WO2004014836A2 - Procede de preparation d'un ester d'un acide carboxylique aromatique porteur d'au moins un groupe perfluoroalkyle - Google Patents
Procede de preparation d'un ester d'un acide carboxylique aromatique porteur d'au moins un groupe perfluoroalkyle Download PDFInfo
- Publication number
- WO2004014836A2 WO2004014836A2 PCT/FR2003/002333 FR0302333W WO2004014836A2 WO 2004014836 A2 WO2004014836 A2 WO 2004014836A2 FR 0302333 W FR0302333 W FR 0302333W WO 2004014836 A2 WO2004014836 A2 WO 2004014836A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acid
- process according
- alkanol
- compound
- nitrile
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/18—Preparation of carboxylic acid esters by conversion of a group containing nitrogen into an ester group
- C07C67/22—Preparation of carboxylic acid esters by conversion of a group containing nitrogen into an ester group from nitriles
Definitions
- the subject of the present invention is a process for preparing an ester of an aromatic carboxylic acid carrying at least one perfluoroalkyl group on the aromatic ring and more particularly a trifluoromethyl group.
- the invention relates in particular to alkyl esters with low carbon condensation.
- the present invention aims to provide a method which overcomes the aforementioned drawbacks and allows access to esters according to a completely different route.
- aromatic carrying at least one perfluoroalkyl group on the aromatic ring is characterized in that it consists in reacting an aromatic compound carrying at least one perfluoroalkyl group and at least one nitrile group on the aromatic cycle, an alkanol and a strong protonic acid, at a temperature of at least 45 ° C, then recovering the ester obtained.
- the aromatic compound involved in the process of the invention contains at least one nitrile group and at least one perfluoroalkyl group corresponding to the general formula:
- R f represents a perfluoroalkyl chain of formula - [CF 2 ] P - CF 3 in which p represents a number ranging from 0 to 10,
- - n is a number at least equal to 1, preferably between 1 and 3.
- the substrates preferably used in the process of the invention correspond to formula (I) in which R f represents a group - CF 3 or - CF 2 - CF 3 , preferably a trifluoromethyl group and n is a number equal to 1 or 2.
- the invention relates more particularly to an aromatic compound carrying at least one nitrile group and at least one trifluoromethyl group corresponding to the general formula:
- - n is a number at least equal to 1, preferably between 1 and 3.
- the ester is obtained directly starting from a nitrile type compound as soon as the reaction is carried out at a temperature of at least 45 ° C.
- An aromatic compound carrying at least one nitrile group and at least one perfluoroalkyl group, preferably trifluoromethyl, corresponding to the general formula (I), is involved in the process.
- the substrates preferably used in the process of the invention correspond to the formula (lai) in which:
- - n is a number at least equal to 1, preferably between 1 and 3,
- - at least one trifluoromethyl group is in position 3, 4 or 5.
- the invention does not exclude the presence of other substituents on the aromatic cycle insofar as they do not interfere with the reaction. Mention may in particular be made of alkyl or aikoxy groups, nitro groups or halogen, chlorine or bromine atoms.
- a starting substrate having good purity.
- a compound comprising less than 10% of water because the presence of water in the medium slows down the reaction kinetics.
- the nitrile type compound is reacted with an alkanol which can be symbolized by the following formula:
- R1 represents an alkyl, cycloalkyl or arylalkyl group.
- alkyl means a linear or branched hydrocarbon chain having from 1 to 15 carbon atoms and preferably from 1 to 4 carbon atoms.
- cycloalkyl is meant a cyclic hydrocarbon group, comprising from 3 to 8 carbon atoms, preferably a cyclopentyl or cyclohexyl group.
- arylalkyl is meant a hydrocarbon group, linear or branched carrying a monocyclic aromatic ring and comprising from 7 to 12 carbon atoms, preferably benzyl.
- alkanol will be used generically to denote all the alkanols corresponding to formula (II).
- the process is more particularly implemented for a lower aliphatic alcohol having from 1 to 4 carbon atoms, such as for example, methanol, ethanol, trifluoroethanol, propanol, isopropyl alcohol, butanol, isobutyl alcohol, sec-butyl alcohol, tert-butyl alcohol; a cycloaliphatic alcohol having from 3 to about 8 carbon atoms, such as, for example, cyclopentanol, cyclohexanol; an aliphatic alcohol carrying an aromatic group having from 7 to about 20 carbon atoms such as for example benzyl alcohol, phenethyl alcohol.
