WO2003070918A3 - Rna interference by modified short interfering nucleic acid - Google Patents
Rna interference by modified short interfering nucleic acid Download PDFInfo
- Publication number
- WO2003070918A3 WO2003070918A3 PCT/US2003/005346 US0305346W WO03070918A3 WO 2003070918 A3 WO2003070918 A3 WO 2003070918A3 US 0305346 W US0305346 W US 0305346W WO 03070918 A3 WO03070918 A3 WO 03070918A3
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- nucleic acid
- rna
- short interfering
- rna interference
- interfering nucleic
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- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
Abstract
Priority Applications (231)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003569811A JP2005517438A (en) | 2002-02-20 | 2003-02-20 | RNA interference-mediated inhibition of gene expression using chemically modified short interfering nucleic acids (siNA) |
CA002459532A CA2459532A1 (en) | 2002-02-20 | 2003-02-20 | Rna interference by modified short interfering nucleic acid |
GB0406022A GB2397818B (en) | 2002-02-20 | 2003-02-20 | Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
AU2003221258A AU2003221258B2 (en) | 2002-02-20 | 2003-02-20 | RNA interference by modified short interfering nucleic acid |
EP03716126A EP1458741B1 (en) | 2002-02-20 | 2003-02-20 | Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
US10/424,339 US20060127891A1 (en) | 2002-02-20 | 2003-04-25 | RNA interference mediated inhibition of MAP kinase gene expression or expression of genes involved in MAP kinase pathway using short interfering nucleic acid (siNA) |
US10/427,160 US7833992B2 (en) | 2001-05-18 | 2003-04-30 | Conjugates and compositions for cellular delivery |
US10/444,853 US8202979B2 (en) | 2002-02-20 | 2003-05-23 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
PCT/US2003/018911 WO2003106476A1 (en) | 2002-02-20 | 2003-06-16 | Nucleic acid mediated inhibition of enterococcus infection and cytolysin toxin activity |
US10/607,933 US20080032942A1 (en) | 2000-08-30 | 2003-06-27 | RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA) |
US10/652,791 US20050106726A1 (en) | 2002-02-20 | 2003-08-29 | RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA) |
US10/693,059 US20080039414A1 (en) | 2002-02-20 | 2003-10-23 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US10/720,448 US8273866B2 (en) | 2002-02-20 | 2003-11-24 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA) |
US10/724,270 US20050080031A1 (en) | 2001-05-18 | 2003-11-26 | Nucleic acid treatment of diseases or conditions related to levels of Ras, HER2 and HIV |
US10/727,780 US20050233329A1 (en) | 2002-02-20 | 2003-12-03 | Inhibition of gene expression using duplex forming oligonucleotides |
US10/757,803 US20050020525A1 (en) | 2002-02-20 | 2004-01-14 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US10/780,447 US7491805B2 (en) | 2001-05-18 | 2004-02-13 | Conjugates and compositions for cellular delivery |
US10/783,128 US20050096284A1 (en) | 2002-02-20 | 2004-02-20 | RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA) |
US10/798,090 US20050014172A1 (en) | 2002-02-20 | 2004-03-11 | RNA interference mediated inhibition of muscarinic cholinergic receptor gene expression using short interfering nucleic acid (siNA) |
US10/800,487 US20050048529A1 (en) | 2002-02-20 | 2004-03-15 | RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA) |
US10/824,036 US20050191638A1 (en) | 2002-02-20 | 2004-04-14 | RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA) |
US10/825,485 US20060160757A1 (en) | 2002-02-20 | 2004-04-15 | RNA interference mediated inhibition hairless of (HR) gene expression using short interfering nucleic acid (siNA) |
US10/826,966 US20050032733A1 (en) | 2001-05-18 | 2004-04-16 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA) |
US10/831,620 US20050148530A1 (en) | 2002-02-20 | 2004-04-23 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US10/830,569 US20050054598A1 (en) | 2002-02-20 | 2004-04-23 | RNA interference mediated inhibition hairless (HR) gene expression using short interfering nucleic acid (siNA) |
US10/832,522 US20050233996A1 (en) | 2002-02-20 | 2004-04-26 | RNA interference mediated inhibition of hairless (HR) gene expression using short interfering nucleic acid (siNA) |
US10/840,731 US20050137153A1 (en) | 2002-02-20 | 2004-05-06 | RNA interference mediated inhibition of alpha-1 antitrypsin (AAT) gene expression using short interfering nucleic acid (siNA) |
US10/844,076 US7176304B2 (en) | 2002-02-20 | 2004-05-11 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US10/844,072 US20050159376A1 (en) | 2002-02-20 | 2004-05-12 | RNA interference mediated inhibition 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA) |
