WO2003076561A3 - Proteine de fusion a recombinase presentant un apport cellulaire ameliore - Google Patents
Proteine de fusion a recombinase presentant un apport cellulaire ameliore Download PDFInfo
- Publication number
- WO2003076561A3 WO2003076561A3 PCT/EP2003/002280 EP0302280W WO03076561A3 WO 2003076561 A3 WO2003076561 A3 WO 2003076561A3 EP 0302280 W EP0302280 W EP 0302280W WO 03076561 A3 WO03076561 A3 WO 03076561A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fusion protein
- recombinase
- cellular uptake
- domain
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003210422A AU2003210422A1 (en) | 2002-03-09 | 2003-03-06 | Recombinase fusion protein with enhanced cellular uptake |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02005468.0 | 2002-03-09 | ||
EP02005468A EP1342781A1 (fr) | 2002-03-09 | 2002-03-09 | Protéine de fusion de recombinase avec une assimilation cellulaire accrue |
US36379702P | 2002-03-13 | 2002-03-13 | |
US60/363,797 | 2002-03-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003076561A2 WO2003076561A2 (fr) | 2003-09-18 |
WO2003076561A3 true WO2003076561A3 (fr) | 2004-01-22 |
Family
ID=27806514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2003/002280 WO2003076561A2 (fr) | 2002-03-09 | 2003-03-06 | Proteine de fusion a recombinase presentant un apport cellulaire ameliore |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2003210422A1 (fr) |
WO (1) | WO2003076561A2 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8927691B2 (en) | 2003-10-24 | 2015-01-06 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
US8952133B2 (en) | 2003-10-24 | 2015-02-10 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to target tissue |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2530248A1 (fr) * | 2003-06-25 | 2005-01-06 | Gencia Corporation | Vecteurs modifies pour la transfection d'organite |
US8062891B2 (en) | 2003-10-24 | 2011-11-22 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to plants |
ES2411962T3 (es) | 2003-10-24 | 2013-07-09 | Gencia Corporation | Métodos y composiciones para suministrar polinucleótidos |
JPWO2007132555A1 (ja) * | 2006-05-11 | 2009-09-24 | 国立大学法人 東京大学 | 細胞膜透過性ペプチドと細胞内におけるその使用 |
WO2008109010A1 (fr) | 2007-03-02 | 2008-09-12 | Arbor Vita Corporation | Traitement des incidents cérébrovasculaires et d'autres maladies sans inhibition des canaux calcium de type n |
JP5709013B2 (ja) | 2009-04-10 | 2015-04-30 | 東亞合成株式会社 | 神経分化誘導ペプチド及びその利用 |
WO2011013700A1 (fr) | 2009-07-29 | 2011-02-03 | 東亞合成株式会社 | Fragment peptidique de support et son utilisation |
WO2011013698A1 (fr) | 2009-07-29 | 2011-02-03 | 東亞合成株式会社 | Fragment peptidique support et son utilisation |
JP5792625B2 (ja) | 2009-11-02 | 2015-10-14 | 東亞合成株式会社 | 細胞増殖促進ペプチド及びその利用 |
WO2011152524A1 (fr) | 2010-06-04 | 2011-12-08 | 東亞合成株式会社 | Peptide favorisant la croissance cellulaire et son utilisation |
US9238796B2 (en) | 2010-06-04 | 2016-01-19 | Toagosei Co. Ltd. | Cell growth-promoting peptide and use thereof |
JP6066222B2 (ja) | 2012-05-28 | 2017-01-25 | 東亞合成株式会社 | 抗菌ペプチド及びその利用 |
WO2014061749A1 (fr) | 2012-10-18 | 2014-04-24 | 東亞合成株式会社 | Peptide synthétique capable de supprimer l'expression du récepteur du tnf de type 2, et son utilisation |
US9943611B2 (en) * | 2012-11-01 | 2018-04-17 | California Institute Of Technology | Reversible gene expression |
JP6425161B2 (ja) * | 2014-04-30 | 2018-11-21 | 国立大学法人名古屋大学 | 投射経路選択的な遺伝子発現制御 |
EP3334756B1 (fr) * | 2015-08-10 | 2020-06-17 | Cellivery Therapeutics, Inc. | Protéine recombinée cre à perméabilité cellulaire améliorée (icp-cre) et son utilisation |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001086989A (ja) * | 1999-09-17 | 2001-04-03 | Univ Osaka | 哺乳類型Creリコンビナーゼ遺伝子 |
WO2001049832A2 (fr) * | 2000-01-07 | 2001-07-12 | Artemis Pharmaceuticals Gmbh | Transduction de recombinases pour ciblage genetique inductible |
-
2003
- 2003-03-06 WO PCT/EP2003/002280 patent/WO2003076561A2/fr not_active Application Discontinuation
- 2003-03-06 AU AU2003210422A patent/AU2003210422A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001086989A (ja) * | 1999-09-17 | 2001-04-03 | Univ Osaka | 哺乳類型Creリコンビナーゼ遺伝子 |
GB2355718A (en) * | 1999-09-17 | 2001-05-02 | Osaka University The President | Modified cre recombinase gene |
WO2001049832A2 (fr) * | 2000-01-07 | 2001-07-12 | Artemis Pharmaceuticals Gmbh | Transduction de recombinases pour ciblage genetique inductible |
Non-Patent Citations (3)
Title |
---|
DATABASE EMBL [online] 23 August 2001 (2001-08-23), UNIV OSAKA: "Mammalian Cre recombinase", XP002200325, Database accession no. AAB98695 * |
HODEL ET AL.: "Dissection of a Nuclear Localization Signal", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 2, 12 January 2001 (2001-01-12), pages 1317 - 1325, XP002200324 * |
JO ET AL.: "Epigenetic regulation of gene structure and function with a cell-permeable Cre recombinase", NATURE BIOTECHNOLOGY, vol. 19, October 2001 (2001-10-01), pages 929 - 933, XP002200323 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8927691B2 (en) | 2003-10-24 | 2015-01-06 | Gencia Corporation | Transducible polypeptides for modifying metabolism |
US8952133B2 (en) | 2003-10-24 | 2015-02-10 | Gencia Corporation | Nonviral vectors for delivering polynucleotides to target tissue |
Also Published As
Publication number | Publication date |
---|---|
WO2003076561A2 (fr) | 2003-09-18 |
AU2003210422A8 (en) | 2003-09-22 |
AU2003210422A1 (en) | 2003-09-22 |
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