WO2003105873A1 - Preparation sur mesure et procede de production de ladite preparation - Google Patents

Preparation sur mesure et procede de production de ladite preparation Download PDF

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Publication number
WO2003105873A1
WO2003105873A1 PCT/JP2002/005901 JP0205901W WO03105873A1 WO 2003105873 A1 WO2003105873 A1 WO 2003105873A1 JP 0205901 W JP0205901 W JP 0205901W WO 03105873 A1 WO03105873 A1 WO 03105873A1
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WO
WIPO (PCT)
Prior art keywords
individual
chicken
meat
tiller
ostrich
Prior art date
Application number
PCT/JP2002/005901
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English (en)
Japanese (ja)
Inventor
正俊 深尾
Original Assignee
株式会社 トーカイビケン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社 トーカイビケン filed Critical 株式会社 トーカイビケン
Priority to PCT/JP2002/005901 priority Critical patent/WO2003105873A1/fr
Priority to AU2002313212A priority patent/AU2002313212A1/en
Publication of WO2003105873A1 publication Critical patent/WO2003105873A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Definitions

  • the present invention relates to tiller-made preparations such as health food preparations and pharmaceutical preparations for the purpose of curing chronic diseases such as cancer, diabetes mellitus and allergy and improving symptoms, and to a method for producing the same.
  • the present invention relates to a tiller-made preparation configured to exert a corresponding health promotion effect and a method for producing the same. More specifically, a tiller-med product obtained by using the biological reactions of healthy osseous chickens to produce active ingredients that exert a health-enhancing effect corresponding to the individual's physiological condition, and then processing the ingredients. And its production method.
  • Conventional health food preparations include food materials that contain high levels of health-promoting substances such as vitamins, minerals, and antioxidants, or foods made of natural products that have been confirmed to have statistically significant health-promoting effects. Material is contained. Further, conventional pharmaceutical preparations contain a drug having a pharmacological effect. Health food preparations and pharmaceutical preparations exert certain health-enhancing or pharmacological effects on those who take them.
  • An object of the present invention is to provide a tiller-made preparation which can be easily taken without side effects and easily exerts a health promotion effect corresponding to an individual's physiological condition, and a method for producing the same.
  • a tiller-made preparation exhibiting a health promotion effect corresponding to an individual's physiological condition.
  • the formulation inoculates a carrier of the physiological information of the individual into the ostrich chicken, and after breeding for a predetermined period, the meat of the ostrich chicken.
  • the carrier is used to inoculate osseous chickens transdermally or orally, with individual serum and urine Preferably, there is only one.
  • the predetermined time period is between 30 and 75 days.
  • the tiller maid preparation is orally ingested from 8 to 12 g of dry meat once a week for at least 10 weeks per adult.
  • the present invention further provides a method for producing a tiller-made preparation.
  • the method includes a step of inoculating a carrier of physiological information of an individual into a ostrich, and a step of drying and crushing the meat of the ostrich bred for a predetermined period of time at 50 ° C or less.
  • FIG. 1 is a graph showing the change in fasting blood glucose level of male A who took the tiller maid preparation of the present invention.
  • the inventor of the present application has found that a tiller-made preparation produced using a crow bone chicken has a remarkable pharmacological action, and has completed the present invention.
  • Cousin chickens are slightly smaller varieties than common chickens.
  • the whole body of the ostrich is covered with silky, thin and soft feathers.
  • the face, skin, meat, bones, and internal organs of the crow bone chicken are dark purple.
  • the earlobe is cobalt blue.
  • the male has a walnut crown on the head, and the female has a fine crown.
  • Cousin chicken is described in old Chinese literature as a medicine for longevity or as a court meal for treating illness and beauty.
  • crow's-bone chickens have been preserved for thousands of years because of their excellent medicinal properties, and have been loved by many people.
  • crow bone chicken is known to have various pharmacological actions such as anticancer action, and is used as a raw material for herbal medicine.
  • the pharmacological effects of osseous chicken have not been studied in detail.
  • Tillermaid preparations contain dried meat of crow bone chicken that reflects the physiological condition (pathological condition) of a particular individual.
  • Tillermade preparations exert a health-promoting or healing effect corresponding to the physiological or pathological condition of the individual.
  • Tiller-made products are health food or pharmaceutical products that are manufactured and used exclusively for a particular individual. That is, a tailor-made product is entrusted and ordered by a specific individual to a manufacturer for the manufacture of a personalized product, and the manufacturer manufactures the product based on the order and provides it to that person. It is a custom-made product.
  • the dried meat of the crow bone chicken is obtained as follows. First, a carrier of physiological information of a specific individual is inoculated into a living body of a crow bone chicken and bred for a predetermined period. By slaughtering the ostrich chicken, the meat is dried and crushed (crushed) at a temperature of 50 ° C or less to obtain a dry powder or a granular material that can be easily ingested. In addition, as the meat of the crow bone chicken, at least one selected from the group consisting of peach meat, breast meat, and fillet meat is preferable.