US10/557,542 US20070032441A1 (en) | 2001-05-18 | 2004-05-24 | Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina) |
US10/861,060 US20050137155A1 (en) | 2001-05-18 | 2004-06-03 | RNA interference mediated treatment of Parkinson disease using short interfering nucleic acid (siNA) |
US10/864,044 US20050171040A1 (en) | 2001-05-18 | 2004-06-09 | RNA interference mediated inhibition of cholesteryl ester transfer protein (CEPT) gene expression using short interfering nucleic acid (siNA) |
US10/863,973 US20050143333A1 (en) | 2001-05-18 | 2004-06-09 | RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA) |
US10/869,638 US20050119211A1 (en) | 2001-05-18 | 2004-06-16 | RNA mediated inhibition connexin gene expression using short interfering nucleic acid (siNA) |
US10/871,222 US20050119212A1 (en) | 2001-05-18 | 2004-06-18 | RNA interference mediated inhibition of FAS and FASL gene expression using short interfering nucleic acid (siNA) |
US10/562,561 US20060247194A1 (en) | 2000-08-30 | 2004-06-25 | Rna interference mediated treatment of alzheimer's disease using short interfering nucleic acid (sina) |
US10/877,889 US20050209179A1 (en) | 2000-08-30 | 2004-06-25 | RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA) |
US10/879,867 US20050124566A1 (en) | 2001-05-18 | 2004-06-28 | RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA) |
US10/881,580 US20060142225A1 (en) | 2001-05-18 | 2004-06-30 | RNA interference mediated inhibition of cyclin dependent kinase-2 (CDK2) gene expression using short interfering nucleic acid (siNA) |
US10/881,118 US20050130181A1 (en) | 2001-05-18 | 2004-06-30 | RNA interference mediated inhibition of wingless gene expression using short interfering nucleic acid (siNA) |
US10/883,218 US20050124567A1 (en) | 2001-05-18 | 2004-07-01 | RNA interference mediated inhibition of TRPM7 gene expression using short interfering nucleic acid (siNA) |
US10/888,269 US20050222064A1 (en) | 2002-02-20 | 2004-07-09 | Polycationic compositions for cellular delivery of polynucleotides |
US10/888,226 US20050124568A1 (en) | 2001-05-18 | 2004-07-09 | RNA interference mediated inhibition of acetyl-CoA-carboxylase gene expression using short interfering nucleic acid (siNA) |
US10/893,010 US20050164224A1 (en) | 2001-05-18 | 2004-07-16 | RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA) |
US10/892,922 US20050124569A1 (en) | 2001-05-18 | 2004-07-16 | RNA interference mediated inhibition of CXCR4 gene expression using short interfering nucleic acid (siNA) |
US10/894,475 US20050070497A1 (en) | 2001-05-18 | 2004-07-19 | RNA interference mediated inhibtion of tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA) |
US10/898,660 US20050196765A1 (en) | 2001-05-18 | 2004-07-23 | RNA interference mediated inhibition of checkpoint Kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA) |
US10/898,311 US20050277608A1 (en) | 2001-05-18 | 2004-07-23 | RNA interference mediated inhibtion of vitamin D receptor gene expression using short interfering nucleic acid (siNA) |
US10/897,902 US20050176663A1 (en) | 2001-05-18 | 2004-07-23 | RNA interference mediated inhibition of protein tyrosine phosphatase type IVA (PRL3) gene expression using short interfering nucleic acid (siNA) |
US10/903,128 US20050182006A1 (en) | 2001-05-18 | 2004-07-30 | RNA interference mediated inhibition of protein kinase C alpha (PKC-alpha) gene expression using short interfering nucleic acid (siNA) |
US10/567,888 US20070093437A1 (en) | 2001-05-18 | 2004-08-06 | Rna interference mediated inhibition of xiap gene expression using short interfering nucleic acid (sina) |
US10/916,095 US20050158735A1 (en) | 2001-05-18 | 2004-08-11 | RNA interference mediated inhibition of proliferating cell nuclear antigen (PCNA) gene expression using short interfering nucleic acid (siNA) |
US10/915,896 US20050159378A1 (en) | 2001-05-18 | 2004-08-11 | RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA) |
US10/916,030 US20050159379A1 (en) | 2001-05-18 | 2004-08-11 | RNA interference mediated inhibition of gastric inhibitory polypeptide (GIP) and gastric inhibitory polypeptide receptor (GIPR) gene expression using short interfering nucleic acid (siNA) |
US10/918,987 US20050203040A1 (en) | 2001-05-18 | 2004-08-16 | RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA) |
US10/918,969 US20050153914A1 (en) | 2001-05-18 | 2004-08-16 | RNA interference mediated inhibition of MDR P-glycoprotein gene expression using short interfering nucleic acid (siNA) |
