WO2004016311A2 - Dispositif d'application d'ultrasons destine a ameliorer les conditions de traitement - Google Patents

Dispositif d'application d'ultrasons destine a ameliorer les conditions de traitement Download PDF

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Publication number
WO2004016311A2
WO2004016311A2 PCT/DE2003/002456 DE0302456W WO2004016311A2 WO 2004016311 A2 WO2004016311 A2 WO 2004016311A2 DE 0302456 W DE0302456 W DE 0302456W WO 2004016311 A2 WO2004016311 A2 WO 2004016311A2
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WO
WIPO (PCT)
Prior art keywords
sound
applicator
film
cavitation
sound applicator
Prior art date
Application number
PCT/DE2003/002456
Other languages
German (de)
English (en)
Other versions
WO2004016311A3 (fr
Inventor
Hans-Werner Bender
Uwe Pliquett
Original Assignee
Hans-Werner Bender
Uwe Pliquett
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2002133293 external-priority patent/DE10233293A1/de
Priority claimed from DE20211073U external-priority patent/DE20211073U1/de
Application filed by Hans-Werner Bender, Uwe Pliquett filed Critical Hans-Werner Bender
Priority to DE10393505T priority Critical patent/DE10393505D2/de
Priority to EP03787708A priority patent/EP1575657A2/fr
Priority to AU2003257394A priority patent/AU2003257394A1/en
Publication of WO2004016311A2 publication Critical patent/WO2004016311A2/fr
Publication of WO2004016311A3 publication Critical patent/WO2004016311A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B2017/22005—Effects, e.g. on tissue
    • A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
    • A61B2017/22008—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing used or promoted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H11/00—Belts, strips or combs for massage purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/16—Physical interface with patient
    • A61H2201/1602—Physical interface with patient kind of interface, e.g. head rest, knee support or lumbar support
    • A61H2201/164—Feet or leg, e.g. pedal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2205/00—Devices for specific parts of the body
    • A61H2205/06—Arms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2205/00—Devices for specific parts of the body
    • A61H2205/10—Leg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2205/00—Devices for specific parts of the body
    • A61H2205/12—Feet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
    • A61H23/02—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive
    • A61H23/0245—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms with electric or magnetic drive with ultrasonic transducers, e.g. piezoelectric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H33/00—Bathing devices for special therapeutic or hygienic purposes
    • A61H33/02—Bathing devices for use with gas-containing liquid, or liquid in which gas is led or generated, e.g. carbon dioxide baths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements

Definitions

  • the invention relates to a sound applicator device for improving the treatment conditions, taking into account the cavitation properties of near-surface liquid layers in the treatment of biological systems and the treatment of surfaces of biological systems in order to trigger physiological / biological reactions on the surface or in the system, to achieve physical / biological effects
  • a sound applicator device for improving the treatment conditions, taking into account the cavitation properties of near-surface liquid layers in the treatment of biological systems and the treatment of surfaces of biological systems in order to trigger physiological / biological reactions on the surface or in the system, to achieve physical / biological effects
  • the biological system having metabolic activity in vivo or in vitro and / or showing physiological reactions or had this in vivo.
  • Skin, leg, foot are examples and in the description below are exemplary and representative of “biological system”, skin also has the meaning of "surface” in the description and represents surface.
  • Fig. 1a shows a possibility to influence the cavitation by the technical design of the sound characteristic and / or the sound emission, using the example of one of the possible forms of the sound characteristic: a sinusoidal frequency-modulated sound burst (1).
  • Fig. 1b shows a possibility of the cavitation and the solubility of gases in a liquid through the technical design of the sound characteristics and / or the sound emission, using the example of one of the possible forms of an asymmetrical signal / waveform with unequal absolute values of the positive (2) and the negative (3) pressure component of the sound wave.
  • Fig. 1a shows a possibility to influence the cavitation by the technical design of the sound characteristic and / or the sound emission, using the example of one of the possible forms of the sound characteristic: a sinusoidal frequency-modulated sound burst (1).
  • Fig. 1b shows a possibility of the cavitation and the solubility of gases in a liquid through the technical design of the sound characteristics and / or the sound emission, using the example of one of the possible
  • 2a shows the example of a treatment of the foot / heel with an inflexible rigid sound applicator (4) that this can not be adapted to a curved surface and the distance between the sound applicator and the foot / heel is very different.
  • 2b shows a possibility of adapting a flexible, shapeable sound applicator (5) to the foot / heel in order to be able to better control the distance of the sound applicator from the foot / heel.
  • Fig. 3a shows as an example the treatment of a foot / leg in CO 2 water as a cavitation medium (6) with a conventional, mechanically inflexible sound applicator (4), in which cavitation-capable gas bubbles (7) are formed in the layer between the sound applicator and the leg.
  • 3b shows an equilibrium reaction. From a highly enriched CO 2 water, in which the carbon dioxide is dissolved in a molecular or associative manner, cavitation-capable and / or resonant gas bubbles are created under the influence of sound.
  • Fig. 4 shows the attachment of the film sound applicator (10) to a leg by wrapping and / or applying the film around the leg.
  • 5a shows schematically and by way of example the use of the film sound applicator (10) as a plaster or plaster-like product, the film sound applicator being directly on and / or on the Skin (11) is attached.
  • the cavitation medium (6) which contacts the skin on one side and the foil sound applicator on the other, opposite side, the sound-emitting side of the foil sound applicator is oriented towards the surface of the skin.
  • 5b shows schematically and by way of example the use of the film sound applicator (10) as a plaster or plaster-like product, the film sound applicator being attached directly to and / or on the skin (11).
  • the cavitation medium (6) and at least one further, sound-conducting layer (9) of any desired, different material are located in the space between the skin (11) and the foil sound applicator (10), the cavitation medium contacting the skin and the at least one further sound-conducting Layer lies between the cavitation medium and the film sound applicator (10), the sound-emitting side of the film sound applicator being oriented toward the surface of the skin.
  • 5c shows schematically and by way of example a composite structure of the film sound applicator made of at least one piezoelectric film, here a PVDF film (8) connected to at least one further sound-conducting layer (9) made of any material. Skin (11), cavitation medium (6) that contacts the skin.
  • FIG. 6a shows the adaptation and alignment of the device, consisting of a foil sound applicator (10) and a spacer (13) on one leg.
  • the film sound applicator (10) or the device is not attached directly to and / or on the skin.
  • the cavitation medium is in the space (12) between the device and the leg.
  • Fig. 6b shows an analog device when adapting to the heel and foot.
  • Fig. 7a shows a device consisting of a foil sound applicator (10) and a hollow body-like spacer (13).
  • the spacer device (13) is closed on one side by the skin (11) and on the other side by the foil sound applicator (10).
  • the cavitation medium (6) In the intermediate space is the cavitation medium (6), which contacts the skin on one side and contacts the foil sound applicator on the other, opposite side.
  • the sound-emitting surface of the sound applicator is oriented towards the surface of the skin.
  • 7b shows a device consisting of a foil sound applicator (10) and a hollow-like spacer (13).
  • the spacer device (13) is closed on one side by the skin (11) and on the other side by the foil sound applicator (10).
  • the cavitation medium (6) that contacts the skin is located in the space between the skin and the foil sound applicator.
  • At least one further sound-conducting layer (9) made of any material is located between the cavitation medium (6) and the film sound applicator (10).
  • 8 shows an embodiment of a film sound applicator (10), at least two piezoelectric films, here PVDF films (8) being connected to one another, with a reference electrode (14) and segmented electrodes (15).
  • FIG. 9 shows an embodiment of a film sound applicator (10) and a device comprising a spacing device and sound applicator, a piezoelectric film, here a PVDF film (8), being selectively (17) attached to a shaped carrier film (16).
  • a film sound applicator 10
  • a device comprising a spacing device and sound applicator, a piezoelectric film, here a PVDF film (8), being selectively (17) attached to a shaped carrier film (16).
  • tap water is available everywhere as a cavitation liquid, but given the concentration of gas or gas bubbles that is important for cavitation and the important requirement that these gas bubbles should be of a size that is smaller than or equal to the resonance size, this necessary quality can rarely be guaranteed.
  • the gas content in tap water is usually very fluctuating, and this depends on many factors (such as the season, local conditions and many other options), and the fact that the gas content decreases with ultrasound during a treatment, so that at At the beginning of a low gas concentration, the cavitation performance drops sharply in the course of treatment, this applies particularly to open systems.
  • the use of tap water as a cavitation liquid therefore often leads to inconsistent, unreproducible and unsatisfactory cavitation conditions.
  • the gas bubble content of the liquid or the cavitation medium is of decisive importance for the effect of the cavitation (gas bubble cavitation).
  • the resonance size of a gas bubble is approx. 0.166 mm at 20 kHz radius of the bubble, approx. 0.0033 mm at 1 MHz radius of the bubble) (the higher the Frequency, the smaller the resonance size), the larger the gas bubbles, they interfere and reduce the cavitation performance.
