US20060247428A1 - RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) - Google Patents

RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) Download PDF

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Publication number
US20060247428A1
US20060247428A1 US11/358,540 US35854006A US2006247428A1 US 20060247428 A1 US20060247428 A1 US 20060247428A1 US 35854006 A US35854006 A US 35854006A US 2006247428 A1 US2006247428 A1 US 2006247428A1
Authority
US
United States
Prior art keywords
sina
nucleotides
antisense
nucleic acid
sirna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/358,540
Inventor
James McSwiggen
Bharat Chowrira
Leonid Beigelman
Dennis Macejak
Shawn Zinnen
Pamela Pavco
Peter Haeberli
David Morrissey
Kathy Fosnaugh
Sharon Jamison
Nassim Usman
James Thompson
Chandra Vargeese
Weimin Wang
Tongqian Chen
Narendra Vaish
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sirna Therapeutics Inc
Original Assignee
Sirna Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US35858002P priority Critical
Priority to US36312402P priority
Priority to PCT/US2002/015876 priority patent/WO2002094185A2/en
Priority to US38678202P priority
Priority to US40678402P priority
Priority to US40837802P priority
Priority to US40929302P priority
Priority to US44012903P priority
Priority to PCT/US2003/005028 priority patent/WO2003074654A2/en
Priority to PCT/US2003/005346 priority patent/WO2003070918A2/en
Priority to US41701203A priority
Priority to US10/427,160 priority patent/US7833992B2/en
Priority to US10/444,853 priority patent/US8202979B2/en
Application filed by Sirna Therapeutics Inc filed Critical Sirna Therapeutics Inc
Priority to US11/358,540 priority patent/US20060247428A1/en
Publication of US20060247428A1 publication Critical patent/US20060247428A1/en
Application status is Abandoned legal-status Critical

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