CN119157768B - Acne-removing and recurrence-preventing composition suitable for acne-sensitive skin and its application - Google Patents

Abstract

The present disclosure provides an anti-acne and anti-recurrence composition suitable for acne sensitive muscles and an application thereof, and belongs to the technical field of cosmetics. According to the acne-removing and relapse-preventing composition, epigallocatechin gallate glucoside, brazilin, roselle flower extract, jujube bark extract, linseed oil unsaponifiable matter and guaiac extract are selected as active ingredients of the acne-removing and relapse-preventing composition, and interact to quickly inhibit the growth of acne-related pathogenic bacteria and regulate skin microecology, effectively inhibit skin inflammation in the whole process of acne, play a role in preventing and inhibiting inflammation, effectively repair skin barrier, reduce redness, simultaneously have the effect of regulating skin grease balance, prevent acne relapse, and further have the effects of removing yellow gas, homogenizing skin color and improving skin roughness, and the acne-removing and relapse-preventing composition is mild and non-irritating, can be used for sensitive skin, and expands the application range of the acne-removing and relapse-preventing composition.

Description

Acne-removing and relapse-preventing composition suitable for acne-sensitive muscles and application thereof

Technical Field

The disclosure relates to the technical field of cosmetics, in particular to an acne-removing and relapse-preventing composition suitable for acne-sensitive muscles and application thereof.

Background

Acne is a common chronic inflammatory skin disease of the sebaceous glands of hair, and mainly occurs in seborrheic parts such as the face, the chest and the back. The course of acne is chronic and recurrent, potentially leading to infection, pigmentation, and scarring. It can even have serious negative effects on the quality of life and psycho-social function of the patient. The pathogenesis of acne is mainly related to increased sebum secretion, hyperkeratosis of hair follicles and sebaceous epithelium, propionibacterium acnes, and inflammatory immunity.

Conventional acne treatments, including drugs, physical therapy and chemotherapy, have serious side effects such as bacterial resistance, disruption of skin barrier function, and inflammatory pigmentation, and acne itself can cause damage to skin barrier function. The use of skin care in the adjuvant treatment of acne has received a great deal of attention. Because of their safety, good tolerability and the effect of improving damaged skin barrier, most of the acne-removing products on the market have slow and unsatisfactory effects, and cannot meet the demands of consumers in daily or special occasions. Secondly, the short-acting acne-removing product contains acid and sulfur, stimulates skin high immune response, has ripening effect, has potential irritation, is not friendly to some sensitive skin people, and importantly, the short-acting acne-removing product is mostly a spot-coating product and is not suitable for long-term maintenance and improvement of acne skin. Moreover, most products ignore post-acne care, which greatly increases the probability of acne recurrence, and in the long term, damage to the skin barrier has been increased, resulting in vicious circle.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides an acne-removing and relapse-preventing composition suitable for acne-sensitive muscles and application thereof.

In order to achieve the aim, the invention adopts the technical scheme that in the first aspect, the acne-removing and relapse-preventing composition suitable for acne-sensitive muscles is provided, and comprises the following components, by weight, 0.01-3 parts of epigallocatechin gallate glucoside, 0.001-0.3 part of brazilin, 1-15 parts of roselle extract, 0.1-1 part of date bark extract, 0.01-3 parts of linseed oil unsaponifiable matter and 1-15 parts of guaiac extract.

In some embodiments, the acne-removing and relapse-preventing composition comprises, by weight, 0.05-1 part of epigallocatechin gallate, 0.005-0.1 part of brazilin, 3-10 parts of roselle flower extract, 0.1-0.5 part of date tree bark extract, 0.05-1 part of linseed oil unsaponifiable matter and 1-8 parts of guaiac extract.

In some embodiments, the acne-removing and relapse-preventing composition comprises, by weight, 0.5-1 part of epigallocatechin gallate glucoside, 0.01-0.1 part of brazilin, 3-8 parts of roselle flower extract, 0.15-0.5 part of date tree bark extract, 0.08-0.5 part of linseed oil unsaponifiable matter and 2-5 parts of guaiacum extract.

In some embodiments, the preparation method of the roselle extract comprises the steps of adding roselle flowers into an acidified ethanol solution for ultrasonic extraction, performing solid-liquid separation after extraction is finished, and drying the obtained filtrate to obtain the roselle extract;

In some embodiments, the preparation method of the American jujube bark extract comprises the steps of adding the American jujube bark into an ethanol water solution for extraction, performing solid-liquid separation after the extraction is finished, and drying the obtained filtrate to obtain the American jujube bark extract.

In some embodiments, the roselle flower extract is prepared with a water content of 4-6%;

And/or the average grain diameter of the roselle flower is less than or equal to 150 mu m;

and/or, the solid-to-liquid ratio of the roselle to the acidified ethanol solution is 1g:30-40mL;

and/or the frequency of the ultrasonic extraction is 120-160Hz;

And/or the ultrasonic extraction time is 25-35min;

and/or the temperature of the ultrasonic extraction is 45-55 ℃;

and/or the pH of the acidified ethanol solution is 2.5-3.5.

In some embodiments, in the preparation method of the jujube bark extract, the solid-to-liquid ratio of the jujube bark to the ethanol aqueous solution is 1g:10-20mL;

And/or the volume percentage of the ethanol in the ethanol water solution is 65-75%;

And/or the extraction mode is one of leaching, reflux extraction and ultrasonic extraction.

In a second aspect, the application of the acne-removing and relapse-preventing composition in preparing cosmetics is provided.

In a third aspect, a cosmetic is provided, which comprises the acne-removing and relapse-preventing composition, wherein the content of the acne-removing and relapse-preventing composition in the cosmetic is 0.1 to 3 weight percent.

In some embodiments, the cosmetic is an acne-removing emulsion, and the acne-removing emulsion comprises, by mass, 0.1-3% of an acne-removing and relapse-preventing composition, 0.05-5% of a thickening agent, 3-20% of a humectant, 0.5-10% of an emulsifying agent, 0.2-5% of a preservative, 0.05-0.1% of a pH regulator, and the balance of water.

