WO2003100036A3 - Sulfolipides antiretroviraux extraits de spirulines, leur procede d'obtention, les compositions les contenant et leur utilisation comme inhibiteurs de la transcriptase inverse des virus vih. - Google Patents

Sulfolipides antiretroviraux extraits de spirulines, leur procede d'obtention, les compositions les contenant et leur utilisation comme inhibiteurs de la transcriptase inverse des virus vih. Download PDF

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Publication number
WO2003100036A3
WO2003100036A3 PCT/FR2003/001612 FR0301612W WO03100036A3 WO 2003100036 A3 WO2003100036 A3 WO 2003100036A3 FR 0301612 W FR0301612 W FR 0301612W WO 03100036 A3 WO03100036 A3 WO 03100036A3
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WO
WIPO (PCT)
Prior art keywords
sulpholipids
same
spirulinae
inhibitors
extracted
Prior art date
Application number
PCT/FR2003/001612
Other languages
English (en)
Other versions
WO2003100036A2 (fr
Inventor
Quoc Kiet Pham
Hubert Durand-Chastel
Original Assignee
Quoc Kiet Pham
Hubert Durand-Chastel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quoc Kiet Pham, Hubert Durand-Chastel filed Critical Quoc Kiet Pham
Priority to AU2003255611A priority Critical patent/AU2003255611A1/en
Priority to US10/512,858 priority patent/US20050245463A1/en
Priority to MXPA04011901A priority patent/MXPA04011901A/es
Publication of WO2003100036A2 publication Critical patent/WO2003100036A2/fr
Publication of WO2003100036A3 publication Critical patent/WO2003100036A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/748—Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/06—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical being a hydroxyalkyl group esterified by a fatty acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P11/00—Preparation of sulfur-containing organic compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouveaux sulfolipides extraits de spirulines, leur procédé d'obtention, les compositions les contenant et leur utilisation comme inhibiteurs des virus VIH-1 et VIH-2. L'invention concerne également une biomasse de spirulines riche en sulfolipides ayant une activité inhibitrice de la transcriptase inverse de VIH-1 et VIH-2, ainsi que l'utilisation desdits sulfolipides ou d'un extrait de biomasse de spiruline riche en sulfolipides pour la préparation d'un médicament pour le traitement prophylactique ou curatif du SIDA.
PCT/FR2003/001612 2002-05-29 2003-05-28 Sulfolipides antiretroviraux extraits de spirulines, leur procede d'obtention, les compositions les contenant et leur utilisation comme inhibiteurs de la transcriptase inverse des virus vih. WO2003100036A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003255611A AU2003255611A1 (en) 2002-05-29 2003-05-28 Novel antiretroviral sulpholipids extracted from spirulinae, method for obtaining same, compositions containing same and use thereof as inhibitors of the hiv virus reverse transcriptase
US10/512,858 US20050245463A1 (en) 2002-05-29 2003-05-28 Novel antiretroviral sulfolipids extracted from spirulinae, method for obtaining same, compositions containing same and use thereof as inhibitors of the hiv virus reverse transcriptase
MXPA04011901A MXPA04011901A (es) 2002-05-29 2003-05-28 Sulfolipidos antiretrovirales novedosos extraidos de las espirulinas, metodo para obtenerlos, composiciones que los contienen y uso de los mismos como inhibidores de la transcriptasa inversa del virus vih.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR02/06546 2002-05-29
FR0206546A FR2840318B1 (fr) 2002-05-29 2002-05-29 Nouveaux sulfolipides antiretroviraux extraits de spirulines, leur procede d'obtention, les compositions les contenant et leur utilisation comme inhibiteurs de la transcriptase inverse des virus vih

Publications (2)

Publication Number Publication Date
WO2003100036A2 WO2003100036A2 (fr) 2003-12-04
WO2003100036A3 true WO2003100036A3 (fr) 2004-05-06

Family

ID=29558799

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2003/001612 WO2003100036A2 (fr) 2002-05-29 2003-05-28 Sulfolipides antiretroviraux extraits de spirulines, leur procede d'obtention, les compositions les contenant et leur utilisation comme inhibiteurs de la transcriptase inverse des virus vih.

