WO2003103621A1 - A series of cosmetic products containing human lysozyme (hlz) and their preparing method - Google Patents

Abstract

This invention relates to a cosmetic product and to its preparing method, it particularly relates to a series of cosmetic products containing Human lysozyme (HLZ) and to their preparing methods. The cosmetic product contains Human lysozyme (HLZ) as an essential ingredient. Its preparation process includes preparing Human lysozyme (HLZ), mixing the materials of the product, cooling the mixture to 45C after homogenizing, and then adding the said HLZ to the mixture, vacuum degassing while stirring the mixture. The present invention has the advantages of easily preparation of materials, simple and brief preparation process, significant treatment effects, and it can be easily generalized for application.

Description

 Technical field:

 The invention relates to a cosmetic and a preparation method thereof, in particular to a human lysozyme series cosmetics and a preparation method thereof.

 Background technique:

 At present, most widely used cosmetics are synthesized with chemical raw materials or added with plant ingredients; such as whitening masks, freckle creams and lotions. Japan uses chicken lysozyme to produce beauty cosmetics. Chicken lysozyme is a heterologous protein that has an allergic reaction to human skin.

 Disclosure of invention:

 The invention provides a series of human lysozyme cosmetics and a preparation method thereof. Since human lysozyme is a genetically engineered product and the gene is derived from the human body, it does not cause allergic reactions to the human body and has a repairing effect on human cells. Moreover, the cost is low, the production process is simple, and the effect is remarkable.

 The technical scheme of the present invention is that the main component of human lysozyme series skin care products is human lysozyme (HLZ), whose content per gram of cosmetics is 0.018-200mg, the active unit is 150U-6 million U, and the purity is 85%. —99.52%. The process is as follows: firstly, the pure human lysozyme is added to 15% water to prepare a human lysozyme aqueous solution for later use, and then the various raw materials are dispersed and homogenized and stirred, and then homogenized and emulsified, cooled to 45 °, and added to prepare Good human lysozyme can be degassed by stirring and vacuum to a certain temperature.

The positive effects of the invention are that raw materials are easily available, the process is simple, and it is easy to popularize and apply. Confirm this The best embodiment:

 A series of cosmetics and processes using human lysozyme as the main raw material are further described in combination with the following examples:

 Example 1: Production of a human lysozyme whitening and removing bean mask

 Formula: (parts by weight)

 (1) Human lysozyme 0.0002-0.6

(2) Kappa resin CP941 0.2-0.5

(3) Carboxymethyl cellulose CMC 0.3-0.6

(4) Polyvinyl alcohol 1788 (PVA) 7-10

(5) Glycerin 6-8

 (6) Tween 80 (T-80) 0.5-1.5

(7) Azone 0.3-1.0

(8) Ethanol. 5-10

 (9) flavor 0.1-0.5

(10) Water 67.6-80.45

(11) Jie Qiongyi II 0.15-0.3 Process:

 1. Firstly disperse the raw material Kabo Resin 941 and carboxymethyl cellulose CMC in glycerin, and add ionized water under stirring to mix well. This process should be prepared 4 hours before production. Then, the raw material polyvinyl alcohol 1788 was added with stirring.

2. Add the well-stirred 1 into the emulsification pot, then add Tween 80, Azone and water-soluble silicone oil and stir to 75 ° C, start homogenization, homogenize at high speed for 10 minutes, and then stop Stop homogenization at high speed, stop after homogenization at low speed for 15 minutes, continue stirring for 10 minutes, and stir at 60 rpm.

 3. Slowly cool with cooling water. When the temperature reaches 50 ° C, add ethanol and flavor and continue to stir until cooling. When the temperature is lower than 45 ° C, add human lysozyme and Jieqiong and homogenize for 2 minutes, then Perform vacuum degassing. Stir until the material is at 40 ° C and stop discharging.

