WO2003014108A1 - Nouveaux derives d'acide carboxylique et de quinoline substitues par 7-(aminomethyl-5-azospiro[2,4]heptane) et leur procede de preparation - Google Patents

Nouveaux derives d'acide carboxylique et de quinoline substitues par 7-(aminomethyl-5-azospiro[2,4]heptane) et leur procede de preparation Download PDF

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Publication number
WO2003014108A1
WO2003014108A1 PCT/CN2002/000249 CN0200249W WO03014108A1 WO 2003014108 A1 WO2003014108 A1 WO 2003014108A1 CN 0200249 W CN0200249 W CN 0200249W WO 03014108 A1 WO03014108 A1 WO 03014108A1
Authority
WO
WIPO (PCT)
Prior art keywords
azospiro
aminomethyl
heptane
acid derivatives
carboxylic acid
Prior art date
Application number
PCT/CN2002/000249
Other languages
English (en)
Chinese (zh)
Inventor
Huiyuan Guo
Jianjun Qi
Original Assignee
Institute Of Medicinal Biotechnology Chinese Academy Of Medical Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute Of Medicinal Biotechnology Chinese Academy Of Medical Sciences filed Critical Institute Of Medicinal Biotechnology Chinese Academy Of Medical Sciences
Publication of WO2003014108A1 publication Critical patent/WO2003014108A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

Abstract

La présente invention se rapporte à de nouveaux dérivés d'acide formique nalixidique et de fluoroquinolone ainsi qu'à leur procédé de préparation. L'invention se rapporte également à un agent antibactérien et à un additif d'alimentation contenant ces nouveaux dérivés. L'invention se rapporte tout particulièrement à un nouveau dérivé d'acide formique nalixidique et de fluoroquinolone représenté par la formule suivante (I), dans laquelle un substituant (7-aminomethyl-5-azospiro[2,4]heptane) est présent en position 7 du noyau quinolone, ce dérivé présentant une activité antibactérienne améliorée. Contrairement aux agents à base de quinolone connus qui possèdent une faible activité dirigée contre les sources Gram positif, ces nouveaux dérivés présentent un spectre antibactérien large. Dans la formule (I), les définitions des substituants sont les mêmes que dans le descriptif.
PCT/CN2002/000249 2001-08-08 2002-04-10 Nouveaux derives d'acide carboxylique et de quinoline substitues par 7-(aminomethyl-5-azospiro[2,4]heptane) et leur procede de preparation WO2003014108A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN01123609.4 2001-08-08
CNB011236094A CN1184221C (zh) 2001-08-08 2001-08-08 有7－(7－氨甲基－5－氮杂螺[2,4]庚烷)取代基的新喹啉羧酸衍生物及其制备方法

Publications (1)

Publication Number Publication Date
WO2003014108A1 true WO2003014108A1 (fr) 2003-02-20

Family

ID=4665183

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Application Number Title Priority Date Filing Date
PCT/CN2002/000249 WO2003014108A1 (fr) 2001-08-08 2002-04-10 Nouveaux derives d'acide carboxylique et de quinoline substitues par 7-(aminomethyl-5-azospiro[2,4]heptane) et leur procede de preparation

Country Status (2)

Country Link
CN (1) CN1184221C (fr)
WO (1) WO2003014108A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008059223A3 (fr) * 2006-11-13 2008-07-31 Cipla Ltd Procédé pour la synthèse de chlorhydrate de moxifloxacine
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
JP5073497B2 (ja) * 2005-09-28 2012-11-14 第一三共株式会社 テトラ置換−５−アザスピロ［２．４］へプタン誘導体の製法およびその光学活性中間体

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1861599A (zh) * 2005-05-11 2006-11-15 孙飘扬 喹诺酮羧酸类衍生物及其制备方法和药物用途
CN103102341A (zh) * 2012-12-14 2013-05-15 浙江普洛康裕制药有限公司 一种巴洛沙星二水合物的制备方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1062906A (zh) * 1990-10-18 1992-07-22 第一制药株式会社 8-氯代喹诺酮衍生物的制备方法
JPH0770110A (ja) * 1993-08-27 1995-03-14 Hokuriku Seiyaku Co Ltd ５，８−ジメチルキノリン−３−カルボン酸誘導体
CN1114959A (zh) * 1994-06-16 1996-01-17 Lg化学株式会社 有7-(4-氨基甲基-3-肟)吡咯烷取代基的新喹啉羧酸衍生物和其制法
CN1191529A (zh) * 1995-05-26 1998-08-26 第一制药株式会社 环状化合物的生产方法
JP2000026296A (ja) * 1998-07-14 2000-01-25 Dai Ichi Seiyaku Co Ltd 感染症治療薬
JP2001002676A (ja) * 1999-06-24 2001-01-09 Dai Ichi Seiyaku Co Ltd キノロンカルボン酸誘導体の製法
US6197974B1 (en) * 1998-10-26 2001-03-06 Abbott Laboratories Enantioselective synthesis of 3-aminopyrrolidines

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1062906A (zh) * 1990-10-18 1992-07-22 第一制药株式会社 8-氯代喹诺酮衍生物的制备方法
JPH0770110A (ja) * 1993-08-27 1995-03-14 Hokuriku Seiyaku Co Ltd ５，８−ジメチルキノリン−３−カルボン酸誘導体
CN1114959A (zh) * 1994-06-16 1996-01-17 Lg化学株式会社 有7-(4-氨基甲基-3-肟)吡咯烷取代基的新喹啉羧酸衍生物和其制法
CN1191529A (zh) * 1995-05-26 1998-08-26 第一制药株式会社 环状化合物的生产方法
JP2000026296A (ja) * 1998-07-14 2000-01-25 Dai Ichi Seiyaku Co Ltd 感染症治療薬
US6197974B1 (en) * 1998-10-26 2001-03-06 Abbott Laboratories Enantioselective synthesis of 3-aminopyrrolidines
JP2001002676A (ja) * 1999-06-24 2001-01-09 Dai Ichi Seiyaku Co Ltd キノロンカルボン酸誘導体の製法

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5073497B2 (ja) * 2005-09-28 2012-11-14 第一三共株式会社 テトラ置換−５−アザスピロ［２．４］へプタン誘導体の製法およびその光学活性中間体
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
WO2008059223A3 (fr) * 2006-11-13 2008-07-31 Cipla Ltd Procédé pour la synthèse de chlorhydrate de moxifloxacine
JP2010509305A (ja) * 2006-11-13 2010-03-25 シプラ・リミテッド モキシフロキサシン塩酸塩の合成方法
US8198451B2 (en) 2006-11-13 2012-06-12 Cipla Limited Process for the synthesis of moxifloxacin hydrochloride
EP2474547A3 (fr) * 2006-11-13 2012-07-25 Cipla Limited Procédé Pour La Synthèse De Chlorhydrate De Moxifloxacine
AU2007320997B2 (en) * 2006-11-13 2012-11-08 Cipla Limited Process for the synthesis of moxifloxacin hydrochloride
JP2014122223A (ja) * 2006-11-13 2014-07-03 Cipla Ltd モキシフロキサシン塩酸塩の合成方法
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents

Also Published As

Publication number Publication date
CN1400209A (zh) 2003-03-05
CN1184221C (zh) 2005-01-12

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