  • the tailor-made preparation may be in the form of powdered dry meat of osseous chicken itself or in a form that can be orally ingested such as tablets, capsules and drinks prepared by processing the dried meat according to a conventional method.
  • Carriers of physiological information of a particular individual include parts of the body (tissue), secretions or excretions carrying information on the physiological condition of that individual.
  • Preferred carriers are serum or urine because they carry more physiological information about their health and are easier to collect.
  • the carrier contains information about the individual's physiological condition (pathology), such as immunoglobulins (antibodies), non-self antigens bound to class I or class II human leukocyte antigen (HLA), toxins, or appropriate amounts.
  • Non-hormones serum cholesterol, neutral fat, blood sugar, GOT (glutamate oxaloacetat e transaminase), GP ⁇ glutamate pyruvate transaminase), ⁇ -GTP (glutamyl transpeptidase), urinary protein, urinary occult blood, urinary bran, urobilinogen Etc. are included in various forms.
  • GOT glutamate oxaloacetat e transaminase
  • GP ⁇ glutamate pyruvate transaminase glutamyl transpeptidase
  • urinary protein urinary occult blood, urinary bran, urobilinogen Etc.
  • the carrier should be collected when the patient is in good physical condition, avoiding stress such as overwork, lack of sleep, and hangover. Is preferred.
  • the carrier is preferably inoculated into adult ostrich chickens at the age of 180 days or older, and inoculated into middle-aged ostrich chickens at the age of 180 to 300 days after birth, where biological reactions are active. More preferred. Sex is not asked. Furthermore, in order to reflect the physiological information carried on the carrier sharply and without omission, it is preferable to inoculate healthy breeding chickens in an environment in which stress is minimized. Environments with reduced stress include, for example, an environment where organic feed and water are provided without pesticides and without antibiotics or sulfa drugs, an environment where seaweed containing high alginate is fed, or Environments with low environmental pollution, noise, and interference from other species. Also, pure crow bones, not hybrids Chicken is preferred.
  • the breeding period from inoculation of the carrier to the osseous chicken to slaughter is preferably 30 to 75 days after the start of the inoculation (from the start of the first inoculation), more preferably 35 to 75 days. 70 days, more preferably 35 to 60 days. If the breeding period is less than 30 days, the active ingredient having a health-promoting effect that reflects the physiological state (pathological state) of a specific individual in the living body of the crow bone chicken (probably an antibody-like substance ) May not be produced sufficiently. On the other hand, if it exceeds 75 days, the amount of the active ingredient may be significantly reduced. In the case of inoculation by oral administration, the breeding period may be extended to about 90 days because it takes a long time to complete all inoculations. In this case, a good tailor-made product may be obtained.
  • Meat collected from slaughtered poultry chicken is dried and crushed to be processed into powdered or granular dried poultry meat of poultry chicken. .
  • all the steps must be carried out at a temperature of 50 ° C or less, and the denaturation of the protein is effective.
  • the heating is performed at a temperature of 40 ° C. or less in order to suppress the temperature to 40 ° C.
  • the drying step is preferably performed by a freeze-drying (freeze-drying) method in order to more effectively suppress denaturation and deactivation of the active ingredient.
  • the dried meat pieces are processed into various forms such as tablets, capsules, drinks and the like, preferably stored in a refrigerator or a freezer, and orally ingested by the client as a tiller-made preparation at appropriate times.
  • Tillermaid Seika [) is orally ingested about 10 g (8 to 12 g) of dry meat of crow bone chicken once a week (preferably every 7 days) per adult. It is most preferably taken for 10 weeks or more, more preferably for 10 to 20 weeks continuously.
  • the Tiller Made preparation When taken for the purpose of healing or ameliorating the symptoms of a specific disease, the Tiller Made preparation is used for the average replacement cycle of the cells in the organs or tissues that make up the disease or condition (physiological changes). It is preferable to take the drug continuously for a period corresponding to (cell life) or an integral multiple thereof. For example, if you have diabetes, you should take it continuously for a period corresponding to the average cell life of the insulin-producing cells of the kidney, and you should take it for twice the life of the cell Is more preferred.
  • Tillermaid preparations contain dried meat from ostrich chicken that reflects the physiological condition of a particular individual. Dried meat of the ostrich chicken is inoculated with a carrier of physiological information of a specific individual to a healthy ostrich chicken so as not to harm the health, and slaughtered after bred for a predetermined period while maintaining the health of the ostrich chicken. It is obtained by drying and crushing the raw meat at a temperature of 50 ° C or less. Tiller-made preparations can be easily ingested because they are made from healthy bovine chicken meat, and there is no risk of side effects such as phytotoxicity if ingested too much.
  • Dried meat of ostrich chicken has a long-lasting, pharmacological action that is effective for everyone and has been specially produced using the biological reactions of healthy ostrich chicken. Contains sexual components. For this reason, the Tillermaid formulation can exert a synergistic effect of promoting health on specific individuals. In addition, tiller maid preparations contain high concentrations of proteins and amino acids, so that metabolism is activated. It can also exert a health promotion effect.
