WO2003020711A1 - Composes dithiazole, inhibiteurs de metalloprotease matricielle et preparations a usage externe pour la peau - Google Patents

Composes dithiazole, inhibiteurs de metalloprotease matricielle et preparations a usage externe pour la peau Download PDF

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Publication number
WO2003020711A1
WO2003020711A1 PCT/JP2002/008649 JP0208649W WO03020711A1 WO 2003020711 A1 WO2003020711 A1 WO 2003020711A1 JP 0208649 W JP0208649 W JP 0208649W WO 03020711 A1 WO03020711 A1 WO 03020711A1
Authority
WO
WIPO (PCT)
Prior art keywords
skin
external preparations
compounds
matrix metalloprotease
metalloprotease inhibitors
Prior art date
Application number
PCT/JP2002/008649
Other languages
English (en)
French (fr)
Inventor
Takuya Hiruma
Koji Kobayashi
Shinji Inomata
Original Assignee
Shiseido Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shiseido Co., Ltd. filed Critical Shiseido Co., Ltd.
Priority to US10/487,411 priority Critical patent/US7348017B2/en
Priority to EP02772819A priority patent/EP1422224B1/en
Priority to KR1020047001888A priority patent/KR100911092B1/ko
Priority to DE60224203T priority patent/DE60224203T2/de
Publication of WO2003020711A1 publication Critical patent/WO2003020711A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Birds (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
PCT/JP2002/008649 2001-08-28 2002-08-28 Composes dithiazole, inhibiteurs de metalloprotease matricielle et preparations a usage externe pour la peau WO2003020711A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/487,411 US7348017B2 (en) 2001-08-28 2002-08-28 Dithiazole compounds, matrix metalloprotease inhibitors and external preparations for the skin
EP02772819A EP1422224B1 (en) 2001-08-28 2002-08-28 Dithiazole compounds, matrix metalloprotease inhibitors and external preparations for the skin
KR1020047001888A KR100911092B1 (ko) 2001-08-28 2002-08-28 디티아졸 화합물 및 매트릭스 메탈로프로테아제 활성저해제, 피부외용제
DE60224203T DE60224203T2 (de) 2001-08-28 2002-08-28 DITHIAZOLVERBINDUNGEN, MATRIX-METALLOPROTEASE-INHIBITOREN UND ZUBEREITUNGEN FÜR DIE ÄUßERLICHE ANWENDUNG AUF DER HAUT

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001258066A JP4825375B2 (ja) 2001-08-28 2001-08-28 ジチアゾール化合物及びマトリックスメタロプロテアーゼ活性阻害剤、皮膚外用剤
JP2001-258066 2001-08-28

Publications (1)

Publication Number Publication Date
WO2003020711A1 true WO2003020711A1 (fr) 2003-03-13

Family

ID=19085645

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008649 WO2003020711A1 (fr) 2001-08-28 2002-08-28 Composes dithiazole, inhibiteurs de metalloprotease matricielle et preparations a usage externe pour la peau

Country Status (7)

