WO2004018475A2 - Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents - Google Patents

Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents Download PDF

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Publication number
WO2004018475A2
WO2004018475A2 PCT/US2003/025772 US0325772W WO2004018475A2 WO 2004018475 A2 WO2004018475 A2 WO 2004018475A2 US 0325772 W US0325772 W US 0325772W WO 2004018475 A2 WO2004018475 A2 WO 2004018475A2
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alkyl
substituted
hydrogen
compound
cancer
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PCT/US2003/025772
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English (en)
French (fr)
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WO2004018475A3 (en
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Ling Jong
Wan-Ru Chao
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Sri International
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Priority to AU2003263878A priority Critical patent/AU2003263878A1/en
Priority to CA2496203A priority patent/CA2496203C/en
Priority to JP2004531045A priority patent/JP4764629B2/ja
Priority to DE60324155T priority patent/DE60324155D1/de
Priority to EP03793096A priority patent/EP1530572B1/en
Publication of WO2004018475A2 publication Critical patent/WO2004018475A2/en
Publication of WO2004018475A3 publication Critical patent/WO2004018475A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
PCT/US2003/025772 2002-08-20 2003-08-15 Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents WO2004018475A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2003263878A AU2003263878A1 (en) 2002-08-20 2003-08-15 Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
CA2496203A CA2496203C (en) 2002-08-20 2003-08-15 Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
JP2004531045A JP4764629B2 (ja) 2002-08-20 2003-08-15 化学療法薬および化学防御薬としてのインドール−３−カルビノール代謝物の類似物
DE60324155T DE60324155D1 (de) 2002-08-20 2003-08-15 Indol-3-carbinol metaboliten als chemotherapeutische und chemopräventive wirkstoffen
EP03793096A EP1530572B1 (en) 2002-08-20 2003-08-15 Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/224,979 2002-08-20
US10/224,979 US6800655B2 (en) 2002-08-20 2002-08-20 Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents

Publications (2)

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WO2004018475A2 true WO2004018475A2 (en) 2004-03-04
WO2004018475A3 WO2004018475A3 (en) 2004-04-01

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PCT/US2003/025772 WO2004018475A2 (en) 2002-08-20 2003-08-15 Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents

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US (4) US6800655B2 (US20040157906A1-20040812-C00031.png)
EP (2) EP1530572B1 (US20040157906A1-20040812-C00031.png)
JP (3) JP4764629B2 (US20040157906A1-20040812-C00031.png)
AT (1) ATE411317T1 (US20040157906A1-20040812-C00031.png)
AU (1) AU2003263878A1 (US20040157906A1-20040812-C00031.png)
CA (1) CA2496203C (US20040157906A1-20040812-C00031.png)
DE (1) DE60324155D1 (US20040157906A1-20040812-C00031.png)
WO (1) WO2004018475A2 (US20040157906A1-20040812-C00031.png)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1811842A2 (en) * 2004-11-06 2007-08-01 The Regents of the University of California 3,3'-diindolylmethane immune activating compositions
JP2008545663A (ja) * 2005-05-27 2008-12-18 クイーンズ ユニバーシティ アット キングストン タンパク質フォールディング障害の治療
WO2010033198A3 (en) * 2008-09-17 2010-08-19 Sri International Analogs of indole-3-carbinol and their use as agents against infection
US8404726B2 (en) 2006-04-18 2013-03-26 Nippon Chemiphar Co. Ltd. Activating agent for peroxisome proliferator activated receptor δ
US8648208B2 (en) 2008-04-15 2014-02-11 Nippon Chemiphar Co. Ltd. Activating agent for peroxisome proliferator activated receptor
CN104030964A (zh) * 2014-06-05 2014-09-10 天津科技大学 双吲哚类化合物及合成方法
CN105218552A (zh) * 2015-09-30 2016-01-06 中国人民解放军军事医学科学院野战输血研究所 一种取代苯基二氢吲哚咔唑衍生物及其制备方法与应用

