WO PCT/EP2003/008889 patent/WO2004022542A2/en not_active Application Discontinuation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5017584A (en) * | 1984-12-20 | 1991-05-21 | Sterling Drug Inc. | Antidepressant 2-(4,5-dihydro-1H-imidazolyl)-dihydro-1H-indoles, -1,2,3,4-tetrahydroquinolines and -1H-indoles, and methods of use thereas |
US5461063A (en) * | 1992-08-10 | 1995-10-24 | Merck Sharp & Dohme Limited | Azabicyclic compounds |
WO1998027093A1 (en) * | 1996-12-18 | 1998-06-25 | Eli Lilly And Company | Combinatorial process for preparing hydrofuroquinoline libraries |
WO1998034115A1 (en) * | 1997-02-04 | 1998-08-06 | Trega Biosciences, Inc. | 4-substituted-quinoline derivatives and 4-substitute-quinoline combinatorial libraries |
WO1998034111A1 (en) * | 1997-02-04 | 1998-08-06 | Trega Biosciences, Inc. | Tricyclic tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries |
WO2001058875A2 (en) * | 2000-02-07 | 2001-08-16 | Grünenthal GmbH | Substituted 1,2,3,4- tetrahydroquinoline-2-carboxylic acid derivatives |
WO2003015715A2 (en) * | 2001-08-20 | 2003-02-27 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives as antithrombotic agents |
Non-Patent Citations (4)
Title |
---|
HOEMANN, MICHAEL Z. ET AL: "Potent In vitro methicillin-resistant Staphylococcus aureus activity of 2-(1H-indol-3-yl)tetrahydroquinoline derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002), 12(2), 129-132, XP002265033 * |
KOBAYASHI S ET AL: "A CONVENIENT METHOD FOR LIBRARY CONSTRUCTION: PARALLEL SYNTHESIS OF BETA-AMINO ESTER AND QUINOLINE DERIVATIVES IN LIQUID PHASE USING LN(OTF)3-CATALYZED THREE-COMPONENT REACTIONS", BIOTECHNOLOGY AND BIOENGINEERING - COMBINATORIAL CHEMISTRY, WILEY, NEW YORK, NY, US, vol. 61, no. 1, 1998, pages 23 - 31, XP002145305, ISSN: 0006-3592 * |
KOBAYASHI S ET AL: "LANTHANIDE TRIFLATE CATALYZED IMINO DIELS-ALDER REACTIONS;CONVENIENT SYNTHESES OF PYRIDINE AND QUINOLINE DERIVATIVES", SYNTHESIS, GEORG THIEME VERLAG. STUTTGART, DE, vol. 9, September 1995 (1995-09-01), pages 1195 - 1202, XP002941298, ISSN: 0039-7881 * |
LEARDINI, R.; ET AL., J. ORG. CHEM., vol. 57, 1992, pages 1842 - 1848, XP002274144 * |
Also Published As
Publication number | Publication date |
---|---|
AU2003258598A1 (en) | 2004-03-29 |
DE10236910A1 (en) | 2004-03-11 |
WO2004022542A2 (en) | 2004-03-18 |
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