WO2003042384A1 - Inducteur de differentiation pour cellules souches d'embryon, procede d'obtention dudit inducteur et utilisation - Google Patents

Inducteur de differentiation pour cellules souches d'embryon, procede d'obtention dudit inducteur et utilisation Download PDF

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Publication number
WO2003042384A1
WO2003042384A1 PCT/JP2002/011894 JP0211894W WO03042384A1 WO 2003042384 A1 WO2003042384 A1 WO 2003042384A1 JP 0211894 W JP0211894 W JP 0211894W WO 03042384 A1 WO03042384 A1 WO 03042384A1
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WIPO (PCT)
Prior art keywords
cells
differentiation
embryo stem
ectodermal
inducer
Prior art date
Application number
PCT/JP2002/011894
Other languages
English (en)
French (fr)
Inventor
Yoshiki Sasai
Hiroo Iwata
Yoshinobu Murakami
Mitsuo Satoh
Masato Kobori
Keiichi Yano
Original Assignee
Kyowa Hakko Kogyo Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co., Ltd. filed Critical Kyowa Hakko Kogyo Co., Ltd.
Priority to US10/495,567 priority Critical patent/US20060281179A1/en
Priority to JP2003544199A priority patent/JP4294482B2/ja
Priority to EP02781768A priority patent/EP1452594A4/en
Priority to CA002467258A priority patent/CA2467258A1/en
Publication of WO2003042384A1 publication Critical patent/WO2003042384A1/ja
Priority to US12/030,314 priority patent/US20080160617A1/en

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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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PCT/JP2002/011894 2001-11-15 2002-11-14 Inducteur de differentiation pour cellules souches d'embryon, procede d'obtention dudit inducteur et utilisation WO2003042384A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/495,567 US20060281179A1 (en) 2001-11-15 2002-11-14 Inducer for differentiation of embryo stem cells into ectodermal cells method of obtaining the same and use thereof
JP2003544199A JP4294482B2 (ja) 2001-11-15 2002-11-14 胚性幹細胞から外胚葉系細胞への分化誘導剤、その取得方法及びその用途
EP02781768A EP1452594A4 (en) 2001-11-15 2002-11-14 INDUCTOR FOR DIFFERENTIATING EMBRYOONAL STEM CELLS TO EODODERMAL CELLS, METHOD FOR OBTAINING THEM AND USE THEREOF
CA002467258A CA2467258A1 (en) 2001-11-15 2002-11-14 Agent for inducing embryonic stem cell to ectodermal cell, method for obtaining the same and use of the same.
US12/030,314 US20080160617A1 (en) 2001-11-15 2008-02-13 Agent for inducing embryonic stem cell to ectodermal cell, method for obtaining the same, and use of the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001350724 2001-11-15
JP2001-350724 2001-11-15

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/495,567 A-371-Of-International US20060281179A1 (en) 2001-11-15 2002-11-14 Inducer for differentiation of embryo stem cells into ectodermal cells method of obtaining the same and use thereof
US12/030,314 Division US20080160617A1 (en) 2001-11-15 2008-02-13 Agent for inducing embryonic stem cell to ectodermal cell, method for obtaining the same, and use of the same

Publications (1)

Publication Number Publication Date
WO2003042384A1 true WO2003042384A1 (fr) 2003-05-22

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PCT/JP2002/011894 WO2003042384A1 (fr) 2001-11-15 2002-11-14 Inducteur de differentiation pour cellules souches d'embryon, procede d'obtention dudit inducteur et utilisation

Country Status (5)

Country Link
US (2) US20060281179A1 (ja)
EP (1) EP1452594A4 (ja)
JP (1) JP4294482B2 (ja)
CA (1) CA2467258A1 (ja)
WO (1) WO2003042384A1 (ja)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004099395A2 (en) * 2003-05-08 2004-11-18 Cellartis Ab A method for the generation of neural progenitor cells
WO2005085426A1 (ja) * 2004-03-04 2005-09-15 Tanabe Seiyaku Co., Ltd. 無フィ−ダ−分化用培地及び霊長類動物胚性幹細胞からの無フィ−ダ−分化方法
WO2006004149A1 (ja) * 2004-07-06 2006-01-12 Kyowa Hakko Kogyo Co., Ltd. 神経細胞の製造方法
JPWO2005080598A1 (ja) * 2004-02-19 2007-08-30 伸弥 山中 体細胞核初期化物質のスクリーニング方法
GB2427876B (en) * 2004-04-09 2009-02-18 Ronald S Goldstein Methods for generating neuronal cells from human embryonic stem cells and uses thereof
WO2010073407A1 (ja) * 2008-12-26 2010-07-01 株式会社大塚製薬工場 幹細胞の分化能の評価方法
US7923246B2 (en) 2004-05-27 2011-04-12 Riken Method of culturing embryonic stem cells with the use of amniotic membrane-origin factor
WO2011074690A1 (en) 2009-12-14 2011-06-23 Kyoto University Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis
JP2012245007A (ja) * 2004-06-18 2012-12-13 Institute Of Physical & Chemical Research 無血清浮遊培養による胚性幹細胞の神経分化誘導法
CN103097535A (zh) * 2010-07-12 2013-05-08 国立大学法人鸟取大学 利用miRNA导入的新型hiPSC制作法
JP2013188203A (ja) * 2012-02-13 2013-09-26 Nippon Menaade Keshohin Kk 幹細胞から外胚葉系細胞への分化誘導剤
WO2013140927A1 (ja) 2012-03-21 2013-09-26 国立大学法人京都大学 アルツハイマー病の治療薬および/または予防薬のスクリーニング方法
JP5700301B2 (ja) * 2009-06-03 2015-04-15 国立大学法人大阪大学 多能性幹細胞からの神経堤細胞群の分化誘導方法
KR20160045145A (ko) * 2013-08-23 2016-04-26 스미또모 가가꾸 가부시끼가이샤 망막 조직 및 망막 관련 세포의 제조 방법
WO2021220731A1 (ja) * 2020-04-30 2021-11-04 オリエンタル酵母工業株式会社 幹細胞用培地及び幹細胞の培養方法

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US7632679B2 (en) * 2002-07-16 2009-12-15 The Trustees Of Columbia University In The City Of New York Systems and methods for screening for modulators of neural differentiation
US20040224302A1 (en) * 2002-07-16 2004-11-11 Thomas Jessel Systems and methods for screening for modulators of neural differentiation
US7803783B2 (en) 2002-12-06 2010-09-28 The Board Of Trustees Of The Leland Stanford Junior University Use of WNT inhibitors to augment therapeutic index of chemotherapy
US20040265995A1 (en) * 2003-04-01 2004-12-30 Tamara Byk sFRP1 and uses thereof
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CA2467258A1 (en) 2003-05-22
EP1452594A4 (en) 2007-01-10
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