 Implementation Column 2: Production of Human Lysozyme Whitening Freckle Cream

 Formula: (parts by weight)

 (1) Human lysozyme solution 0.0003-0.15

(2) Dimethicone 200cst 2.0-5.0

 (3) 18 alcohol 3.0-6.0

 (4) Glyceryl octanodecanoate / GTCC 2.5-5.0

 (5) Isooctyl palmitate / GD— 5103 4.0-7.0

 (6) Vitamin E / VE 0.3-0.7

 (7) Emulsifier Montanov 68 1.0-3.0

 (8) Glycerin 5-8

 (9) Emulsifier HR-St 1.0-3.0

 (10) Hyaluronic acid HA 0.01-0.04

(11) Thickener SepiGEL305 1.0-2.0

 (12) Jie Qiongyi II 1.0-2.0

(13) Flavor 0.10-0.20 deionized water 70.0-75.0 Process: _A

 4

1. Add raw materials dimethyl silicone oil 200cst, 18 alcohol, octyl decanoate / GTCC, isooctyl palmitate / GD-5103, vitamin E / VE, emulsifier Montanov 68 into the oil phase chemical pan, stir Heat to 85 ° C _; 2. Add raw material glycerin, emulsifier HR-S _t , hyaluronic acid HA, Jieqiong II and deionized water to the emulsification pot and stir to 87-89 ° C; 3. start the vacuum pump Vacuum the emulsification pot to 0.06Mpa, stop the vacuum, pump the oil phase into the emulsification pot for high-speed homogenization for 10 minutes, stirring at 70 revolutions, and stop after high-speed homogenization; homogenize at low speed for 10 minutes, stop homogenization, and continue stirring 10 minutes, the speed is 60 rpm; 4. Slow cooling with water, add the raw material thickener SepiGEL305 when the temperature is 60 ° C, homogenize for 2 minutes and vacuum degas; 5. add 45% raw material deionized water and human Lysozyme solution, shut down and discharge when stirring to 40 ° C.

 Example 3: Production of human lysozyme whitening essence (transparent type) and (emulsion type) Formula: (parts by weight)

 ①Human lysozyme solution 0. 00018— 0. 18, ② Kabo resin CP9410.2— 0.5, ③ Glycerin 5— 8 ④ VE (vitamin E) 0.5— 1.0, ⑤ HA (hyaluronic acid) 0.05— 0.15, ⑥ go Ionized water 90—93, Tong Jieqiong — Π 0. 1-0. 3. Pupa flavor 0.1-0.3, ⑨ EDTA -Na0.08-0.15;

 Craft:

Disperse the raw material Kappa resin CP941 and HA (hyaluronic acid) in glycerin, then add the raw material deionized water, pour the mixture into the reaction tank, and heat. The stirring speed is 80 rpm at 80 ° C. After the Kappa resin CP941 is completely dissolved, the heating is stopped, and the raw material VE (vitamin E) and human lysozyme solution and Jieqiong II, flavor, EDTA_Na are homogenized at low speed for 5 minutes when the water is cooled to 45 ° C, and the temperature reaches Discharge at 40 ° C. Preparation of whitening essence (emulsion type): ① human lysozyme solution 0.00018—0.18, ② thickener (SEPIGEL502) 1.0—3.0, ③ glycerin 5—7, ④ silicone grease (SF-9031.) 0.2—0.7 , ⑤ hydrogenated castor oil (PEG40) 0.2-0.6, ⑥ water-soluble silicone oil 0.1-0.5, ⑦ HR-SLO.3- 1.0, ⑧ deionized water 90%, ⑨Geoma II 0.1- 0.3, ⑩ essence 0.1- 0.3. The process steps are as follows: the raw material thickener (SEPIGEL502) and silicone grease (SF—9031) are evenly dispersed in glycerin, poured into the reaction, stirred and mixed before use; and then the raw material hydrogenated castor oil (PEG40), water-soluble silicone oil, HR_Si Deionized water is mixed and poured into an oil-phase pan and heated for 60Ό. After homogenization, when the temperature drops to 45 ° C, slowly pour into the above-mentioned spare material and stir at 70 rpm. Stop when it reaches 1/2 and stir. After 5 seconds, continue to stir the remaining 1/2 and add human lysozyme solution, Gemma II, and flavor. After homogenizing at low speed for 5 seconds, vacuum degas and discharge.