US10/918,896 US20050164966A1 (en) | 2001-05-18 | 2004-08-16 | RNA interference mediated inhibition of type 1 insulin-like growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US10/919,964 US20050176665A1 (en) | 2001-05-18 | 2004-08-17 | RNA interference mediated inhibition of hairless (HR) gene expression using short interfering nucleic acid (siNA) |
US10/919,584 US20050233997A1 (en) | 2001-05-18 | 2004-08-17 | RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA) |
US10/919,866 US20050176664A1 (en) | 2001-05-18 | 2004-08-17 | RNA interference mediated inhibition of cholinergic muscarinic receptor (CHRM3) gene expression using short interfering nucleic acid (siNA) |
US10/922,034 US20050164967A1 (en) | 2001-05-18 | 2004-08-19 | RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA) |
US10/923,640 US20050136436A1 (en) | 2001-05-18 | 2004-08-19 | RNA interference mediated inhibition of G72 and D-amino acid oxidase (DAAO) gene expression using short interfering nucleic acid (siNA) |
US10/923,580 US20050159382A1 (en) | 2001-05-18 | 2004-08-19 | RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA) |
US10/922,626 US20050159380A1 (en) | 2001-05-18 | 2004-08-19 | RNA interference mediated inhibition of angiopoietin gene expression using short interfering nucleic acid (siNA) |
US10/922,544 US20050153915A1 (en) | 2001-05-18 | 2004-08-19 | RNA interference mediated inhibition of early growth response gene expression using short interfering nucleic acid (siNA) |
US10/921,554 US20060142226A1 (en) | 2001-05-18 | 2004-08-19 | RNA interference mediated inhibition of cholesteryl ester transfer protein (CETP) gene expression using short interfering nucleic acid (siNA) |
US10/923,379 US20050239731A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of MAP kinase gene expression using short interfering nucleic acid (siNA) |
US10/923,536 US20070042983A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
US10/923,330 US20050153916A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of telomerase gene expression using short interfering nucleic acid (siNA) |
US10/923,516 US20050176025A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of B-cell CLL/Lymphoma-2 (BCL-2) gene expression using short interfering nucleic acid (siNA) |
US10/923,522 US20050159381A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of chromosome translocation gene expression using short interfering nucleic acid (siNA) |
US10/922,675 US20050182007A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA) |
US10/923,270 US20050233344A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of platelet derived growth factor (PDGF) and platelet derived growth factor receptor (PDGFR) gene expression using short interfering nucleic acid (siNA) |
US10/922,761 US20050267058A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (sINA) |
US10/923,470 US20050227935A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of TNF and TNF receptor gene expression using short interfering nucleic acid (siNA) |
US10/923,201 US20050182009A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of NF-Kappa B / REL-A gene expression using short interfering nucleic acid (siNA) |
US10/923,451 US20050256068A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of stearoyl-CoA desaturase (SCD) gene expression using short interfering nucleic acid (siNA) |
US10/923,476 US20050288242A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of RAS gene expression using short interfering nucleic acid (siNA) |
US10/923,182 US20050176666A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of GPRA and AAA1 gene expression using short interfering nucleic acid (siNA) |
US10/923,473 US20050191618A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA) |
US10/923,475 US20050227936A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of TGF-beta and TGF-beta receptor gene expression using short interfering nucleic acid (siNA) |
US10/923,181 US20050187174A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA) |
US10/923,115 US20050079610A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA) |
US10/923,354 US20050176024A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of epidermal growth factor receptor (EGFR) gene expression using short interfering nucleic acid (siNA) |
US10/923,142 US20050182008A1 (en) | 2000-02-11 | 2004-08-20 | RNA interference mediated inhibition of NOGO and NOGO receptor gene expression using short interfering nucleic acid (siNA) |
US10/923,329 US20050164968A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of ADAM33 gene expression using short interfering nucleic acid (siNA) |
US10/923,380 US20050196767A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acis (siNA) |
