WO2004014341A1 - Composition pharmaceutique pour administration orale contenant du florfenicol en tant que principe actif - Google Patents

Composition pharmaceutique pour administration orale contenant du florfenicol en tant que principe actif Download PDF

Info

Publication number
WO2004014341A1
WO2004014341A1 PCT/KR2003/001266 KR0301266W WO2004014341A1 WO 2004014341 A1 WO2004014341 A1 WO 2004014341A1 KR 0301266 W KR0301266 W KR 0301266W WO 2004014341 A1 WO2004014341 A1 WO 2004014341A1
Authority
WO
WIPO (PCT)
Prior art keywords
florfenicol
pharmaceutical composition
oral administration
surfactant
administration according
Prior art date
Application number
PCT/KR2003/001266
Other languages
English (en)
Inventor
Si-Young Chang
Jae-Seung Choi
Sung-Bae Park
Jong-Myung Park
Byeung-Gie Kim
Ji-Hoon Park
Original Assignee
Dae Han New Pharm Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dae Han New Pharm Co., Ltd. filed Critical Dae Han New Pharm Co., Ltd.
Priority to AU2003244259A priority Critical patent/AU2003244259A1/en
Publication of WO2004014341A1 publication Critical patent/WO2004014341A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide

Definitions

  • the present invention relates to a pharmaceutical composition comprising florfenicol as an active ingredient, and more particularly to a pharmaceutical composition for oral administration comprising a florfenicol-containing microemulsion as an effective ingredient which is obtained by adding an oil and a surfactant to a solution of florfenicol in a hydrophilic or amphiphilic dispersion medium.
  • a pharmaceutical composition for oral administration comprising a florfenicol- containing microemulsion as an effective ingredient wherein the microemulsion is obtained by adding an oil and a surfactant to a solution of florfenicol in a hydrophilic or amphiphilic dispersion medium.
  • microemulsion containing florfenicol as an active ingredient enables the provision of the pharmaceutical composition comprising the active ingredient in the high concentration with excellent bioavailability in which the concentration of the active ingredient can be easily controlled by drinking water upon oral administration.
  • the hydrophilic or amphiphilic solvent as a dispersion medium is at least one solvent selected from the group consisting of diethyleneglycol monoethylether,
  • the weight ratio of the florfenicol to the hydrophilic or amphiphilic solvent is preferably within the range of 1: 0.5 ⁇ 5, and more preferably 1: 1 ⁇ 3.
  • the surfactant preferably has a hydrophilic lipophlic balance (HLB) of 1 ⁇ 20.
  • the surfactant usable in the present invention is at least one compound selected from the group consisting of reaction products between vegetable hardened oils and ethylene glycol (e.g., Cremophor RH40, Cremophor RH60); polyethylene sorbitan fatty acid esters (e.g., Tween 20, Tween 40); polyoxyethylene fatty acid esters; polyoxyethylene-polyoxypropylene copolymers; and ester group transfer reaction products between vegetable oil triglycerides and polyalkylenepolyols (e.g., Labrafil, Labrasol).
  • the surfactant includes polyethyleneglycol 40 castor hardened oil and polyethyleneglycol 35 castor hardened oil.
  • the oil used in the present invention is at least one compound selected from the group consisting of vegetable oils, esterification products of vegetable oils and highly unsaturated fatty acids.
  • the weight ratio of the florfenicol to the oil is preferably within the range of 1: 0.1 ⁇ 10, and more preferably 1: 0.5 ⁇ 3. When the ratio is less than 1: 0.1, addition effect of the oil is none or little. When the ratio exceeds 1 : 10, there is a risk of phase separation.
  • this range is given only for the purpose of illustration, and is not to be construed as limiting the scope ofthe invention.
  • the pharmaceutical composition for oral administration of the present invention comprising the florfenicol-containing microemulsion may further comprise various medically acceptable additives.
  • these additives include antioxidants (butylparahydroxy benzoic acid, butylhydroquinone, tocopherol, etc.), viscosity enhancing agents (sodium alginate, carboxymethylcellulose, methylcellulose, tragacanth, agar, polyvinylpyrrolidone, etc.), aromatics (orange oil, peppermint, vanilla, cocoa, etc.), preservative agents (methyl paraoxybenzoate, propyl paraoxybenzoate, sodium benzoylbenzoate, benzalkonium chloride, etc), colorants (Red #40, Yellow #4, Green #3, Blue #1), and the like.
  • antioxidants butylparahydroxy benzoic acid, butylhydroquinone, tocopherol, etc.
  • viscosity enhancing agents sodium alginate, carboxymethylcellulose, methylcellulose, trag
  • Fig. 1 is a graph showing the concentration of an active ingredient in blood, measured at predetermined time intervals after a pharmaceutical composition of the present invention is orally administered into male rats.
  • the pharmaceutical composition for oral administration according to the present invention comprises a high concentration active ingredient with excellent bioavailability in which the concentration of the active ingredient can be easily controlled by drinking water upon oral administration.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Composition pharmaceutique pour administration orale contenant une micro-émulsion à base de florfénicol en tant que principe actif, ladite micro-émulsion étant obtenue par ajout d'une huile et d'un tensioactif à une solution de florfénicol dans un milieu de dispersion hydrophile ou amphiphile. Ladite composition pharmaceutique pour administration orale possède une forte concentration de principe actif présentant une excellente biodisponibilité, la concentration du principe actif pouvant être facilement régulée par absorption d'eau lors de la prise orale du médicament.
PCT/KR2003/001266 2002-08-13 2003-06-27 Composition pharmaceutique pour administration orale contenant du florfenicol en tant que principe actif WO2004014341A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003244259A AU2003244259A1 (en) 2002-08-13 2003-06-27 Oral injectable pharmaceutical composition comprising florfenicol as an active ingredient