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US6800655B2 (en) * 2002-08-20 2004-10-05 Sri International Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
US8080577B2 (en) * 2004-05-06 2011-12-20 Bioresponse, L.L.C. Diindolylmethane formulations for the treatment of leiomyomas
EP1838303B1 (en) 2004-12-30 2011-02-09 Bioresponse LLC Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associates conditions
KR101345002B1 (ko) 2005-01-21 2013-12-31 아스텍스 테라퓨틱스 리미티드 제약 화합물
CN1807413B (zh) * 2005-09-28 2010-05-05 中国医学科学院医药生物技术研究所 咔唑磺酰胺衍生物及其制备方法
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
EP2073803B1 (en) 2006-10-12 2018-09-19 Astex Therapeutics Limited Pharmaceutical combinations
BRPI0717753B1 (pt) 2006-10-27 2022-04-12 Bioresponse, Llc Uso de uma composição compreendendo 50-250 mg de um ou mais indóis relacionados com dim e um ou mais agentes anti-protozoários, e, composição
US7807705B2 (en) * 2007-05-18 2010-10-05 The Ohio State University Research Foundation Potent indole-3-carbinol-derived antitumor agents
US20100292316A1 (en) * 2007-07-18 2010-11-18 Research Development Foundation Improved therapeutic methods and compositions comprising chroman ring compounds
KR101477613B1 (ko) * 2009-03-31 2014-12-30 롬엔드하스전자재료코리아유한회사 신규한 유기 전자재료용 화합물 및 이를 포함하는 유기 전자 소자
WO2010118339A2 (en) * 2009-04-09 2010-10-14 University Of Kansas Formulations of indole-3-carbinol derived antitumor agents with increased oral bioavailability
CN102724978A (zh) * 2009-08-14 2012-10-10 塞伦尼斯治疗公司 用于治疗或预防炎症或能量代谢/产生相关疾病的PPARδ配体的用途
US8153680B2 (en) * 2009-08-25 2012-04-10 The Ohio State University Research Foundation Alkyl indole-3-carbinol-derived antitumor agents
DE102009052428A1 (de) * 2009-11-10 2011-05-12 Merck Patent Gmbh Verbindung für elektronische Vorrichtungen
AU2011248175A1 (en) * 2010-05-06 2012-10-25 Merck Sharp & Dohme Corp. Aza-Indole derivatives useful as modulators of FAAH
JP6034853B2 (ja) * 2011-04-01 2016-11-30 エスアールアイ インターナショナルＳＲＩ Ｉｎｔｅｒｎａｔｉｏｎａｌ リポキシゲナーゼ阻害剤
WO2015042170A1 (en) 2013-09-17 2015-03-26 Wayne State University Compositions and uses of combinations of dim-related indoles and selected anti-androgen compounds
US9969686B2 (en) * 2014-08-05 2018-05-15 Wisconsin Alumni Research Foundation Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them
US9918965B2 (en) 2015-04-10 2018-03-20 Bioresponse, L.L.C. Self-emulsifying formulations of DIM-related indoles
CA3030582A1 (en) 2015-07-22 2017-01-26 The Royal Institution For The Advancement Of Learning/Mcgill University Compounds and uses thereof in the treatment of cancers and other medical conditions
CN110698654B (zh) * 2018-07-10 2021-04-02 中国科学院长春应用化学研究所 基于三聚吲哚的超支化共轭聚电解质及其制备方法和用途

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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1811842A2 (en) * 2004-11-06 2007-08-01 The Regents of the University of California 3,3'-diindolylmethane immune activating compositions
EP1811842A4 (en) * 2004-11-06 2008-02-27 Univ California 3,3'-DIINDOLYLMETHANE IMMUNA-ACTIVE COMPOSITIONS
EP2314294A3 (en) * 2004-11-06 2011-09-14 The Regents of The University of California 3,3'-diindolylmethane immune activating compositions
JP2008545663A (ja) * 2005-05-27 2008-12-18 クイーンズ ユニバーシティ アット キングストン タンパク質フォールディング障害の治療
US8404726B2 (en) 2006-04-18 2013-03-26 Nippon Chemiphar Co. Ltd. Activating agent for peroxisome proliferator activated receptor δ
US8648208B2 (en) 2008-04-15 2014-02-11 Nippon Chemiphar Co. Ltd. Activating agent for peroxisome proliferator activated receptor
WO2010033198A3 (en) * 2008-09-17 2010-08-19 Sri International Analogs of indole-3-carbinol and their use as agents against infection
US8278341B2 (en) 2008-09-17 2012-10-02 Sri International Analogs of indole-3-carbinol and their use as agents against infection
CN104030964A (zh) * 2014-06-05 2014-09-10 天津科技大学 双吲哚类化合物及合成方法
CN104030964B (zh) * 2014-06-05 2016-06-29 天津科技大学 双吲哚类化合物及合成方法
CN105218552A (zh) * 2015-09-30 2016-01-06 中国人民解放军军事医学科学院野战输血研究所 一种取代苯基二氢吲哚咔唑衍生物及其制备方法与应用
CN105218552B (zh) * 2015-09-30 2018-02-27 中国人民解放军军事医学科学院野战输血研究所 一种取代苯基二氢吲哚咔唑衍生物及其制备方法与应用

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WO2004018475A3 (en) 2004-04-01
EP1623985A2 (en) 2006-02-08
US20090023796A1 (en) 2009-01-22
US7666897B2 (en) 2010-02-23
US6800655B2 (en) 2004-10-05
US20060128785A1 (en) 2006-06-15
EP1623985A3 (en) 2011-06-08
US20040157906A1 (en) 2004-08-12
US7078427B2 (en) 2006-07-18
EP1530572B1 (en) 2008-10-15
JP2006036796A (ja) 2006-02-09
US7429610B2 (en) 2008-09-30
JP4764629B2 (ja) 2011-09-07
ATE411317T1 (de) 2008-10-15
JP5599236B2 (ja) 2014-10-01
AU2003263878A1 (en) 2004-03-11
EP1623985B1 (en) 2016-02-17
EP1530572A2 (en) 2005-05-18
DE60324155D1 (de) 2008-11-27
JP2010195840A (ja) 2010-09-09
CA2496203A1 (en) 2004-03-04
JP4699171B2 (ja) 2011-06-08
CA2496203C (en) 2012-03-27
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US20040043965A1 (en) 2004-03-04

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