US10/922,340 US20050170371A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA) |
US10/922,554 US20080188430A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA) |
US10/942,560 US20050209180A1 (en) | 2001-05-18 | 2004-09-15 | RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA) |
US10/944,611 US20050233998A1 (en) | 2001-05-18 | 2004-09-16 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US10/962,898 US20050222066A1 (en) | 2001-05-18 | 2004-10-12 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
HK04107996.5A HK1065049A1 (en) | 2002-02-20 | 2004-10-15 | Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
US10/981,966 US20050266422A1 (en) | 2002-02-20 | 2004-11-05 | Fluoroalkoxy, nucleosides, nucleotides, and polynucleotides |
US11/001,347 US20050261219A1 (en) | 2001-05-18 | 2004-12-01 | RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (siNA) |
US11/011,913 US20050209182A1 (en) | 2002-02-20 | 2004-12-14 | Nucleic acid mediated inhibition of enterococcus infection and cytolysin toxin activity |
US11/014,373 US20050196781A1 (en) | 2001-05-18 | 2004-12-15 | RNA interference mediated inhibition of STAT3 gene expression using short interfering nucleic acid (siNA) |
US11/031,668 US20060019913A1 (en) | 2001-05-18 | 2005-01-06 | RNA interference mediated inhibtion of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA) |
US11/035,813 US20060025361A1 (en) | 2001-05-18 | 2005-01-14 | RNA interference mediated inhibition of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA) |
US11/054,047 US20050287128A1 (en) | 2001-05-18 | 2005-02-09 | RNA interference mediated inhibition of TGF-beta and TGF-beta receptor gene expression using short interfering nucleic acid (siNA) |
US11/058,582 US20050260620A1 (en) | 2001-05-18 | 2005-02-15 | RNA interference mediated inhibition of retinolblastoma (RBI) gene expression using short interfering nucleic acid (siNA) |
US11/063,415 US20050277133A1 (en) | 2001-05-18 | 2005-02-22 | RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA) |
US11/098,303 US20050282188A1 (en) | 2001-05-18 | 2005-04-04 | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
US11/140,328 US20060019917A1 (en) | 2001-05-18 | 2005-05-27 | RNA interference mediated inhibition of stromal cell-derived factor-1 (SDF-1) gene expression using short interfering nucleic acid (siNA) |
US11/205,646 US20080161256A1 (en) | 2001-05-18 | 2005-08-17 | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
US11/217,936 US20060148743A1 (en) | 2001-05-18 | 2005-09-01 | RNA interference mediated inhibition of histone deacetylase (HDAC) gene expression using short interfering nucleic acid (siNA) |
US11/234,730 US20070270579A1 (en) | 2001-05-18 | 2005-09-23 | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
US11/259,603 US20060241075A1 (en) | 2001-05-18 | 2005-10-26 | RNA interference mediated inhibition of desmoglein gene expression using short interfering nucleic acid (siNA) |
US11/265,730 US20070179104A1 (en) | 2001-05-18 | 2005-11-02 | RNA interference mediated inhibition of winged helix nude (WHN) gene expression using short interfering nucleic acid (siNA) |
US11/299,254 US20060217331A1 (en) | 2001-05-18 | 2005-12-08 | Chemically modified double stranded nucleic acid molecules that mediate RNA interference |
US11/299,391 US7517864B2 (en) | 2001-05-18 | 2005-12-09 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
US11/311,826 US20060211642A1 (en) | 2001-05-18 | 2005-12-19 | RNA inteference mediated inhibition of hepatitis C virus (HVC) gene expression using short interfering nucleic acid (siNA) |
US11/332,655 US20060276422A1 (en) | 2001-05-18 | 2006-01-13 | RNA interference mediated inhibition of B7-H1 gene expression using short interfering nucleic acid (siNA) |
US11/358,807 US20060217335A1 (en) | 2002-02-20 | 2006-02-21 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/358,932 US20060217337A1 (en) | 2002-02-20 | 2006-02-21 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/358,862 US20060287266A1 (en) | 2002-02-20 | 2006-02-21 | RNA interference mediated ihibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/358,443 US20060217334A1 (en) | 2002-02-20 | 2006-02-21 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/358,540 US20060247428A1 (en) | 2002-02-20 | 2006-02-21 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/358,924 US20060247429A1 (en) | 2002-02-20 | 2006-02-21 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/358,863 US20060217336A1 (en) | 2002-02-20 | 2006-02-21 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/369,108 US20070160980A1 (en) | 2001-05-18 | 2006-03-06 | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