  • Resonance vibrations of gas bubbles are very high in energy and can exert a great mechanical force on their surroundings and thereby achieve positive effects that are desirable in terms of treatment (e.g. change in the permeability of the skin).
  • cavitation In terms of treatment, cavitation only works close to and on the skin.
  • the adhesion of the gas or the gases to the skin or the skin of the gases can be improved and increased by physical and / or chemical measures and thus gases can be enriched on the surface.
  • Cavitation processes primarily have a surface effect, but this does not rule out a depth effect. The situation is completely different in the case of cavitation-free ultrasound coupling, this mainly has a deep effect (e.g. when treating muscle problems).
  • other media are also suitable for cavitation, especially if they contain liquids or become liquid or partially liquid under the influence of sound and allow gas bubbles to vibrate. Gas bubbles in skin pores can also vibrate under sound.
  • the cavitation can be influenced in many ways, e.g. B. by the technical designs of the ultrasound devices (this is taken into account, for example, by EP 0 330 636 B1, EP 0 442 278 B1, EP 0 595 783 A2, WO 98/07470, UltraPuls Bandelin electronic GmbH, Berlin).
  • the effective sound pressure levels of these devices are up to over 400 kPa (zero to peak measured).
  • the influencing of cavitation processes by internal or external influences, by the technical design of the ultrasound devices or by physical and / or chemical influences is well known and should therefore not be discussed further. The same applies to the solubility of gases in liquids and their release from liquids.
  • the angle of incidence is then not optimal.
  • Sound applicator is very inadequate and can be poorly or not adapted to the anatomical conditions or cannot be carried out at all.
  • Blocks in an array construction The arrangement is relatively flexible and can be placed around a leg like a bandage.
  • the system is coupled directly to the skin without the use of a coupling medium.
  • piezoelectric polymer or PVDF foils for therapy transducers has long been known and there are corresponding devices both in the high-frequency ultrasound and in the low-frequency ultrasound range.
  • these transducers are not sufficiently flexible and movable, since the ends of the PVDF films are firmly fixed to corresponding, mechanically fixed abutments.
  • DE 101 36 403 describes an electroactive active substance patch using polymer films and a PVDF film, but this is not an ultrasound system and also not a cavitation system, the polymers cited there are suitable for these applications, possibly also for sound applicators.
  • Piezoelectric polymer films and PVDF films vibrate laterally in the plane of the film when electrodes are applied by means of contraction and expansion movements.
  • the film In order to obtain a transverse vibration perpendicular to the film (in the z direction), the film needs an acoustic circuit or an acoustic mass as a counterweight. Therefore, for example, the film must be firmly fixed at both ends in a kind of abutment, e.g. B. by mechanical attachment to a mechanically inflexible solid or by another mechanically fixed device.
  • a kind of abutment e.g. B.
  • the arrangement (again when the two ends are attached) of the film is in the form of a hollow cylinder ((US 0006400065B1 and US 0006239535B1), in which transverse vibrations are generated by radial vibrations of the film. This is described in the sources mentioned.
  • porous piezoelectric polymers which are said to have a higher piezoelectric effect than comparable other foils (information on this, for example, at Internet addresses such as: http: //www.vdivde-it/de/innonet/doks/ pp / iu_pp11.pdf).
  • Gases and gas-containing liquids have long been used therapeutically or cosmetically, especially as carbonated water, whereby the carbon dioxide is readily soluble.
  • Carbon dioxide is present in water in the form of molecules and in the form of associated molecules. In addition in the form of the smallest gas bubbles.
  • the carbon dioxide also reacts with water to form an acid and the known dissociation equilibrium is formed from the constituents, the acid and the ion constituents.
  • Natural sources are available for gaseous liquids or water.
  • the carbonic acid water (if it is very enriched with C0 2 and the concentration of C0 2 in water can often be over 500 ppm or even well over 1000 ppm, whereby the carbonic acid water is fairly stable with regard to the gas content) is used successfully in medicine, in balneology, in cosmetics, in the wellness area (the CO 2 gas diffuses through the skin into the tissue).
  • the CO 2 gas diffuses through the skin into the tissue.
  • Mitsubishi Rayon has developed a method of introducing C0 2 gas into water using hollow fiber membrane gas exchangers in such a way that a highly concentrated, highly enriched solution is created and this solution is stable.
  • the C0 2 gas is mostly molecular or associative dissolved in the water (as a supersaturated solution) and only a few tiny gas bubbles, if any, are present.
  • the invention of protection claim 1 is based on the problem that cavitation processes are desired and / or advantageous for many applications with sound, especially with ultrasound in the frequency range from 20 kHz to 20 MHz. Cavitation processes do not always take place to the desired extent and with sufficient strength. Tap water is often used as the cavitation medium, although tap water cannot provide constant and often insufficiently high cavitation conditions and performance. This applies even more towards the end of a treatment or during treatment in cavitation media, the volume and / or layer thickness of which is limited. In such cases, the provision of cavitation-capable gas bubbles in sufficient numbers is problematic.
  • Another problem is that with the known sound applicators the thin cavitation layers and small cavitation volumes mentioned cannot be set and maintained safely. Another problem is that the known sound applicators, regardless of the coupling medium and / or cavitation medium, cannot adequately adapt surface structures individually. Another problem that is independent of the coupling medium and / or cavitation medium is that, for example, patients move during the treatment and thus the distance and the orientation of the sound applicator to the surface to be treated are changed.
  • the solution to the problem consists in a sound applicator device for acting on a surface of a biological system with a sound applicator and a coupling medium and / or cavitation medium, wherein the cavitation medium should contain at least one gas, the cavitation medium consisting of a liquid or a mixture of different liquids and / or a liquid preparation and / or another medium capable of cavitation.
  • Water or a water-containing medium is a common coupling medium and / or cavitation medium.
  • the cavitation medium should be gas-containing, any gas or gas mixture of any concentration should be present in the cavitation medium.
  • the gas and / or the gas mixture should be enriched in the cavitation medium in any concentration, the concentration of the gas or the gas mixture in the cavitation medium when enriched above 20 ppm, preferably between approximately 100 ppm to 500 ppm, more preferably between approximately 500ppm and 1000 ppm, particularly preferably over 1000 ppm, carbon dioxide being soluble in water even at high concentrations of over 100 ppm to over 1000 ppm and will therefore be one of the preferred gases.
  • the cavitation medium should contain cavitation-capable and / or resonant gas bubbles and / or these gas bubbles should arise under the influence of sound, with the result that cavitation can potentially arise and / or cavitation occurs.
  • the cavitation medium should contain at least one gas which is capable of cavitation and / or resonance under the influence of sound and / or causes gas bubbles to form due to the effect of sound and these gas bubbles are capable of cavitation and / or resonance. It would also be possible, if the gas in the cavitation medium is in the form of gas bubbles which are smaller and / or equal to the resonance size. It would also be advantageous if the gas is dissolved in the cavitation medium, even better molecularly and / or in an associative form. For example, carbon dioxide dissolved in water meets these requirements to a large extent and will therefore be one of the preferred cavitation media.
  • cavitation-capable and / or resonance-capable gas bubbles in the cavitation medium before and / or during and / or after exposure to sound, cavitation can start more easily and / or faster and / or more intensely and / or evenly and also starts at a lower intensity Performance requirements for the sound applicator can be reduced.
  • the cavitation medium contains cavitation-capable and / or resonant gas bubbles and / or develops them under the influence of sound
  • the sound applicator preferably being an ultrasound applicator for generating sound waves in the frequency range from 20 kHz to 20 MHz, better an ultrasound applicator for generating sound waves in the frequency range from 20 kHz to 800 kHz and particularly preferably an ultrasound applicator for generating sound waves in the frequency range from 20 kHz to 100 kHz.
  • the cavitation is independent of the sound applicator used, the sound applicator can be a mechanically inflexible or a flexible sound applicator. Further possible, the sound applicator can fully or partially immerse in the cavitation medium or touch it at the boundary layer. Also possible, the sound applicator can be of any shape.
  • the cavitation medium contains only one gas or only one gas mixture.
  • the cavitation medium can contain or add at least one further, arbitrary substance and / or constituent, and this substance is gaseous and / or solid and / or liquid and / or vaporous and / or colloidal and / or the like and / or a mixture and / or combination and / or a composition thereof.
  • the at least one further, arbitrary substance is soluble and / or insoluble and / or partially soluble and / or spuriously soluble and / or genuinely soluble and / or colloidally soluble and / or the like.