In some embodiments, the thickener comprises at least one of xanthan gum, carbomer, acrylamide dimethyl taurate/VP copolymer, cellulose;

and/or the humectant comprises at least one of glycerin, butylene glycol, sodium hyaluronate;

and/or the emulsifier comprises at least one of coco-caprylate/caprate, polydimethylsiloxane, hydrogenated palm kernel oil, cetostearyl alcohol, polyglycerol-6 distearate, and polymethylsilsesquioxane;

And/or the preservative comprises at least one of 1, 3-propanediol, 1, 2-hexanediol and p-hydroxyacetophenone;

And/or the pH regulator comprises at least one of arginine and disodium ethylenediamine tetraacetate.

Compared with the prior art, the acne-removing and relapse-preventing composition has the beneficial effects that epigallocatechin gallate glucoside, brazilin, roselle flower extract, jujube bark extract, linseed oil unsaponifiable matter and guaiac extract are selected as active ingredients of the acne-removing and relapse-preventing composition, and can quickly inhibit the growth of acne-related pathogenic bacteria and regulate skin microecology, effectively inhibit skin inflammation in the whole process of acne, play a role in preventing and inhibiting inflammation, effectively repair skin barrier, reduce redness, regulate skin grease balance and prevent acne relapse, and in addition, the acne-removing and relapse-preventing composition also has the effects of removing yellow gas, homogenizing skin color and improving skin roughness, is mild and non-irritating, can be used for sensitive skin, and expands the application range of acne-removing products.

Drawings

FIG. 1 is a graph showing the results of the anti-acne test in effect example 3 using the emulsions of application example 1 for days D0 and D7;

FIG. 2 is a graph showing the results of the anti-acne test using the emulsions of comparative application example 1 for days D0 and D7 in effect example 3.

Detailed Description

To facilitate an understanding of the present disclosure, the present disclosure will be described more fully below. This disclosure may, however, be embodied in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

The term as used herein:

"by. Preparation method synonymous with" comprising ". The terms "comprising," "including," "having," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, step, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, step, method, article, or apparatus.

The term "consisting of" excludes any unspecified element, step or component. If used in a claim, such phrase will cause the claim to be closed, such that it does not include materials other than those described, except for conventional impurities associated therewith. When the phrase "consisting of" appears in a clause of the claim body rather than immediately following the subject, it is limited to only the elements described in that clause, and other elements are not excluded from the claim as a whole.

When an equivalent, concentration, or other value or parameter is expressed as a range, preferred range, or a range bounded by a list of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1-5" is disclosed, the described range should be interpreted to include the ranges of "1-4", "1-3", "1-2 and 4-5", "1-3 and 5", and the like. When a numerical range is described herein, unless otherwise indicated, the range is intended to include its endpoints and all integers and fractions within the range.

In these examples, the parts and percentages are by mass unless otherwise indicated.

"Parts by mass" means a basic unit of measurement showing the mass ratio of a plurality of components, and 1 part may be any unit mass, for example, 1g, 2.689g, or the like. If we say that the mass part of the A component is a part and the mass part of the B component is B part, the ratio a: B of the mass of the A component to the mass of the B component is expressed. Or the mass of the A component is aK, the mass of the B component is bK (K is any number and represents a multiple factor). It is not misunderstood that the sum of the parts by mass of all the components is not limited to 100 parts, unlike the parts by mass.

"And/or" is used to indicate that one or both of the illustrated cases may occur, e.g., a and/or B include (a and B) and (a or B). In a first aspect, an anti-acne and anti-recurrence composition suitable for acne-sensitive muscles is provided, wherein the anti-acne and anti-recurrence composition comprises, by weight, 0.01-3 parts of epigallocatechin gallate glucoside, 0.001-0.3 part of brazilin, 1-15 parts of roselle extract, 0.1-1 part of jujube bark extract, 0.01-3 parts of linseed oil unsaponifiable matter and 1-15 parts of guaiacum extract.

Specifically, the weight parts of the epigallocatechin gallate glucoside may be, but are not limited to, 0.01 part, 0.05 part, 0.1 part, 0.2 part, 0.5 part, 0.7 part, 1 part, 1.3 part, 1.5 part, 1.8 part, 2 parts, 2.2 parts, 2.5 parts, 2.7 parts, 3 parts, preferably 0.05 to 1 part, more preferably 0.5 to 1 part.

Specifically, the weight part of the brazilin may be, but is not limited to, 0.001 part, 0.005 part, 0.01 part, 0.03 part, 0.05 part, 0.07 part, 0.1 part, 0.12 part, 0.15 part, 0.18 part, 0.2 part, 0.22 part, 0.25 part, 0.27 part, 0.3 part, preferably 0.005-0.1 part, more preferably 0.01-0.1 part.

Specifically, the roselle extract may be 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, 10.5 parts, 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts, 14 parts, 14.5 parts, 15 parts, preferably 3-10 parts, more preferably 3-8 parts.

Specifically, the weight part of the jujube bark extract can be, but is not limited to, 0.1 part, 0.15 part, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.4 part, 0.45 part, 0.5 part, 0.55 part, 0.6 part, 0.65 part, 0.7 part, 0.75 part, 0.8 part, 0.85 part, 0.9 part, 0.95 part, 1 part, preferably 0.1-0.5 part, more preferably 0.15-0.5 part.

Specifically, the weight parts of the unsaponifiable matter of the linseed oil may be, but are not limited to, 0.01 part, 0.05 part, 0.1 part, 0.3 part, 0.5 part, 0.7 part, 1 part, 1.2 part, 1.5 part, 1.7 part, 2 parts, 2.3 parts, 2.5 parts, 2.8 parts, 3 parts, preferably 0.05 to 1 part, more preferably 0.08 to 0.5 part.

Specifically, the guaiacum extract may be 1 part, 1.2 parts, 1.5 parts, 1.7 parts, 2 parts, 2.3 parts, 2.5 parts, 2.8 parts, 3 parts, 3.5 parts, 4 parts, 4.3 parts, 4.5 parts, 4.8 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 9 parts, 10 parts, 11 parts, 11.5 parts, 12 parts, 13 parts, 14 parts, 14.5 parts, 15 parts, preferably 1 to 8 parts, more preferably 2 to 5 parts by weight.

According to the acne-removing and relapse-preventing composition, epigallocatechin gallate glucoside, brazilin, roselle flower extract, date tree bark extract, linseed oil unsaponifiable matter and guaiac tree extract are selected as active ingredients of the acne-removing and relapse-preventing composition, and interact to quickly inhibit the growth of acne-related pathogenic bacteria and regulate skin microecology, effectively inhibit skin inflammation in the whole process of acne, play a role in preventing and inhibiting inflammation, effectively repair skin barrier, reduce redness, simultaneously have the effect of regulating skin grease balance, prevent acne relapse, and further have the effects of removing yellow gas, homogenizing skin color and improving skin roughness, and the acne-removing and relapse-preventing composition is mild and non-irritating, can be used for sensitive skin, and expands the application crowd range of the acne-removing and relapse-preventing composition.