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020020047910A KR20040015624A (ko) 2002-08-13 2002-08-13 플로르페니콜을 활성성분으로 함유하는 경구투여용약제학적 조성물
KR10-2002-0047910 2002-08-13

Publications (1)

Publication Number Publication Date
WO2004014341A1 true WO2004014341A1 (fr) 2004-02-19

Family

ID=31713128

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2003/001266 WO2004014341A1 (fr) 2002-08-13 2003-06-27 Composition pharmaceutique pour administration orale contenant du florfenicol en tant que principe actif

Country Status (3)

Country Link
KR (1) KR20040015624A (fr)
AU (1) AU2003244259A1 (fr)
WO (1) WO2004014341A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009019604A2 (fr) * 2007-08-09 2009-02-12 Ems S/A Systèmes d'administration pour solubiliser des principes actifs pharmaceutiques insolubles dans l'eau.
FR2925335A1 (fr) * 2007-12-21 2009-06-26 Ceva Sante Animale Sa Compositions orales liquides de florfenicol diluables dans l'eau de boisson
FR2925855A1 (fr) * 2007-12-26 2009-07-03 Virbac Sa Sa Composition liquide autoemulsionnable de florfenicol destinee a etre incorporee a l'eau de boisson des animaux d'elevage.
AU2005318187B2 (en) * 2004-12-21 2010-12-16 Intervet International B.V. Injectable veterinary composition
CN106236705A (zh) * 2016-08-30 2016-12-21 瑞普（天津）生物药业有限公司 一种可用于饮水给药的氟苯尼考溶液剂及其制备方法
CN109125262A (zh) * 2018-09-11 2019-01-04 江苏农牧科技职业学院 氟苯尼考纳米乳及其制备方法
US10905759B2 (en) 2016-08-19 2021-02-02 Sementis Limited Vector-based attenuated poxvirus vaccines

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992004016A1 (fr) * 1990-08-29 1992-03-19 Schering Corporation Composition pharmaceutique de florfenicol
US5932243A (en) * 1993-05-27 1999-08-03 Novartis Ag Galenical formulations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992004016A1 (fr) * 1990-08-29 1992-03-19 Schering Corporation Composition pharmaceutique de florfenicol
US5932243A (en) * 1993-05-27 1999-08-03 Novartis Ag Galenical formulations

