WO2004006999A1 - Dispositif d'injection intradermique et sous cutanee - Google Patents
Dispositif d'injection intradermique et sous cutanee Download PDFInfo
- Publication number
- WO2004006999A1 WO2004006999A1 PCT/CH2003/000455 CH0300455W WO2004006999A1 WO 2004006999 A1 WO2004006999 A1 WO 2004006999A1 CH 0300455 W CH0300455 W CH 0300455W WO 2004006999 A1 WO2004006999 A1 WO 2004006999A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- force
- piston
- spring
- generators
- liquid product
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
- F02K—JET-PROPULSION PLANTS
- F02K9/00—Rocket-engine plants, i.e. plants carrying both fuel and oxidant therefor; Control thereof
- F02K9/08—Rocket-engine plants, i.e. plants carrying both fuel and oxidant therefor; Control thereof using solid propellants
- F02K9/28—Rocket-engine plants, i.e. plants carrying both fuel and oxidant therefor; Control thereof using solid propellants having two or more propellant charges with the propulsion gases exhausting through a common nozzle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/48—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for varying, regulating, indicating or limiting injection pressure
- A61M5/482—Varying injection pressure, e.g. by varying speed of injection
Definitions
- the present invention relates to a device for hypodermic injection of drugs or other pharmaceutical compositions, such as growth hormones, insulin, heparin and various DNAs in liquid form.
- the invention relates in particular to a needle-less injection device.
- the force / displacement curve which depends on the type of elastomeric material used and its structure and which is a non-linear property of the material used, may, in certain injection cases, not be adapted to the ideal profile. force / displacement required.
- the aim of the present invention is to produce a hypodermic injection device without a needle, making it possible to extend the range of use of the injector by modifying the profile of the curve force / displacement.
- hypodermic injection device according to claim 1.
- the invention allows to change the characteristic of the force / displacement curve by the use of one or more movable walls 3, 3a between which are placed crosslinked polymer discs 10, 10a.
- These perforated discs in the center can have different characteristics (hardness, cells, diameter, thickness, geometric shape) making it possible to modify the characteristic of the force / displacement curve given by the use of a single entropic spring.
- Each of the movable walls 3, 3a may or may not be provided with a spacer 20 making it possible to limit the crushing force of the elastic block (spring or entropic generator).
- the free movable walls 3a are cascaded with or without spacers 20 depending on the profile of the force / displacement curve that is desired, but one can also combine the elastic block (s) (entropic spring) with a metal spring classic or a molecular spring (polysiloxane) or a torr-shaped rubber balloon 30 filled with nitrogen 30a
- a rubber balloon 30 is pressurized with nitrogen, which generates the secondary force (low pressure) necessary to transfer the liquid into the body.
- the high pressure is generated by a flattened block of elastomer between the walls 2a and 3a.
- Another advantage of the cascade segmentation of the free movable walls 3a makes it possible to create a double or triple different injection pressure by the use of materials having different force / displacement characteristics. For example: entropic spring / metal spring; entropic spring / molecular spring; entropic spring / gas balloon; without using a non-linear curve as in the case of the entropic spring alone.
- FIG. 1 is a longitudinal section of a 2-stage cascade injection device in a state of charge before injection.
- FIG. 2 is a longitudinal section of a figurel device during the discharge phase.
- FIG. 3 is a longitudinal section of 'a device similar to the figure but using a torr-shaped balloon pressurized by nitrogen
- Figure 4 is a diagram showing the force generated as a function of the displacement (x) of the piston rod 4 for different characteristics of springs B and C with respect to the simple entropic spring A.
- an injection device 1 for the administration of a liquid 6 under the skin 14 of a human patient or an animal comprises a bulb 7 provided with a piston 5 forming an integral part of the bulb, a transmission element 4, retaining means 9 and force generating elements 10; 10a between two or more free movable walls 3a and a fixed wall 2a forming an integral part of the injector body and a wall 3 connected to the movable piston 5 (4, 5).
- This (mobile) wall 3 is connected to the piston rod 4 in a fixed or adjustable manner. If an adjustment of the piston rod 4 stroke is necessary, then these two elements will be provided with a thread.
- the free movable walls 3a are themselves sliding on the piston rod 4.
- the movable walls 3, 3a can be provided with spacers 20 (stops) which allow, according to their length L, to modify the shape of the curve and to move the point d inflection to a specific value.
- Figure 1 shows the injector in a state of charge just before injection.
- This injector is made up of a cascade arrangement of two entropic generators / springs 10 and 10a having different force / displacement characteristics. It consists of the alveolar crosslinked polymer disc 10 for the element generating the low pressure and a solid polymer disc 10a for the element creating the primary pressure used to pierce the patient's skin. Each disc is pierced in its center by a hole allowing the piston rod 4 to slide through.
