WO2003025004A3 - Polypeptides purifies intervenant dans le traitement d'acides nucleiques - Google Patents

Polypeptides purifies intervenant dans le traitement d'acides nucleiques Download PDF

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Publication number
WO2003025004A3
WO2003025004A3 PCT/CA2002/001411 CA0201411W WO03025004A3 WO 2003025004 A3 WO2003025004 A3 WO 2003025004A3 CA 0201411 W CA0201411 W CA 0201411W WO 03025004 A3 WO03025004 A3 WO 03025004A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid processing
purified bacterial
polypeptides involved
bacterial polypeptides
Prior art date
Application number
PCT/CA2002/001411
Other languages
English (en)
Other versions
WO2003025004A2 (fr
Inventor
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Muhammad Zahoor Alam
Cheryl Arrowsmith
Donald Awrey
Bryan Beattie
Veronica Canadien
Brian Cox
Megan Domagala
Simon Houston
Qin Li
Kathleen Nethery
Ivy Ng
Hui Ouyang
Benjamin Pinder
Bay Sheldrick
Cristina Viola
Olga Wrezel
Original Assignee
Affinium Pharm Inc
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Muhammad Zahoor Alam
Cheryl Arrowsmith
Donald Awrey
Bryan Beattie
Veronica Canadien
Brian Cox
Megan Domagala
Simon Houston
Qin Li
Kathleen Nethery
Ivy Ng
Hui Ouyang
Benjamin Pinder
Bay Sheldrick
Cristina Viola
Olga Wrezel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharm Inc, Aled Edwards, Akil Dharamsi, Masoud Vedadi, Muhammad Zahoor Alam, Cheryl Arrowsmith, Donald Awrey, Bryan Beattie, Veronica Canadien, Brian Cox, Megan Domagala, Simon Houston, Qin Li, Kathleen Nethery, Ivy Ng, Hui Ouyang, Benjamin Pinder, Bay Sheldrick, Cristina Viola, Olga Wrezel filed Critical Affinium Pharm Inc
Priority to AU2002328215A priority Critical patent/AU2002328215A1/en
Publication of WO2003025004A2 publication Critical patent/WO2003025004A2/fr
Publication of WO2003025004A3 publication Critical patent/WO2003025004A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/04—Processes using organic exchangers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8804—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 automated systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

la présente invention concerne des cibles polypeptidiques pour bactéries pathogènes. Sont également décrites les caractéristiques biochimiques et biophysiques de ces polypeptides.
PCT/CA2002/001411 2001-09-18 2002-09-18 Polypeptides purifies intervenant dans le traitement d'acides nucleiques WO2003025004A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002328215A AU2002328215A1 (en) 2001-09-18 2002-09-18 Purified bacterial polypeptides involved in nucleic acid processing

Applications Claiming Priority (22)

Application Number Priority Date Filing Date Title
US32304001P 2001-09-18 2001-09-18
US60/323,040 2001-09-18
US32542101P 2001-09-27 2001-09-27
US32530701P 2001-09-27 2001-09-27
US60/325,307 2001-09-27
US60/325,421 2001-09-27
US32589101P 2001-09-28 2001-09-28
US60/325,891 2001-09-28
US32633701P 2001-10-01 2001-10-01
US60/326,337 2001-10-01
US32677401P 2001-10-03 2001-10-03
US60/326,774 2001-10-03
US32719301P 2001-10-04 2001-10-04
US60/327,193 2001-10-04
US34092201P 2001-10-30 2001-10-30
US60/340,922 2001-10-30
US33870901P 2001-11-05 2001-11-05
US60/338,709 2001-11-05
US33326901P 2001-11-06 2001-11-06
US60/333,269 2001-11-06
US34167901P 2001-12-18 2001-12-18
US60/341,679 2001-12-18

Publications (2)

Publication Number Publication Date
WO2003025004A2 WO2003025004A2 (fr) 2003-03-27
WO2003025004A3 true WO2003025004A3 (fr) 2004-03-04

Family

ID=27582772

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/001411 WO2003025004A2 (fr) 2001-09-18 2002-09-18 Polypeptides purifies intervenant dans le traitement d'acides nucleiques

Country Status (2)

Country Link
AU (1) AU2002328215A1 (fr)
WO (1) WO2003025004A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1492038A1 (fr) * 2003-06-27 2004-12-29 Centre National De La Recherche Scientifique (Cnrs) Structure cristalline de la protéine du facteur de processivité clamp de ADN polymerase et un ligand et cette usage
DE112005000590T5 (de) * 2004-03-10 2007-04-26 Basf Ag Polynukleotidphosphorylase (PNPase) als Ziel für Herbizide
EP1786900A1 (fr) * 2004-08-16 2007-05-23 AstraZeneca AB Structure cristalline de l'ump kinase et utilisations de celle-ci

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0786519A2 (fr) * 1996-01-05 1997-07-30 Human Genome Sciences, Inc. Polynucléotides et séquences de Staphylococcus aureus
US6037123A (en) * 1995-09-15 2000-03-14 Microcide Pharmaceuticals, Inc. Methods of screening for compounds active on Staphylococcus aureus target genes
WO2001070955A2 (fr) * 2000-03-21 2001-09-27 Elitra Pharmaceuticals, Inc. Identification de genes esentiels dans des procaryotes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037123A (en) * 1995-09-15 2000-03-14 Microcide Pharmaceuticals, Inc. Methods of screening for compounds active on Staphylococcus aureus target genes
EP0786519A2 (fr) * 1996-01-05 1997-07-30 Human Genome Sciences, Inc. Polynucléotides et séquences de Staphylococcus aureus
WO2001070955A2 (fr) * 2000-03-21 2001-09-27 Elitra Pharmaceuticals, Inc. Identification de genes esentiels dans des procaryotes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ROSAMOND J ET AL: "Harnessing the power of the genome in the search for new antibiotics", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 287, no. 5460, 17 March 2000 (2000-03-17), pages 1973 - 1976, XP002226396, ISSN: 0036-8075 *

Also Published As

Publication number Publication date
WO2003025004A2 (fr) 2003-03-27
AU2002328215A1 (en) 2003-04-01

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