 Example 4: Production of whitening skin lotion after bath with human lysozyme

 Formula: (parts by weight) ① human lysozyme solution 0.00001—0.05, ② thickener (SEPIGEL502) 1.5-3.5, ③ glycerin 6-9, ④ mannose aldol silanol 2-4, ⑤ hydrogenated castor oil ( PEG40) 0.5- 1.5, ⑥ water-soluble silicone oil 0.2- 1.0, ⑦ HR— S! O.2-1.0, ⑧ deionized water 85.2%, ⑨Geoma 110.1-0.3, ⑩ essence 0.1- 0.3

 Process: A. Add raw materials ② and ④ to ③ and stir them together; B. Add raw materials ⑤⑥⑦ to raw materials ，, pour into the reaction tank to stir well and turn on high-speed homogenization for minutes; C. With phase A stirred Slowly pour into phase B of the reaction tank for high-speed homogenization for 10 minutes, then add raw materials ①⑨⑩, and vacuum degas for 1 minute at low-speed homogenization to discharge.

Example 5: Production of human lysozyme whitening and moisturizing freckle extract Formula (parts by weight): ① Human lysozyme solution 0.0005—0.2, ② Hyaluronic acid (HA) 0.05—0, 2, ③ Glycerin 6—8, ④ EDTA- NaO.05— 0 · 2, ⑤ Hydroxyco-amine Fatty silanol 3.0—5.0, ⑥Han gum 0.3—0.5, ⑦Geoma 110.1—0.3, ⑧Deionized water 80-93, ⑨Fragrance 11-11

 Process: Disperse the raw materials ②④⑥ evenly into the raw materials ③, then add the raw materials ⑤ and ⑧. Stir thoroughly and pour into the reaction tank, homogenize at low temperature for 5 seconds, then add ①⑨ and stir at 60 rpm. .

Claims

Rights request 1. A series of human lysozyme cosmetics, characterized in that the main component of the cosmetics is human lysozyme (HLZ), ^ the content per gram of cosmetics is 0.018-200mg, the active unit is 150U-6 million U, and the purity is 85% —99.52%.  2. A series of human lysozyme cosmetics according to claim 1, wherein the human lysozyme content per gram of cosmetics is 0.018-180 mg.  3. A series of human lysozyme cosmetics, which is characterized by the following processes: First, prepare human lysozyme for later use, first disperse and homogenize various raw materials, and then stir, homogenize and emulsify and cool to 45. °, put the prepared human lysozyme into it, and then degas and stir to a certain temperature.  4. A series of human lysozyme cosmetics according to claim 1, characterized in that the cosmetics include a human-lysozyme-removing whitening mask, which contains 0.2-200 mg of human lysozyme per gram, and the active unit is 150U—6 million U, with a purity of 89% -99%. 5. A series of human lysozyme cosmetics according to claim 1, wherein the cosmetics include human lysozyme-based whitening and freckle removing cream, which contains 0.3-150 mg of human lysozyme per gram, and the active unit is 200U—4 million U, with a purity of 89% —99%. 6. A series of human lysozyme cosmetics according to claim 1, characterized in that the cosmetics include transparent type whitening essence and emulsion type whitening essence containing human lysozyme, and each gram contains human Lysozyme 0.018-180mg, active unit is 180U-1 million U, purity is 89% -99%. 7. A human lysozyme series cosmetic according to claim 1, characterized in that: The cosmetic comprises a bath-whitening moisturizing lotion containing human lysozyme, containing 0.1-50 mg of human lysozyme per gram, an active unit of 160U-800,000 U, and a purity of 89% -99%. 8. A series of human lysozyme cosmetics according to claim 1, characterized in that-said cosmetics include human lysozyme-whitening and moisturizing freckle essence, which contains 0.5-200 mg of human lysozyme per gram. ， Activity unit is 250U— 5 million U, purity is 89% —