WO2003068381A1 - Procede pour la production de nanogouttes monodispersees et dispositif pour l'execution de ce procede - Google Patents

Procede pour la production de nanogouttes monodispersees et dispositif pour l'execution de ce procede Download PDF

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Publication number
WO2003068381A1
WO2003068381A1 PCT/EP2003/001418 EP0301418W WO03068381A1 WO 2003068381 A1 WO2003068381 A1 WO 2003068381A1 EP 0301418 W EP0301418 W EP 0301418W WO 03068381 A1 WO03068381 A1 WO 03068381A1
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WO
WIPO (PCT)
Prior art keywords
fluid
module
microfluidic reactor
focusing module
fluids
Prior art date
Application number
PCT/EP2003/001418
Other languages
German (de)
English (en)
Inventor
Steffen Hardt
Volker Hessel
Original Assignee
INSTITUT FüR MIKROTECHNIK MAINZ GMBH
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Filing date
Publication date
Application filed by INSTITUT FüR MIKROTECHNIK MAINZ GMBH filed Critical INSTITUT FüR MIKROTECHNIK MAINZ GMBH
Publication of WO2003068381A1 publication Critical patent/WO2003068381A1/fr

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40Mixing liquids with liquids; Emulsifying
    • B01F23/41Emulsifying
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40Mixing liquids with liquids; Emulsifying
    • B01F23/41Emulsifying
    • B01F23/414Emulsifying characterised by the internal structure of the emulsion
    • B01F23/4143Microemulsions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30Injector mixers
    • B01F25/31Injector mixers in conduits or tubes through which the main component flows
    • B01F25/313Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
    • B01F25/3131Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit with additional mixing means other than injector mixers, e.g. screens, baffles or rotating elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30Injector mixers
    • B01F25/31Injector mixers in conduits or tubes through which the main component flows
    • B01F25/313Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
    • B01F25/3132Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit by using two or more injector devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/42Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/45Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/05Mixers using radiation, e.g. magnetic fields or microwaves to mix the material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/05Mixers using radiation, e.g. magnetic fields or microwaves to mix the material
    • B01F33/052Mixers using radiation, e.g. magnetic fields or microwaves to mix the material the energy being electric fields for electrostatically charging of the ingredients or compositions for mixing them
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/05Mixers using radiation, e.g. magnetic fields or microwaves to mix the material
    • B01F33/053Mixers using radiation, e.g. magnetic fields or microwaves to mix the material the energy being magnetic or electromagnetic energy, radiation working on the ingredients or compositions for or during mixing them
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/05Mixers using radiation, e.g. magnetic fields or microwaves to mix the material
    • B01F33/054Mixers using radiation, e.g. magnetic fields or microwaves to mix the material the energy being in the form of a laser to modify the characteristics or conditions of the products, e.g. for heating
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers
    • B01F33/301Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3011Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers
    • B01F33/301Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3012Interdigital streams, e.g. lamellae
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90Heating or cooling systems
    • B01F35/94Heating or cooling systems using radiation, e.g. microwaves or electromagnetic radiation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/04Making microcapsules or microballoons by physical processes, e.g. drying, spraying

Abstract

L'invention concerne un procédé et un dispositif servant à produire des nanogouttes monodispersées. L'invention vise à obtenir une répartition de taille mieux contrôlable et une forme plus régulière des nanogouttes qu'avec les procédés et les dispositifs déjà connus. Le procédé selon l'invention pour la production de nanogouttes monodispersées est caractérisé en ce qu'on introduit dans un fluide A s'écoulant en continu un deuxième fluide B non miscible, en ce que le fluide B est entouré par le fluide A et en ce que la section d'écoulement (16, 25) du fluide B rétrécit dans le sens d'écoulement (2) de sorte que le fluide B se désagrège en gouttes individuelles (26) en raison de son instabilité hydrodynamique. L'invention concerne également un réacteur microfluidique pour l'exécution de ce procédé, dans lequel on introduit dans un premier flux continu d'un fluide A un deuxième flux d'un fluide B, le fluide B étant entouré par le fluide A et les fluides A et B n'étant pas miscibles. Le réacteur selon l'invention est caractérisé par un module de focalisation (1) comprenant une trémie d'entrée (3) rétrécissant dans le sens d'écoulement (2) et à l'extrémité (4) à petite ouverture de laquelle est raccordé un conduit de formation de gouttes (5).
PCT/EP2003/001418 2002-02-13 2003-02-13 Procede pour la production de nanogouttes monodispersees et dispositif pour l'execution de ce procede WO2003068381A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10206083A DE10206083B4 (de) 2002-02-13 2002-02-13 Verfahren zum Erzeugen monodisperser Nanotropfen sowie mikrofluidischer Reaktor zum Durchführen des Verfahrens
DE10206083.5 2002-02-13

Publications (1)

