WO2003068966A3 - REGULATION OF HUMAN Ca2+-PERMEABLE NONSELECTIVE CATION CHANNEL - Google Patents

REGULATION OF HUMAN Ca2+-PERMEABLE NONSELECTIVE CATION CHANNEL Download PDF

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Publication number
WO2003068966A3
WO2003068966A3 PCT/EP2003/001284 EP0301284W WO03068966A3 WO 2003068966 A3 WO2003068966 A3 WO 2003068966A3 EP 0301284 W EP0301284 W EP 0301284W WO 03068966 A3 WO03068966 A3 WO 03068966A3
Authority
WO
WIPO (PCT)
Prior art keywords
human
cation channel
nonselective cation
regulation
permeable nonselective
Prior art date
Application number
PCT/EP2003/001284
Other languages
French (fr)
Other versions
WO2003068966A2 (en
Inventor
Rainer H Koehler
Original Assignee
Bayer Healthcare Ag
Rainer H Koehler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Rainer H Koehler filed Critical Bayer Healthcare Ag
Priority to AU2003218650A priority Critical patent/AU2003218650A1/en
Publication of WO2003068966A2 publication Critical patent/WO2003068966A2/en
Publication of WO2003068966A3 publication Critical patent/WO2003068966A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Reagents that regulate human Ca2+-permeable nonselective cation channel and reagents which bind to human Ca2+-permeable nonselective cation channel gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to central and peripheral nervous system, gastro-intestinal, cardiovascular, hematological and genito-urinary disorders, cancer, COPD and asthma.
PCT/EP2003/001284 2002-02-12 2003-02-10 REGULATION OF HUMAN Ca2+-PERMEABLE NONSELECTIVE CATION CHANNEL WO2003068966A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003218650A AU2003218650A1 (en) 2002-02-12 2003-02-10 REGULATION OF HUMAN Ca2+-PERMEABLE NONSELECTIVE CATION CHANNEL

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US35575102P 2002-02-12 2002-02-12
US60/355,751 2002-02-12
US38438302P 2002-06-03 2002-06-03
US60/384,383 2002-06-03
US38673502P 2002-06-10 2002-06-10
US60/386,735 2002-06-10
US40663402P 2002-08-29 2002-08-29
US60/406,634 2002-08-29

Publications (2)

Publication Number Publication Date
WO2003068966A2 WO2003068966A2 (en) 2003-08-21
WO2003068966A3 true WO2003068966A3 (en) 2004-01-22

Family

ID=27739375

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/001284 WO2003068966A2 (en) 2002-02-12 2003-02-10 REGULATION OF HUMAN Ca2+-PERMEABLE NONSELECTIVE CATION CHANNEL

Country Status (2)

Country Link
AU (1) AU2003218650A1 (en)
WO (1) WO2003068966A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001077331A1 (en) * 2000-04-07 2001-10-18 Millenium Pharmaceuticals, Inc. Human trp-like calcium channel protein-2 (tlcc-2)
WO2002081625A2 (en) * 2001-04-03 2002-10-17 Curagen Corporation Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001077331A1 (en) * 2000-04-07 2001-10-18 Millenium Pharmaceuticals, Inc. Human trp-like calcium channel protein-2 (tlcc-2)
WO2002081625A2 (en) * 2001-04-03 2002-10-17 Curagen Corporation Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BARGAL RUTH ET AL: "Identification of the gene causing mucolipidosis type IV.", NATURE GENETICS, vol. 26, no. 1, AF249319, September 2000 (2000-09-01), pages 120 - 123, XP002251503, ISSN: 1061-4036 *
BASSI M T ET AL: "CLONING OF THE GENE ENCODING A NOVEL INTEGRAL MEMBRANE PROTEIN, MUCOLIPIDIN-AND IDENTIFICATION OF THE TWO MAJOR FOUNDER MUTATIONS CAUSING MUCOLIPIDOSIS TYPE IV", AMERICAN JOURNAL OF HUMAN GENETICS, AMERICAN SOCIETY OF HUMAN GENETICS, CHICAGO, IL, US, vol. 67, no. 5, November 2000 (2000-11-01), pages 1110 - 1120, XP001016216, ISSN: 0002-9297 *
DATABASE EMBL [online] EBI; 11 September 2000 (2000-09-11), "Homo sapiens mRNA for mucolipidin (ML4 gene)", XP002251217, Database accession no. AJ293970 *
DATABASE EMBL [online] EBI; 29 October 2002 (2002-10-29), "Homo sapiens mucolipin 2 (MCOLN2) mRNA, complete cds", XP002251540, Database accession no. AY083533 *
DATABASE EMBL [online] EBI; 7 September 2000 (2000-09-07), "Homo sapiens mucolipidosis type IV protein (MLIV) mRNA, complete cds", XP002251218, Database accession no. AF249319 *
DATABASE EMBL [online] EBI; 8 February 2001 (2001-02-08), "Musculus 14 days embryo liver cDNA, weakly similar to mucolipidin", XP002251216, Database accession no. AK014467 *
DI PALMA FEDERICA ET AL: "Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 99, no. 23, AK019454, 12 November 2002 (2002-11-12), November 12 2002 2002, pages 14994 - 14999, XP002251215, ISSN: 0027-8424 *
MONTELL C: "Physiology, phylogeny, and functions of the TRP superfamily of cation channels.", SCIENCE'S STKE [ELECTRONIC RESOURCE]: SIGNAL TRANSDUCTION KNOWLEDGE ENVIRONMENT. UNITED STATES 10 JUL 2001, vol. 2001, no. 90, 10 July 2001 (2001-07-10), pages RE1, XP001154060, ISSN: 1525-8882 *

Also Published As

Publication number Publication date
AU2003218650A1 (en) 2003-09-04
WO2003068966A2 (en) 2003-08-21

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