WO2003066071A1 - Formulations comprising psychotropic drugs and selenium - Google Patents

Formulations comprising psychotropic drugs and selenium Download PDF

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Publication number
WO2003066071A1
WO2003066071A1 PCT/GB2003/000490 GB0300490W WO03066071A1 WO 2003066071 A1 WO2003066071 A1 WO 2003066071A1 GB 0300490 W GB0300490 W GB 0300490W WO 03066071 A1 WO03066071 A1 WO 03066071A1
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WO
WIPO (PCT)
Prior art keywords
selenium
drug
daily dose
per day
formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2003/000490
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English (en)
French (fr)
Other versions
WO2003066071A8 (en
Inventor
Krishnarao Sitaramrao Waddadi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laxdale Ltd
Original Assignee
Laxdale Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laxdale Ltd filed Critical Laxdale Ltd
Priority to NZ534304A priority Critical patent/NZ534304A/en
Priority to JP2003565495A priority patent/JP2005525329A/ja
Priority to AU2003244454A priority patent/AU2003244454A1/en
Priority to EP03737361A priority patent/EP1478374A1/en
Publication of WO2003066071A1 publication Critical patent/WO2003066071A1/en
Anticipated expiration legal-status Critical
Publication of WO2003066071A8 publication Critical patent/WO2003066071A8/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Definitions