- the diameter of the discs must be 20 to 30% smaller than the inside diameter of the body of the injector 2a or of the spacer 20 so that when they are flattened, the material can flow outwards. without touching the outer wall which will considerably modify its characteristics.
- the entropic spring does not change volume during flattening.
- a free space 13 and 13a is arranged to avoid contact of the spring 10 and 10a with the housing 2a or the spacer 20.
- the injector is loaded by moving the movable walls 3, 3a against the fixed wall 2a by pulling on the piston rod 4 by various mechanical means (lever arm, nut) or pneumatic (air cylinder ).
- the trigger 9 is stowed on the piston rod 4 so as to keep the injector in a state of charge ready for use.
- pressure F By applying pressure F to the trigger 9, the latter releases the piston rod 4 which will push the piston 5 and eject the liquid 6 through the orifice 6b.
- the single-use bulb 7 consists of a body 7 of glass or poly carbonate provided at its end with a nozzle transforming the pressure energy into kinetic energy communicated to the micro jet of liquid.
- Figure 2 shows the injector after triggering at the end of injection into the intra dermal part 15.
- the force generated by the spring 10a will create a high pressure in the capsule 7 necessary to pierce the patient's skin (channel 15a) then when the trigger is complete then the spring relay 10 arrives which will generate a low pressure to allow the liquid to be transferred from the capsule 7 to the area to be injected15.
- the empty cells 16 are completely flattened and during expansion as shown in FIG. 2, they resume their original shapes 16 '
- Figure 3 shows a variant of the figurel, or the spring 10 is replaced by a balloon or a torr rubber 30 pressurized with nitrogen.
- the nitrogen present at the low rate of diffusion through the rubber membrane which allows to keep the pressure over a long period without significant loss of pressure.
- This gas spring 30 will generate the secondary force necessary to transfer the liquid from the capsule 7 to the zone 15.
- the primary force will be generated by the entropic spring 10a.
- Figure 4 shows a diagram of the force generated by the entropic spring as a function of the displacement of the piston rod 4.
- the diameter of the piston 5 will determine the pressure in MPa that will be created inside the container 7 during injection.
- Curve A_ is the characteristic shape of an entropic spring. as described in patent applications PCT / IB 02/02703 and PCT / IB02 / 04494.
- Curve B is the characteristic shape generated by two springs mounted in cascade and provided with a spacer 20 as described in this patent. We can see that the inflection point (I) is very marked which is not the case in curve A.
- the major advantage is that the injection depth is very precise and is independent of the hardness of the skin.
- Curve C shows a cascade arrangement of three springs with different characteristics. This assembly comprises two free movable walls 3a and 3b, and a movable wall 3 stowed on the piston rod 4 provided with a spacer 20. This arrangement makes it possible to generate three different injection pressures during the discharge of the injector .
- Figures 1 and 2 shows an injector whose trigger is located behind the entropic spring. We can also make the same injector with the trigger located between the bulb and the entropic spring.
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Combustion & Propulsion (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03763563A EP1558306B1 (fr) | 2002-07-11 | 2003-07-08 | Dispositif d injection intradermique et sous cutanee |
AU2003243876A AU2003243876B2 (en) | 2002-07-11 | 2003-07-08 | Device for intradermal and subcutaneous injection |
DE60310754T DE60310754D1 (de) | 2002-07-11 | 2003-07-08 | Vorrichtung für die intradermale und subkutane injektion |
JP2004520264A JP4234676B2 (ja) | 2002-07-11 | 2003-07-08 | 皮内及び皮下注射装置 |
US11/033,027 US20050187516A1 (en) | 2002-07-11 | 2005-01-11 | Intradermal and subcutaneous injection device |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB0202703 | 2002-07-11 | ||
IBPCT/IB02/02703 | 2002-07-11 | ||
IB0204494 | 2002-10-28 | ||