The extract of the roselle is capable of protecting the skin from being disturbed by the outside, has the functions of resisting oxidization and bacteria, resisting microorganisms and regulating immunity, and the unsaponifiable linseed oil mainly contains linolenic acid, linoleic acid, oleic acid, stearic acid and palmitic acid, has the functions of resisting inflammation and enhancing synergism, can promote metabolism of skin cells, enhances elasticity and luster of the skin, and contains rich lignin, quinones, saponins, sesquiterpenes and triterpenes, and has the functions of resisting inflammation, resisting viruses, resisting bacteria, converging and protecting.

Specifically, the component content of each component in the acne-removing and relapse-preventing composition can influence the overall performance of the acne-removing and relapse-preventing composition, and when the weight parts of epigallocatechin gallate glucoside, brazilin, roselle extract, jujube bark extract, linseed oil unsaponifiable matter and guaiac extract are in the preferred ranges, the acne-removing, repairing and oil-controlling effects of the acne-removing and relapse-preventing composition are better.

In some embodiments, the preparation method of the roselle extract comprises the steps of adding roselle flowers into an acidified ethanol solution for ultrasonic extraction, performing solid-liquid separation after extraction is finished, and drying the obtained filtrate to obtain the roselle extract;

in the preparation method of the roselle flower extract, each parameter meets at least one of the following parameters:

Specifically, the water content of the roselle flower is 4-6%, such as but not limited to 4%, 4.2%, 4.4%, 4.6%, 4.8%, 5%, 5.3%, 5.5%, 5.7%, 6%;

in order to obtain the roselle flower with the water content, the roselle flower needs to be dried, the drying mode is not particularly limited, as long as the water content of the roselle flower can reach 4-6%, such as air drying, drying and vacuum freeze drying, and in order to keep the content of the active ingredients in the roselle flower, the vacuum freeze drying is selected.

Specifically, the drying steps of roselle flowers are as follows:

After the roselle is pre-frozen, the roselle is placed in a vacuum freeze drying oven with the vacuum degree of 80-100Pa and the temperature of (-45 ℃) to (-40 ℃) and the heating rate of 2-3 ℃ per minute to 38-42 ℃, the temperature is kept for 10-14 hours, then the roselle is heated to 48-52 ℃ with the heating rate of 0.2-0.4 ℃ per minute, the temperature is kept for 1.5-2.5 hours, then the temperature is reduced to 18-22 ℃, and the water content of the roselle is kept to 4-6%.

The roselle flowers are dried in a multi-stage heating and cooling mode, so that the effective active ingredients in the roselle flowers can be reserved to the greatest extent, and the effects of acne removal, barrier repair and grease secretion reduction of the acne removal and relapse prevention composition are improved.

Specifically, the average particle size of the roselle flower is less than or equal to 150 μm, and can be, for example, but not limited to, 1 μm, 5 μm, 10 μm, 30 μm, 50 μm, 70 μm, 90 μm, 110 μm, 130 μm, 150 μm;

Specifically, the solid-to-liquid ratio of the roselle flower to the acidified ethanol solution is 1g:30-40mL, and for example, but not limited to, 1g:30mL, 1g:32mL, 1g:34mL, 1g:36mL, 1g:38mL, 1g:40mL;

in particular, the frequency of the ultrasonic extraction is 120-160Hz, such as but not limited to 120Hz, 125Hz, 130Hz, 135Hz, 140Hz, 145Hz, 150Hz, 155Hz, 160Hz;

Specifically, the ultrasonic extraction time is 25-35min, such as, but not limited to, 25min, 27min, 29min, 31min, 33min, 35min;

in particular, the temperature of the ultrasonic extraction is 45-55 ℃, such as but not limited to 45 ℃, 47 ℃, 49 ℃, 51 ℃, 53 ℃ and 55 ℃;

specifically, the pH of the acidified ethanol solution is 2.5-3.5, and may be, for example, but not limited to, 2.5, 2.7, 2.9, 3.1, 3.3, 3.5.

In some embodiments, the acidified ethanol solution is prepared by adding hydrochloric acid to an aqueous ethanol solution and mixing well to obtain an acidified ethanol solution having a pH of 2.5-3.5.

Specifically, the addition amount of hydrochloric acid is not particularly limited as long as the pH of the acidified ethanol solution can be made to be 2.5 to 3.5.

Specifically, the volume fraction of ethanol in the ethanol aqueous solution is 50-70%, for example, 50%, 53%, 55%, 58%, 60%, 62%, 65%, 67%, 70%.

In some embodiments, the preparation method of the American jujube bark extract comprises the steps of adding the American jujube bark into an ethanol water solution for extraction, performing solid-liquid separation after the extraction is finished, and drying the obtained filtrate to obtain the American jujube bark extract.

In the preparation method of the jujube bark extract, each parameter meets at least one of the following parameters:

Specifically, the solid-to-liquid ratio of the jujube bark to the ethanol water solution is 1g:10-20mL, such as but not limited to 1g:10mL, 1g:12mL, 1g:14mL, 1g:16mL, 1g:18mL, 1g:20mL;

Specifically, the volume percentage of the ethanol in the ethanol water solution is 50-70%, for example, 50%, 53%, 55%, 58%, 60%, 62%, 65%, 67%, 70%;

Specifically, the extraction mode is one of leaching, reflux extraction and ultrasonic extraction.

Specifically, the temperature of leaching, reflux extraction, ultrasonic extraction is 55-75deg.C, such as 55deg.C, 57 deg.C, 59 deg.C, 61 deg.C, 63 deg.C, 65 deg.C, 67 deg.C, 69 deg.C, 71 deg.C, 73 deg.C, 75 deg.C;

The leaching time is 40-56h, such as, but not limited to, 40h, 44h, 48h, 52h, 56h;

the reflux extraction time is 4-8h, such as but not limited to 4h, 5h, 6h, 7h, 8h;

The ultrasonic extraction time is 1-2h, and the ultrasonic extraction power is 200-300W.