US11/395,833 US20060287267A1 (en) | 2001-05-18 | 2006-03-31 | RNA interference mediated inhibition of respiratory syncytial virus (RSV) expression using short interfering nucleic acid (siNA) |
US11/448,115 US20060216747A1 (en) | 2001-05-18 | 2006-06-06 | RNA interference mediated inhibition of checkpoint kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA) |
US11/450,856 US20060270623A1 (en) | 2001-05-18 | 2006-06-09 | RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA) |
US11/455,205 US20070049543A1 (en) | 2001-05-18 | 2006-06-16 | RNA interference mediated inhibition of 11 beta-hydroxysteroid dehydrogenase-1 (11 beta-HSD-1) gene expression using short interfering nucleic acid siNA |
US11/487,788 US20070173473A1 (en) | 2001-05-18 | 2006-07-17 | RNA interference mediated inhibition of proprotein convertase subtilisin Kexin 9 (PCSK9) gene expression using short interfering nucleic acid (siNA) |
US11/488,374 US20080249040A1 (en) | 2001-05-18 | 2006-07-18 | RNA interference mediated inhibition of sterol regulatory element binding protein 1 (SREBP1) gene expression using short interfering nucleic acid (siNA) |
US11/499,521 US7989612B2 (en) | 2002-02-20 | 2006-08-04 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/499,533 US20060293272A1 (en) | 2002-02-20 | 2006-08-04 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/499,828 US7956176B2 (en) | 2002-09-05 | 2006-08-04 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/499,529 US7923547B2 (en) | 2002-09-05 | 2006-08-04 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/499,633 US20070004665A1 (en) | 2002-02-20 | 2006-08-04 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/499,520 US20070004663A1 (en) | 2002-02-20 | 2006-08-04 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/502,876 US20060281175A1 (en) | 2002-02-20 | 2006-08-11 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/502,875 US20070004667A1 (en) | 2002-02-20 | 2006-08-11 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/502,885 US20060292691A1 (en) | 2002-02-20 | 2006-08-11 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/502,893 US20060275903A1 (en) | 2002-02-20 | 2006-08-11 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/592,039 US20070185049A1 (en) | 2001-05-18 | 2006-11-02 | RNA interference mediated inhibition of histone deacetylase (HDAC) gene expression using short interfering nucleic acid (siNA) |
US11/676,124 US8846894B2 (en) | 2002-02-20 | 2007-02-16 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US11/684,465 US20070161596A1 (en) | 2000-08-30 | 2007-03-09 | RNA INTERFERENCE MEDIATED TREATMENT OF ALZHEIMER'S DISEASE USING SHORT INTERFERING NUCLEIC ACID (siNA) |
US11/748,029 US20090239931A1 (en) | 2001-05-18 | 2007-05-14 | RNA INTERFERENCE MEDIATED INHIBITION OF PROTEIN TYROSINE PHOSPHATASE-1B (PTP-1B) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
US11/756,240 US20090299045A1 (en) | 2001-05-18 | 2007-05-31 | RNA Interference Mediated Inhibition Of Interleukin and Interleukin Gene Expression Using Short Interfering Nucleic Acid (siNA) |
US11/879,470 US20080033156A1 (en) | 2002-02-20 | 2007-07-17 | Polycationic compositions for cellular delivery of polynucleotides |
US11/851,090 US20080249294A1 (en) | 2001-05-18 | 2007-09-06 | RNA Interference Mediated Inhibition of Gene Expression Using Short Interfering Nucleic Acid (siNA) |
US12/105,010 US8232383B2 (en) | 2002-02-20 | 2008-04-17 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US12/166,991 US20090137507A1 (en) | 2002-02-20 | 2008-07-02 | RNA INTERFERENCE MEDIATED INHIBITION OF ANGIOPOIETIN GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
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US10/444,853 Continuation-In-Part US8202979B2 (en) | 2000-02-11 | 2003-05-23 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
US11/299,391 Continuation-In-Part US7517864B2 (en) | 2001-05-18 | 2005-12-09 | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
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US10/826,966 Continuation-In-Part US20050032733A1 (en) | 2000-02-11 | 2004-04-16 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA) |
US10/840,731 Continuation-In-Part US20050137153A1 (en) | 2002-02-20 | 2004-05-06 | RNA interference mediated inhibition of alpha-1 antitrypsin (AAT) gene expression using short interfering nucleic acid (siNA) |
US10/923,536 Continuation-In-Part US20070042983A1 (en) | 2001-05-18 | 2004-08-20 | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) |
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