- a lower aliphatic alcohol having from 1 to 4 carbon atoms such as for example, methanol, ethanol, trifluoroethanol, propanol, isopropyl alcohol, butanol, isobutyl alcohol, sec-butyl alcohol, tert-butyl alcohol
- methanol or ethanol is preferably used in the process of the invention.
- the amount of alkanol used is at least equal to the stoichiometric amount of the reaction.
- the alkanol is used in an amount such that the ratio between the number of moles of alkanol and the number of moles of compound of nitrile type (I) varies between approximately 1 and approximately 20, preferably between 2 and 6.
- the concentration of the nitrile type compound in the medium can be at least 50% by weight, preferably between 70 and 85% by weight. It should be noted that the process of the invention does not exclude the use of an organic solvent.
- a condition which governs the choice of the solvent is that it must not react under the conditions of the reaction.
- a second requirement is that it must meet certain basic characteristics. Indeed, said solvent should not be too basic. To determine whether a solvent meets this requirement, its basicity is assessed by reference to the "donor number".
- a polar organic solvent is chosen having a donor number less than or equal to 10. The lower bound has no critical character.
- An organic solvent preferably having a donor number between 2 and 10 is chosen.
- organic solvents which meet the aforementioned basicity characteristics, which can be used in the process of the invention, mention may more particularly be made of aromatic ether oxides and, more particularly, diphenyl oxide. Mention may also be made of aliphatic, cycloaliphatic, aromatic, halogenated or not.
- aliphatic hydrocarbons there may be mentioned more particularly paraffins such as in particular, hexane, cyclohexane, methylcyclohexane, petroleum ether type petroleum fractions. Mention may more particularly be made of aromatic hydrocarbons such as, in particular, benzene, toluene, xylenes, cumene, petroleum fractions consisting of a mixture of alkylbenzenes, in particular solvesso type fractions.
- organic solvents there may be mentioned aliphatic halogenated hydrocarbons and more particularly, n-chlorobutane, dichloromethane, 1, 2-dichloroethane; halogenated aromatic hydrocarbons, and more particularly, mono- or dichlorobenzene.
- the amount of organic solvent to be used can be variable. It can be as important as that of the reagents. Thus, the solvent can represent from 10 to 50% of the weight of the reaction medium.
- the compound of nitrile and Palcanol type is reacted in the presence of a strong protonic acid.
- strong acid is meant in the present invention, a protonic acid having a pKa in water lower than that of the starting nitrile type compound.
- PKa is defined as the ionic dissociation constant of the acid / base couple, when water is used as a solvent.
- hydracids such as hydrochloric acid, hydrobromic acid; halogenated or non-halogenated oxyacids such as sulfuric acid, perchloric acid; halogenated or non-halogenated sulfonic acids such as fluorosulfonic acid, chlorosulfonic acid or trifluoromethanesulfonic acid, methanesulfonic acid, ethanesulfonic acid, ethanedisulfonic acid, benzenesulfonic acid, benzenedisulfonic acids, toluenesulfonic acids, xylenesulfonic acids, naphthalene sulfonic acids and naphthalenedisulfonic acids; halocarboxylic acids such as in particular trichloroacetic acid.
- Use is preferably made of concentrated acid solutions because the presence of water in the medium slows down the reaction kinetics.
- a hydrochloric acid solution at 37% by weight, a sulfuric acid solution of at least 95%, preferably greater than 98%.
- hydrochloric acid is used in gaseous form.
- the amount of acid expressed by the ratio of the number of proton equivalents to the number of moles of nitrile-type compound can vary between approximately 1 and approximately 10, and preferably between 2 and 4.
- the process of the invention is generally carried out under atmospheric pressure but preferably under a controlled atmosphere of inert gases.
- An atmosphere of rare gases, preferably argon, can be established, but it is more economical to use nitrogen.
- the invention can be implemented according to several embodiments.
- a first variant consists in charging the nitrile type compound and the alkanol, optionally an organic solvent, then in introducing the acid, preferably a bubbling of hydrochloric acid.
- One of the characteristics of the process of the invention is the choice of the reaction temperature.