  • the active ingredient is produced individually based on the carrier of the physiological information of a specific individual, the physiological condition of the individual is reflected to the smallest detail, and the physiological condition of the person The health promotion effect corresponding to can be exhibited.
  • multiple types of physiological information are carried on the carrier and are multifaceted (comprehensive). Therefore, a multifaceted health-promoting effect can be obtained with the Tillermade formulation. If a specific individual is suffering from a disease such as a chronic disease, the carrier will contain physiological information about the person's pathological condition, and will have a significant healing effect or improvement effect on the disease. Can be demonstrated.
  • the tiller-made preparation of the present embodiment is not limited to the effect of improving a single symptom as in conventional health food preparations and pharmaceutical preparations, and exhibits a multifaceted improvement effect for a plurality of symptoms. It can exhibit excellent efficacy as a panacea.
  • Tiller-made products are manufactured by inoculating the serum or urine of a specific individual into bovine hens, so that a multifaceted health promotion effect corresponding to the physiological condition of a specific individual is easily and reliably achieved. Can be obtained.
  • serum and urine provide detailed and detailed physiological information on the physiological and pathological states of the individual, as evidenced by the fact that there are many types of diseases that are medically detected in medical examinations. It is definitely included. For this reason, by producing dried meat of ostrich chicken using such a carrier carrying useful physiological information, the health condition of the individual and the It is easy to obtain an extremely multifaceted and accurate effect on the improvement of the pathological condition.
  • the biological defense reaction represented by the immune reaction shows the maximum activity at the peak 30 to 75 days from the start of the reaction, and the bovine chicken in the peak state is collected and used. By doing so, it is possible to obtain the maximum health promotion effect significantly easily. Furthermore, by drying before the activity is lost, the physicochemical and biological effects on the active ingredient can be minimized, so that the activity of the active ingredient can be continuously maintained for a long period of time. This makes it easier to hold them.
  • Tillermade products are designed to take 8 to 12 g of dry meat of crow boned chicken once per week per adult, and to be taken continuously for at least 10 weeks, thereby promoting health. The effect can be significantly increased.
  • the method of ingesting the tiller maid preparation is the most efficient and aggressive way to elicit the biological response of the administered individual, similar to when the carrier of the physiological information is orally administered to the ostrich. Therefore, it is optimal for enhancing health promotion effects.
  • Serum from a Japanese male A (59 years old, weighing 60 kg) suffering from mild adult-type diabetes and mild chronic allergic monodermatitis was collected.
  • the fasting blood glucose level of Male A has been around 150 to 20 Omg / d1 continuously for several years.
  • Male A took 6 units of insulin before and during the test before and during the test, and took 2.5 mg eudalcon (Eu glucon: product name) 2.5 mg tablets after breakfast and 1 tablet after dinner .
  • Three 180- to 250-day-old healthy ostrich chickens kept in a stress-reduced environment were injected intravenously with 1 ml of serum. After 30 days, three hens were slaughtered and peaches, mune and fillet were collected in a sanitary manner.
  • the minced raw meat was freeze-dried with a freeze dryer.
  • the lyophilized chicken was carefully ground in a food processor at 50 ° C or less.
  • Tiller-made preparations were manufactured by bagging 10 g of the ground meat pieces. Keep the tiller maid product in the freezer was tubed.
  • Male A continuously ingested one bag of tillermaid once a week.
  • the fasting blood glucose level of male A was measured daily to determine the weekly average (monthly average before the first week of administration). As shown in Figure 1, the blood glucose level of male A declined steadily over time, with fasting blood glucose levels of 11 Omg / d1 at week 10 and 11 at week 11.
  • the dose was 2 mg Zdl and at week 12 was 102 mg Zd1.
  • subjective symptoms of Male A gradually and clearly subsided. Male A also felt reduced physical fatigue.
  • the serum of a particular individual may be transdermally administered to the ostrich
  • the urine of the same individual may be orally administered to the ostrich at the same time or at a different time.
  • Blood may be used as a carrier for physiological information. In this case, a healing effect on diseases of blood cells or blood coagulation can be exerted.
  • a specific component may be separated and purified from serum or urine, and only the separated component may be inoculated into ostriches.
  • a body tissue cancer cell or the like collected by a biopsy may be used as a carrier for physiological information. In these cases, a highly specific healing effect on the target disease can be exerted by narrowing down the carriers of the physiological information in advance.
  • the dried product in addition to the dried meat of the osseous chicken, various components derived from the osseous chicken (eg, eggs (egg yolk, egg white, eggshell, eggshell membranes), internal organs (heart and liver), epidermis, bone , Blood, cockscomb, etc.).
  • the dried product is preferably manufactured by drying and pulverizing at 50 ° C. or lower.

