WO2003035091A1 - Preparation ai et son utilisation pour prevenir et traiter une infection par le virus de l'immunodeficience humaine - Google Patents

Preparation ai et son utilisation pour prevenir et traiter une infection par le virus de l'immunodeficience humaine Download PDF

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Publication number
WO2003035091A1
WO2003035091A1 PCT/JP2002/009481 JP0209481W WO03035091A1 WO 2003035091 A1 WO2003035091 A1 WO 2003035091A1 JP 0209481 W JP0209481 W JP 0209481W WO 03035091 A1 WO03035091 A1 WO 03035091A1
Authority
WO
WIPO (PCT)
Prior art keywords
hiv
indigo
solution
cells
preparation
Prior art date
Application number
PCT/JP2002/009481
Other languages
English (en)
Japanese (ja)
Inventor
Osami Aki
Shinobu Matsuda
Naoki Yamamoto
Original Assignee
Matsuda, Tasuku
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matsuda, Tasuku filed Critical Matsuda, Tasuku
Priority to JP2003537657A priority Critical patent/JP4121957B2/ja
Publication of WO2003035091A1 publication Critical patent/WO2003035091A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • AIDS & HIV (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une nouvelle préparation d'origine végétale efficace pour prévenir et traiter le virus de l'immunodéficience humaine (VIH). L'invention concerne essentiellement une préparation ai (polrgoum indigo) provenant de tadeai (Polygonum tinctorium Lour.) qui est une plante appartenant à Polygonaceae et , notamment, un composant possédant un effet anti-VIH remarquable contenu dans un extrait aqueux de sukumo (feuille fermentée de ai). Dans le procédé dans lequel un antigène CD4 se lie à un récepteur de chémokine via un antigène de surface gp120 et envahit des cellules, le composant contenu dans l'extrait aqueux de sukumo possède un effet inhibant la liaison de l'antigène. Ce composant inhibe également la réplication et la prolifération du VIH dans les cellules associées à l'infection. En outre, l'extrait aqueux de sukumo présente une faible toxicité et de ce fait est exempt d'effets secondaires même en cas d'administration prolongée pour traiter une infection par le VIH. On peut donc l'utiliser de manière sûre.
PCT/JP2002/009481 2001-10-23 2002-09-17 Preparation ai et son utilisation pour prevenir et traiter une infection par le virus de l'immunodeficience humaine WO2003035091A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2003537657A JP4121957B2 (ja) 2001-10-23 2002-09-17 藍調製物、ならびにそのヒト免疫不全ウイルスの感染予防または治療における用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-363447 2001-10-23
JP2001363447 2001-10-23

Publications (1)

Publication Number Publication Date
WO2003035091A1 true WO2003035091A1 (fr) 2003-05-01

Family

ID=19173783

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/009481 WO2003035091A1 (fr) 2001-10-23 2002-09-17 Preparation ai et son utilisation pour prevenir et traiter une infection par le virus de l'immunodeficience humaine

Country Status (2)

Country Link
JP (1) JP4121957B2 (fr)
WO (1) WO2003035091A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006115202A1 (fr) * 2005-04-25 2006-11-02 Fuji Sangyo Co., Ltd. Composition pour diminuer la toxicite de la nicotine
JP2008019227A (ja) * 2006-07-14 2008-01-31 Toyokatsu Horikawa 生理活性物質及びその製造方法
WO2008062861A1 (fr) 2006-11-24 2008-05-29 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Poudre d'extrait de plante contenant de l'indigo, procédé de fabrication de celle-ci et utilisation de celle-ci
CN103623070A (zh) * 2013-04-02 2014-03-12 汕头市创美中药饮片有限公司 何首乌的炮制生产工艺

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04124137A (ja) * 1990-09-13 1992-04-24 Higashimaru Shoyu Kk アンジオテンシン変換酵素阻害剤
JP2001031581A (ja) * 1998-06-30 2001-02-06 Hayashibara Biochem Lab Inc 生理活性抽出物
JP2001064131A (ja) * 1999-08-27 2001-03-13 Riaru Kagaku Kk 染毛剤およびそれを用いた染毛方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04124137A (ja) * 1990-09-13 1992-04-24 Higashimaru Shoyu Kk アンジオテンシン変換酵素阻害剤
JP2001031581A (ja) * 1998-06-30 2001-02-06 Hayashibara Biochem Lab Inc 生理活性抽出物
JP2001064131A (ja) * 1999-08-27 2001-03-13 Riaru Kagaku Kk 染毛剤およびそれを用いた染毛方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AU T.K. ET AL.: "A comparison of HIV-1 integrase by aqueous and methanol extracts of Chinese medicinal herbs", LIFE SCI., vol. 68, no. 14, 2001, pages 1687 - 1694, XP002961310 *
TATEFUJI TOMOKI ET AL.: "Antiviral effect of polygonum tinctorium lour", NATURAL MEDICINES, vol. 53, no. 6, 1999, pages 297 - 301, XP002960800 *
XU H.X. ET AL.: "Screening of traditional medicines for their inhibitory activity against HIV protease", PHYTOTHER. RES., vol. 10, no. 3, 1996, pages 207 - 210, XP002961308 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006115202A1 (fr) * 2005-04-25 2006-11-02 Fuji Sangyo Co., Ltd. Composition pour diminuer la toxicite de la nicotine
JP2008019227A (ja) * 2006-07-14 2008-01-31 Toyokatsu Horikawa 生理活性物質及びその製造方法
WO2008062861A1 (fr) 2006-11-24 2008-05-29 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Poudre d'extrait de plante contenant de l'indigo, procédé de fabrication de celle-ci et utilisation de celle-ci
CN103623070A (zh) * 2013-04-02 2014-03-12 汕头市创美中药饮片有限公司 何首乌的炮制生产工艺

Also Published As

Publication number Publication date
JP4121957B2 (ja) 2008-07-23
JPWO2003035091A1 (ja) 2005-02-10

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