WO2003025008A3 - Nouveaux polypeptides purifies impliques dans le traitement de proteines - Google Patents

Nouveaux polypeptides purifies impliques dans le traitement de proteines Download PDF

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Publication number
WO2003025008A3
WO2003025008A3 PCT/CA2002/001429 CA0201429W WO03025008A3 WO 2003025008 A3 WO2003025008 A3 WO 2003025008A3 CA 0201429 W CA0201429 W CA 0201429W WO 03025008 A3 WO03025008 A3 WO 03025008A3
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WO
WIPO (PCT)
Prior art keywords
protein processing
polypeptides involved
bacterial polypeptides
bacterial
involved
Prior art date
Application number
PCT/CA2002/001429
Other languages
English (en)
Other versions
WO2003025008A2 (fr
Inventor
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Muhammad Zahoor Alam
Donald Awrey
Bryan Beattie
Veronica Canadien
Megan Domagala
Simon Houston
Dhushy Kanagarajah
Sasha Necakov
Kathleen Nethery
Ivy Ng
Kamran Mansoury
Merry-Lynn Mcdonald
Benjamin Pinder
Bay Sheldrick
Cristina Viola
Original Assignee
Affinium Pharm Inc
Aled Edwards
Akil Dharamsi
Masoud Vedadi
Muhammad Zahoor Alam
Donald Awrey
Bryan Beattie
Veronica Canadien
Megan Domagala
Simon Houston
Dhushy Kanagarajah
Sasha Necakov
Kathleen Nethery
Ivy Ng
Kamran Mansoury
Merry-Lynn Mcdonald
Benjamin Pinder
Bay Sheldrick
Cristina Viola
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharm Inc, Aled Edwards, Akil Dharamsi, Masoud Vedadi, Muhammad Zahoor Alam, Donald Awrey, Bryan Beattie, Veronica Canadien, Megan Domagala, Simon Houston, Dhushy Kanagarajah, Sasha Necakov, Kathleen Nethery, Ivy Ng, Kamran Mansoury, Merry-Lynn Mcdonald, Benjamin Pinder, Bay Sheldrick, Cristina Viola filed Critical Affinium Pharm Inc
Priority to AU2002328225A priority Critical patent/AU2002328225A1/en
Publication of WO2003025008A2 publication Critical patent/WO2003025008A2/fr
Priority to US10/806,062 priority patent/US20050214773A1/en
Priority to US10/922,802 priority patent/US20050187718A1/en
Publication of WO2003025008A3 publication Critical patent/WO2003025008A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1229—Phosphotransferases with a phosphate group as acceptor (2.7.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01069—Protein-Npi-phosphohistidine-sugar phosphotransferase (2.7.1.69), i.e. sucrose phosphotransferase system II
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
    • C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
    • C12Y601/01001—Tyrosine-tRNA ligase (6.1.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
    • C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
    • C12Y601/0101—Methionine-tRNA ligase (6.1.1.10)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
    • C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
    • C12Y601/01021—Histidine-tRNA ligase (6.1.1.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des cibles polypeptidiques pour des bactéries pathogènes. Elle concerne également les caractéristiques biochimiques et biophysiques de ces polypeptides.
PCT/CA2002/001429 2001-09-21 2002-09-20 Nouveaux polypeptides purifies impliques dans le traitement de proteines WO2003025008A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002328225A AU2002328225A1 (en) 2001-09-21 2002-09-20 Bacterial polypeptides involved in protein processing
US10/806,062 US20050214773A1 (en) 2001-09-21 2004-03-22 Novel purified polypeptides from bacteria
US10/922,802 US20050187718A1 (en) 2001-09-21 2004-08-20 Novel purified polypeptides from Streptococcus pneumoniae

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US32417601P 2001-09-21 2001-09-21
US60/324,176 2001-09-21
US32443901P 2001-09-24 2001-09-24
US60/324,439 2001-09-24
US32471301P 2001-09-25 2001-09-25
US32469001P 2001-09-25 2001-09-25
US60/324,690 2001-09-25
US60/324,713 2001-09-25
US32633601P 2001-10-01 2001-10-01
US60/326,336 2001-10-01
US34146601P 2001-12-17 2001-12-17
US60/341,466 2001-12-17
US34176401P 2001-12-18 2001-12-18
US60/341,764 2001-12-18
US34191801P 2001-12-19 2001-12-19
US60/341,918 2001-12-19

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/806,062 Continuation-In-Part US20050214773A1 (en) 2001-09-21 2004-03-22 Novel purified polypeptides from bacteria
US10/922,802 Continuation-In-Part US20050187718A1 (en) 2001-09-21 2004-08-20 Novel purified polypeptides from Streptococcus pneumoniae

Publications (2)

Publication Number Publication Date
WO2003025008A2 WO2003025008A2 (fr) 2003-03-27
WO2003025008A3 true WO2003025008A3 (fr) 2005-04-14

Family

ID=27575389

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/001429 WO2003025008A2 (fr) 2001-09-21 2002-09-20 Nouveaux polypeptides purifies impliques dans le traitement de proteines

Country Status (2)

Country Link
AU (1) AU2002328225A1 (fr)
WO (1) WO2003025008A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10359351A1 (de) 2003-12-16 2005-07-21 Merck Patent Gmbh DNA-Sequenz und rekombinante Herstellung von Gruppe-4 Majorallergenen aus Getreiden
WO2005108626A2 (fr) * 2004-05-07 2005-11-17 Replidyne, Inc. Mutants de mrs staphylococciques et methodes d'utilisation
WO2009062241A1 (fr) * 2007-11-13 2009-05-22 Monash University Structure cristalline d'une enzyme bactérienne et ses utilisations

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0785268A1 (fr) * 1996-01-19 1997-07-23 Smithkline Beecham Plc Methionyl-tRNA synthétase de Staphylococcus Aureus
WO2001070955A2 (fr) * 2000-03-21 2001-09-27 Elitra Pharmaceuticals, Inc. Identification de genes esentiels dans des procaryotes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0785268A1 (fr) * 1996-01-19 1997-07-23 Smithkline Beecham Plc Methionyl-tRNA synthétase de Staphylococcus Aureus
WO2001070955A2 (fr) * 2000-03-21 2001-09-27 Elitra Pharmaceuticals, Inc. Identification de genes esentiels dans des procaryotes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BROWN MURRAY J B ET AL: "Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A.", BIOCHEMISTRY, vol. 39, no. 20, 23 May 2000 (2000-05-23), pages 6003 - 6011, XP002249801, ISSN: 0006-2960 *
DATABASE GSP [online] EBI; 10 September 1997 (1997-09-10), HODGSON ET AL.: "Methionyl-tRNA synthetase from Staphylococcus aureus WCUH - useful for protection against bacterial infections", XP002249726, Database accession no. AAW20051 *
DATABASE GSP [online] EBI; 14 February 2002 (2002-02-14), HASELBECK ET AL.: "Staphylococcus aureus cellular proliferation protein #1590", XP002249727, Database accession no. AAU37420 *

Also Published As

Publication number Publication date
AU2002328225A1 (en) 2003-04-01
WO2003025008A2 (fr) 2003-03-27

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