Country Status (6)

Country Link
US (1) US20050245463A1 (fr)
CN (1) CN100404662C (fr)
AU (1) AU2003255611A1 (fr)
FR (1) FR2840318B1 (fr)
MX (1) MXPA04011901A (fr)
WO (1) WO2003100036A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD2516C2 (ro) * 2004-04-07 2005-03-31 Валериу РУДИК Remediu medicamentos antiinflamator, antiseptic şi antifungic sub formă de gel
WO2006078284A2 (fr) * 2004-05-04 2006-07-27 University Of South Carolina Methodes et compositions de traitement antiviral faisant appel a des algues et a des cyanobacteries
MD2671G2 (ro) * 2004-08-10 2005-08-31 Валериу РУДИК Remediu medicamentos antivirotic şi antiherpetic sub formă de gel
CA2810928A1 (fr) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Analogues nucleotidiques substitues
CA2860234A1 (fr) 2011-12-22 2013-06-27 Alios Biopharma, Inc. Analogues de nucleotide phosphorothioate substitue
CN104321333A (zh) 2012-03-21 2015-01-28 沃泰克斯药物股份有限公司 硫代氨基磷酸酯核苷酸前药的固体形式
WO2013142157A1 (fr) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Combinaisons pharmaceutiques comprenant un analogue thionucléotidique
JP6765371B2 (ja) * 2014-07-24 2020-10-07 リーテファックス ベーフェー アジュバント
KR20170025977A (ko) * 2015-08-31 2017-03-08 재단법인차세대융합기술연구원 옥시리스 마리나로부터 분리된 신규 화합물
CN107778337B (zh) * 2016-08-26 2020-12-08 国投生物科技投资有限公司 超临界二氧化碳萃取螺旋藻中糖脂的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002521A1 (fr) * 1989-08-15 1991-03-07 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce Compositions antivirales contenant des derives de glycerol de sulfoquinovosyle et des analogues de ceux-ci et procedes les utilisant
FR2768744A1 (fr) * 1997-09-19 1999-03-26 Quoc Kiet Pham Procede de culture mixotrophique de spirulines pour la production d'une biomasse riche en acides gras polyinsatures omega 6 et/ou en sulfolipides
EP1172107A1 (fr) * 1999-02-26 2002-01-16 Toyo Suisan Kaisha, Ltd. Medicaments contenant des derives du sulfopyranosylacylglycerol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5456924A (en) * 1988-12-23 1995-10-10 Immunotec Research Corporation Ltd. Method of treatment of HIV-seropositive individuals with dietary whey proteins
SE9601677D0 (sv) * 1996-05-02 1996-05-02 Scotia Lipidteknik Ab New use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002521A1 (fr) * 1989-08-15 1991-03-07 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce Compositions antivirales contenant des derives de glycerol de sulfoquinovosyle et des analogues de ceux-ci et procedes les utilisant
FR2768744A1 (fr) * 1997-09-19 1999-03-26 Quoc Kiet Pham Procede de culture mixotrophique de spirulines pour la production d'une biomasse riche en acides gras polyinsatures omega 6 et/ou en sulfolipides
EP1172107A1 (fr) * 1999-02-26 2002-01-16 Toyo Suisan Kaisha, Ltd. Medicaments contenant des derives du sulfopyranosylacylglycerol

