WO2004005334A3 - Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes - Google Patents

Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes Download PDF

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Publication number
WO2004005334A3
WO2004005334A3 PCT/FR2003/002085 FR0302085W WO2004005334A3 WO 2004005334 A3 WO2004005334 A3 WO 2004005334A3 FR 0302085 W FR0302085 W FR 0302085W WO 2004005334 A3 WO2004005334 A3 WO 2004005334A3
Authority
WO
WIPO (PCT)
Prior art keywords
allergen
nucleic acid
acid molecule
mite
euroglyphus
Prior art date
Application number
PCT/FR2003/002085
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English (en)
Other versions
WO2004005334A2 (fr
Inventor
Veronique Gomord
David Lienard
Ree Ronald Van
Oort Erica Van
De Borne Francois Dorlhac
Laurent Alain Didier
Loic Faye
Original Assignee
Stallergenes Sa
D Expl Ind De Tabacs Et Allume
Veronique Gomord
David Lienard
Ree Ronald Van
Oort Erica Van
De Borne Francois Dorlhac
Laurent Alain Didier
Loic Faye
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stallergenes Sa, D Expl Ind De Tabacs Et Allume, Veronique Gomord, David Lienard, Ree Ronald Van, Oort Erica Van, De Borne Francois Dorlhac, Laurent Alain Didier, Loic Faye filed Critical Stallergenes Sa
Priority to AU2003269011A priority Critical patent/AU2003269011A1/en
Publication of WO2004005334A2 publication Critical patent/WO2004005334A2/fr
Publication of WO2004005334A3 publication Critical patent/WO2004005334A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Insects & Arthropods (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention se rapporte à une molécule d'acide nucléique purifiée comprenant ou constituée par une séquence polynucléotidique codant pour (i) la forme mature d'un allergène protéique d'un acarien du genre 10 Dermatophagoides et (ii) un propeptide placé à l'extrémité N-terminale dudit allergène protéique. Ladite séquence nucléotidique code aussi pour (iii) un peptide signal placé à l'extrémité N-terminale dudit propeptide. L'invention concerne aussi l'utilisation de cette molécule d'acide nucléique pour la préparation d'allergènes recombinants. La présente invention concerne également le procédé d'obtention dudit allergène.
PCT/FR2003/002085 2002-07-05 2003-07-04 Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes WO2004005334A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003269011A AU2003269011A1 (en) 2002-07-05 2003-07-04 Nucleic acid molecule encoding an allergen preprotein of a mite of genus dermatophagoides or euroglyphus and use thereof for protecting said allergen in plants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR02/08485 2002-07-05
FR0208485A FR2841906B1 (fr) 2002-07-05 2002-07-05 Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes

Publications (2)

Publication Number Publication Date
WO2004005334A2 WO2004005334A2 (fr) 2004-01-15
WO2004005334A3 true WO2004005334A3 (fr) 2004-05-06

Family

ID=29725218

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2003/002085 WO2004005334A2 (fr) 2002-07-05 2003-07-04 Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes

Country Status (3)