  • the at least one other substance can have a cosmetic and / or nourishing and / or therapeutic and / or diagnostic and / or physiological effect, for example with a cleaning and / or washing-active and / or surface-active and / or stimulating and / or constructing effect and / or regulating and / or metabolism regulating and / or hormone regulating and / or healing and / or enzymatic and / or enzymatically degrading and / or enzymatically converting and / or vasodilating and / or toxic and / or antitoxic and / or germicidal and / or antimicrobial and / or antibacterial and / or bactericidal and / or antifungal and / or analgesic and / or thrombolytic and / or fibrinolytic and / or metabolically active and / or metabolism-influencing and / or nutritional and / or growth-stimulating and / or growth-promoting and / or growth-inhibiting and
  • the at least one further arbitrary substance is an active ingredient and / or a preparation and / or a salt and / or a compound and / or an organic compound and / or an inorganic compound and / or a substance and / or a biomaterial and / or a Carrier material or a combination and / or mixture thereof is or contains, such as preparation of active ingredient and / or medicament and / or therapeutic agent and / or antibiotics and / or care substance and / or cosmetic and / or topical substance and / or topically active substance and / or diagnostic agent and / or vitamin and / or hormone and / or realeasing hormone and / or their precursors and / or enzyme and / or nutrient and / or steroid and / or protein and / or amino acid and / or oligonucleotides and / or a lipid and / or growth factor and / or cell poison and / or toxin (e.g.
  • butolino toxin and / or microorganism and / or component / component from gene therapy and / or genetic engineering and / or blood component and / or carbohydrate and / or poly sugar and / or sugar and / or fatty acid and / or detergent substance and / or means of transport (for others Substances, compounds, materials, active substances and the like) and / or surface-active and / or surface-influencing substances (compounds, substances and the like) and / or soluble or insoluble active substance preparations and / or vasodilating substances and compounds and / or cleaning agents or also a combination of several of these substances, and / or an organic compound and / or an inorganic compound and / or a metal-organic compound and / or a salt and / or substance and / or substrate and / or compound and / or preparation and / or material, and / or biomaterial and / or carrier material and / or carrier substance and / or carrier particles (from e.g.
  • the cavitation medium can be expanded by adding at least one further arbitrary substance and / or its physical and / or chemical properties and / or its physical and / or chemical state can be changed, the viscosity only as an example .
  • the cavitation medium can be added by adding at least any other substance as a real solution and / or colloidal solution and / or colloid (e.g.
  • hydrocolloid as a hydrocolloid
  • sol and / or suspension and / or emulsion and / or Dispersion and / or Newtonian liquid and / or non-Newtonian liquid and / or in other state and / or solution forms.
  • the sound applicator better the ultrasound applicator, even better the ultrasound applicator with sound emission in the frequency range from 20 kHz to 100 kHz, should preferably be a flexible sound applicator made of a piezoelectric bending vibrator and / or a piezoelectric film, better made of a piezoelectric polymer film and even better made of one piezoelectric PVDF film and / or a porous piezoelectric polymer / polymer film may be further possible, the flexible sound applicator should consist of an array system consisting of piezoelectric elements, for example piezoelectric crystals and / or other piezoelectric elements, or the sound applicator should consist of one Combination of different piezoelectric foil / foils and / or piezoelectric elements exist.
  • the description below is for the flexible sound applicator and / or the various devices (the film sound applicator and / or the device made of sound applicator or film sound applicator and cavitation medium and / or the device made of sound applicator or film Sound applicator and spacer and / or the device made of sound applicator or foil sound applicator, spacer and cavitation medium and / or the device made of cavitation medium and spacer) using at least one piezoelectric PVDF film, whereby it is expressly pointed out that basically other suitable piezoelectric Foils, piezoelectric polymers, porous piezoelectric
  • Polymers / polymer films, piezoelectric array systems can be suitable for this and then their use for the flexible sound applicator or the devices are also considered to be further possibilities.
  • this flexible sound applicator has at least two PVDF foils connected to one another.
  • the connection of the at least two PVDF films connected to one another is carried out by calendering and / or by any other suitable means and / or methods and / or processes which are for example chemical and / or mechanical / physical in nature and / or also using any suitable materials and / or parts and / or substances suitable for this.
  • PVDF foils that can be connected to one another, especially if the individual foils have certain properties and / or characteristics and this is taken into account when connecting, resulting in new foils with new properties and / or new characteristics.
  • an acoustic mass as a counterweight can be achieved, for example, by the design of the film.
  • a sound applicator can be referred to as a film sound applicator (10), especially if it consists of connected PVDF films and does not contain any further supporting and / or shaping and / or mechanical elements and is also used like a plaster according to FIG. 5a can be, wherein the at least two PVDF films (bimorph films) connected to one another can each have different properties and / or features, for example different textures. When connected, it is a film with at least two layers that draws its acoustic mass from the structure of the film.
  • the film sound applicator (10) if at least two piezoelectric films, preferably PVDF films, with different textures are connected to one another, the texture has patterns and the sound energy density is thereby influenced and / or a concentration of the sound energy can be achieved , for example a punctiform concentration, whereby special modes are achieved by inhomogeneous texture whereby the at least two piezoelectric PVDF foils with their texture and / or texture patterns can be adapted to the application in order to direct the modes according to the geometric conditions of the object, for example the Biological system to achieve, wherein the at least two piezoelectric foils are connected to each other so that the respective
  • Texture directions have an angle of 0 ° to 180 "to one another, preferably at an angle of greater than 0 degrees, preferably of about 90 degrees. Contraction or dilation, depending on the polarity, depends on the texture of the PVDF film, instead of biphase control, segmented Electrodes also have a contraction / dilation pattern due to different texture.
  • a film sound applicator 10 by interconnecting and / or connecting at least two piezoelectric films, preferably PVDF films, with alternating activation in the x and z directions, the film sound applicator being at least two PVDF connected to one another Has foils, and between the foils a reference electrode is arranged which electrically contacts the PVDF foils, the
  • the piezoelectric / piezoelectric foil / foils having segmented electrodes, the piezoelectric / piezoelectric foil / foils being arranged on the respective outer surfaces of the piezoelectric foil / foils, the segmented electrodes being the first piezoelectric film, and the segmented electrodes of the further piezoelectric film, are arranged opposite one another and are poled differently.
  • PVDF films show a linear electrostrictive effect, i.e. the polarity decides between contraction and dilation. With alternating arrangement of segmented electrodes, contracting and dilating areas can be created (pattern of contraction and dilation). Initially, this does not lead to strong transverse modes. However, if two foils are connected together with a reference electrode and the segments are alternately switched in the z direction, biphase control generates transverse modes that are independent of the resonance frequency of the foil.
  • a film sound applicator if the sound applicator has a wave-shaped piezoelectric film, preferably PVDF film, the piezoelectric film being fixed in its troughs, so that they act as vibration nodes when the piezoelectric film contracts and dilates.
  • the troughs of the piezoelectric film are fixed to a carrier material which is arranged adjacent to the piezoelectric film, preferably PVDF film, the carrier material being a carrier film, the carrier material on its surface oriented to the piezoelectric film having a structure with elevations, such as has a wave structure or a knob structure and the wave troughs of the piezoelectric film are fixed to the elevations of the structure lying opposite them.
  • the carrier material or the carrier film is elastic and / or flexible and / or highly viscous and / or inelastic, and / or plastically and / or elastically deformable.
  • at least one carrier film is structured, this structure can be a wave structure, this structure can be a nub structure, this structure can have a shape other than that mentioned.
  • the piezoelectric film, better PVDF film is connected to the carrier film at the structural vertices of the carrier film with a fixation. The application of a voltage, which causes a contraction of the PVDF film, leads to a tightening with a strong z component in the movement due to the fixation. At least one piezoelectric film is connected to at least one carrier film or carrier material.
  • the carrier material can be at least one mechanical element of the spacer device and / or serve as a spacer device (Fig. 6a, Fig. 6b).
  • the device made of carrier material or carrier film and PVDF film is used, for example, in the form of a plaster or plaster-like product and / or is used Use as a foil sound applicator and / or is used as a device and / or other possible uses.
  • At least one piezoelectric film preferably PVDF film
  • any other, preferably sound-conducting, materials preferably PVDF film
  • This at least one piezoelectric film is combined and / or connected and / or attached with at least one additional, sound-conducting layer, made of any different material.
  • the film sound applicator preferably consists of a multilayer, one-component or multi-component composite structure composed of preferably at least one piezoelectric film, in particular at least one piezoelectric PVDF film, and at least one further, additional, sound-conducting layer, this at least one further additional sound-conducting layer Layer of different, suitable, sound-conducting any material from individual material components and / or a mixture and / or composition and / or composition and / or combination of different, any material and / or one or more components and / or from one or more substances and / or consists of one or more connections, further possible, this at least one additional sound-conducting layer made of any sound-conducting material, a solid and / or a solid / solid solid and / or a flexible solid and / or a gas and / or a liquid and / or a preparation and / or a liquid-containing preparation and / or a water-containing preparation and / or a liquid-containing substance
  • this at least one additional sound-conducting layer for example a film and / or a PVDF film and / or a thin metal layer and / or a metal film and / or a gel and / or a hydrocolloid gel and / or of other, other materials can. It is also possible for this at least one additional sound-conducting layer made of sound-conducting material of any kind to have characteristics dependent thereon, for example condition and / or properties and / or shape and / or size and / or layer thickness and / or other characteristics.