IBPCT/IB02/04494 | 2002-10-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004006999A1 true WO2004006999A1 (fr) | 2004-01-22 |
Family
ID=30117181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CH2003/000455 WO2004006999A1 (fr) | 2002-07-11 | 2003-07-08 | Dispositif d'injection intradermique et sous cutanee |
Country Status (5)
Country | Link |
---|---|
US (2) | US20050154347A1 (fr) |
JP (2) | JP4234676B2 (fr) |
AU (2) | AU2003243875B2 (fr) |
DE (2) | DE60319831T2 (fr) |
WO (1) | WO2004006999A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1693078A1 (fr) * | 2005-02-19 | 2006-08-23 | Tecpharma Licensing AG | Dispositif d'administration |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090137949A1 (en) * | 2007-11-26 | 2009-05-28 | Bioject Inc. | Needle-free injection device with nozzle auto-disable |
US8617099B2 (en) | 2007-11-26 | 2013-12-31 | Bioject Inc. | Injection device plunger auto-disable |
ES2527448T3 (es) * | 2008-04-28 | 2015-01-23 | Zogenix, Inc. | Nuevas formulaciones para el tratamiento de la migraña |
SE0900371A1 (sv) * | 2009-03-24 | 2010-09-25 | Istvan Bartha | Anordning för distribution av flytande läkemedel |
EP2488234A1 (fr) * | 2009-10-16 | 2012-08-22 | Sanofi-Aventis Deutschland GmbH | Dispositif d'administration de médicaments |
US8734384B2 (en) | 2010-09-15 | 2014-05-27 | Zogenix, Inc. | Needle-free injectors and design parameters thereof that optimize injection performance |
US8967570B2 (en) * | 2011-10-31 | 2015-03-03 | United Technologies Corporation | Blind retention mount |
KR101575039B1 (ko) | 2012-07-19 | 2015-12-07 | (주)아모레퍼시픽 | 노즐 장치 및 이를 포함하는 최소 침습형 주입 장치 |
KR102017563B1 (ko) * | 2014-03-20 | 2019-09-03 | (주)아모레퍼시픽 | 약액주입장치 |
ES2910028T3 (es) | 2015-05-10 | 2022-05-11 | Kolorpen Ltd | Dispositivo y método para la inyección repetitiva sin aguja |
US10842467B2 (en) * | 2015-12-15 | 2020-11-24 | Portal Instruments, Inc. | Biospecimen extraction apparatus |
US10828425B2 (en) * | 2017-06-23 | 2020-11-10 | Shl Medical Ag | Needle shield remover and a medicament delivery device comprising the needle shield remover |
CN110500201B (zh) * | 2019-07-31 | 2021-01-12 | 西安航天动力研究所 | 一种斜槽式针栓喷注器头部结构 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB681098A (en) * | 1949-07-07 | 1952-10-15 | Scherer Corp R P | Hypo-jet injector |
US5911703A (en) * | 1997-05-22 | 1999-06-15 | Avant Drug Delivery Systems, Inc. | Two-stage fluid medicament jet injector |
US6258062B1 (en) * | 1999-02-25 | 2001-07-10 | Joseph M. Thielen | Enclosed container power supply for a needleless injector |
US20020055712A1 (en) * | 1999-12-23 | 2002-05-09 | Arnold Neracher | Injection device and propulsion system therefor |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1455234A1 (de) * | 1963-01-24 | 1969-01-16 | Lemfoerder Kunststoff Gmbh & C | Auflaufpuffer aus elastomeren Werkstoffen fuer Fahrzeuge |
DE1475137B2 (de) * | 1965-05-15 | 1971-02-25 | Rix, Johannes Dipl Ing , 3500 Kassel | Hohlfelder insbesondere zum auffangen von stoessen bei fahrzeugen |
DE1231966B (de) * | 1966-08-20 | 1967-01-05 | Lemfoerder Kunststoff G M B H | Stufenfoermiger Druckfederkoerper aus elastomerem Werkstoff |
US3515382A (en) * | 1968-08-30 | 1970-06-02 | Richard J Gallagher | Compression spring |
FR2188736A5 (en) * | 1972-06-01 | 1974-01-18 | Kleber Colombes | Rubber springs for compressive loads - comprising stackable modular ele-ments with partially divergent surfaces offering progressive resistance |
FR2324494A1 (fr) * | 1975-09-22 | 1977-04-15 | Kleber Colombes | Attelage automatique ferroviaire |
BE859468A (nl) * | 1977-10-07 | 1978-04-07 | Poppe Willy | Schuimveer |
US5569189A (en) * | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
US5730723A (en) * | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
FR2739562B1 (fr) * | 1995-10-09 | 1998-04-24 | Moreau Defarges Alain | Dispositif d'injection par jet sans aiguille, comportant une cartouche surmoulee |
US6264629B1 (en) * | 1998-11-18 | 2001-07-24 | Bioject, Inc. | Single-use needle-less hypodermic jet injection apparatus and method |
US6602222B1 (en) * | 2000-10-13 | 2003-08-05 | Cambridge Biostability Ltd. | Disposable injection device |
US6676630B2 (en) * | 2002-06-04 | 2004-01-13 | Bioject Medical Technologies, Inc. | Needle-free injection system |
