WO2003056029A3 - Test de detection a haute sensibilite et en continu d'une proteine tyrosine phosphatase (ptpase) au moyen de 6,8-difluoro-4-methyl-ombelliferylphosphate - Google Patents

Test de detection a haute sensibilite et en continu d'une proteine tyrosine phosphatase (ptpase) au moyen de 6,8-difluoro-4-methyl-ombelliferylphosphate Download PDF

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Publication number
WO2003056029A3
WO2003056029A3 PCT/EP2002/014755 EP0214755W WO03056029A3 WO 2003056029 A3 WO2003056029 A3 WO 2003056029A3 EP 0214755 W EP0214755 W EP 0214755W WO 03056029 A3 WO03056029 A3 WO 03056029A3
Authority
WO
WIPO (PCT)
Prior art keywords
difluoro
phosphatase
tyrosine
umbelliferylphosphate
ptpase
Prior art date
Application number
PCT/EP2002/014755
Other languages
German (de)
English (en)
Other versions
WO2003056029A2 (fr
Inventor
Stefan Welte
Norbert Tennagels
Stefan Petry
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2002100173 external-priority patent/DE10200173A1/de
Priority claimed from DE2002136329 external-priority patent/DE10236329A1/de
Priority to CA002471601A priority Critical patent/CA2471601A1/fr
Priority to MXPA04006361A priority patent/MXPA04006361A/es
Priority to JP2003556546A priority patent/JP2005512600A/ja
Priority to EP02796734A priority patent/EP1466009A2/fr
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Priority to IL16283202A priority patent/IL162832A0/xx
Priority to AU2002361217A priority patent/AU2002361217A1/en
Priority to KR10-2004-7010451A priority patent/KR20040073539A/ko
Publication of WO2003056029A2 publication Critical patent/WO2003056029A2/fr
Publication of WO2003056029A3 publication Critical patent/WO2003056029A3/fr
Priority to NO20043244A priority patent/NO20043244L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un procédé permettant de déceler une protéine tyrosine phosphatase dans une matière biologique au moyen de 6,8-difluoro-4-méthyl-ombelliférylphosphate (DiFMUP).
PCT/EP2002/014755 2002-01-04 2002-12-24 Test de detection a haute sensibilite et en continu d'une proteine tyrosine phosphatase (ptpase) au moyen de 6,8-difluoro-4-methyl-ombelliferylphosphate WO2003056029A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
KR10-2004-7010451A KR20040073539A (ko) 2002-01-04 2002-12-24 6,8-디플루오로-4-메틸-움벨리페릴포스페이트를 사용하는고감수성의 연속적단백질-티로신-포스파타제(ＰＴＰａｓｅ) 시험
AU2002361217A AU2002361217A1 (en) 2002-01-04 2002-12-24 Highly sensitive and continuous protein-tyrosine-phosphatase (PTPase) test using 6,8 difluoro-4-methyl-umbelliferylphosphate
MXPA04006361A MXPA04006361A (es) 2002-01-04 2002-12-24 Un ensayo de deteccion de proteinas del tipo tirosina fosfatasas (ptpasas) continuo y altamente sensible que usa fosfato de 6,8-difluoro-4-metilumbeliferilo.
JP2003556546A JP2005512600A (ja) 2002-01-04 2002-12-24 ６，８−ジフルオロ−４−メチルウンベリフェリルホスフェートを用いた高感度連続的蛋白質チロシンホスファターゼ（ＰＴＰａｓｅ）試験
EP02796734A EP1466009A2 (fr) 2002-01-04 2002-12-24 Test de detection a haute sensibilite et en continu d'une proteine tyrosine phosphatase (ptpase) au moyen de 6,8-difluoro-4-methyl-ombelliferylphosphate
CA002471601A CA2471601A1 (fr) 2002-01-04 2002-12-24 Test de detection a haute sensibilite et en continu d'une proteine tyrosine phosphatase (ptpase) au moyen de 6,8-difluoro-4-methyl-ombelliferylphosphate
IL16283202A IL162832A0 (en) 2002-01-04 2002-12-24 Highly sensitive and continous protein-tyrosine-phosphatase (ptpase) test using 6,8 difluoro-4-methylumbe
NO20043244A NO20043244L (no) 2002-01-04 2004-08-02 Meget folsom og kontinuerlig protein-tyrosin-fosfatase (PTPASE) test ved anvendelse av 6,8-difluor-4-metyl-umbelliferylfosfat (DiFMUP)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE2002100173 DE10200173A1 (de) 2002-01-04 2002-01-04 Ein hochsensitiver und kontinuerlicher Protein Tyrosin-Phosphatase (PTPase) Test unter Verwendung von 6,8 Difluoro-4-methyl-umbelliferylphosphat (DiFMUP)
DE10200173.1 2002-01-04
DE2002136329 DE10236329A1 (de) 2002-08-08 2002-08-08 Ein hochsensitiver und kontinuierlicher Protein Tyrosin-Phosphatase (PTPase) Test unter Verwendung von 6,8 Difluoro-4-methyl-umbelliferylphosphat (DiFMUP)
DE10236329.3 2002-08-08