Abstract

L'invention concerne une préparation conçue pour être facilement prise sans entraîner d'effet secondaire et pour produire une amélioration rapide et appropriée de l'état de santé physiologique d'un sujet. Cette préparation sur mesure contient de la viande de poulet noir séchée associée à l'état physiologique d'un sujet. Pour produire cette viande de poulet noir séchée, on inocule dans un poulet noir un sérum ou de l'urine comportant des données correspondant à l'état physiologique du sujet, on nourrit le poulet pendant une période de 30 à 75 jours, puis on sèche et on broie la viande à une température ne dépassant par 50 °C. Cette préparation sur mesure est administrée par voie orale de façon continue pendant 10 semaines ou plus à raison d'une dose de 8 à 12 g/semaine pour un adulte.
PCT/JP2002/005901 2002-06-13 2002-06-13 Preparation sur mesure et procede de production de ladite preparation WO2003105873A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/JP2002/005901 WO2003105873A1 (fr) 2002-06-13 2002-06-13 Preparation sur mesure et procede de production de ladite preparation
AU2002313212A AU2002313212A1 (en) 2002-06-13 2002-06-13 Tailor-made preparation and process for producing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2002/005901 WO2003105873A1 (fr) 2002-06-13 2002-06-13 Preparation sur mesure et procede de production de ladite preparation

Publications (1)

Publication Number Publication Date
WO2003105873A1 true WO2003105873A1 (fr) 2003-12-24

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PCT/JP2002/005901 WO2003105873A1 (fr) 2002-06-13 2002-06-13 Preparation sur mesure et procede de production de ladite preparation

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AU (1) AU2002313212A1 (fr)
WO (1) WO2003105873A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0225254A2 (fr) * 1985-11-25 1987-06-10 Ghen Corporation Substance contenant un anticorps spécifique à partir d'oeufs, méthode de production et son utilisation
JPH0587815A (ja) * 1991-02-08 1993-04-06 Taiyo Kagaku Co Ltd 抗血漿型グルタチオンパーオキシダーゼ抗体及びこれを用いた診断薬
JPH05252909A (ja) * 1991-02-22 1993-10-05 Yoshio Murai 烏骨鶏の血粉の製造方法
JPH06329700A (ja) * 1993-05-19 1994-11-29 Taiyo Kagaku Co Ltd 特異的鶏卵抗体の製造法
JPH08259462A (ja) * 1994-12-05 1996-10-08 Adtec Kk 抗パルボウイルス感染症組成物
WO1998014209A1 (fr) * 1996-10-02 1998-04-09 Ovimmune, Inc. Administration orale d'anticorps a base de jaune d'oeuf de poule pour le traitement de maladies

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0225254A2 (fr) * 1985-11-25 1987-06-10 Ghen Corporation Substance contenant un anticorps spécifique à partir d'oeufs, méthode de production et son utilisation
JPH0587815A (ja) * 1991-02-08 1993-04-06 Taiyo Kagaku Co Ltd 抗血漿型グルタチオンパーオキシダーゼ抗体及びこれを用いた診断薬
JPH05252909A (ja) * 1991-02-22 1993-10-05 Yoshio Murai 烏骨鶏の血粉の製造方法
JPH06329700A (ja) * 1993-05-19 1994-11-29 Taiyo Kagaku Co Ltd 特異的鶏卵抗体の製造法
JPH08259462A (ja) * 1994-12-05 1996-10-08 Adtec Kk 抗パルボウイルス感染症組成物
WO1998014209A1 (fr) * 1996-10-02 1998-04-09 Ovimmune, Inc. Administration orale d'anticorps a base de jaune d'oeuf de poule pour le traitement de maladies

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KANEYOSHI AKAMATSU, 15 October 1980, ISHIYAKU PUB., INC., article "New revision Wakan'yaku", pages: 824 - 829, XP002971367 *

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