Specifically, the roselle flower extract and/or the date tree bark extract prepared by the method can further improve the acne removing, repairing and oil controlling effects of the acne removing and relapse preventing composition.

In the preparation process of the roselle extract and the date palm bark extract, the solid-liquid separation mode is not particularly limited as long as the solid and the liquid can be separated, for example, filtration and centrifugation, and in order to shorten the preparation time of the roselle extract and the date palm bark extract, the centrifugation is selected as the solid-liquid separation mode.

Specifically, the rotational speed of centrifugation is 3000-5000r/min, and the time of centrifugation is 10-20min.

The skilled artisan can use means well known in the art to mix epigallocatechin gallate glucoside, brazilin, roselle flower extract, date tree bark extract, linseed oil unsaponifiable matter and guaiac wood extract uniformly to obtain an anti-acne and anti-recurrence composition, such as mechanical stirring, homogenization, ultrasound, or the like.

The preparation method of the acne-removing and relapse-preventing composition comprises the following steps of fully mixing epigallocatechin gallate glucoside, brazilin, roselle flower extract, date palm bark extract, linseed oil unsaponifiable matter and guaiac extract to obtain the acne-removing and relapse-preventing composition.

After mixing, a uniform and stable acne-removing and relapse-preventing composition is obtained, so that the active ingredients are fully mixed, and the full release of the active ingredients is facilitated.

In a second aspect, the application of the acne-removing and relapse-preventing composition in preparing cosmetics is provided.

In a third aspect, a cosmetic is provided, which comprises the acne-removing and relapse-preventing composition, wherein the content of the acne-removing and relapse-preventing composition in the cosmetic is 0.1 to 3 weight percent.

The content of the acne-removing and relapse-preventing composition in the cosmetic can be, but is not limited to, 0.1wt%, 0.3wt%, 0.5wt%, 0.7wt%, 0.9wt%, 1.2wt%, 1.4wt%, 1.6wt%, 1.8wt%, 2wt%, 2.3wt%, 2.5wt%, 2.8wt%, 3wt%.

The acne-removing and relapse-preventing composition with a specific proportion is added into the cosmetics, so that good acne-removing, repairing and oil-controlling effects can be achieved for the cosmetics. When the cosmetic of the present application contains less than 0.1wt% of the above-mentioned anti-acne and anti-recurrence composition of the present application, sufficient anti-acne or repairing effects cannot be expected, or oil control effects, and when it contains more than 3wt%, undesired reactions such as allergy may occur or there is a problem in skin safety.

In addition to the use of the anti-acne composition as an active ingredient, the ingredients contained in the cosmetic composition of the present invention include ingredients commonly used in cosmetic compositions, such as conventional adjuvants, e.g., antioxidants, stabilizers, solubilizers, vitamins, colorants, pigments, and fragrances and carriers.

The cosmetic composition of the present invention may be prepared as any formulation conventionally prepared in the art, and may be formulated into, for example, a solution, a suspension, an emulsion, a paste, a gel, a cream, a lotion, a powder, a soap, a surfactant-containing cleanser, an oil, a powdery foundation, an emulsion foundation, a waxy foundation, a spray, etc., but the present invention is not limited thereto. More specifically, the cosmetic composition of the present invention can be prepared as a preparation of emollient water, nourishing lotion, nourishing cream, massage cream, essence, mask, eye cream, skin cleansing foam, skin cleansing water, moisturizing cream, fermentation cream, ampoule, shampoo, conditioner, spray or powder.

When the formulation of the present invention is a paste, cream or gel, at least one selected from animal oil, vegetable oil, wax, paraffin wax, starch, tragacanth, cellulose derivative, polyethylene glycol, silicone (silicone), bentonite, silica, talc and zinc oxide may be used as a carrier ingredient.

When the formulation of the present invention is a powder or spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder can be used as carrier ingredients. Especially when the formulation of the invention is a spray, a propellant (such as chlorofluorocarbon, propane/butane or dimethyl ether) may be additionally included.

When the formulation of the present invention is a solution or emulsion, a solvent, a solubilizer or an emulsifier may be used as a carrier component. For example, at least one selected from the group consisting of water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, butylene glycol, 1,3-butyl glycol oil, polyoxyethylene hydrogenated castor oil, glycerol, aliphatic esters, phenoxyethanol, triethanolamine, polyethylene glycol, beeswax, polysorbate 60, sorbitan sesquioleate, paraffin, sorbitan stearate, glycerol monostearate (lipophilicity), stearic acid, glycerol stearate/PEG-400 stearate, carboxyl polymers (carboxy polymers), sitosterol, polyglyceryl 2-oleate, ceramide, cholesterol, steareth-4, dicetyl phosphate, macadamia nut oil (macadamiaoil), carboxyvinyl polymers, xanthan gum and fatty acid esters of sorbitan may be used.

When the formulation of the present invention is a suspension, at least one selected from the group consisting of liquid diluents such as water, ethanol, glycerin, butylene glycol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline cellulose, hydroxyethyl cellulose, sodium hyaluronate, phenoxyethanol, aluminum metahydroxide (aluminum metahydroxide), bentonite, stearic acid, cetyl alcohol, glycerin monostearate, polyoxyethylene sorbitan monostearate, sorbitan sesquioleate, glycerin monostearate/glycerin stearate/polyoxyethylene stearate, waxes, paraffin waxes, squalane, caprylic/capric triglyceride, carboxyvinyl polymer, triethanolamine, agar and tragacanth may be used as the carrier ingredient.

When the formulation of the present invention is a surfactant-containing detergent, at least one selected from the group consisting of fatty alcohol sulfate, fatty alcohol ether sulfate, sulfosuccinic monoester, isethionate (isethionate), imidazoline (iminozonium) derivative, methyltaurin salt, sarcosinate, fatty acid amide ether sulfate, alkylamidobetaine (alkylamido betaine), fatty alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, lanolin derivative, and ethoxylated glycerol fatty acid ester may be used as a carrier component.

In some embodiments, the cosmetic is an acne-removing emulsion, and the acne-removing emulsion comprises, by mass, 0.1-3% of an acne-removing and relapse-preventing composition, 0.05-5% of a thickening agent, 3-20% of a humectant, 0.5-10% of an emulsifying agent, 0.2-5% of a preservative, 0.05-0.1% of a pH regulator, and the balance of water.