  • this at least one additional sound-conducting layer made of sound-conducting material of any kind to be dependent on it, for example homogeneous or inhomogeneous and / or amorphous and / or porous and / or solid and / or liquid and / or gaseous and / or colloidal and / or rigid and / or flexible and / or viscous and / or electrically conductive and / or electrically non-conductive and / or has other properties.
  • this at least one additional sound-conducting layer can significantly influence the function and / or performance and / or the area of application and / or the shape and / or other features and / or properties of the film sound applicator.
  • this at least one further sound-conducting layer made of any different material can have different functions, for. B. electrical conductor, and / or transport layer and / or structure layer and / or other functions and / or different, any properties. It is also possible to have at least one additional sound-conducting layer made of sound-conducting any material as a result of which initially has any function. Further possible, through a multi-layer, single or multi-component structure and composite solution, the properties of a single, normal film, through the choice and composition of the materials can be changed and adapted to the requirements, the function, the application, the task and the like of the sound applicator. Furthermore, according to the requirements, the application area of the sound applicator is broad and thus the requirements for the sound applicator.
  • the film sound applicator (10) can in principle also be referred to in composite form as a PVDF film, as a PVDF film with new properties. Further possible, such a design of the film sound applicator can, for example, improve the use in the form of a plaster and / or the power output can be improved and / or transverse vibrations can be generated and / or the service life can be increased and / or the Stability can be improved.
  • piezoelectric foils By means of internal structure and / or patterns and / or components and / or composition and / or inclusions, piezoelectric foils, especially polymer foils and / or PVDF foils, for example, can be changed in their properties and / or their performance and / or their characteristics and adapted to requirements become
  • piezoelectric foils in particular polymer foils and / or PVDF foils
  • piezoelectric foils can also be used, for example, in their properties and / or their performance and / or their Features are changed and requirements are adapted, and further by the combination of internal structure and / or patterns and / or components and / or, composition and / or inclusions and external structure, by bonding with other films and / or other materials and / or substances and / or devices can also change piezoelectric foils, especially polymer foils and / or PVDF foils, for example in their properties and / or their performance and / or their characteristics and adapt them to requirements.
  • FIG. 3a shows an example of the treatment of a foot / leg in gas-containing water with a conventional, planar sound applicator.
  • the sound applicator is immersed in the water and is advantageously aimed at the leg. Cavitation predominantly occurs in the area between the sound applicator and the leg.
  • Fig. 3b shows an equilibrium reaction of the dissolved state and bubble state with C0 2 and water as a cavitation medium for explanation.
  • Cavitated gas bubbles are released under the influence of sound from an enriched CO 2 water in which the CO 2 is also dissolved in a molecular or associative manner.
  • the action of sound creates cavitation-capable and / or resonable gas bubbles in the cavitation medium, such that gas bubbles are released from the cavitation medium due to the sound (transition from the dissolved to the blistered state), gas bubbles in the cavitation medium due to the sound caused by rectified / rectified diffusion and other known physical / chemical processes such as mutual Attraction increase in size, or already resonant
  • FIG. 4 shows the attachment of the foil sound applicator (10) to a leg by the sound applicator being wrapped around and / or attached to the leg.
  • the foil sound applicator can also be attached to other limbs and / or parts of the body. A flat and / or sleeve-like or hose-like attachment is possible if it is a foil sound applicator.
  • the film sound applicator can be applied or attached and / or attached with any suitable adhesive and / or adhesive.
  • This attachment but only the hose-like or sleeve-like attachment, not the flat attachment, also works with a normal, textured piezoelectric PVDF film (8), with an at least partially ferroelectric PVDF film, and the non-ferroelectric parts must be one if possible have high viscosity in the lateral direction. Since this arrangement is not a resonance phenomenon, the mechanical energy can be transferred to the object in any low frequency range and in this way high-energy transverse vibration modes can be generated in the desired frequency range by using a resonance-independent z-mode (perpendicular to the film) cuff-like or tubular arrangement is achieved.
  • FIG. 5a shows schematically and by way of example the use of a film sound applicator (10) and the attachment and fastening of the film sound applicator to and / or on the skin (11).
  • the attachment and attachment takes place in the edge area of the film sound applicator, in the space between the skin (11) and the sound-emitting side of the film sound applicator (10) is the cavitation medium (6).
  • the attachment is carried out using a suitable adhesive and / or adhesive.
  • the film sound applicator is used like a plaster and / or a plaster-like product and / or in the form of a plaster.
  • the foil sound applicator can have any size.
  • the foil sound applicator is attached over a large area and / or over a small area. Also possible, the film sound applicator can be completely and / or partially placed and / or attached around a leg and / or another limb and / or around another part of the body. It is also possible that the film sound applicator can have the size of an adhesive and / or active substance plaster and / or a wound plaster and / or other sizes. Also possible, the foil sound applicator is attached with any suitable adhesive and / or adhesive. Further possible, the application and attachment of the foil sound applicator on and / or on the skin takes place in the Edge area of the foil sound applicator.
  • edge area of the foil sound applicator is attached and attached to or on the skin in whole or in part. Further possible, the attachment and attachment of the film sound applicator to and / or on the skin is carried out with any suitable suitable adhesive and / or partial or full surface. It is also possible that any suitable adhesive and / or adhesive does not contain a mechanical part. It is also possible that any suitable adhesive and / or adhesive is based on chemicals, for example it is an adhesive or another adhesive and / or adhesive. It is also possible that any suitable adhesive can be taken up again, and the film sound applicator can be removed from the skin and applied again several times. It is also possible that any adhesive and / or adhesive contains at least one mechanical part and / or is at least one mechanical part. Also possible, any adhesive and / or adhesive is based on mechanical / physical effects and / or mechanisms.
  • the space between the surface of the skin and the surface of the sound applicator i.e. the layer thickness of the cavitation medium and the volume available to the cavitation medium
  • the volume will predominantly be small and / or low, the layer thickness will be narrow.
  • gas enrichment of the cavitation medium will be advantageous for cavitation processes.
  • FIG. 5b shows schematically and by way of example and without details the structure of a multi-layer, single- or multi-component sound applicator, consisting of a piezoelectric film, preferably a piezoelectric PVDF film (8) connected to at least one additional sound-conducting layer (9) made of any material ,
  • 5c shows schematically and by way of example and without details the multilayer structure consisting of a film sound applicator (10) and at least one further sound-conducting layer (9) made of any desired different material.
  • the additional sound-conducting layer and / or component is, for example, a gel, a hydrocolloid, e.g. B. as a carrier layer or another carrier layer for an active ingredient which is released during the treatment.
  • the additional sound-conducting layer and / or component is, for example, a film, a polymer film, a PVDF film or a metal film or a combination. All examples correspond perfectly to the description for a multi-layer single or multi-component flat sound applicator, but they result in different designs, with different properties and areas of application. Embodiments are described in FIGS. 8 and 9.
  • 6a shows as an example the adaptation and alignment of the device, consisting of a foil sound applicator (10) and a spacer (13) on one leg.
  • the film sound applicator (10) or the device is not attached directly to and / or on the skin.
  • the cavitation medium is in the space (12) between the device and the leg.
  • the device is positioned at any distance from the leg, the sound-emitting surface of the film sound applicator is directed towards the skin surface.
  • This device provides the film sound applicator with hold and / or stability and / or position and / or shape.
  • 6b shows, analogous to FIG.
  • 6a as a further example of the attachment and adaptation of the device, consisting of a foil sound applicator (10) and spacing device, to a foot and / or heel.
  • 7a shows the attachment of the film sound applicator (10) to a further spacing device (13), which is shaped like a hollow body, is sealed on one side by the skin (11) and on the other side by the flat sound applicator (10) ,
  • the coupling medium for.
  • the cavitation medium (6) In the space between the skin and the sound-emitting surface of the film sound applicator.
  • the spacer contains at least one mechanical element or the spacer contains at least one other arbitrary element. It is also possible for the spacer device to contain at least one mechanical element and additionally at least one other arbitrary element. It is also possible that the spacing device can consist of any different material, can have any shape and / or any size and / or any properties. The choice of materials will depend on this and will narrow it down, for which application and / or use the device comprising the film sound applicator and spacing device is intended, which properties and / or which determination and / or which function the device should have. With a corresponding design of the spacer device shaped like a hollow body, the device becomes a plaster-like product.
  • FIG. 7b shows a further example of a device comprising a film sound applicator (10) and a hollow body-like spacer (13). Additionally equipped with at least one further, sound-conducting layer (9) made of any different material, the cavitation medium being between the surface of the skin and the additional layer, the at least one additional layer being between the cavitation medium and the sound-emitting surface of the film sound applicator.
  • this at least one additional sound-conducting layer can consist of different, any material and / or substance and / or of a mixture and / or composition and / or combination and / or composition and / or combination thereof and in any state and / or Shape and / or size are available, different, any
  • It can be a solid or flexible solid (for example a film, a PVDF film) and / or a liquid and / or gas and / or a liquid-containing preparation and / or a gel and / or a hydrocolloid and / or any other material and / or fabric.