Publication Number Publication Date
WO2003068381A1 true WO2003068381A1 (fr) 2003-08-21

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PCT/EP2003/001418 WO2003068381A1 (fr) 2002-02-13 2003-02-13 Procede pour la production de nanogouttes monodispersees et dispositif pour l'execution de ce procede

Country Status (2)

Country Link
DE (1) DE10206083B4 (fr)
WO (1) WO2003068381A1 (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1415708A3 (fr) * 2002-11-01 2004-12-29 Hitachi, Ltd. Reacteur chimique et dispositif
WO2006051153A2 (fr) * 2004-11-09 2006-05-18 Nanolab Systems Oy Procedes et dispositifs pour simplifier la production de nanoparticules, et leurs applications
US7307104B2 (en) 2003-05-16 2007-12-11 Velocys, Inc. Process for forming an emulsion using microchannel process technology
US7485671B2 (en) 2003-05-16 2009-02-03 Velocys, Inc. Process for forming an emulsion using microchannel process technology
US7556776B2 (en) 2005-09-08 2009-07-07 President And Fellows Of Harvard College Microfluidic manipulation of fluids and reactions
EP1913994A3 (fr) * 2006-10-20 2009-12-02 Hitachi Plant Technologies, Ltd. Appareil d'émulsion et appareil de fabrication de grains fins
US7816411B2 (en) 2004-10-01 2010-10-19 Velocys, Inc. Multiphase mixing process using microchannel process technology
US7943671B2 (en) 2005-08-08 2011-05-17 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Formation of an emulsion in a fluid microsystem
US9573099B2 (en) 2011-05-23 2017-02-21 President And Fellows Of Harvard College Control of emulsions, including multiple emulsions
US9664619B2 (en) 2008-04-28 2017-05-30 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
US10195571B2 (en) 2011-07-06 2019-02-05 President And Fellows Of Harvard College Multiple emulsions and techniques for the formation of multiple emulsions
US10316873B2 (en) 2005-03-04 2019-06-11 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
WO2020074721A1 (fr) 2018-10-11 2020-04-16 Emulco Laboratories C.V.B.A. Procédé pour produire des émulsions et émulsion de polyisobutène aqueuse
US10874997B2 (en) 2009-09-02 2020-12-29 President And Fellows Of Harvard College Multiple emulsions created using jetting and other techniques

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3930495B2 (ja) 2004-06-16 2007-06-13 三菱重工業株式会社 ニッケル超微粒子分散液体ナトリウムの製造方法、装置、液体ナトリウムの漏洩検出方法
JP4661942B2 (ja) * 2008-05-13 2011-03-30 ソニー株式会社 マイクロチップとその流路構造
EP2827979A1 (fr) 2012-03-22 2015-01-28 Universiteit Twente Appareil et procédé de production en masse d'un agent de microbulles monodispersées
DE102012010959B4 (de) * 2012-05-30 2019-03-28 Technische Universität Dresden Vorrichtung zur Bereitstellungkonstanter Strömungsverhältnisse vonunterschiedlichen Fluidphasen in Mikrokanalelementen
DE102017105194A1 (de) 2017-03-10 2018-09-13 Little Things Factory Gmbh Fokussiereinrichtung, Tropfengenerator und Verfahren zum Erzeugen einer Vielzahl von Tröpfchen

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FR1296788A (fr) * 1961-04-28 1962-06-22 Teerverwertung Gmbh Procédé pour transformer en grenailles sphériques des matières fusibles, solides à la température ambiante
US3329745A (en) * 1965-10-05 1967-07-04 Grange Lee D La Process for making gelled spherical particles of oxides
CH563807A5 (en) * 1973-02-14 1975-07-15 Battelle Memorial Institute Fine granules and microcapsules mfrd. from liquid droplets - partic. of high viscosity requiring forced sepn. of droplets
US3933679A (en) * 1972-01-14 1976-01-20 Gulf Oil Corporation Uniform microspheroidal particle generating method
US3962383A (en) * 1972-10-03 1976-06-08 Yoshiro Hagiwara Method and apparatus for manufacturing seamless material-filled capsules
US4251195A (en) * 1975-12-26 1981-02-17 Morishita Jinta Company, Limited Apparatus for making miniature capsules
US4422985A (en) * 1982-09-24 1983-12-27 Morishita Jintan Co., Ltd. Method and apparatus for encapsulation of a liquid or meltable solid material
WO1996011053A1 (fr) * 1994-10-07 1996-04-18 Warner-Lambert Company Procede de fabrication de capsules sans soudure
WO2000062913A1 (fr) * 1999-04-16 2000-10-26 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Procede et micromelangeur pour la realisation d'une dispersion