Country Link
US (1) US7348017B2 (ja)
EP (1) EP1422224B1 (ja)
JP (1) JP4825375B2 (ja)
KR (1) KR100911092B1 (ja)
CN (1) CN1319957C (ja)
DE (1) DE60224203T2 (ja)
WO (1) WO2003020711A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010016681A3 (en) * 2008-08-04 2010-06-03 Snu R&Db Foundation Pharmaceutical composition containing 1,2-dithiolthione derivative for preventing or treating disease caused by overexpression of lxr-alpha
US20120064060A1 (en) * 2004-06-23 2012-03-15 Ono Pharmaceutical Co., Ltd. Compound having s1p receptor binding potency and use thereof
WO2012049153A1 (en) 2010-10-12 2012-04-19 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRE20010042A1 (it) * 2001-04-24 2002-10-24 Corghi Spa Dispositivo sollevatore per macchine smontagomme
KR101127390B1 (ko) 2003-04-15 2012-03-23 웰스태트 테러퓨틱스 코포레이션 대사 질환의 치료용 화합물
CA2561741C (en) * 2004-04-05 2016-09-27 Alnylam Pharmaceuticals, Inc. Processes and reagents for oligonucleotide synthesis and purification
CA2585276A1 (en) * 2004-10-29 2006-06-08 Merck & Co., Inc. N-(pyridin-3-yl)-2-phenylbutanamides as androgen receptor modulators
BRPI0615948A2 (pt) * 2005-09-07 2011-05-31 Plexxikon Inc composto ativo de ppar, sua composição, seu kit e seu uso
US20090203851A1 (en) * 2006-06-02 2009-08-13 Dsm Ip Assets B.V. Process for the Preparation of a Hydroxy-Aromatic Resin: Hydroxy-Aromatic Resin, and Modification Thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3753908A (en) * 1971-08-30 1973-08-21 Chevron Res Oxidation inhibited lubricating oil compositions with extreme pressure properties
DE2228364A1 (de) * 1972-06-10 1973-12-20 Bergwerksverband Gmbh Verfahren zur herstellung von 3-acylamino-1,2,4-dithiazolin-5-thionen (acylxanthanwasserstoffe)
WO1995019956A1 (en) * 1994-01-20 1995-07-27 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
WO1996040745A2 (en) * 1995-06-07 1996-12-19 Proscript, Inc. Amino acid amides of 5-amino-1,3,4-thiadiazones and their use as inhibitors for matrix metalloproteinases
WO1997040031A1 (en) * 1996-04-23 1997-10-30 Pharmacia & Upjohn Company Thiadiazolyl(thio)ureas useful as matrix metalloprotease inhibitors
WO1998054198A1 (en) * 1997-05-30 1998-12-03 Hybridon, Inc. Novel sulfur transfer reagents for oligonucleotide synthesis
WO1999032111A1 (en) * 1997-12-22 1999-07-01 Bayer Corporation INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830869A (en) * 1996-06-21 1998-11-03 Mitchell; Mark Allen Thiadiazole amide MMP inhibitors
DE69716449T2 (de) 1996-08-28 2003-08-07 Procter & Gamble Substituierte zyklische amine als metalloproteaseinhibitoren

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3753908A (en) * 1971-08-30 1973-08-21 Chevron Res Oxidation inhibited lubricating oil compositions with extreme pressure properties
DE2228364A1 (de) * 1972-06-10 1973-12-20 Bergwerksverband Gmbh Verfahren zur herstellung von 3-acylamino-1,2,4-dithiazolin-5-thionen (acylxanthanwasserstoffe)
WO1995019956A1 (en) * 1994-01-20 1995-07-27 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
WO1996040745A2 (en) * 1995-06-07 1996-12-19 Proscript, Inc. Amino acid amides of 5-amino-1,3,4-thiadiazones and their use as inhibitors for matrix metalloproteinases
WO1997040031A1 (en) * 1996-04-23 1997-10-30 Pharmacia & Upjohn Company Thiadiazolyl(thio)ureas useful as matrix metalloprotease inhibitors
WO1998054198A1 (en) * 1997-05-30 1998-12-03 Hybridon, Inc. Novel sulfur transfer reagents for oligonucleotide synthesis
WO1999032111A1 (en) * 1997-12-22 1999-07-01 Bayer Corporation INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1422224A4 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120064060A1 (en) * 2004-06-23 2012-03-15 Ono Pharmaceutical Co., Ltd. Compound having s1p receptor binding potency and use thereof
US8653305B2 (en) * 2004-06-23 2014-02-18 Ono Pharmaceutical Co., Ltd. Compound having S1P receptor binding potency and use thereof
WO2010016681A3 (en) * 2008-08-04 2010-06-03 Snu R&Db Foundation Pharmaceutical composition containing 1,2-dithiolthione derivative for preventing or treating disease caused by overexpression of lxr-alpha
US9370504B2 (en) 2008-08-04 2016-06-21 Snu R&Db Foundation Pharmaceutical composition containing 1,2-dithiolthione derivative for preventing or treating disease caused by overexpression of LXR-α
WO2012049153A1 (en) 2010-10-12 2012-04-19 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof

Also Published As

Publication number Publication date
KR20040032149A (ko) 2004-04-14
EP1422224B1 (en) 2007-12-19
DE60224203D1 (de) 2008-01-31
US20040236111A1 (en) 2004-11-25
CN1549809A (zh) 2004-11-24
JP2003064065A (ja) 2003-03-05
JP4825375B2 (ja) 2011-11-30
CN1319957C (zh) 2007-06-06
US7348017B2 (en) 2008-03-25
EP1422224A4 (en) 2005-11-09
KR100911092B1 (ko) 2009-08-06
DE60224203T2 (de) 2008-12-04
EP1422224A1 (en) 2004-05-26

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