Specifically, the mass percentage of the acne-removing and relapse-preventing composition can be, but is not limited to, 0.1%, 0.3%, 0.5%, 0.7%, 1.1%, 1.5%, 1.8%, 2%, 2.2%, 2.4%, 2.6%, 2.8%, 3%;

Specifically, the mass percent of the thickener may be, but is not limited to, 0.05%, 0.1%, 0.3%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%;

Specifically, the mass percentage of the humectant can be, but is not limited to, 3%, 5%, 7%, 9%, 11%, 13%, 15%, 17%, 20%;

Specifically, the mass percentage of the emulsifier can be, but is not limited to, 0.5%, 1%, 1.5%, 3%, 4%, 5%, 7%, 8%, 10%;

Specifically, the mass percent of the preservative can be, but is not limited to, 0.2%, 0.5%, 1%, 1.5%, 2%, 3%, 4%, 5%;

specifically, the mass percentage of the pH adjuster may be, but is not limited to, 0.05%, 0.08%, 0.1%.

In some embodiments, the thickener comprises at least one of xanthan gum, carbomer, acrylamide dimethyl taurate/VP copolymer, cellulose;

in some embodiments, the humectant comprises at least one of glycerin, butylene glycol, sodium hyaluronate;

In some embodiments, the emulsifier comprises at least one of coco-caprylate/caprate, dimethicone, hydrogenated palm kernel oil, cetostearyl alcohol, polyglycerol-6 distearate, polymethylsilsesquioxane;

In some embodiments, the preservative comprises at least one of 1, 3-propanediol, 1, 2-hexanediol, p-hydroxyacetophenone;

In some embodiments, the pH adjuster comprises at least one of arginine, disodium edetate.

The cosmetic of the present invention may be prepared by any suitable method known in the art. For example, the preparation may be carried out according to a process known in the art using equipment such as a dissolution tank, an emulsifying pot, a disperser, a transfer pump, etc., which are commonly used in the cosmetic field. For example, water-soluble substances can be put into an aqueous-phase dissolution kettle, oil-soluble substances (such as sunscreens and grease) can be put into an oil-phase dissolution kettle, the temperatures of the two kettles are respectively heated to about 80 ℃, wherein the raw materials which are easy to agglomerate can be pre-dispersed by a disperser, for example, powder-containing substances (such as zinc oxide and titanium dioxide) can be dispersed by a proper solvent and a dispersing agent, then homogenized for 5-10min, the oil phase is added, homogenized for 5-10min again, after homogenization is finished, the oil phase and the water phase are delivered into an emulsifying pot for homogenization and emulsification for about 5-15min, after the emulsification is finished, the temperature of the raw materials is reduced to normal temperature, essence, preservative and the like are optionally added, the pH of the products is adjusted according to requirements, and after relevant detection indexes are qualified, the raw materials can be filled.

The above preparation process is merely exemplary, and those skilled in the art can increase or decrease or adjust the preparation according to the requirements of the preparation formulation, thereby preparing various preparation formulations such as spray, emulsion, gel/jelly, cream, air cushion/foundation, and the like.

In order to further understand the present application, the antioxidant composition of the present application, the preparation method and effect thereof will be described in further detail with reference to specific examples. The raw materials involved in the application are all available commercially.

The following description of the raw materials used in the examples and comparative examples is provided, but is not limited to these materials:

The preparation method of the roselle pollen comprises the steps of pre-freezing roselle flowers for 3 hours, placing the roselle flowers in a vacuum freeze-drying oven with the vacuum degree of 80Pa and the cold trap temperature of-40 ℃, heating a heating plate to 40 ℃ after 30 minutes, preserving heat for 12 hours, heating to 50 ℃ after 30 minutes, preserving heat for 2 hours, cooling to 20 ℃ after 30 minutes, continuously stopping drying until the water content of the roselle flowers is 5%, crushing, sieving with a 100-mesh sieve, and placing the obtained undersize product into a dryer for standby.

The acidified ethanol solution 1 is self-made and is prepared by adding hydrochloric acid into ethanol water solution with volume fraction of 60%, and mixing uniformly to obtain pH=3 acidified ethanol solution 1;

the acidified ethanol solution 2 is prepared by adding hydrochloric acid into ethanol water solution with volume fraction of 50%, and mixing uniformly to obtain pH=3 acidified ethanol solution 2;

the acidified ethanol solution 3 is self-made and is prepared by adding hydrochloric acid into ethanol water solution with the volume fraction of 70%, and uniformly mixing to obtain pH=3 acidified ethanol solution 3;

The roselle pollen extract 1 is prepared by adding roselle pollen into acidified ethanol solution 1, extracting with solid-to-liquid ratio of 1g to 35mL of the acidified ethanol solution 1 at 140kHz and 50 ℃ for 30min, repeatedly extracting for 3 times, centrifuging the obtained product at 3000r/min for 15min after extraction, and concentrating the supernatant to remove ethanol to obtain roselle pollen extract 1;

The roselle pollen extract 2 is prepared by adding roselle pollen into acidified ethanol solution 2, extracting with solid-to-liquid ratio of 1g to 35mL of the solution 2 at 120kHz and 50 ℃ for 30min, repeatedly extracting for 3 times, centrifuging the obtained product at 3000r/min for 15min after extraction, collecting supernatant, and concentrating the supernatant to remove ethanol to obtain roselle pollen extract 2;

The roselle pollen extract 3 is prepared by adding roselle pollen into acidified ethanol solution 3, extracting with solid-to-liquid ratio of 1g to 35mL of the solution 3 at 160kHz and 50 ℃ for 30min, repeating the extraction for 3 times, centrifuging the obtained product at 3000r/min for 15min after the extraction is finished, and concentrating the supernatant to remove ethanol to obtain roselle pollen extract 3;

the jujube bark extract 1 is prepared by home-made and the preparation method comprises the following steps:

drying commercial jujube bark to constant weight, pulverizing, sieving with 100 mesh sieve, collecting undersize, weighing 1g undersize powder, adding into 15mL 70% ethanol solution, soaking at 60deg.C for 48 hr, filtering after soaking, collecting filtrate, concentrating under reduced pressure, and drying to obtain jujube bark extract 1;

the jujube bark extract 2 is prepared by home-made and the preparation method is as follows:

Drying commercial jujube bark to constant weight, crushing, sieving with a 100-mesh sieve, collecting undersize, weighing 1g of undersize powder, adding into 15mL of 70% ethanol solution, carrying out reflux extraction at 60 ℃ for 6 hours, filtering after extraction, collecting filtrate, concentrating under reduced pressure, and drying to obtain jujube bark extract 2;

the jujube bark extract 3 is self-made, and the preparation method comprises the following steps:

Drying commercial jujube bark to constant weight, crushing, sieving with a 100-mesh sieve, collecting undersize, weighing 1g of undersize powder, adding into 15mL of 70% ethanol solution, performing ultrasonic extraction for 60min at 60 ℃ under the condition of ultrasonic power of 266W, filtering after ultrasonic extraction is finished, collecting filtrate, concentrating under reduced pressure, and drying to obtain jujube bark extract 3;

Epigallocatechin gallate, trade name: EGCG, manufacturer: qi Hua Du;

brazilin is derived from lignum sappan, 98%, and the manufacturer is carbofuran;

linseed oil unsaponifiables, trade name: The manufacturer is an source;

guaiacum extract with the trade name L2-DZ-SCB3675-X is prepared from zhenghe.

