WO2003030793A1 - Hydrating nasal gel and applicator - Google Patents
Hydrating nasal gel and applicator Download PDFInfo
- Publication number
- WO2003030793A1 WO2003030793A1 PCT/US2002/032606 US0232606W WO03030793A1 WO 2003030793 A1 WO2003030793 A1 WO 2003030793A1 US 0232606 W US0232606 W US 0232606W WO 03030793 A1 WO03030793 A1 WO 03030793A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gel
- nasal
- hydrating
- centipoise
- tissue
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
Definitions
- FIG. 2 is a side view of one embodiment of the nasal gel applicator of the present invention.
- the Brookfield viscometer is fitted with a number 4 spindle operating at 10 rpm, and at the higher end of the range, the Brookfield viscometer is fitted with a TE heliopathic spindle operating at 0.3 rpm.
- the hydrating nasal gel of the present invention includes a controlled-release agent that physically or chemically entrains, retains or entraps water, so that moisture will be progressively released over a substantial period of time. If water is released too quickly, the product will be ineffective. If the water is released too slowly, the hydrating nasal gel will be ineffective in providing moisture to the nasal tissues. Water should preferably be released from the entraining or water binding agent at such a rate that it maintains moisture in the environment of the nasal cavity and/or in the nasal linings or tissues for a substantial period of time.
- a hydrating nasal gel was prepared according to the formula shown in Table II. Table II
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02769063A EP1450739A4 (de) | 2001-10-12 | 2002-10-11 | Hydratisierendes nasengel und applikator |
JP2003533828A JP2005505587A (ja) | 2001-10-12 | 2002-10-11 | 含水性の点鼻ゲル及びその塗布装置 |
MXPA04003359A MXPA04003359A (es) | 2001-10-12 | 2002-10-11 | Gel nasal hidratante y dispositivo aplicador. |
CA002463384A CA2463384A1 (en) | 2001-10-12 | 2002-10-11 | Hydrating nasal gel and applicator |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32912301P | 2001-10-12 | 2001-10-12 | |
US32912201P | 2001-10-12 | 2001-10-12 | |
US60/329,122 | 2001-10-12 | ||
US60/329,123 | 2001-10-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003030793A1 true WO2003030793A1 (en) | 2003-04-17 |
Family
ID=26986653
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/032606 WO2003030793A1 (en) | 2001-10-12 | 2002-10-11 | Hydrating nasal gel and applicator |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1450739A4 (de) |
JP (1) | JP2005505587A (de) |
CA (1) | CA2463384A1 (de) |
MX (1) | MXPA04003359A (de) |
WO (1) | WO2003030793A1 (de) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6949262B1 (en) | 2003-05-27 | 2005-09-27 | Lousal Enterprises, Inc. | Skin and mucosal treatment formulation |
GB2431874A (en) * | 2005-11-03 | 2007-05-09 | Cst Medical Ltd | Lubricant |
WO2009104966A1 (en) * | 2008-02-20 | 2009-08-27 | Cornelis Boegem | Applicator for nasal ointment |
CN106727277A (zh) * | 2015-11-22 | 2017-05-31 | 中国人民解放军第三军医大学 | 一种含薄荷脑的鼻腔原位凝胶喷雾剂及其制备方法 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9757388B2 (en) | 2011-05-13 | 2017-09-12 | Acerus Pharmaceuticals Srl | Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels |
US20130040923A1 (en) | 2011-05-13 | 2013-02-14 | Trimel Pharmaceuticals Corporation | Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
US20130045958A1 (en) | 2011-05-13 | 2013-02-21 | Trimel Pharmaceuticals Corporation | Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
CN110613679A (zh) * | 2011-05-15 | 2019-12-27 | 埃瑟尔斯生物医药有限公司 | 控释鼻腔睾酮凝胶、用于经鼻给药的方法和预充式多剂量施药器系统 |
US11744838B2 (en) | 2013-03-15 | 2023-09-05 | Acerus Biopharma Inc. | Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4781923A (en) * | 1987-07-20 | 1988-11-01 | Pellico Michael A | Antiseptic gels |