  • a solid or flexible solid for example a film, a PVDF film
  • the choice of materials will depend on and limit them, for which application / use the flat sound applicator is intended, which properties and / or determinations it should have and / or which functions.
  • FIG. 9 shows specific explanations for the construction of a film sound applicator (10). Fig.
  • FIG. 8 shows an embodiment of a foil sound applicator (10), at least two piezoelectric foils, preferably PVDF foils (8) are connected to one another, with a reference electrode (14) and segmented electrodes (15), the foil sound applicator having at least two piezoelectric foils connected to one another, preferably PVDF foils (8), and between a reference electrode (14) is arranged on the foils, which makes electrical contact with the piezoelectric foils, the reference electrode being switched to zero potential, the piezoelectric / piezoelectric foil / foils, better PVDF foils (8), having segmented electrodes (15), the Piezoelectric / piezoelectric foil / foils, better PVDF foils, is / are arranged on the respectively outer surfaces of the piezoelectric foil / foils, the segmented electrodes of the first piezoelectric foil, better PVDF foil, and the segmented electrodes of the further piezoelectric foil , better PVDF film, are arranged opposite each other and differ are pole
  • FIG. 9 shows an embodiment of a film sound applicator (10) and a device comprising a spacing device and sound applicator, a piezoelectric film, preferably a PVDF film (8), being attached at a point (17) to a shaped carrier film (16).
  • Carrier film is, the carrier material on its surface oriented to the piezoelectric film having a structure with elevations, such as a wave structure or a nub structure or another structure or shape, and fixing the troughs of the piezoelectric film to the elevations (18) of the structure opposite them ( 17), the carrier film is elastic and / or flexible and / or highly viscous and / or inelastic.
  • the application of a voltage, which causes a contraction of the PVDF film leads to a tightening with a strong z component in the movement due to the fixation.
  • the carrier film or the carrier material is not structured but only the PVDF film is structured (wavy and / or knob-shaped and / or another structure). Further possible, the carrier film or the carrier material is structured (wave-shaped and / or knob-shaped and / or other structure), but not the PVDF film.
  • the layer thickness of the carrier film and / or of the carrier material is arbitrary, preferably less than 0.5 mm, more preferably less than 0.05 mm, most preferably 50 micrometers or less.
  • the point connections (17) can be mechanical connections, for example
  • row-shaped connections are also possible (17) and / or another type, also possible as mechanical connections.
  • the distance between the individual connections (17) is arbitrary, preferably less than 2 mm, even more preferably less than 0.5 mm.
  • the distance between the carrier film and the PVDF film is arbitrary, is preferably less than 1 mm, more preferably less than 0.1 mm.
  • the coupling layer can be enriched with an active substance for the purpose of transdermal medication.
  • spacer device with at least one mechanical element, the film sound applicator and / or the spacer device and / or the device made from both can be provided completely at the edges (e.g. if the interior is to be closed off from the outside) or only partially (e.g. B. if there is to be a permeability between the interior and the outside environment, for example in the subaqual treatment for a liquid). In special cases, full-surface gluing can also be useful. Openings in the film, at the edges or in the surface and / or additional feed and discharge lines can improve the liquid, gas, active substance or substance exchange, e.g. B. in subaqual application and other applications.
  • the device can be a flat carrier and / or a frame and / or another suitable holder and / or other.
  • the attachment of the foil sound applicator to the spacing device can influence the function of the sound applicator.
  • the attachment can be done mechanically / physically or chemically, for example by screwing, by gluing and other suitable methods.
  • the spacer can be stable and firm and not very malleable. This only appears to contradict the demand for flexibility, because the shape is already determined by the application (e.g. molded parts for the leg, arm, sole of the foot, etc.) and can be manufactured industrially as molded parts.
  • the spacing device can also be flexible and flexible so that it can be individually adapted to and for the patient (e.g. as the simplest solution, the frame consists of a stable but flexible metal profile [e.g. a wire or round bar]).
  • the film sound applicator can be firmly connected to the spacer device as a device as a part or else, the film sound applicator and the spacer device as a device can be separated from one another, so the spacer device and film sound applicator are at least 2 parts (the film sound applicator can therefore in the event of a defect or in the treatment of different patients).
  • the materials used for the spacing device are tailored to the requirements and can be different, if appropriate, any materials or material connections (e.g. plastic, metal).
  • the film sound applicator can be distributed over the surface in addition to or instead of the attachment mentioned above and can be attached at certain points to the spacing device. At least one foil transducer can be attached to a spacer. Further design options for this described basic model to improve handling and / or effectiveness are possible.
  • the advantages of this solution include - in the case of subaqual treatment - a significantly improved exchange of the liquid layer between the sound applicator and the leg and thus a better supply of gas bubbles in this layer.
  • Another advantage is that, unlike the plaster, this system can be used several times.
  • Another advantage is that this system is especially suitable for subaqual treatment.
  • a disadvantage compared to the plaster is the reduced flexibility in adaptation and application.
  • the spacer can be of any shape (e.g. plan shape [e.g. round, oval, angular, polygonal and the like], outline shape [e.g. cylindrical, conical, ring-shaped, tire-shaped and the like], volume shape [e.g.
  • dimensional shape [e.g. flat, wide, flat and the like), have any size and can consist of different, if appropriate, any material and / or combinations thereof (e.g. As plastic, carbon fibers, rubber, metal, ceramic, glass or another material).
  • the spacing device can then, as can be seen from the description of the materials, have different properties (e.g. firm, rigid, flexible, soft, hard, plastically and elastically mouldable and other properties).
  • Functions of the spacing device include providing a volume for holding other substances (e.g. a liquid, an active ingredient, a coupling medium and the like), making contact with and / or attaching them to the skin, and further, to give the foil sound applicator support, shape and stability.
  • substances e.g. a liquid, an active ingredient, a coupling medium and the like
  • the spacing device flexible and surfaces can be adapted, e.g. B. consisting of a flexible, soft rubber or plastic ring or hoop, and the foil sound applicator is attached to this ring or hoop by suitable methods, methods, means (z. B. glued, screwed or other mechanical and / or physically and / or chemically), this can represent a type of plaster that can provide more volume, for example more liquid volume, than the plaster of FIGS. 5a and 5b. If the treatment takes place subaqual, it makes sense to replace the liquid and gas with the appropriate inlets and outlets. B. openings in the spacer or in the film sound applicator to improve.
  • the film sound applicator with the spacer device can be industrially produced as a one-piece system or the parts are not manufactured until Use put together.
  • the device further includes a spacer device to ensure a distance between the surface of the sound applicator oriented towards the surface of the biological system and the surface of the biological system
  • the spacer device being a mechanical element, such as a flat carrier Frame, a linkage, wherein the mechanical element is made of plastic, metal, ceramic, glass, rubber or a combination thereof, wherein the mechanical element is plastically or elastically deformable, wherein the mechanical element and the sound applicator are interconnected, wherein the mechanical element and the sound applicator are detachably connected to each other, wherein at least one layer of a sound guide between the surface of the sound applicator oriented towards the biological surface and the surface of the biological system
  • the material is present, the sound-conducting material being a metal, gel, hydrocolloid gel, a plaster or any combination thereof, the sound-conducting material being a carrier substance for a substance which can have a cosmetic, nourishing, therapeutic, diagnostic and / or physiological effect , wherein in the area of at least
  • the gas should be enriched in the cavitation medium. It is also possible that the gas-containing cavitation medium should come from a natural source and / or be of natural origin. It is also possible for the gas or at least one of the gases to be introduced into the cavitation medium by a technical route / method and / or by a physical route / method and / or by a chemical route / method. It is also possible to add the gas or at least one of the gases into the cavitation medium for further enrichment of a gas-containing cavitation medium by technical means / method and / or by physical means / method and / or by chemical means
  • Path / procedure is introduced. It is also possible to introduce the gas or at least one of the gases into the cavitation medium before and / or during the treatment. It is also possible that the gas-containing cavitation medium is generated by gas exchangers and or by injecting the gas with pressure and / or other technical and / or physical methods, preferably the extraction of carbonated water. It is also possible that the gas-containing cavitation medium is obtained by chemical means / processes, for example by lowering the pH of water containing carbonate / hydrogen carbonate and / or by one and / or more chemical reactions / reactions, and / or by hydrolysis and / or through other methods procedures. It is also possible for the gas or gases to be introduced into the cavitation medium via carrier substances (e.g.
  • the gas-containing cavitation medium can also be obtained by introducing one or more substances. It is also possible that the gas-containing cavitation medium can also be obtained by introducing any suitable substance or several suitable substances into a gas-containing liquid and / or gas-containing liquid mixture.
  • the skin is a source of gas bubbles. It is also possible for the gas to be enriched on the skin, this being possible before and / or during and / or after the sound treatment. It is also possible for the skin to be enriched with gas bubbles by means of further physical or chemical measures and / or improved
  • the cavitation medium consists of a There is liquid or a mixture of different liquids and / or a liquid-containing preparation and / or another medium capable of cavitation, which can be liquid-containing and / or water-containing media, preparations, compositions and other suitable substances. It is also possible that these can be hydrocolloids and hydrocolloid-like preparations or derivatives and others. Further possible, this can also be cavitation media that build up during treatment, e.g. B.