Examples 1 to 6 and comparative examples 1 to 6

The invention provides an anti-acne and anti-recurrence composition suitable for acne sensitive muscles, wherein the components of the anti-acne and anti-recurrence composition are shown in table 1;

The preparation method of the acne-removing and relapse-preventing compositions of the examples 1-6 and the comparative examples 1-6 comprises the step of uniformly mixing the components according to the weight parts of the table 1 to obtain the acne-removing and relapse-preventing composition.

TABLE 1

Example 7

The embodiment of the invention provides an acne-removing and relapse-preventing composition suitable for acne-sensitive muscles, which is different from embodiment 1 only in that roselle extract 2 is used for replacing roselle extract 1.

Example 8

The embodiment of the invention provides an acne-removing and relapse-preventing composition suitable for acne-sensitive muscles, which is different from embodiment 1 only in that roselle extract 3 is used for replacing roselle extract 1.

Example 9

The embodiment of the invention provides an acne-removing and relapse-preventing composition suitable for acne-sensitive muscles, which is different from embodiment 1 only in that the date palm bark extract 1 is replaced by the date palm bark extract 2.

Example 10

The embodiment of the invention provides an acne-removing and relapse-preventing composition suitable for acne-sensitive muscles, which is different from embodiment 1 only in that the date palm bark extract 3 is used for replacing the date palm bark extract 1.

Comparative example 7

The embodiment of the invention provides an acne-removing and relapse-preventing composition suitable for acne-sensitive muscles, which is different from the embodiment 1 only in that epigallocatechin gallate is used for replacing epigallocatechin gallate.

Comparative example 8

The embodiment of the invention provides an acne-removing and relapse-preventing composition suitable for acne-sensitive muscles, which is different from embodiment 1 only in that farnesin is used for replacing brazilin.

Comparative example 9

The embodiment of the invention provides an acne-removing and relapse-preventing composition suitable for acne-sensitive muscles, which is different from embodiment 1 only in that hibiscus extract is used for replacing roselle extract 1.

Comparative example 10

The embodiment of the invention provides an acne-removing and relapse-preventing composition suitable for acne-sensitive muscles, which is different from embodiment 1 only in that magnolia bark extract is used for replacing jujube bark extract 1.

Comparative example 11

The embodiment of the invention provides an acne-removing and relapse-preventing composition suitable for acne-sensitive muscles, which is different from embodiment 1 only in that olive oil unsaponifiable matter is used for replacing linseed oil unsaponifiable matter.

Comparative example 12

The embodiment of the invention provides an acne-removing and relapse-preventing composition suitable for acne-sensitive muscles, which is different from embodiment 1 only in that tetrandra extract is used for replacing guaiac extract.

Application examples 1 to 11, comparative application examples 1 to 12 and blank application examples

The invention provides acne-removing emulsion, which comprises the following components in percentage by mass as shown in table 2, wherein the acne-removing and relapse-preventing compositions used in application examples 1-10 are the acne-removing and relapse-preventing compositions prepared in examples 1-10 respectively, the acne-removing and relapse-preventing compositions used in comparative application examples 1-12 are the acne-removing and relapse-preventing compositions prepared in comparative examples 1-12 respectively, and the acne-removing and relapse-preventing composition used in application example 11 is the acne-removing and relapse-preventing composition prepared in example 1;

the preparation method of the acne-removing emulsion of the application example, the comparative application example and the blank application example comprises the following steps:

(1) Mixing the component A with water, stirring, heating to 80 ℃, homogenizing for 5min at a rotation speed of 1200rpm, and preserving heat for later use after homogenizing to obtain a prefabricated component A;

(2) Mixing the component B, heating to 80 ℃, homogenizing for 5min at a rotation speed of 1200rpm, and preserving heat for later use after homogenizing to obtain a prefabricated component B;

(3) Mixing the components C, heating to 60 ℃ and melting to obtain a prefabricated component C;

(4) Heating the prefabricated component A to 80 ℃, adding the prefabricated component B at the rotation speed of 300rpm, stirring and mixing, cooling to 60 ℃, adding the prefabricated component C at the rotation speed of 300rpm, stirring and mixing, cooling to below 45 ℃, adding the acne-removing and relapse-preventing composition and essence, continuously stirring for 5min, finally adding arginine to adjust the pH to 5.0-6.5, stopping stirring, and discharging to obtain the acne-removing emulsion.

TABLE 2

Effect example 1 inflammatory factor IL-1 beta level test

The present effect example explores the anti-inflammatory effects of the anti-acne and anti-recurrence compositions prepared in examples 1 to 10 and comparative examples 1 to 12.