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
AYEHUNIE S ET AL: "INHIBITION OF HIV-1 REPLICATION BY AN AQUEOUS EXTRACT OF SPIRULINA PLATENSIS (ARTHROSPIRA PLATENSIS)", JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, LIPPINCOT-RAVEN, XX, vol. 18, no. 1, 1998, pages 7 - 12, XP001055551, ISSN: 1077-9450 *
BLINKOVA L P ET AL: "Biological activity of Spirulina platensis.", ZHURNAL MIKROBIOLOGII EPIDEMIOLOGII I IMMUNOBIOLOGII, no. 2, March 2001 (2001-03-01), pages 114 - 118, XP008012772, ISSN: 0372-9311 *
D.M. GORDON ET AL: "synthesis of a Cyanobacterial sulfolipid: Confirmation of its structure, stereochemistry, and Anti-HIV-1 activity", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 114, 1992, pages 659 - 663, XP002271064 *
DURAND-CHASTEL HUBERT: "Production of Spirulina biomass rich in gamma-linolenic acid and sulfolipids.", BULLETIN DE L'INSTITUT OCEANOGRAPHIQUE (MONACO), no. SPEC. ISSUE 19, 1999, pages 541 - 546, XP008012812, ISSN: 0304-5722 *
GUSTAFSON K R ET AL: "AIDS-ANTIVIRAL SULFOLIPIDS FROM CYANOBACTERIA (BLUE-GREEN ALGAE)", JOURNAL OF THE NATIONAL CANCER INSTITUTE, US DEPT. OF HEALTH, EDICATIONAND WELFARE, PUBLIC HEALTH, US, vol. 81, no. 16, 16 August 1989 (1989-08-16), pages 1254 - 1258, XP001055127, ISSN: 0027-8874 *
HANASHIMA S ET AL: "STRUCTURE-ACTIVITY RELATIONSHIP OF A NOVEL GROUP OF MAMMALIAN DNA POLYMERASE INHIBITORS SYNHTHETIC SULFOQUINOVOSYLACYLGLYCEROLS", JAPANESE JOURNAL OF CANCER RESEARCH, JAPANESE CANCER ASSOCIATION, TOKYO, JP, vol. 91, October 2000 (2000-10-01), pages 1073 - 1083, XP002945479, ISSN: 0910-5050 *
KIET PHAM QUOC ET AL: "Biosynthesis of eukaryotic lipid molecular species by the cyanobacterium Spirulina platensis", BIOCHIMICA AND BIOPHYSICA ACTA, vol. 1168, 1993, pages 94 - 99, XP008012741 *
KIET PHAM QUOC ET AL: "Effect of growth temperature on the biosynthesis of eukaryotic lipid molecular species by the cyanobacterium Spirulina platensis", BIOCHIMICA BIOPHYSICA ACTA, vol. 1346, no. 3, 23 June 1997 (1997-06-23), pages 237 - 246, XP002055201 *
MORIMOTO T ET AL: "STUDIES ON GLYCOLIPIDS. VII. ISOLATION OF TWO NEW SULFOQUINOVOSYL DIACYLGLYCEROLS FROM THE GREEN ALGA CHLORELLA VULGARIS", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, JP, vol. 41, no. 9, 1993, pages 1545 - 1548, XP002928282, ISSN: 0009-2363 *
S. LOYA ET AL: "The inhibition of the Reverse transcriptase of HIV-1 by the natural Sulfoglycolipids from cyanobacteria: Contribution of different moieties to their high potency", JOURNAL OF NATURAL PRODUCTS, vol. 61, 1998, pages 891 - 895, XP002228775 *
XUE CHANGHU ET AL: "Molecular species composition of glycolipids from Sprirulina platensis.", FOOD CHEMISTRY, vol. 77, no. 1, May 2002 (2002-05-01), May, 2002, pages 9 - 13, XP002228776, ISSN: 0308-8146 *

Also Published As

Publication number Publication date
MXPA04011901A (es) 2005-03-31
WO2003100036A2 (fr) 2003-12-04
CN100404662C (zh) 2008-07-23
US20050245463A1 (en) 2005-11-03
FR2840318A1 (fr) 2003-12-05
FR2840318B1 (fr) 2004-12-03
AU2003255611A1 (en) 2003-12-12
CN1656212A (zh) 2005-08-17

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