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005318187B2 (en) * 2004-12-21 2010-12-16 Intervet International B.V. Injectable veterinary composition
GB2451811A (en) * 2007-08-09 2009-02-18 Ems Sa Delivery composition for solubilising water-insoluble pharmaceutical active ingredients
US9278065B2 (en) 2007-08-09 2016-03-08 Ems S/A Delivery systems for solubilising water-insoluble pharmaceutical active ingredients
US20120177692A1 (en) * 2007-08-09 2012-07-12 Ems S/A Delivery systems for solubilising water-insoluble pharmaceutical active ingredients
WO2009019604A2 (fr) * 2007-08-09 2009-02-12 Ems S/A Systèmes d'administration pour solubiliser des principes actifs pharmaceutiques insolubles dans l'eau.
WO2009019604A3 (fr) * 2007-08-09 2009-07-23 Ems Sa Systèmes d'administration pour solubiliser des principes actifs pharmaceutiques insolubles dans l'eau.
WO2009083520A2 (fr) * 2007-12-21 2009-07-09 Ceva Sante Animale Compositions orales liquides de florfenicol diluables dans l'eau de boisson
WO2009083520A3 (fr) * 2007-12-21 2009-12-03 Ceva Sante Animale Compositions orales liquides de florfenicol diluables dans l'eau de boisson
FR2925335A1 (fr) * 2007-12-21 2009-06-26 Ceva Sante Animale Sa Compositions orales liquides de florfenicol diluables dans l'eau de boisson
WO2009106714A3 (fr) * 2007-12-26 2009-12-17 Virbac Sa Composition liquide autoemuls ionnable de florfeni col destinee a etre incorporee a l'eau de boisson des animaux d'elevage
WO2009106714A2 (fr) 2007-12-26 2009-09-03 Virbac Sa Composition liquide autoemuls ionnable de florfeni col destinee a etre incorporee a l'eau de boisson des animaux d'elevage
US20110028560A1 (en) * 2007-12-26 2011-02-03 Virbac Sa Self-emulsifiable liquid florfenicol composition intended to be incorporated into the drinking water of livestock
FR2925855A1 (fr) * 2007-12-26 2009-07-03 Virbac Sa Sa Composition liquide autoemulsionnable de florfenicol destinee a etre incorporee a l'eau de boisson des animaux d'elevage.
US9339460B2 (en) 2007-12-26 2016-05-17 Virbac Sa Self-emulsifiable liquid florfenicol composition intended to be incorporated into the drinking water of livestock
US10905759B2 (en) 2016-08-19 2021-02-02 Sementis Limited Vector-based attenuated poxvirus vaccines
CN106236705A (zh) * 2016-08-30 2016-12-21 瑞普（天津）生物药业有限公司 一种可用于饮水给药的氟苯尼考溶液剂及其制备方法
CN109125262A (zh) * 2018-09-11 2019-01-04 江苏农牧科技职业学院 氟苯尼考纳米乳及其制备方法
CN109125262B (zh) * 2018-09-11 2020-12-25 江苏农牧科技职业学院 氟苯尼考纳米乳及其制备方法

Also Published As

Publication number Publication date
KR20040015624A (ko) 2004-02-19
AU2003244259A1 (en) 2004-02-25

Similar Documents

Publication Publication Date Title
FI119175B (fi) Tokoferolikoostumuksia biologisesti aktiivisten aineiden antamiseksi
EP0715856B1 (fr) Composition antifongique stockable dans la keratine pour usage externe
EP0515310B1 (fr) Composition topique de terbinafine
CA2294033C (fr) Composition pharmaceutique pour composes acides lipophiles sous forme d'une formulation autoemulsifiante
US4849418A (en) Transdermally absorbable water-containing preparations of arylpropionic acid derivatives and process for preparing same
JPH0345044B2 (fr)
WO2004014341A1 (fr) Composition pharmaceutique pour administration orale contenant du florfenicol en tant que principe actif
AU3495093A (en) Liposomal piroxicam formulations
CA2074503C (fr) Formulation pharmaceutique contenant du penciclovir
WO2004014340A1 (fr) Composition injectable comprenant du florfenicol comme principe actif
WO2018060870A1 (fr) Composition pharmaceutique de l'ivermectine et son procédé de préparation
KR100342945B1 (ko) 항진균제의 외용 약제 조성물 및 이의 제조방법
ES2325373T3 (es) Composicion farmaceutica destinada a la administracion oral de un derivado de pirazol-3-carboxamida.
CN100386074C (zh) 维甲酸或其类似物口服制剂
JP4734910B2 (ja) 難水溶性薬剤用可溶化剤組成物
JPH0366618A (ja) 薬学的配合物
EP0021847B1 (fr) Compositions injectables de sulfonamide à effet prolongé
JPH04356420A (ja) チアミン・コバルト・クロロフィリン錯化合物含有組成物
GB1593354A (en) Liquid pharmaceutical formulations
WO1995017179A1 (fr) Preparation dermatologique stable contenant de l'acide mycophenolique
JPS63146817A (ja) 外用抗真菌剤
EP0625898B1 (fr) Formulations liposomiques au piroxicam
JP2894843B2 (ja) 外用抗炎症剤
WO2021099901A1 (fr) Composition pharmaceutique topique stable
WO2010102991A2 (fr) Émulsions de riluzole liquides

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PH PL PT RO RU SC SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP