WO2004011498A3 - Derives de peptide natriuretique de longue duree - Google Patents

Derives de peptide natriuretique de longue duree Download PDF

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Publication number
WO2004011498A3
WO2004011498A3 PCT/CA2003/001097 CA0301097W WO2004011498A3 WO 2004011498 A3 WO2004011498 A3 WO 2004011498A3 CA 0301097 W CA0301097 W CA 0301097W WO 2004011498 A3 WO2004011498 A3 WO 2004011498A3
Authority
WO
WIPO (PCT)
Prior art keywords
long lasting
natriuretic peptide
peptide derivatives
peptide
derivatives
Prior art date
Application number
PCT/CA2003/001097
Other languages
English (en)
Other versions
WO2004011498A2 (fr
Inventor
Dominique P Bridon
Peter Bakis
Julie Carette
France Leclaire
Roger Leger
Martin Robitaille
Original Assignee
Conjuchem Inc
Dominique P Bridon
Peter Bakis
Julie Carette
France Leclaire
Roger Leger
Martin Robitaille
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002488348A priority Critical patent/CA2488348A1/fr
Priority to EP03771007A priority patent/EP1530588A2/fr
Priority to AU2003246500A priority patent/AU2003246500A1/en
Priority to JP2004523679A priority patent/JP2006514607A/ja
Priority to US10/471,348 priority patent/US20040266673A1/en
Application filed by Conjuchem Inc, Dominique P Bridon, Peter Bakis, Julie Carette, France Leclaire, Roger Leger, Martin Robitaille filed Critical Conjuchem Inc
Publication of WO2004011498A2 publication Critical patent/WO2004011498A2/fr
Publication of WO2004011498A3 publication Critical patent/WO2004011498A3/fr
Priority to US11/040,810 priority patent/US20050176641A1/en
Priority to US11/067,556 priority patent/US7601691B2/en
Priority to US11/923,222 priority patent/US7906482B2/en
Priority to US11/926,843 priority patent/US20080199532A1/en
Priority to US12/253,856 priority patent/US20090275506A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des dérivés de peptide natriurétique (NP) de longue durée. Le dérivé NP comprend un peptide NP et une entité réactive couplée au peptide NP. L'entité réactive peut se lier par covalence avec une fonctionnalité sur un composant sanguin. D'une manière plus spécifique, l'invention concerne des dérivés NP ayant une demi-vie in vivo prolongée ainsi qu'une méthode de traitement des maladies et des troubles cardio-vasculaires, tels que l'insuffisance cardiaque globale décompensée aiguë et l'insuffisance cardiaque globale chronique.
PCT/CA2003/001097 1999-05-17 2003-07-29 Derives de peptide natriuretique de longue duree WO2004011498A2 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CA002488348A CA2488348A1 (fr) 2002-07-31 2003-07-29 Derives de peptide natriuretique de longue duree
EP03771007A EP1530588A2 (fr) 2002-07-31 2003-07-29 Derives de peptide natriuretique de longue duree
AU2003246500A AU2003246500A1 (en) 2002-07-31 2003-07-29 Long lasting natriuretic peptide derivatives
JP2004523679A JP2006514607A (ja) 2002-07-31 2003-07-29 長時間持続性ナトリウム排泄増加性ペプチド誘導体
US10/471,348 US20040266673A1 (en) 2002-07-31 2003-07-29 Long lasting natriuretic peptide derivatives
US11/040,810 US20050176641A1 (en) 2000-05-17 2005-01-21 Long lasting natriuretic peptide derivatives
US11/067,556 US7601691B2 (en) 1999-05-17 2005-02-25 Anti-obesity agents
US11/923,222 US7906482B2 (en) 1999-05-17 2007-10-24 Anti-obesity agents
US11/926,843 US20080199532A1 (en) 1999-05-17 2007-10-29 Long Lasting Natriuretic Peptide Derivatives
US12/253,856 US20090275506A1 (en) 2000-05-17 2008-10-17 Long lasting natriuretic peptide derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40019902P 2002-07-31 2002-07-31
US40041302P 2002-07-31 2002-07-31
US60/400,413 2002-07-31
US60/400,199 2002-07-31

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/471,348 A-371-Of-International US20040266673A1 (en) 1999-05-17 2003-07-29 Long lasting natriuretic peptide derivatives
US11/040,810 Continuation US20050176641A1 (en) 1999-05-17 2005-01-21 Long lasting natriuretic peptide derivatives

Publications (2)

Publication Number Publication Date
WO2004011498A2 WO2004011498A2 (fr) 2004-02-05
WO2004011498A3 true WO2004011498A3 (fr) 2004-06-24

Family

ID=31191354

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2003/001097 WO2004011498A2 (fr) 1999-05-17 2003-07-29 Derives de peptide natriuretique de longue duree

Country Status (5)

Country Link
EP (1) EP1530588A2 (fr)
JP (2) JP2006514607A (fr)
AU (1) AU2003246500A1 (fr)
CA (1) CA2488348A1 (fr)
WO (1) WO2004011498A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7662773B2 (en) 2002-11-26 2010-02-16 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
US9173950B2 (en) 2012-05-17 2015-11-03 Extend Biosciences, Inc. Vitamin D-ghrelin conjugates
US9585934B2 (en) 2014-10-22 2017-03-07 Extend Biosciences, Inc. Therapeutic vitamin D conjugates

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601691B2 (en) 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
DE60226702D1 (de) 2001-02-16 2008-07-03 Conjuchem Biotechnologies Inc Lang wirkendes glucagon-ähnliches peptid-2 für die behandlung von gastrointestinalen krankheiten und störungen
US20050272650A1 (en) 2004-02-17 2005-12-08 Mohapatra Shyam S Materials and methods for treatment of inflammatory and cell proliferation disorders
AU2003268531A1 (en) 2002-09-06 2004-03-29 University Of South Florida Materials and methods for treatment of allergic diseases
US7648962B2 (en) * 2002-11-26 2010-01-19 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
ES2887039T3 (es) 2004-04-21 2021-12-21 Alexion Pharma Inc Conjugados para administración ósea y procedimiento de uso de estos para dirigir proteínas al hueso
ATE496060T1 (de) 2004-07-15 2011-02-15 Univ Queensland Proteinartige verbindungen und anwendungen davon
MX2007010930A (es) * 2005-03-07 2008-03-14 Mondobiotech Licensing Out Ag Formulacion de aviptadil.
WO2006108686A2 (fr) * 2005-04-14 2006-10-19 Aic Agonistes bnp
US20080227713A1 (en) * 2005-10-03 2008-09-18 Protter Andrew A Oxidized Human Bnp
CA2656990A1 (fr) 2006-04-28 2007-11-08 University Of South Florida Matieres et procedes destines a reduire une inflammation par inhibition du recepteur du peptide natriuretique auriculaire
JP5010913B2 (ja) * 2006-12-31 2012-08-29 寿子 小出 心房利尿ホルモンファミリー分子を活性物質として含有する組織再生製剤また該製剤をもちいる組織再生方法、および心房利尿ホルモンファミリー分子を活性物質として含有する発毛、増毛、育毛剤および皮膚組織修復改善剤また該製剤を用いる発毛、増毛、育毛促進方法および皮膚組織修復改善方法
KR20080098216A (ko) * 2007-05-04 2008-11-07 한미약품 주식회사 캐리어 물질을 이용한 나트륨 배설 펩타이드 약물 결합체
JP2010530222A (ja) * 2007-06-06 2010-09-09 べーリンガー インゲルハイム インターナショナル ゲーエムベーハー ナトリウム利尿融合タンパク質
EP2173773A4 (fr) * 2007-07-06 2010-07-07 Theratechnologies Inc Protéines de fusion bifonctionnelles de l'hormone de stimulation des alpha-mélanocytes (alpha-msh) et de la protéine natriurétique auriculaire (pna), et leurs utilisations dans l'hypertension et la lésion rénale aiguë
WO2012013597A1 (fr) 2010-07-28 2012-02-02 Justus-Liebig-Universität Giessen Substances et utilisation desdites substances pour influer sur les récepteurs peptidiques natriurétiques
DE102010032482A1 (de) 2010-07-28 2012-02-02 Justus-Liebig-Universität Giessen Stoffe zur Beeinflussung der natriuretischen Peptid-Rezeptoren A und B und deren Verwendung
CA2823066A1 (fr) 2010-12-27 2012-07-05 Alexion Pharma International Sarl Compositions contenant des peptides natriuretiques et leurs methodes d'utilisation
CN103402534B (zh) * 2011-02-23 2016-10-12 麦德林制药私人有限公司 用于治疗充血性心力衰竭的治疗方法
US10184942B2 (en) 2011-03-17 2019-01-22 University Of South Florida Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer
CN102286092B (zh) 2011-09-14 2014-01-01 深圳翰宇药业股份有限公司 利拉鲁肽的固相合成方法
US10052366B2 (en) 2012-05-21 2018-08-21 Alexion Pharmaceuticsl, Inc. Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
US10822596B2 (en) 2014-07-11 2020-11-03 Alexion Pharmaceuticals, Inc. Compositions and methods for treating craniosynostosis
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
WO2016065052A1 (fr) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Conjugués insuline vitamine d
WO2016090251A1 (fr) 2014-12-05 2016-06-09 Alexion Pharmaceuticals, Inc. Traitement de crise avec une phosphatase alcaline recombinée
EP3250227A2 (fr) 2015-01-28 2017-12-06 Alexion Pharmaceuticals, Inc. Méthodes de traitement d'un sujet atteint d'une déficience en phosphatase alcaline
KR20180010267A (ko) * 2015-05-29 2018-01-30 가부시키가이샤 이기스 환상 펩티드 및 그 환상 펩티드를 포함한 의약, 외용제 및 화장료
MX2018002121A (es) 2015-08-17 2018-06-18 Alexion Pharma Inc Elaboracion de fosfatasas alcalinas.
US11229686B2 (en) 2015-09-28 2022-01-25 Alexion Pharmaceuticals, Inc. Reduced frequency dosage regimens for tissue non-specific alkaline phosphatase (TNSALP)-enzyme replacement therapy of hypophosphatasia
JP2018533571A (ja) 2015-10-30 2018-11-15 アレクシオン ファーマシューティカルズ， インコーポレイテッド 患者の頭蓋縫合早期癒合症を治療するための方法
EP3426286A4 (fr) 2016-03-08 2019-12-04 Alexion Pharmaceuticals, Inc. Méthodes de traitement de l'hypophosphatasie chez l'enfant
JP2019513711A (ja) 2016-04-01 2019-05-30 アレクシオン ファーマシューティカルズ， インコーポレイテッド アルカリホスファターゼによって筋力低下を治療すること
EP3436020A4 (fr) 2016-04-01 2019-12-25 Alexion Pharmaceuticals, Inc. Méthodes de traitement de l'hypophosphatasie chez les adolescents et les adultes
US10988744B2 (en) 2016-06-06 2021-04-27 Alexion Pharmaceuticals, Inc. Method of producing alkaline phosphatase
US11116821B2 (en) 2016-08-18 2021-09-14 Alexion Pharmaceuticals, Inc. Methods for treating tracheobronchomalacia
EP3600383A4 (fr) 2017-03-31 2020-10-28 Alexion Pharmaceuticals, Inc. Méthodes de traitement de l'hypophosphatasie (hpp) chez l'adulte et l'adolescent
WO2019190752A1 (fr) 2018-03-30 2019-10-03 Alexion Pharmaceuticals, Inc. Production de glycoprotéines
WO2024086680A2 (fr) 2022-10-21 2024-04-25 Eli Lilly And Company Peptides natriurétiques à action prolongée et leurs utilisations
CN116284329B (zh) * 2023-04-28 2023-12-08 成都奥达生物科技有限公司 一种长效利钠肽化合物

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WO1990014362A1 (fr) * 1989-05-24 1990-11-29 Abbott Laboratories Derives de peptides atriaux
CA2373252C (fr) * 1999-05-17 2007-08-07 Conjuchem Inc. Peptides antiangiogeniques durables
JP2003508501A (ja) * 1999-09-07 2003-03-04 コンジュケム，インコーポレーテッド 生物学的結合のための肺送達

Patent Citations (1)

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Non-Patent Citations (1)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7662773B2 (en) 2002-11-26 2010-02-16 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
US9173950B2 (en) 2012-05-17 2015-11-03 Extend Biosciences, Inc. Vitamin D-ghrelin conjugates
US9289507B2 (en) 2012-05-17 2016-03-22 Extend Biosciences, Inc. Carriers for improved drug delivery
US9585934B2 (en) 2014-10-22 2017-03-07 Extend Biosciences, Inc. Therapeutic vitamin D conjugates

Also Published As

Publication number Publication date
CA2488348A1 (fr) 2004-02-05
AU2003246500A1 (en) 2004-02-16
JP2010047614A (ja) 2010-03-04
EP1530588A2 (fr) 2005-05-18
WO2004011498A2 (fr) 2004-02-05
JP2006514607A (ja) 2006-05-11

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