  • Clozapine is one drug which carries a high risk (GJ Killian et al, Lancet 1999; 354: 1841-5. L La Grenade et al, N Engl J Med 2001; 345: 224-5). Clozapine can also cause depression of white cell counts and in the worst cases complete loss of normal white blood cell production (agranulocytosis) .
  • the present invention relates to the co-administration of selenium together with a drug for the treatment or prevention of psychiatric or neurological disorders and particularly with clozapine.
  • the invention provides pharmaceutical formulations comprising a drug for the treatment or prevention of psychiatric or neurological disorders together with any biologically assimilable form of selenium, such that when the drug is administered the daily dose of selenium is between 10 ⁇ g and 2000 ⁇ g per day.
  • the daily dose of selenium provided by the formulations of the present invention is between 50 ⁇ g and 500 ⁇ g/day and very preferably between 150 and 300 ⁇ g/day.
  • the selenium may be provided in the form of selenium yeast, selenomethionine, selenocysteine or any appropriate selenite or selenate compound. This may form a component of the formulation. Alternatively the selenium may be chemically linked to the drug to form a selenium-drug derivative.
  • the drug of the formulations of the present invention is one used for the prevention or treatment of psychiatric or neurological disorders.
  • the drug may be one approved by a regulatory authority for such a treatment, including the US Food and Drug
  • the preferred invention is not to combine selenium with other multi-vitamin preparations, which have not been approved for administration to patients with psychiatric or neurological disorders .
  • the drug is one used for the treatment or prevention of psychiatric disorders including schizophrenia and bipolar disorder.
  • the drug clozapine is particularly suited for the formulations of the present invention.
  • the formulations are preferably orally administrable .
  • the selenium and the drug may be formulated separately but provided in the same pack with instructions for co-administration.
  • the present invention provides a pack containing the selenium and the drug packaged for co-administration.
  • a method for the treatment or prevention of any neurological or psychiatric disease by the co- administration of a drug conventionally used to treat that disease together with selenium in any biologically assimilable form in a daily dose of between 10 ⁇ g and 2000 ⁇ g selenium per day.
  • the treatment may be by separate administration of the drug and the selenium, or by administration of a formulation of the first aspect of the invention.
  • the invention further provides use of a formulation of the first aspect of the invention in the manufacture of a medicament for the treatment or prevention of any neurological or psychiatric disease.
  • the treatments are of psychiatric or neurological disorders.
  • the invention is used to treat psychiatric disorders including but not limited to schizophrenia, bipolar disorder, depression, anxiety disorders and personality disorders.
  • the invention is for the treatment or prevention of neurological disorders including but not limited to epilepsies, Parkinson's disease, dementias of both Alzheimer and vascular types, Huntington's disease, spinocerebellar ataxias, Friedreich's ataxia, myotonic dystrophy, amyotrophic lateral sclerosis and multiple sclerosis.
  • the present invention also provides a method for the reduction of side effects caused by administration of a drug for the treatment of a psychiatric or neurological disorder to a patient by the co-administration, separately or in a formulation according to the first aspect of the invention, of the drug together with selenium in any biologically assimilable form to provide a daily dose of between 10 ⁇ g and 2000 ⁇ g selenium per day.
  • the preferred range of selenium to used will be in the range of 50 to 500 ⁇ g/day and very preferably in the range of 150 to 300 ⁇ g/day.
  • the present invention is described in particular with reference to the treatment of cardiovascular illness in patients who are also being treated for psychiatric and neurological disorders.
  • the cause of the risk of developing this illness is unknown and multiple factors may be involved.
  • One pilot study has reported that schizophrenic patients on clozapine, a drug conventionally used to treat schizophrenia, have low selenium levels (LA Linday et al, J Clin Psychopharmacol 1995; 15: 353-60). This looked at only a few patients, however, did not analyse selenium in schizophrenic patients on other drugs, and did not look at selenium levels in patients with other disorders .
  • Selenium is a constituent of many enzymes, particularly ones involved in antioxidant defences (MP Rayman, Lancet 2000; 232-240). Selenium deficiency leads to a particular risk of cardiovascular disease, especially myocarditis and cardiomyopathy. Selenium deficiency also increases susceptibility to the serious cardiac complications of viral infections (MA Beck et al, Nature Medicine 1995; 1: 433-6).
  • the present invention is based on the inventor's suggestion that selenium deficiency is a major cause of the cardiovascular and perhaps other problems which are associated with the ingestion of drugs for psychiatric and neurological disorders, and especially clozapine where selenium will also be helpful in preventing the depression of white cell counts and agranulocytosis .
  • the selenium may be provided in any form which may be 20 assimilated by the body.
  • Many selenium supplements are prepared by growing yeast or possibly other microorganisms on selenium-containing medium and such yeast or other micro-organism derived sources would be appropriate.
  • Selenium may also be chelated or 25 otherwise linked to a range of other compounds, and in particular amino acids.
  • Selenomethionine and selenocysteine are common naturally occurring compounds which are widely used as selenium supplements.
  • Inorganic salts of selenite and also selenate may be used. Any assimilable form of selenium may be employed.
  • the selenium may be incorporated into the actual drug delivery system whether that be tablets, liquids or emulsions, hard or soft gelatin capsules, powders, drinks, foods or any other appropriate system which may be used by those skilled in the art to deliver either a drug or a selenium product.
  • the selenium will actually be incorporated into the drug formulation or may be chemically linked to the drug to form a selenium-drug derivative.
  • the selenium may be in any biologically assimilable form including yeast selenium, selenomethionine, selenocysteine, sodium selenite or sodium selenate.
  • the formulation is a liquid or an emulsion with or without flavouring. 4. As in example 1 where the formulation is in any other form appropriate for oral administration including a powder or a liquid.
  • the drug is any drug for the treatment of schizophrenia including but not limited to chlorpromazine, haloperidol, risperidone, olanzapine, quetiapine, zotepine, amisulpiride, ziprasidone, sertindole, ethyl eicosapentaenoate or aripiprazole.
  • the drug is any drug for the treatment of depression including but not limited to amitriptyline, lofepramine, dothiepin, doxepin, trimipra ine, imipramine, clomipramine, protriptyline, nortriptyline, venlafaxine, fluoxetine, fluvoxamine, sertraline, paroxetine, citalopram, escitalopram, reboxetine, mirtazepine, nefazodone, trazodone, moclobemide, viloxazine, maprotiline, phenelzine, tranylcypromine or ethyl-eicosapentaenoate.
  • the drug is any drug for the treatment of bipolar disorder, including but not limited to lithium salts, valproic acid and its derivatives and carbamazepine .
  • the drug is any drug for the treatment of anxiety including but not limited to any benzodiazepines, any beta-blockers and buspirone. 10. As in examples 1-4 where the drug is any drug for the treatment of epilepsy including but not limited to carbamazepine, lamotrigine, sodium valproate, phenytoin, benzodiazepines, barbiturates, topiramate, gabapentin or vigabatrin.
  • the drug is any drug for the treatment of Parkinson's disease including but not limited to levodopa, benserazide, carbidopa, selegiline, tolcapone, bromocriptine, ropinirole, apomorphine, pergolide, other dopamine receptor agonists, amantadine or anticholinergic drugs.
  • the drug is any drug for the treatment of Huntington's disease, Friedreich's ataxia, myotonic dystrophy, amyotrophic lateral sclerosis, multiple sclerosis or any other neurodegenerative disease including but not limited to ethyl-eicosapentaenoate, riluzole, lofepramine and ⁇ yclo-oxygenase 2 inhibitors.
  • the drug is any drug for the treatment of any form of dementia including but not limited to donepezil, rivastigmine, or galantamine or any cholergic drug.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Mycology (AREA)
  • Psychiatry (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Inorganic Chemistry (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PCT/GB2003/000490 2002-02-07 2003-02-04 Formulations comprising psychotropic drugs and selenium Ceased WO2003066071A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
NZ534304A NZ534304A (en) 2002-02-07 2003-02-04 Formulations comprising psychotropic drugs and selenium
JP2003565495A JP2005525329A (ja) 2002-02-07 2003-02-04 向精神薬とセレンから成る配合物
AU2003244454A AU2003244454A1 (en) 2002-02-07 2003-02-04 Formulations comprising psychotropic drugs and selenium
EP03737361A EP1478374A1 (en) 2002-02-07 2003-02-04 Formulations comprising psychotropic drugs and selenium