Country Link
AU (1) AU2003269011A1 (fr)
FR (1) FR2841906B1 (fr)
WO (1) WO2004005334A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1908777B1 (fr) * 2006-10-06 2016-02-03 Stallergenes Protéines de fusion d'acarien
EP1908776A1 (fr) * 2006-10-06 2008-04-09 Stallergenes Sa Proteines de fusion provenant de mite
PT2083856E (pt) * 2007-08-15 2010-12-23 Circassia Ltd Péptidos para a dessensibilização contra alergénios
CN101977929B (zh) 2008-03-25 2016-10-19 拜尔工业制药有限公司 用于治疗变态反应的主要1类和2类螨变应原的低变应原性杂合蛋白
US8821887B2 (en) 2008-08-15 2014-09-02 Circassia Limited T-cell antigen peptide from allergen for stimulation of IL-10 production
CA2789174C (fr) * 2010-02-12 2021-08-24 Laboratorios Leti, S.L. Unipersonal Procede de fabrication d'un extrait d'allergenes
FR3004462B1 (fr) * 2013-04-15 2016-04-01 Angany Genetics Production commerciale de peptidases c1a par expression transitoire chez les plantes
RU2548727C2 (ru) * 2013-08-15 2015-04-20 Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства Аллерготропины для лечения аллергии, вызываемой клещами домашней пыли
CN106520993A (zh) * 2016-12-12 2017-03-22 盐城卫生职业技术学院 一种快速检测室尘中粉尘螨变应原第1组分含量的荧光实时定量pcr的方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992004445A1 (fr) * 1990-09-11 1992-03-19 The Western Australian Research Institute For Child Health Ltd. Clonage et mise en sequence d'allergenes de dermatophagoides (acariens de la poussiere domestique)
WO1998006861A2 (fr) * 1996-08-15 1998-02-19 Agrivax Incorporated Administration d'antigenes tolerogeniques via des plantes comestibles ou des produits derives de plantes
WO2000020612A2 (fr) * 1998-10-07 2000-04-13 Syngenta Participations Ag Proteines vegetales a action therapeutique
WO2001029078A2 (fr) * 1999-10-15 2001-04-26 Heska Corporation Procede de production et d'utilisation de proteines de groupe 1 d'acarien
WO2001096385A1 (fr) * 2000-06-10 2001-12-20 Smithkline Beecham Biologicals S.A. Allergene recombinant de dermaphagoides a codon optimise
WO2002040676A2 (fr) * 2000-11-16 2002-05-23 Alk-Abelló A/S Nouveaux allergenes mutants

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992004445A1 (fr) * 1990-09-11 1992-03-19 The Western Australian Research Institute For Child Health Ltd. Clonage et mise en sequence d'allergenes de dermatophagoides (acariens de la poussiere domestique)
WO1998006861A2 (fr) * 1996-08-15 1998-02-19 Agrivax Incorporated Administration d'antigenes tolerogeniques via des plantes comestibles ou des produits derives de plantes
WO2000020612A2 (fr) * 1998-10-07 2000-04-13 Syngenta Participations Ag Proteines vegetales a action therapeutique
WO2001029078A2 (fr) * 1999-10-15 2001-04-26 Heska Corporation Procede de production et d'utilisation de proteines de groupe 1 d'acarien
WO2001096385A1 (fr) * 2000-06-10 2001-12-20 Smithkline Beecham Biologicals S.A. Allergene recombinant de dermaphagoides a codon optimise
WO2002040676A2 (fr) * 2000-11-16 2002-05-23 Alk-Abelló A/S Nouveaux allergenes mutants

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BEST E A ET AL: "A RECOMBINANT GROUP 1 HOUSE DUST MITE ALLERGEN, RDER F 1, WITH BIOLOGICAL ACTIVITIES SIMILAR TO THOSE OF THE NATIVE ALLERGEN", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA, US, vol. 20, no. 3, December 2000 (2000-12-01), pages 462 - 471, XP000992188, ISSN: 1046-5928 *
DATABASE EMBL 23 July 1994 (1994-07-23), CHUA K.Y. ET AL.: "Dermatophagoides pteronyssinus Der p 1 allergen preproenzyme mRNA, complete cds.", XP002264597 *
SALMON V ET AL: "PRODUCTION OF HUMAN LACTOFERRIN IN TRANSGENIC TOBACCO PLANTS", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, US, vol. 13, no. 1, June 1998 (1998-06-01), pages 127 - 135, XP000863470, ISSN: 1046-5928 *

Also Published As

Publication number Publication date
AU2003269011A8 (en) 2004-01-23
AU2003269011A1 (en) 2004-01-23
WO2004005334A2 (fr) 2004-01-15
FR2841906B1 (fr) 2006-08-18
FR2841906A1 (fr) 2004-01-09

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