- the upper limit of the temperature is preferably lower than the boiling temperature of the alkanol.
- lower is generally meant two or three degrees less.
- the temperature is advantageously chosen between 45 ° C and 60 ° C, preferably between 50 ° C and 60 ° C.
- the lower critical limit is greater than 45 ° C but preferably corresponds to the temperature at which the alkyl halide appears, for example in the case of the use of hydrochloric acid. It should be noted that the yield is higher the higher the temperature chosen.
- the addition of the acid is carried out gradually, continuously or in fractions over a period preferably varying between 3 and 8 hours.
- the ester is obtained in the reaction medium which can be recovered in a conventional manner. Water can be added so that the salts formed are dissolved and the acid obtained remains in the organic phase.
- reaction medium is left to settle then the organic and aqueous phases are separated.
- the product obtained is in the organic phase and can optionally be extracted with an immiscible organic solvent and mention may in particular be made of toluene or monochlorobenzene.
- the compound of the nitrile type and the alkanol is reacted as previously described, optionally in the presence of an organic solvent, then the acid is preferably introduced. bubbling of hydrochloric acid.
- the addition of the acid is gradual and can be done between 3 and 8 hours.
- the water formed during the reaction is removed by distillation. Water may be accompanied by excess alcohol depending on its boiling point.
- the distillation is carried out at a temperature between 40 ° C and 120 ° C, at atmospheric pressure or under reduced pressure ranging from 10 mm of mercury to atmospheric pressure, preferably between 10 and 200 mm mercury.
- the alkanol is used in an amount such that the ratio between the number of moles of alkanol and the number of moles of compound of nitrile type (I) varies between approximately 1 and approximately 3.
- the amount of acid expressed by the ratio of the number of proton equivalents to the number of moles of nitrile-type compound varies between approximately 1 and approximately 2.
- the ester corresponding to the formula is obtained (III).
- the ester obtained can be separated in a conventional manner and in particular as previously described, that is to say addition of water, separation of the organic and aqueous phases and optionally extraction in an appropriate organic solvent.
- the process of the invention provides access to the esters with high reaction kinetics, a high conversion rate and a good reaction yield.
- the conversion rate (TT) corresponds to the ratio between the number of substrates transformed and the number of moles of substrate engaged.
- the yield (RR) corresponds to the ratio between the number of moles of product formed and the number of moles of substrate used.
- the temperature is always maintained at 60 ° C during this introduction and then maintained for 1 hour.
- the reactor is placed under reduced pressure of 100 mm of mercury to distill the methanol and the water at a temperature of 70 - 75 ° C.
- the volume of the distillate is 350 ml.
- gaseous hydrochloric acid is introduced with the same protocol, ie 219 g of gaseous hydrochloric acid in 2 hours, allowing the temperature to rise to 60 ° C and maintaining this value.
- the reaction requires 3 hours of maintenance at 60 ° C.
- reaction mass is cooled to 40 ° C. and then water (1000 g) is added to dissolve the ammonium chloride, the aqueous and organic layers are separated by decantation. The organic layer is washed with bicarbonate water (1%) to neutralize it.
- Example 1 is repeated, but maintaining a temperature of 40 ° C for 6 hours.
- the product formed mainly at a rate of 90% is the iminoester hydrochloride of formula:
- the latter precipitates in the medium and can therefore be separated by filtration.