The cell line used was Mouse macrophage RAW264.7, cell resource center from basic medical institute of China medical sciences, fetal bovine serum (FBS, gibco), DMEM high sugar culture medium (DMEM, gibco), dimethyl sulfoxide (DMSO, sigma), phosphate buffer (PBS, gibco), thiazole blue (MTT, sigma), mouse tumor necrosis factor-alpha ELISA kit (Mouse TNF-alpha ELISA kit, boster), mouse interleukin-1 beta ELISA kit (Mouse IL-1 beta ELISA kit, boster). The experimental set-up is as in table 3. The specific operation is as follows:

(1) Inoculating, namely inoculating cells into a 24-well plate, and incubating for 18-24h at 37 ℃ in a 5% CO2 incubator;

(2) Preparing a test object and a positive control according to the table 3;

(3) Sample feeding according to the test group and concentration settings of Table 3, cells in 24 well plates were plated for 18-24h for group feeding, 3 multiplex wells were set for each treatment group. Adding cell culture medium into the blank control group and the negative control group, adding cell culture medium containing corresponding concentration sample into the sample group, and continuously culturing for 18-24h at 37 ℃ in a 5% CO2 incubator;

(4) LPS induction, namely sucking out the culture medium in the plate after culturing for 18-24 hours, adding PBS for light washing once, adding a blank control group into the cell culture medium, adding a negative control group, a sample group and a positive control group into the cell culture medium containing LPS, continuously culturing for 18-24 hours at 37 ℃, and collecting supernatant after a 5% CO2 incubator;

(5) Detecting the content of inflammatory factors, namely taking cell supernatant of each hole, and detecting the content of the inflammatory factors of cells according to the operation instruction of an ELISA kit;

(6) And (3) data processing, namely processing and plotting all data obtained in the test through Excel software. Statistical analysis was performed using SPSS17.0, and group comparisons were performed using one-way analysis of variance (ANOVA), and differences were judged to be significant when P <0.05, and the results are shown in table 4.

TABLE 3 Table 3

TABLE 4 Table 4

Note that significance is expressed in # for the P value <0.0001, # for the negative control, P value <0.05, # for the P value <0.01, # for the P value <0.0001, # for the P value >0.05, # for ns.

Interleukin-1 beta (IL-1 beta) plays an important role in the immunomodulation and inflammatory response processes, and is thought to be one of the major endogenous mediators of the fever response in the process. IL-1β is a key inflammatory mechanism driving the host's response to Pseudomonas acnes infection, exacerbating skin acne. The test evaluates the ability of examples 1-10 and comparative examples 1-12 to reduce expression and secretion of cellular inflammatory factors based on an LPS-induced mouse macrophage (RAW 264.7) inflammation model, and further predicts the ability of the compositions to inhibit further occurrence of inflammatory reaction, so as to prove the acne removal effect of the composition for preventing recrudescence.

As can be seen from the detection results in Table 4, the average concentration value of the cell inflammatory factor is 31.47-38.71pg/mL after the anti-acne and anti-recurrence composition of examples 1-10 provided by the invention is applied, which indicates that the anti-acne and anti-recurrence composition of the invention has a remarkable inhibition effect on the IL-1β over-expression induced by lipopolysaccharide LPS, wherein the inhibition effect of example 1 is the best.

Comparative example 1 and comparative examples 1 to 12 revealed that the absence of any one of epigallocatechin gallate, brazilin, roselle extract, date palm bark extract, linseed oil unsaponifiable matter, guaiacum extract or the replacement with other functional analogues, the average concentration of the cell inflammatory factor was more than 40pg/mL, indicating that the absence of any one of epigallocatechin gallate, brazilin, roselle extract, date palm bark extract, linseed oil unsaponifiable matter, guaiacum extract or the replacement with other functional analogues, resulted in a decrease in the anti-inflammatory effect of the anti-acne and anti-recurrence composition.

Effect example 2 inhibition test of Propionibacterium acnes

The effect example explores the inhibition effect of the anti-acne and anti-recurrence compositions prepared in examples 1-10 and comparative examples 1-12 on Propionibacterium acnes.

Adding a sample into a bacterial solution with a certain concentration by adopting a 96-well plate crystal violet staining method, enabling the final administration mass concentration to be 200 mug/mL, culturing for 6 days under the anaerobic condition of 37 ℃, discarding floating cells at the upper layer, washing with sterile water, adding formaldehyde for fixing for 10min, standing for 5min after removal, dyeing a biological film with 0.1% crystal violet for 20min, adding 955 ethanol for decolorizing for 15min after removal of dye, taking 100 mug of decolorizing solution into a blank well plate, measuring absorbance at 570nm wavelength by using an enzyme-labeled instrument, calculating the formation percentage of the biological film of each experimental group by taking the biological film without adding the composition as 100%, and the results are shown in table 5.

TABLE 5

Note that significance is expressed in # with P <0.05, P <0.01, P <0.0001, and P >0.05 as ns, respectively, compared to the placebo.

The total detection rate of propionibacterium acnes in the acne facial skin lesions is higher than that of the facial skin of a normal person. Bacteria isolated from skin lesions of the face in acne are mainly propionibacterium acnes, and inhibition of the activity of propionibacterium acnes can effectively improve the severity of acne. The experiment tests the inhibition rate of propionibacterium acnes biological film to evaluate the antibacterial capability of the acne-removing and relapse-preventing composition.

From the experimental results in Table 5, it is shown that the anti-acne and anti-recurrence compositions of examples 1 to 10 of the present invention have a biofilm formation rate of 50.13 to 63.57%, which indicates that the anti-acne and anti-recurrence composition of the present invention has an obvious inhibition effect on Propionibacterium acnes.

Comparative example 1 and comparative examples 1 to 12 revealed that the absence of any one of epigallocatechin gallate, brazilin, roselle extract, date palm bark extract, linseed oil unsaponifiable matter, guaiacum extract or the replacement with other functional analogues, the biofilm formation rate was all greater than 88%, indicating that the absence of any one of epigallocatechin gallate, brazilin, roselle extract, date palm bark extract, linseed oil unsaponifiable matter, guaiacum extract or the replacement with other functional analogues, resulted in a significant decrease in the inhibition effect of the anti-acne and anti-recurrence composition on propionibacterium acnes.

Effect example 3 human efficacy test

The effect examples test the effects of application examples 1 to 11, comparative application examples 1 to 12 and blank application examples on improvement of acne, skin moisture content, redness and oil of human body.

The specific test method is as follows:

184 sensitive skin volunteers (lactic acid stinging score > 3) aged 45-60 were selected according to the cosmetic safety Specification (2015) test and randomly divided into 23 groups of 8 people each, and the volunteers had at least 2-3 obvious acnes. Under normal conditions, the volunteer continuously uses the product on the whole face for 7 days (D7) and then stops using the product for 7 days (T7), the volunteer takes a proper amount of emulsion to be smeared on the face after the volunteer is in the morning and evening after face cleaning and moisturizing, the skin is massaged and absorbed, the acne area can be smeared repeatedly, and the whole face is used for 1 time each in the morning and evening, and is visited every day. The volunteers visited the test area on the day after washing the face without applying any product, and were sitting still for 20min in an air-conditioning room with a temperature of 21+ -1deg.C and a humidity of 50+ -10%. The improvement of the face acne index was quantified and photographed by an instrument, including Visia (IPP) test of the red area a of the face, acne count (classification count: acne, pimple, respectively assessed by VISIA and doctor), TEWAMETER TM Hex test of the percutaneous water loss TEWL, sebumeter SM 815 test of the amount of grease. The improvement ratio before and after use = (X pre-use average value-X post-use average value)/X pre-use average value X100%, and the calculation results are shown in table 6.