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DE4120613A1 (de) * 1991-06-20 1992-03-05 Suesse Harald Selbstregulierender hochdrucktrennstrahlbeschleuniger
US5344676A (en) * 1992-10-23 1994-09-06 The Board Of Trustees Of The University Of Illinois Method and apparatus for producing nanodrops and nanoparticles and thin film deposits therefrom
GB9318241D0 (en) * 1993-09-02 1993-10-20 Univ Mcgill Distribution of fine bubbles or droplets in a fluid
DE19510651A1 (de) * 1994-06-03 1995-12-07 Bayer Ag Wäßrige 2-Komponenten-Polyurethanlack-Emulsionen und Verfahren zu deren Herstellung
US6187214B1 (en) * 1996-05-13 2001-02-13 Universidad De Seville Method and device for production of components for microfabrication
DE10007816A1 (de) * 2000-02-21 2001-09-06 Bayer Ag Verfahren zur Herstellung von Nanosuspensionen

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1296788A (fr) * 1961-04-28 1962-06-22 Teerverwertung Gmbh Procédé pour transformer en grenailles sphériques des matières fusibles, solides à la température ambiante
US3329745A (en) * 1965-10-05 1967-07-04 Grange Lee D La Process for making gelled spherical particles of oxides
US3933679A (en) * 1972-01-14 1976-01-20 Gulf Oil Corporation Uniform microspheroidal particle generating method
US3962383A (en) * 1972-10-03 1976-06-08 Yoshiro Hagiwara Method and apparatus for manufacturing seamless material-filled capsules
CH563807A5 (en) * 1973-02-14 1975-07-15 Battelle Memorial Institute Fine granules and microcapsules mfrd. from liquid droplets - partic. of high viscosity requiring forced sepn. of droplets
US4251195A (en) * 1975-12-26 1981-02-17 Morishita Jinta Company, Limited Apparatus for making miniature capsules
US4422985A (en) * 1982-09-24 1983-12-27 Morishita Jintan Co., Ltd. Method and apparatus for encapsulation of a liquid or meltable solid material
WO1996011053A1 (fr) * 1994-10-07 1996-04-18 Warner-Lambert Company Procede de fabrication de capsules sans soudure
WO2000062913A1 (fr) * 1999-04-16 2000-10-26 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Procede et micromelangeur pour la realisation d'une dispersion

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7374726B2 (en) 2002-11-01 2008-05-20 Hitachi, Ltd. Chemical reactor
EP1415708A3 (fr) * 2002-11-01 2004-12-29 Hitachi, Ltd. Reacteur chimique et dispositif
US7485671B2 (en) 2003-05-16 2009-02-03 Velocys, Inc. Process for forming an emulsion using microchannel process technology
US7307104B2 (en) 2003-05-16 2007-12-11 Velocys, Inc. Process for forming an emulsion using microchannel process technology
US7816411B2 (en) 2004-10-01 2010-10-19 Velocys, Inc. Multiphase mixing process using microchannel process technology
WO2006051153A3 (fr) * 2004-11-09 2006-06-29 Nanolab Systems Oy Procedes et dispositifs pour simplifier la production de nanoparticules, et leurs applications
WO2006051153A2 (fr) * 2004-11-09 2006-05-18 Nanolab Systems Oy Procedes et dispositifs pour simplifier la production de nanoparticules, et leurs applications
US10316873B2 (en) 2005-03-04 2019-06-11 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
US7943671B2 (en) 2005-08-08 2011-05-17 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Formation of an emulsion in a fluid microsystem
US7556776B2 (en) 2005-09-08 2009-07-07 President And Fellows Of Harvard College Microfluidic manipulation of fluids and reactions
EP1913994A3 (fr) * 2006-10-20 2009-12-02 Hitachi Plant Technologies, Ltd. Appareil d'émulsion et appareil de fabrication de grains fins
US9664619B2 (en) 2008-04-28 2017-05-30 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
US10828641B2 (en) 2008-04-28 2020-11-10 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
US11498072B2 (en) 2008-04-28 2022-11-15 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
US10874997B2 (en) 2009-09-02 2020-12-29 President And Fellows Of Harvard College Multiple emulsions created using jetting and other techniques
US9573099B2 (en) 2011-05-23 2017-02-21 President And Fellows Of Harvard College Control of emulsions, including multiple emulsions
US10195571B2 (en) 2011-07-06 2019-02-05 President And Fellows Of Harvard College Multiple emulsions and techniques for the formation of multiple emulsions
WO2020074721A1 (fr) 2018-10-11 2020-04-16 Emulco Laboratories C.V.B.A. Procédé pour produire des émulsions et émulsion de polyisobutène aqueuse
EP3646941A2 (fr) 2018-10-11 2020-05-06 Emulco Laboratories C.V.B.A. Procédé de production d'émulsions et émulsion aqueuse de polyisobutène

Also Published As

Publication number Publication date
DE10206083A1 (de) 2003-08-21
DE10206083B4 (de) 2009-11-26

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