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03755627A EP1525179A2 (fr) | 2002-07-25 | 2003-07-23 | Procede de preparation d un ester d un acide carboxylique aromatique porteur d au moins un groupe perfluoroalkyle |
US10/521,825 US20060128984A1 (en) | 2002-07-25 | 2003-07-23 | Method of preparing an ester of an aromatic carboxylic acid bearing at least one perfluoroalkyl group |
AU2003273467A AU2003273467A1 (en) | 2002-07-25 | 2003-07-23 | Method of preparing an ester of an aromatic carboxylic acid bearing at least one perfluoroalkyl group |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0209443A FR2842803B1 (fr) | 2002-07-25 | 2002-07-25 | Procede de preparation d'un ester d'un acide carboxylique aromatique porteur d'au moins un groupe trifluoromethyle |
FR0209443 | 2002-07-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004014836A2 true WO2004014836A2 (fr) | 2004-02-19 |
WO2004014836A3 WO2004014836A3 (fr) | 2004-04-08 |
Family
ID=30011474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2003/002333 WO2004014836A2 (fr) | 2002-07-25 | 2003-07-23 | Procede de preparation d'un ester d'un acide carboxylique aromatique porteur d'au moins un groupe perfluoroalkyle |
Country Status (5)
Country | Link |
---|---|
US (1) | US20060128984A1 (fr) |
EP (1) | EP1525179A2 (fr) |
AU (1) | AU2003273467A1 (fr) |
FR (1) | FR2842803B1 (fr) |
WO (1) | WO2004014836A2 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103145611B (zh) * | 2013-03-19 | 2015-04-29 | 山东省食品药品检验研究院 | 1,6-二氢-2-甲基-6-氧-(3,4’-双吡啶)-5-甲酸甲酯及制备方法 |
CN103641686B (zh) * | 2013-12-09 | 2015-07-01 | 连云港市华通化学有限公司 | 2,3,5,6-四氟-1,4-对苯二甲醇的合成方法 |
CN104529932A (zh) * | 2014-12-24 | 2015-04-22 | 大连百傲化学股份有限公司 | 一种2-丁基-1,2-苯并异噻唑啉-3-酮的合成方法 |
CN107417587A (zh) * | 2017-03-22 | 2017-12-01 | 京博农化科技股份有限公司 | 一种1‑环丙基‑3‑(2‑甲硫基‑4‑三氟甲基苯基)丙‑1,3‑二酮的合成方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3915975A (en) * | 1971-04-20 | 1975-10-28 | Pfizer | Substituted alkyl esters of quinoxaline-di-N-oxide-2-carboxylic acid |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4307113A (en) * | 1978-04-20 | 1981-12-22 | Sandoz, Inc. | Anthranilic acid derivatives |
US4868333A (en) * | 1987-11-16 | 1989-09-19 | Ici Americas Inc. | Production of 2-nitro-4-trifluoromethylbenzoic acid |
-
2002
- 2002-07-25 FR FR0209443A patent/FR2842803B1/fr not_active Expired - Fee Related
-
2003
- 2003-07-23 US US10/521,825 patent/US20060128984A1/en not_active Abandoned
- 2003-07-23 AU AU2003273467A patent/AU2003273467A1/en not_active Abandoned
- 2003-07-23 WO PCT/FR2003/002333 patent/WO2004014836A2/fr not_active Application Discontinuation
- 2003-07-23 EP EP03755627A patent/EP1525179A2/fr not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3915975A (en) * | 1971-04-20 | 1975-10-28 | Pfizer | Substituted alkyl esters of quinoxaline-di-N-oxide-2-carboxylic acid |
Non-Patent Citations (3)
Title |
---|
P. CAUBÈRE ET AL.: "AN EFFICIENT COBALT CATALYZED ALKOXYCARBONYLATION OF ARYL AND HETEROARYL HALIDES" SYNTHETIC COMMUNICATIONS., vol. 23, no. 10, 1993, pages 1361-1370, XP008011905 MARCEL DEKKER, NEW YORK, NY., US ISSN: 0039-7911 cité dans la demande * |
PFEIFFER P ET AL: "ZUR VERESTERUNG AROMATISCHER UND OLEFINISCHER NITRILE" JUSTUS LIEBIGS ANNALEN DER CHEMIE, VERLAG CHEMIE, WEINHEIM,, DE, 1928, pages 158-190, XP008015982 ISSN: 0075-4617 * |
S. DE BROUWER: "SUR L'ACIDE ORTHOTRIFLUORTOLUIQUE ET LE NITROTRIFLUORCRESOL 1-3-6" BULLETIN DES SOCIETES CHIMIQUES BELGES., vol. 39, 1930, pages 298-308, XP001149847 ISSN: 0037-9646 * |
Also Published As
Publication number | Publication date |
---|---|
FR2842803B1 (fr) | 2006-02-03 |
US20060128984A1 (en) | 2006-06-15 |
AU2003273467A8 (en) | 2004-02-25 |
FR2842803A1 (fr) | 2004-01-30 |
WO2004014836A3 (fr) | 2004-04-08 |
AU2003273467A1 (en) | 2004-02-25 |
EP1525179A2 (fr) | 2005-04-27 |
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