TABLE 6

Note that the differences were statistically significant (P < 0.05) compared to the blank application.

From the experimental results in table 6, it is known that the anti-acne emulsion of examples 1 to 11 of the present invention has a D7 improvement rate of 38.1 to 43.8%, a T7 improvement rate of 17.2 to 23.5%, a pimple D7 improvement rate of 28.5 to 34.6%, a T7 improvement rate of 15.1 to 19.8%, a TEWL D7 improvement rate of 15.3 to 19.4%, a T7 improvement rate of 7.6 to 11.3%, a red area a of the face having a D7 improvement rate of 24.0 to 30.8%, a T7 improvement rate of 15.2 to 19.5%, a fat amount having a D7 improvement rate of 22.0 to 25.8%, a T7 improvement rate of 14.3 to 18.3%, and shows that the anti-acne and anti-recurrence composition of the present invention can effectively improve acne, pimple, a, TEWL and fat amount of sensitive skin, i.e., has good anti-acne, repairing and oil control effects.

From application examples 1 and comparative application examples 1 to 12, it is known that the absence of any one of epigallocatechin gallate, brazil sappan extract, roselle flower extract, date tree bark extract, linseed oil unsaponifiable matter, guaiac extract or the replacement with other functional analogues, the D7 improvement rate of acne is less than 19%, the T7 improvement rate is less than 4%, the D7 improvement rate of pimple is less than 13%, the T7 improvement rate is less than 5%, the D7 improvement rate of TEWL is less than 6.5%, the T7 improvement rate is less than 1%, the D7 improvement rate of facial red area a is less than 12%, the T7 improvement rate is less than 3%, the D7 improvement rate of the amount of grease is less than 10%, the T7 improvement rate is less than 3%, indicates that the absence of any one of epigallocatechin gallate glucoside, brazilin, roselle flower extract, date tree bark extract, linseed oil unsaponifiable matter, guaiac extract or the replacement with other functional analogues, results in remarkable anti-acne, anti-recurrence, anti-acne, anti-recurrence, and anti-acne compositions.

Finally, it should be noted that the above-mentioned embodiments illustrate rather than limit the scope of the invention, and that those skilled in the art will understand that the technical scheme of the invention may be modified or equally substituted without departing from the spirit and scope of the technical scheme of the invention.

Claims (7)

1. The acne-removing and relapse-preventing composition is characterized by comprising, by weight, 0.01-3 parts of epigallocatechin gallate glucoside, 0.001-0.3 part of brazilin, 1-15 parts of roselle flower extract, 0.1-1 part of jujube bark extract, 0.01-3 parts of linseed oil unsaponifiable matter and 1-15 parts of guaiac extract;

The preparation method of the roselle pollen extract comprises the steps of adding roselle pollen into an acidified ethanol solution, extracting the roselle pollen and the acidified ethanol solution for 30min under the ultrasonic conditions of 140kHz and 50 ℃ for 3 times, centrifuging the obtained product at the rotating speed of 3000r/min for 15min after the extraction is finished, and rotationally concentrating the supernatant to remove ethanol to obtain the roselle pollen extract, wherein the preparation method of the acidified ethanol solution comprises the steps of adding hydrochloric acid into an ethanol aqueous solution with the volume fraction of 60%, and uniformly mixing to obtain an acidified ethanol solution with the pH of=3;

The preparation method of the jujube bark extract comprises the steps of drying commercial jujube bark to constant weight, crushing, sieving with a 100-mesh sieve, collecting undersize, weighing 1g of undersize powder, adding into 15mL of 70% ethanol solution, soaking for 48 hours at 60 ℃, filtering after soaking, collecting filtrate, concentrating under reduced pressure, and drying to obtain the jujube bark extract.

2. The acne-removing and relapse-preventing composition according to claim 1, wherein the acne-removing and relapse-preventing composition comprises, by weight, 0.05-1 part of epigallocatechin gallate, 0.005-0.1 part of brazilin, 3-10 parts of roselle extract, 0.1-0.5 part of date tree bark extract, 0.05-1 part of linseed oil unsaponifiable matter and 1-8 parts of guaiac extract.

3. The acne-removing and relapse-preventing composition according to claim 1, wherein the acne-removing and relapse-preventing composition comprises, by weight, 0.5-1 part of epigallocatechin gallate glucoside, 0.01-0.1 part of brazilin, 3-8 parts of roselle extract, 0.15-0.5 part of date tree bark extract, 0.08-0.5 part of linseed oil unsaponifiable matter and 2-5 parts of guaiacum extract.

4. Use of the acne-removing relapse prevention composition according to any one of claims 1 to 3 in the preparation of cosmetics.

5. A cosmetic comprising the acne-removing and recurrence-preventing composition according to any one of claims 1 to 3, wherein the content of the acne-removing and recurrence-preventing composition in the cosmetic is 0.1 to 3wt%.

6. The cosmetic according to claim 5, wherein the cosmetic is an anti-acne emulsion, and the anti-acne emulsion comprises, by mass, 0.1-3% of an anti-acne and anti-recurrence composition, 0.05-5% of a thickener, 3-20% of a humectant, 0.5-10% of an emulsifier, 0.2-5% of a preservative, 0.05-0.1% of a pH regulator, and the balance of water.

7. The cosmetic product of claim 6, wherein the thickener comprises at least one of xanthan gum, carbomer, acrylamide dimethyl taurate/VP copolymer, cellulose;

and/or the humectant comprises at least one of glycerin, butylene glycol, sodium hyaluronate;

and/or the emulsifier comprises at least one of coco-caprylate/caprate, polydimethylsiloxane, hydrogenated palm kernel oil, cetostearyl alcohol, polyglycerol-6 distearate, and polymethylsilsesquioxane;

And/or the preservative comprises at least one of 1, 3-propanediol, 1, 2-hexanediol and p-hydroxyacetophenone;

And/or the pH regulator comprises at least one of arginine and disodium ethylenediamine tetraacetate.