  • cavitation-suitable media are also those that allow cavitation due to their low viscosity and / or form a liquid film on the skin, whereby the cavitation medium is then, regardless of the state of aggregation, liquid during treatment (this can be a thin liquid film such as with a hydrocolloid).
  • the mechanical / physical and / or chemical effect of sound better of ultrasound (20 kHz - 20 MHz), even better of ultrasound in the frequency range of 20 kHz - 100 kHz at
  • Influence on the cavitation medium is initially independent of the sound applicator used, the type and its shape under comparable conditions.
  • the sound applicator can be flexible or mechanically inflexible and rigid.
  • the electrodes for the power supply correspond to the respective state of the art and can be vapor-deposited or attached and / or attached and / or applied to the film in another suitable manner and / or method and / or method.
  • the electrodes consist of conductive, suitable, any material in any shape and / or design, for. B. in the form of a metal film, an electrically conductive plastic or other electrically conductive material and / or material suitable for electrodes and / or combinations of different materials and other possible solutions.
  • the electrodes are an integral part of the invention and if they play an essential role in the functionality of the invention, they are part of the invention.
  • the power supply can take place from the outside (external) via appropriate technical options (e.g. supply line from a transformer, a battery and other options for power supply). Also possible, the power supply can be powered internally by batteries,
  • Technical solutions are also available and are on the market for sound generation (sound generator) and / or control and / or electronic control available.
  • the sound generator and / or the control and / or the electronic control can be portable, and / or a hand-held device and / or can be worn on the body and / or other designs for the sound generator and / or the control and / or the electronic control.
  • the device contains an energy source and / or a sound generator and / or control unit, the energy source being a transformer, a battery, a foil battery, a photovoltaic cell or a fuel cell, the control device or the sound generator having an electronic circuit, wherein the energy source and / or the control device and / or the sound generator is / are integrated in the film / films.
  • cleaning and hygiene are important aspects, this being particularly important if the foil sound applicator is to be used several times and / or by different patients / people. Especially when the flat sound applicator is not a disposable item but is used and used several times (also with different people).
  • the training must be such that easy cleaning and disinfection is possible, if necessary through a chemically and physically resistant protective layer that is applied either on both sides or on one side.
  • the type, material, etc. of the protective layer are well known. If materials come into direct contact with the skin, these materials must also be biocompatible. It is also possible to attach and / or attach the sound applicator or the film sound applicator and / or the device made of sound applicator or film sound applicator and
  • any suitable adhesive and / or adhesive is an adhesive or any other suitable means and / or consists of chemical substances and / or products and / or compounds and / or other substances, as individual components and / or as a mixture.
  • any suitable adhesive and / or adhesive does not contain any mechanical elements. It is also possible that any suitable adhesive and / or adhesive contains at least one mechanical element. It is also possible that any suitable adhesive and / or adhesive consists of mechanical elements, for example in the form of a device or in another form.
  • any suitable adhesive and / or adhesive can have any different adhesive and / or holding capacity, for example, it can be reabsorbed and / or easily removed, it can be firmly connected and / or other forms of adhesive and / or or holding ability are possible.
  • any suitable adhesive and / or adhesive is based, for example, on chemical and / or mechanical and / or physical processes and / or principles and / or effects and / or facts and / or properties and / or modes of action and other possibilities and possible solutions.
  • the foil sound applicator can be equipped with devices consisting of at least one mechanical Element consist, fixed or loose and / or detachably connected to a device, for. B. with a spacer. Further possible, the film sound applicator can be connected to devices that do not contain a mechanical element, fixedly or loosely and / or removably to form a device. Also possible, the foil sound applicator is used and / or used several times. Further possible, the foil sound applicator is not used multiple times and / or is not used multiple times. Also possible, the foil sound applicator is a single-use item, intended for single use. Also possible, the foil sound applicator is not a single-use item, intended for repeated use.
  • the film sound applicator is intended for short-term treatment for a period of less than one minute to two hours, preferably up to 30 minutes. Further possible, the film sound applicator is intended for long-term treatment for a period of 2 hours to several years, preferably up to 6 months, more preferably up to 4 weeks, most preferably up to 1 week.
  • the film sound applicator or the device can serve as a base and / or basic product and / or starting product and / or component for other products and / or can be built into other products and / or can be fully integrated into other products, with the films Sound applicator and / or the product remains outside the body, the film sound applicator and / or the product entering the body and / or being implanted and / or in another way and / or way and / or method and / or method in the body is introduced.
  • corresponding products are new products and / or are products adapted to the film sound applicator and / or the film sound applicator is adapted to other products and / or the film sound applicator is completely integrated into new and / or existing products, wherein the combination and / or integration of the film sound applicator with and / or in foreign products has various, any, different reasons, such as a combination therapy and / or a product improvement and / or other reasons.
  • one or more layers of different, arbitrary material and / or substance can be applied to the film sound applicator or the resulting devices on the side facing away from the sound-emitting side.
  • the film sound applicator or the resulting devices can be equipped on the side facing away from the sound-emitting side with a device, for example for receiving any substances, active substances and / or other substances.
  • This facility also provides a volume to hold any substance, e.g. B. a reservoir.
  • This device contains elements that are electrical and / or acoustic and / or are electromagnetic and / or magnetic and / or chemical in nature and / or based on mechanical / physical and / or chemical mechanisms and / or reactions and / or bases.
  • the film sound applicator and the resulting devices have openings for the exchange of any substances and / or substance combinations, such as liquids, gases, active substances. Furthermore, the substances or substance combinations diffuse through these openings. Furthermore, the substances or substance connections are transported through these openings by further mechanical / physical and / or chemical processes and / or forces, e.g. B. by pressure, negative pressure and the like. Further possible, the features of the spacing devices, as described for example for FIGS. 6a, 6b, 7a, 7b, apply if applicable and / or sensible and / or necessary and / or advantageous and / or intended for all spacing devices.
  • the features of the additional further sound-conducting layer apply, if applicable and / or sensible and / or necessary and / or advantageous and / or intended for all sound-conducting layers.
  • the design of the film sound applicator and / or the additional further sound-conducting layers apply, if applicable and / or sensible and / or necessary and / or advantageous and / or intended for all devices made of film sound applicator and spacer.
  • film sound applicator and / or the device made of sound applicator or film sound applicator and cavitation medium and / or the device made of sound applicator or film sound applicator and spacer device and / or the device made of sound applicator or film sound applicator, spacer device and cavitation medium and / or the device comprising the cavitation medium and spacer is attached and / or aligned in a stationary manner, is attached and / or aligned in a stationary manner on surfaces.
  • film sound applicator and / or the device made of sound applicator or film sound applicator and cavitation medium and / or the device made of sound applicator or film sound applicator and spacer device and / or the device made of sound applicator or film sound applicator, spacer device and cavitation medium and / or the device consisting of cavitation medium and spacer is movably attached and / or aligned, is movably attached and / or aligned on surfaces.
  • the film sound applicator is arranged such that the sound-emitting side of the film sound applicator is aligned in the direction of the surface. Also possible, the film sound applicator is arranged in such a way that the sound-emitting side of the film sound applicator is oriented in any direction and / or angle, between 0 degrees and 180 degrees, to the surface. Further possible, the foil sound applicator is arranged in such a way that the sound-emitting side of the foil sound applicator is attached to the spacing device rotated at an angle of 180 degrees, for example FIG. 7a, which shows the sound-emitting surface, with otherwise the same attachment from the skin path. Also possible, the foil sound applicator is coupled to the surface by a cavitation medium.
  • the foil sound applicator coupled by a different coupling medium instead of the cavitation medium. Also possible, the foil sound applicator is coupled to the surface without a coupling medium. It is also possible that the film sound applicator is coupled by air or another, any gas and / or by any gas mixture. Also possible, the foil sound applicator is coupled to the surface by direct contact with the surface.
  • film sound applicator and / or the device made of sound applicator or film sound applicator and cavitation medium and / or the device made of sound applicator or film sound applicator and spacer device and / or the device made of sound applicator or film sound applicator, spacer device and cavitation medium and / or the device made of cavitation medium and spacing device is used in the field of human or veterinary medicine, care or in the areas of wellness, baths, cures, physical therapy, sports medicine, hydrotherapy, cosmetics, fitness, biotechnology, life science, bioscience, chemistry, technology, Food technology, surveillance technology, monitoring, sensor technology, as a receiving or transmitting unit, sports technology, pharmacy, analytics, application or process technology, vehicle construction,
  • the flat sound applicator is very versatile and flexible to use, also in combination with third-party products or when integrating and / or implementing in third-party products.
  • the low weight allows it to be left on the skin and enables long-term treatment, e.g. B. also for transdermal medication, pain treatment and others.