WO1992019275A2 (en) * | 1991-05-04 | 1992-11-12 | The Procter & Gamble_Company | Cosmetic compositions |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4863725A (en) * | 1982-10-27 | 1989-09-05 | Deckner George E | Novel clear oil-free moisturizer composition |
GB2133691B (en) * | 1983-01-21 | 1986-05-21 | Leo Ab | Smoking substitutes for nasal administration |
US4724231A (en) * | 1985-04-16 | 1988-02-09 | Nastech Pharmaceutical, Inc. | Nasel compositions containing vitamin B12 |
HU9201465D0 (en) * | 1989-10-31 | 1992-07-28 | Columbia Lab Inc | Process and apparatus for making tissues wet |
IL101056A (en) * | 1992-02-24 | 1997-03-18 | Res & Dev Co Ltd | Composition for nasal treatment |
FR2694189B1 (fr) * | 1992-07-30 | 1994-09-02 | Sederma Sa | Nouvelle méthode destinée à augmenter la viscosité des compositions cosmétiques. |
GB9218834D0 (en) * | 1992-09-05 | 1992-10-21 | Procter & Gamble | Nasal spray products |
GB9324250D0 (en) * | 1993-11-25 | 1994-01-12 | Minnesota Mining & Mfg | Inhaler |
FR2744919B1 (fr) * | 1996-02-21 | 1998-03-27 | Stoa Sa | Nouvelles compositions pour le traitement et la protection des mamelles des animaux de traite |
JPH09253208A (ja) * | 1996-03-21 | 1997-09-30 | Unisia Jecs Corp | 鼻腔用投薬器 |
WO1997047310A1 (fr) * | 1996-06-12 | 1997-12-18 | Stoa S.A. | Compositions pharmaceutiques a base de gels de type glyceryl poly(meth)acrylate |
US5989535A (en) * | 1997-08-15 | 1999-11-23 | Soma Technologies | Polymeric bioadhesive emulsions and suspensions and methods of treatment |
US6080783A (en) * | 1998-09-01 | 2000-06-27 | Gum Tech International, Inc. | Method and composition for delivering zinc to the nasal membrane |
AU2862200A (en) * | 1999-01-27 | 2000-08-18 | Bruce H. Levin | Compositions, kits, apparatus, and methods for inhibiting cerebral neurovasculardisorders and muscular headaches |
DE19961307A1 (de) * | 1999-12-18 | 2001-07-12 | Krewel Meuselbach Gmbh | Medizinprodukt zur Befeuchtung und Reinigung der Nasenschleimhaut |
WO2001070270A2 (en) * | 2000-03-23 | 2001-09-27 | Collaborative Technologies, Inc. | Base compositions for preparing surfactant free topical compositions |
-
2002
- 2002-10-11 EP EP02769063A patent/EP1450739A4/de not_active Withdrawn
- 2002-10-11 WO PCT/US2002/032606 patent/WO2003030793A1/en active Application Filing
- 2002-10-11 MX MXPA04003359A patent/MXPA04003359A/es unknown
- 2002-10-11 CA CA002463384A patent/CA2463384A1/en not_active Abandoned
- 2002-10-11 JP JP2003533828A patent/JP2005505587A/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4781923A (en) * | 1987-07-20 | 1988-11-01 | Pellico Michael A | Antiseptic gels |
WO1992019275A2 (en) * | 1991-05-04 | 1992-11-12 | The Procter & Gamble_Company | Cosmetic compositions |
Non-Patent Citations (1)
Title |
---|
See also references of EP1450739A4 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6949262B1 (en) | 2003-05-27 | 2005-09-27 | Lousal Enterprises, Inc. | Skin and mucosal treatment formulation |
GB2431874A (en) * | 2005-11-03 | 2007-05-09 | Cst Medical Ltd | Lubricant |
WO2009104966A1 (en) * | 2008-02-20 | 2009-08-27 | Cornelis Boegem | Applicator for nasal ointment |
NL2002550C2 (nl) * | 2008-02-20 | 2010-05-26 | Cornelis Boegem | Balsem voor het afdekken van slijmvliezen tegen in de lucht aanwezige allergene stoffen, het gebruik van de balsem en een applicator voor de balsem. |
CN106727277A (zh) * | 2015-11-22 | 2017-05-31 | 中国人民解放军第三军医大学 | 一种含薄荷脑的鼻腔原位凝胶喷雾剂及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
MXPA04003359A (es) | 2004-11-29 |
EP1450739A1 (de) | 2004-09-01 |
JP2005505587A (ja) | 2005-02-24 |
EP1450739A4 (de) | 2008-12-17 |
CA2463384A1 (en) | 2003-04-17 |
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