Publications (2)

Publication Number Publication Date
WO2003056029A2 WO2003056029A2 (fr) 2003-07-10
WO2003056029A3 true WO2003056029A3 (fr) 2004-04-01

Family

ID=26010898

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/014755 WO2003056029A2 (fr) 2002-01-04 2002-12-24 Test de detection a haute sensibilite et en continu d'une proteine tyrosine phosphatase (ptpase) au moyen de 6,8-difluoro-4-methyl-ombelliferylphosphate

Country Status (12)

Country Link
EP (1) EP1466009A2 (fr)
JP (1) JP2005512600A (fr)
KR (1) KR20040073539A (fr)
CN (1) CN1612939A (fr)
AU (1) AU2002361217A1 (fr)
BR (1) BR0215452A (fr)
CA (1) CA2471601A1 (fr)
IL (1) IL162832A0 (fr)
MX (1) MXPA04006361A (fr)
NO (1) NO20043244L (fr)
RU (1) RU2004123794A (fr)
WO (1) WO2003056029A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100350045C (zh) * 2003-08-21 2007-11-21 北京农业生物技术研究中心 玉米酪氨酸蛋白磷酸酶基因及其编码蛋白与应用
EP1949894B1 (fr) * 2007-01-25 2016-06-29 Roche Diagnostics GmbH Amélioration des inhibiteurs de phosphatase contenant du vanadium avec des polyols
US8008035B2 (en) 2007-01-25 2011-08-30 Roche Diagnostics Operations, Inc. Enhancement of vanadium-containing phosphatase inhibitors
CN113155787A (zh) * 2020-12-29 2021-07-23 武汉合研生物医药科技有限公司 一种突变酶shp2 e76k的活性检测方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061410A1 (fr) * 1998-05-12 1999-12-02 American Home Products Corporation Diphenyles 2,3,5-substitues utiles pour le traitement de la resistance insulinique et de l'hyperglycemie

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061410A1 (fr) * 1998-05-12 1999-12-02 American Home Products Corporation Diphenyles 2,3,5-substitues utiles pour le traitement de la resistance insulinique et de l'hyperglycemie

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GOLDSTEIN B J: "Protein-tyrosine phosphatase 1B (PTP1B): a novel therapeutic target for type 2 diabetes mellitus, obesity and related states of insulin resistance.", CURRENT DRUG TARGETS. IMMUNE, ENDOCRINE AND METABOLIC DISORDERS. NETHERLANDS NOV 2001, vol. 1, no. 3, November 2001 (2001-11-01), pages 265 - 275, XP001153562, ISSN: 1568-0088 *
KERBY M ET AL: "A fluorogenic assay using pressure-driven flow on a microchip.", ELECTROPHORESIS. GERMANY OCT 2001, vol. 22, no. 18, October 2001 (2001-10-01), pages 3916 - 3923, XP001153559, ISSN: 0173-0835 *
MALAMAS M S ET AL: "Novel Benzofuran and Benzothiophene Biphenyls as Inhibitors of Protein Tyrosine Phophatase 1B with Antihyperglycemic Properties", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 43, no. 7, 6 April 2000 (2000-04-06), pages 1293 - 1310, XP002190818, ISSN: 0022-2623 *
MATTER WILLIAM F ET AL: "Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 283, no. 5, 25 May 2001 (2001-05-25), pages 1061 - 1068, XP002247489, ISSN: 0006-291X *
WROBEL JAY ET AL: "PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo(b)naphtho(2,3-d)furans and 11-arylbenzo(b)naphtho(2,3-d)thiophenes", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, no. 17, 26 August 1999 (1999-08-26), pages 3199 - 3202, XP002181876, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
WO2003056029A2 (fr) 2003-07-10
CA2471601A1 (fr) 2003-07-10
AU2002361217A1 (en) 2003-07-15
JP2005512600A (ja) 2005-05-12
CN1612939A (zh) 2005-05-04
NO20043244L (no) 2004-08-02
RU2004123794A (ru) 2005-04-20
BR0215452A (pt) 2004-11-23
IL162832A0 (en) 2005-11-20
EP1466009A2 (fr) 2004-10-13
KR20040073539A (ko) 2004-08-19
MXPA04006361A (es) 2004-10-04

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