  • the flat sound applicator is thin and not bulky.
  • the flat sound applicator can be designed as a disposable item. The low weight enables attachment to the skin and follows the patient's movements during treatment, the treatment conditions with regard to distance and cavitation remain guaranteed.
  • the low weight enables increased mobility of the patient during the treatment as well as for the user, the treatment can be carried out almost anywhere. Bedside treatment of bedsores is possible.
  • the individual adaptation of the foil sound applicator makes it possible for each patient to be provided with their own equipment for the period and that the patient may be able to take care of themselves, simply by putting on the sound applicator or its holder or device and switching on the power supply.
  • the flexibility and high adaptability allows a better combination with other treatment methods and products. Several treatments are possible at the same time. This saves work, time and costs. Further possible, the goal of the application was given above and is to be clarified again with examples for understanding, the general, comprehensive execution made at the beginning should not be restricted.
  • An application example is the combination of sound treatment, better ultrasound treatment with a treatment with one or more active substances (active substance in the sense of any chemical products, compounds, substances, preparations, mixtures, molecules, compositions, biomaterials or other active substances [e.g. drugs , Medicines, care substances, care products, enzymes, vitamins, proteins, cosmetics and others], which by themselves or in connection with the application of sound [and especially sound in the frequency range from 20 kHz to 100 kHz] a positive [e.g. . healing], negative, regulating, building up or breaking down / dissolving, physiological, biological, metabolic mechanical or other effects on the biological system inside and / or on the surface and independent of the time sequence of the treatment [active substance and sound simultaneously or in any chronological order]).
  • active substances active substance in the sense of any chemical products, compounds, substances, preparations, mixtures, molecules, compositions, biomaterials or other active substances [e.g. drugs , Medicines, care substances, care products, enzymes, vitamins, proteins, cosmetics and others], which by themselves
  • At least one active ingredient is added to the cavitation medium or this at least one active ingredient is applied at a different time than the sound treatment takes place (preferably after the sound treatment).
  • other direct or indirect effects e.g. the mechanical effect of cavitation as well as the effects of sound waves [especially sound in the frequency range from 20 kHz to 100 kHz]
  • other effects whether known or unknown at present, on the biological System or the surface of the biological system are captured by statements made at the beginning, this also includes a physiological / biological effect, metabolism, mechanical stimuli and others, but also the delivery and / or removal of products from the biological system (e.g. Metabolic products, drug delivery and other modes of action) or for control and other.
  • Treatment is to be understood both as a combination treatment (e.g. with one or more active ingredients, or with other (active) methods or products [e.g. physical methods, wound dressings with a special effect] or only using the cavitation fluid.
  • combination treatment e.g. with one or more active ingredients, or with other (active) methods or products [e.g. physical methods, wound dressings with a special effect] or only using the cavitation fluid.
  • the product design of the sound delivery device corresponds to the current technical status, whereby this also with regard to the signal and wave form (e.g. asymmetrical pressure values which differ in the absolute values, or symmetrical forms and the like) Sound characteristic (e.g. with regard to the different forms of sound bursts such as sinusoidal, sawtooth-shaped, rectangular, and other technically possible forms) of the frequency (this affects the frequency range as well as whether only one frequency or at least two frequencies simultaneously or at least two frequencies in succession Application), the sound emission (e.g. pulsed, continuous, sweep form, frequency modulated or a combination thereof and the like) applies.
  • the signal and wave form e.g. asymmetrical pressure values which differ in the absolute values, or symmetrical forms and the like
  • Sound characteristic e.g. with regard to the different forms of sound bursts such as sinusoidal, sawtooth-shaped, rectangular, and other technically possible forms
  • the sound emission e.g. pulsed, continuous, sweep form, frequency modulated or a combination thereof and
  • the gas generation can be influenced by the sound (acoustic pressure), whereby the technical design of the sound applicator, similar to cavitation, influences the formation of bubbles. Temperature, external pressure, pH change and other physical and / or chemical parameters also influence gas formation.
  • the sound pressure should be between 1 and 1000 kPa (measured zero to peak).
  • the performance of these films, better PVDF films can be influenced by the voltage applied, film properties and geometry, heat dissipation, combination with other materials, structure and other parameters, e.g. B. to increase the sound pressure output and / or the transverse sound pressure output, durability, stability and other performance increases.
  • the films described and claimed should also apply if other flexible sound-emitting systems are used instead of the film sound applicator (10), these other flexible sound-emitting systems, for example a normal textured, piezoelectric PVDF- Film and / or another piezoelectric film and / or a piezoelectric polymer film / polymers - this also applies in particular to the use of porous piezoelectric polymers / polymer films - and / or another piezoelectric bending vibrator and / or another flexible piezoelectric system and / or another flexibly designed piezoelectric element (e.g. B. a
  • the cavitation medium in particular the gas-containing cavitation medium and devices (the film sound applicator and / or the device made of sound applicator or film sound applicator and cavitation medium and / or the device consisting of sound applicator or film sound applicator and spacer device and / or the device of sound applicator or foil sound applicator, spacer and
  • Cavitation medium and / or the device consisting of cavitation medium and spacer), instead of the film sound applicator (10) can be used with other and / or additional flexible sound-emitting systems, these other flexible sound-emitting systems, for example a normal textured, piezoelectric PVDF film and / or are another piezoelectric film and / or a piezoelectric polymer film and / or another piezoelectric bending vibrator and / or another flexible piezoelectric system and / or another flexibly designed piezoelectric element (e.g. a micro / array system) also applies in particular to the use of porous piezoelectric polymers.
  • the arrangement of a cavitation medium and a sound applicator in particular an ultrasound applicator, very particularly an ultrasound applicator from 20 kHz to 100 kHz, can be used and applied to all suitable sound applicators.
  • Cavitation medium contains at least one gas in an enriched concentration.
  • the cavitation medium consists of a liquid or a mixture of different liquids and / or a liquid-containing preparation and / or another medium capable of cavitation, preferably water or water.
  • the concentration of the gas in the cavitation medium is preferably between about 100 ppm to over 1000 ppm, more preferably between about 500 ppm and over 1000 ppm, particularly preferably over 1000 ppm
  • the device wherein the cavitation medium contains at least one further substance which can have a cosmetic, nourishing, therapeutic, diagnostic and / or physiological effect.
  • the at least one further substance is or contains an active ingredient, a preparation, a compound, a substance, a biomaterial, a carrier material or a combination thereof.
  • the cavitation medium is capable of cavitation and / or resonance
  • the sound applicator preferably being an ultrasound applicator for generating
  • Sound waves in the frequency range from 20 kHz to 20 MHz is better an ultrasound applicator for generating sound waves in the frequency range from 20 kHz to 800 kHz and especially preferably an ultrasonic applicator for generating sound waves in the frequency range from 20 kHz to 100 kHz.
  • the sound applicator is a film sound applicator with at least one piezoelectric film, preferably a PVDF film.
  • the film sound applicator has at least two piezoelectric films connected to one another, preferably with different textures, even more preferably PVDF films with different textures,
  • the device the at least two piezoelectric foils being connected to one another in such a way that the respective texture directions have an angle of greater than 0 degrees, preferably of about 90 degrees,
  • the device a reference electrode being arranged between the foils and making electrical contact with the piezoelectric foils,
  • the sound applicator has a wave-shaped piezoelectric film, the piezoelectric film being fixed in its troughs, so that they act as a vibration node in the contraction and dilation of the piezoelectric film, 18.
  • the troughs of the piezoelectric film on a carrier material are fixed, which is arranged adjacent to the piezoelectric film,
  • the carrier material has a structure with elevations, such as a wave structure or a nub structure, on its surface oriented to the piezoelectric film and the wave troughs of the piezoelectric film on the opposite ones
  • the device further comprising an energy source and / or a sound generator and / or a control device
  • Device wherein the energy source is a transformer, a battery, such as a foil battery, a photovoltaic cell or a fuel cell.
  • control device and / or the sound generator has an electronic circuit.
  • Device wherein the energy source and / or the control device and / or the sound generator is / are integrated in the film / films.
  • the device further comprising a spacing device to ensure a distance between the surface of the sound applicator oriented towards the surface of the biological system and the surface of the biological system.
  • the spacing device contains a mechanical element, such as a flat carrier, a frame, a linkage.
  • the device wherein the mechanical element is made of plastic, metal, ceramic, glass, rubber or a combination thereof.
  • the device, the mechanical element being plastically or elastically deformable.
  • the sound-conducting material is a metal, gel, hydrocolloid gel, a plaster or any combination thereof.
  • the sound-conducting material is a carrier substance for a substance that can have a cosmetic, nourishing, therapeutic, diagnostic and / or physiological effect.