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0202900.7A GB0202900D0 (en) 2002-02-07 2002-02-07 Novel formulations of drugs
GB0202900.7 2002-02-07

Publications (2)

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WO2003066071A1 true WO2003066071A1 (en) 2003-08-14
WO2003066071A8 WO2003066071A8 (en) 2006-08-17

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PCT/GB2003/000490 Ceased WO2003066071A1 (en) 2002-02-07 2003-02-04 Formulations comprising psychotropic drugs and selenium

Country Status (8)

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US (1) US6919330B2 (https=)
EP (1) EP1478374A1 (https=)
JP (1) JP2005525329A (https=)
AU (1) AU2003244454A1 (https=)
GB (1) GB0202900D0 (https=)
NZ (1) NZ534304A (https=)
TW (1) TW200404558A (https=)
WO (1) WO2003066071A1 (https=)

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FR2873376A1 (fr) * 2004-07-23 2006-01-27 Tetrahedron Sas Nouveaux seleno-hydroxyacides et leurs derives, applications en nutrition, cosmetique et pharmacie
US7071879B2 (en) 2004-06-01 2006-07-04 Ems Technologies Canada, Ltd. Dielectric-resonator array antenna system
EP1774972A1 (en) * 2005-10-14 2007-04-18 Alltech, Inc. Use of selenium compounds, especially selenium yeasts in the treatment of Alzheimer, neurodegenerative diseases and diabetes
WO2007109851A1 (en) 2006-03-29 2007-10-04 Velacor Therapeutics Pty Ltd Treatment of neurodegenerative diseases
WO2008119109A1 (en) * 2007-03-29 2008-10-09 Velacor Therapeutics Pty Ltd Treatment of neurological disorders
WO2009043106A1 (en) * 2007-10-03 2009-04-09 Velacor Therapeutics Pty Ltd Inorganic selenium and angiogenesis
EP1803460A4 (en) * 2004-10-05 2009-12-09 Inovex Co Ltd PROPHYLACTIC OR THERAPEUTIC PREPARATION AND METHOD AGAINST A MENTAL SYMPTOM
EP2012806A4 (en) * 2006-04-24 2010-07-28 Alltech Inc METHOD AND COMPOSITIONS FOR MODIFYING CELL FUNCTIONS
US8865763B2 (en) 2005-10-14 2014-10-21 Alltech, Inc. Methods and compositions for altering cell function
US8871715B2 (en) 2005-10-14 2014-10-28 Alltech, Inc. Use of selenium compounds, especially selenium yeasts for altering cognitive function

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JP5710092B2 (ja) * 2004-09-24 2015-04-30 ユニヴァーシティ オヴ メリーランド、バルティモア 有機リン中毒を治療する方法
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Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7071879B2 (en) 2004-06-01 2006-07-04 Ems Technologies Canada, Ltd. Dielectric-resonator array antenna system
FR2873376A1 (fr) * 2004-07-23 2006-01-27 Tetrahedron Sas Nouveaux seleno-hydroxyacides et leurs derives, applications en nutrition, cosmetique et pharmacie
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US20030175361A1 (en) 2003-09-18
AU2003244454A1 (en) 2003-09-02
US6919330B2 (en) 2005-07-19
JP2005525329A (ja) 2005-08-25
GB0202900D0 (en) 2002-03-27
TW200404558A (en) 2004-04-01
WO2003066071A8 (en) 2006-08-17

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