-
2003
- 2003-07-08 WO PCT/CH2003/000455 patent/WO2004006999A1/fr active IP Right Grant
- 2003-07-08 AU AU2003243875A patent/AU2003243875B2/en not_active Ceased
- 2003-07-08 DE DE60319831T patent/DE60319831T2/de not_active Expired - Fee Related
- 2003-07-08 DE DE60310754T patent/DE60310754D1/de not_active Expired - Lifetime
- 2003-07-08 JP JP2004520264A patent/JP4234676B2/ja not_active Expired - Fee Related
- 2003-07-08 JP JP2004520263A patent/JP4234675B2/ja not_active Expired - Fee Related
- 2003-07-08 AU AU2003243876A patent/AU2003243876B2/en not_active Ceased
-
2005
- 2005-01-10 US US11/032,499 patent/US20050154347A1/en not_active Abandoned
- 2005-01-11 US US11/033,027 patent/US20050187516A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB681098A (en) * | 1949-07-07 | 1952-10-15 | Scherer Corp R P | Hypo-jet injector |
US5911703A (en) * | 1997-05-22 | 1999-06-15 | Avant Drug Delivery Systems, Inc. | Two-stage fluid medicament jet injector |
US6258062B1 (en) * | 1999-02-25 | 2001-07-10 | Joseph M. Thielen | Enclosed container power supply for a needleless injector |
US20020055712A1 (en) * | 1999-12-23 | 2002-05-09 | Arnold Neracher | Injection device and propulsion system therefor |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1693078A1 (fr) * | 2005-02-19 | 2006-08-23 | Tecpharma Licensing AG | Dispositif d'administration |
Also Published As
Publication number | Publication date |
---|---|
AU2003243875B2 (en) | 2006-07-06 |
US20050154347A1 (en) | 2005-07-14 |
DE60310754D1 (de) | 2007-02-08 |
JP2005532127A (ja) | 2005-10-27 |
AU2003243875A1 (en) | 2004-02-02 |
DE60319831D1 (de) | 2008-04-30 |
DE60319831T2 (de) | 2009-04-16 |
JP4234675B2 (ja) | 2009-03-04 |
AU2003243876A1 (en) | 2004-02-02 |
JP4234676B2 (ja) | 2009-03-04 |
JP2005532126A (ja) | 2005-10-27 |
AU2003243876B2 (en) | 2008-01-17 |
US20050187516A1 (en) | 2005-08-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2004006999A1 (fr) | Dispositif d'injection intradermique et sous cutanee | |
EP1202763B1 (fr) | Seringue sans aiguille avec injecteur a elements superposes | |
EP1708768B1 (fr) | Seringue sans aiguille avec un injecteur receptacle amortissant | |
CA2406560C (fr) | Seringue sans aiguille fonctionnant avec un chargement pyrotechnique bicompositions | |
EP1263489B1 (fr) | Seringue sans aiguille pour l'injection d'un liquide contenu dans une ampoule pre-remplie | |
CA2411814C (fr) | Seringue sans aiguille munie d'un reservoir modulable | |
EP1229951B1 (fr) | Seringue sans aiguille avec un moyen de poussee temporairement retenu | |
FR2805749A1 (fr) | Seringue sans aiguille a deux niveaux de vitesse d'injection | |
EP1237599B1 (fr) | SERINGUE SANS AIGUILLE FONCTIONNANT AVEC ENTRAíNEMENT DU PRINCIPE ACTIF PAR EFFET TUBE A CHOC | |
CN1308970A (zh) | 无针式皮下注射系统 | |
EP1558306B1 (fr) | Dispositif d injection intradermique et sous cutanee | |
CA2324045A1 (fr) | Seringue sans aiguille pour l'injection sous-cutanee de poudres medicamenteuses | |
EP1246657B1 (fr) | Seringue sans aiguille fonctionnant par effet tube a choc, avec maintien prealable du principe actif sur le cote | |
EP1276526B1 (fr) | Seringue sans aiguille munie d'un opercule contenant le principe actif | |
CA2430449A1 (fr) | Systeme d'injecteur et d'ampoule sans aiguille | |
EP1242133B1 (fr) | Seringue sans aiguille munie d'un tube d'ejection a section constante | |
CA2370276A1 (fr) | Seringue sans aiguilles | |
WO2017001795A1 (fr) | Dispositif d'injection sans aiguille équipé d'un ressort de compression | |
EP3810524B1 (fr) | Dispositif de conditionnement et distribution d'un produit avec flacon et embout muni de joncs annulaires | |
WO2017153652A1 (fr) | Dispositif d'injection sans aiguille équipé d'une buse d'injection perfectionnée |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2003763563 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004520264 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003243876 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 20038216582 Country of ref document: CN |
|
WWP | Wipo information: published in national office |
Ref document number: 2003763563 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 2003763563 Country of ref document: EP |