  • Device wherein the surface of the sound applicator oriented towards the surface of the biological system has an annular, tubular or cuff-like design
  • Device wherein the distance between the surface of the sound applicator oriented to the surface of the biological system and the surface of the biological system is 5 cm and less, preferably less than 2 cm to less than 0.0001 mm or can be adapted to this distance.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Preparation (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention concerne un système destiné à améliorer les propriétés de cavitation de couches de liquide proches de la surface, ainsi qu'un applicateur d'ultrasons flexible, adaptable et déformable utilisé à des fins de traitement. Les phénomènes de cavitation dans la zone proche de la surface lors du traitement de systèmes biologiques sont difficiles à contrôler et à maintenir constants. Selon l'invention, l'effet d'une cavitation dans des couches de liquide proches de la surface peut être amélioré au moyen d'un agent de cavitation (6) enrichi en gaz et au moyen d'un applicateur d'ultrasons, de préférence un applicateur d'ultrasons à structure en feuilles (10), pour des ultrasons situés dans une plage de fréquence comprise entre 20 et 100 kHz, cet applicateur d'ultrasons pouvant s'adapter de façon particulièrement satisfaisante à des surfaces (11) et étant formé de feuilles PVDF assemblées. Le dispositif et l'applicateur d'ultrasons selon l'invention sont destinés en particulier au traitement de systèmes biologiques dans le domaine des sciences de la vie.
PCT/DE2003/002456 2002-07-22 2003-07-22 Dispositif d'application d'ultrasons destine a ameliorer les conditions de traitement WO2004016311A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE10393505T DE10393505D2 (de) 2002-07-22 2003-07-22 Schallapplikator-Vorrichtung zur Verbesserung der Behandlungsbedingungen
EP03787708A EP1575657A2 (fr) 2002-07-22 2003-07-22 Dispositif d'application d'ultrasons comprenant un applicateur d'ultrasons plat et flexible et une substance de cavitation
AU2003257394A AU2003257394A1 (en) 2002-07-22 2003-07-22 Ultrasonic applicator device with a flat, flexible ultrasonic applicator and cavitation medium

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE2002133293 DE10233293A1 (de) 2002-07-22 2002-07-22 Anordnung zur Verbesserung der Kavitations- und Wirkeigenschaften bei der Behandlung von Oberflächen biologischer Systeme
DE20211073.7 2002-07-22
DE10233293.2 2002-07-22
DE20211073U DE20211073U1 (de) 2002-07-22 2002-07-22 Anordnung zur Anreicherung oberflächennaher Flüssigkeitsschichten mit Gasblasen

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WO2004016311A2 true WO2004016311A2 (fr) 2004-02-26
WO2004016311A3 WO2004016311A3 (fr) 2004-05-06

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006129099A1 (fr) * 2005-06-02 2006-12-07 Cancercure Technology As Systeme de traitement a ultrasons
WO2006131113A1 (fr) * 2005-06-09 2006-12-14 Hans-Werner Bender Element support comme module pour un dispositif de traitement
WO2009118002A2 (fr) * 2008-03-27 2009-10-01 Hans-Werner Bender Destruction de germes au moyen de dioxyde de carbone et traitement par cavitation d'adjuvants
EP3446743A1 (fr) * 2013-03-15 2019-02-27 Carewear Corp. Transducteur ultrasonore
US10639498B2 (en) 2016-05-26 2020-05-05 Carewear Corp. Photoeradication of microorganisms with pulsed purple or blue light
US11020605B2 (en) 2018-05-29 2021-06-01 Carewear Corp. Method and system for irradiating tissue with pulsed blue and red light to reduce muscle fatigue, enhance wound healing and tissue repair, and reduce pain

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3816774A (en) * 1972-01-28 1974-06-11 Victor Company Of Japan Curved piezoelectric elements
US4056742A (en) * 1976-04-30 1977-11-01 Tibbetts Industries, Inc. Transducer having piezoelectric film arranged with alternating curvatures
US4578613A (en) * 1977-04-07 1986-03-25 U.S. Philips Corporation Diaphragm comprising at least one foil of a piezoelectric polymer material
US4787888A (en) * 1987-06-01 1988-11-29 University Of Connecticut Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a)
US4833659A (en) * 1984-12-27 1989-05-23 Westinghouse Electric Corp. Sonar apparatus
EP0504881A2 (fr) * 1991-03-22 1992-09-23 Katsuro Tachibana Amplificateur pour la thérapie des maladies à ultrason et composition pharmaceutique liquide le contenant
EP0557780A1 (fr) * 1992-02-25 1993-09-01 Siemens Aktiengesellschaft Transducteur ultrasonore à couche polymère piézoélectrique
EP0562326A1 (fr) * 1992-03-23 1993-09-29 Siemens Aktiengesellschaft Transducteur ultrasonore atmosphérique
US5267985A (en) * 1993-02-11 1993-12-07 Trancell, Inc. Drug delivery by multiple frequency phonophoresis
EP0642843A1 (fr) * 1993-09-14 1995-03-15 The Whitaker Corporation Détecteur de proximité avec un film polymère piézoélectrique
US6096000A (en) * 1997-06-23 2000-08-01 Ekos Corporation Apparatus for transport of fluids across, into or from biological tissues
US20020045850A1 (en) * 1996-06-28 2002-04-18 Stephen Rowe Ultrasound enhancement of transdermal transport
WO2002038216A1 (fr) * 2000-10-16 2002-05-16 Meditron As Bande medicale
US20020062101A1 (en) * 1996-11-27 2002-05-23 The General Hospital Corporation, Massachusetts Corporation Compound delivery using impulse transients

Patent Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3816774A (en) * 1972-01-28 1974-06-11 Victor Company Of Japan Curved piezoelectric elements
US4056742A (en) * 1976-04-30 1977-11-01 Tibbetts Industries, Inc. Transducer having piezoelectric film arranged with alternating curvatures
US4578613A (en) * 1977-04-07 1986-03-25 U.S. Philips Corporation Diaphragm comprising at least one foil of a piezoelectric polymer material
US4833659A (en) * 1984-12-27 1989-05-23 Westinghouse Electric Corp. Sonar apparatus
US4787888A (en) * 1987-06-01 1988-11-29 University Of Connecticut Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a)
EP0504881A2 (fr) * 1991-03-22 1992-09-23 Katsuro Tachibana Amplificateur pour la thérapie des maladies à ultrason et composition pharmaceutique liquide le contenant
EP0557780A1 (fr) * 1992-02-25 1993-09-01 Siemens Aktiengesellschaft Transducteur ultrasonore à couche polymère piézoélectrique
EP0562326A1 (fr) * 1992-03-23 1993-09-29 Siemens Aktiengesellschaft Transducteur ultrasonore atmosphérique
US5267985A (en) * 1993-02-11 1993-12-07 Trancell, Inc. Drug delivery by multiple frequency phonophoresis
EP0642843A1 (fr) * 1993-09-14 1995-03-15 The Whitaker Corporation Détecteur de proximité avec un film polymère piézoélectrique
US20020045850A1 (en) * 1996-06-28 2002-04-18 Stephen Rowe Ultrasound enhancement of transdermal transport
US20020062101A1 (en) * 1996-11-27 2002-05-23 The General Hospital Corporation, Massachusetts Corporation Compound delivery using impulse transients
US6096000A (en) * 1997-06-23 2000-08-01 Ekos Corporation Apparatus for transport of fluids across, into or from biological tissues
WO2002038216A1 (fr) * 2000-10-16 2002-05-16 Meditron As Bande medicale

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006129099A1 (fr) * 2005-06-02 2006-12-07 Cancercure Technology As Systeme de traitement a ultrasons
WO2006131113A1 (fr) * 2005-06-09 2006-12-14 Hans-Werner Bender Element support comme module pour un dispositif de traitement
WO2009118002A2 (fr) * 2008-03-27 2009-10-01 Hans-Werner Bender Destruction de germes au moyen de dioxyde de carbone et traitement par cavitation d'adjuvants
WO2009118002A3 (fr) * 2008-03-27 2009-11-26 Hans-Werner Bender Destruction de germes au moyen de dioxyde de carbone et traitement par cavitation d'adjuvants
EP3446743A1 (fr) * 2013-03-15 2019-02-27 Carewear Corp. Transducteur ultrasonore
US11083619B2 (en) 2013-03-15 2021-08-10 Carewear Corp. Organic LED light and ultrasonic transducer device in a flexible layer configuration with electrical stimulation
US12059370B2 (en) 2013-03-15 2024-08-13 Carewear Corp. Flexible skin therapy device having phosphorus material with light and transparent electrical stimulation layers
US10639498B2 (en) 2016-05-26 2020-05-05 Carewear Corp. Photoeradication of microorganisms with pulsed purple or blue light
US11020605B2 (en) 2018-05-29 2021-06-01 Carewear Corp. Method and system for irradiating tissue with pulsed blue and red light to reduce muscle fatigue, enhance wound healing and tissue repair, and reduce pain

Also Published As

Publication number Publication date
WO2004016311A3 (fr) 2004-05-06
EP1575657A2 (fr) 2005-09-21
DE10393505D2 (de) 2005-06-23
AU2003257394A8 (en) 2004-03-03
AU2003257394A1 (en) 2004-03-03

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