WO2003074721A3 - Procede de fabrication de riboflavine - Google Patents

Procede de fabrication de riboflavine Download PDF

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Publication number
WO2003074721A3
WO2003074721A3 PCT/EP2003/002101 EP0302101W WO03074721A3 WO 2003074721 A3 WO2003074721 A3 WO 2003074721A3 EP 0302101 W EP0302101 W EP 0302101W WO 03074721 A3 WO03074721 A3 WO 03074721A3
Authority
WO
WIPO (PCT)
Prior art keywords
producing riboflavin
transcription terminators
riboflavin
producing
transcription
Prior art date
Application number
PCT/EP2003/002101
Other languages
German (de)
English (en)
Other versions
WO2003074721A2 (fr
Inventor
Henning Althoefer
Original Assignee
Basf Ag
Henning Althoefer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag, Henning Althoefer filed Critical Basf Ag
Priority to JP2003573166A priority Critical patent/JP2005527200A/ja
Priority to EP03704701A priority patent/EP1483398A2/fr
Priority to AU2003206964A priority patent/AU2003206964A1/en
Priority to CA002477849A priority patent/CA2477849A1/fr
Priority to KR10-2004-7013634A priority patent/KR20040096643A/ko
Publication of WO2003074721A2 publication Critical patent/WO2003074721A2/fr
Publication of WO2003074721A3 publication Critical patent/WO2003074721A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P25/00—Preparation of compounds containing alloxazine or isoalloxazine nucleus, e.g. riboflavin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

L'invention concerne des terminateurs de transcription, un organisme contenant au moins un de ces terminateurs de transcription, ainsi qu'un procédé de fabrication de riboflavine. Ledit procédé consiste à cultiver un organisme capable de produire de la riboflavine, comportant au moins un de ces terminateurs de transcription, le terminateur de transcription correspondant étant combiné de façon fonctionnelle à au moins un gène « rib ».
PCT/EP2003/002101 2002-03-02 2003-02-28 Procede de fabrication de riboflavine WO2003074721A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2003573166A JP2005527200A (ja) 2002-03-02 2003-02-28 リボフラビン製造法
EP03704701A EP1483398A2 (fr) 2002-03-02 2003-02-28 Procede de fabrication de riboflavine
AU2003206964A AU2003206964A1 (en) 2002-03-02 2003-02-28 Method for producing riboflavin
CA002477849A CA2477849A1 (fr) 2002-03-02 2003-02-28 Procede de fabrication de riboflavine
KR10-2004-7013634A KR20040096643A (ko) 2002-03-02 2003-02-28 리보플라빈의 제조 방법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10209363.6 2002-03-02
DE10209363A DE10209363A1 (de) 2002-03-02 2002-03-02 Verfahren zur Herstellung von Riboflavin

Publications (2)

Publication Number Publication Date
WO2003074721A2 WO2003074721A2 (fr) 2003-09-12
WO2003074721A3 true WO2003074721A3 (fr) 2003-12-24

Family

ID=27740616

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/002101 WO2003074721A2 (fr) 2002-03-02 2003-02-28 Procede de fabrication de riboflavine

Country Status (8)

Country Link
EP (1) EP1483398A2 (fr)
JP (1) JP2005527200A (fr)
KR (1) KR20040096643A (fr)
CN (1) CN1639353A (fr)
AU (1) AU2003206964A1 (fr)
CA (1) CA2477849A1 (fr)
DE (1) DE10209363A1 (fr)
WO (1) WO2003074721A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4520219B2 (ja) * 2004-05-28 2010-08-04 協和発酵バイオ株式会社 ５−アミノレブリン酸の製造法
KR101335853B1 (ko) * 2011-12-01 2013-12-02 씨제이제일제당 (주) Ｌ-아미노산 및 리보플라빈을 동시에 생산하는 미생물 및 이를 이용한 ｌ-아미노산 및 리보플라빈을 생산하는 방법
CN106434819A (zh) * 2016-12-22 2017-02-22 广济药业（孟州）有限公司 一种提高枯草芽孢杆菌发酵生产核黄素的产量的方法
CN110964769B (zh) * 2019-11-29 2022-11-11 河南巨龙生物工程股份有限公司 一种提高枯草芽孢杆菌发酵生产核黄素收率的方法
CN113801910A (zh) * 2021-08-30 2021-12-17 湖北广济药业股份有限公司 一种纯天然核黄素的制备方法
CN113755551A (zh) * 2021-09-30 2021-12-07 天津科技大学 一种提高核黄素产量的发酵方法
CN113817654B (zh) * 2021-11-08 2023-06-20 通辽梅花生物科技有限公司 一种生产核黄素的发酵培养基及发酵方法
KR20230168477A (ko) * 2022-06-07 2023-12-14 씨제이제일제당 (주) 리보플라빈 생산능이 향상된 코리네박테리움 속 미생물 및 이를 이용한 리보플라빈을 생산하는 방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995026406A2 (fr) * 1994-03-25 1995-10-05 Basf Aktiengesellschaft Biosynthese de la riboflavine dans des champignons
EP0821063A2 (fr) * 1996-07-24 1998-01-28 F. Hoffmann-La Roche Ag Production améliorée de riboflavine
WO1999061623A2 (fr) * 1998-05-28 1999-12-02 Basf Aktiengesellschaft Procede genetique de production de riboflavine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995026406A2 (fr) * 1994-03-25 1995-10-05 Basf Aktiengesellschaft Biosynthese de la riboflavine dans des champignons
EP0821063A2 (fr) * 1996-07-24 1998-01-28 F. Hoffmann-La Roche Ag Production améliorée de riboflavine
US6322995B1 (en) * 1996-07-24 2001-11-27 F. Hoffmann-La Roche Ag Riboflavin production
WO1999061623A2 (fr) * 1998-05-28 1999-12-02 Basf Aktiengesellschaft Procede genetique de production de riboflavine

Also Published As

Publication number Publication date
AU2003206964A8 (en) 2003-09-16
EP1483398A2 (fr) 2004-12-08
KR20040096643A (ko) 2004-11-16
WO2003074721A2 (fr) 2003-09-12
CN1639353A (zh) 2005-07-13
AU2003206964A1 (en) 2003-09-16
DE10209363A1 (de) 2003-09-11
JP2005527200A (ja) 2005-09-15
CA2477849A1 (fr) 2003-09-12

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