WO2003013617A3 - Konjugate makrocyclischer metallkomplex mit biomolekülen und deren verwendung zur herstellung von mitteln für die nmr- und radiodiagnostik sowie die radiotherapie - Google Patents

Konjugate makrocyclischer metallkomplex mit biomolekülen und deren verwendung zur herstellung von mitteln für die nmr- und radiodiagnostik sowie die radiotherapie Download PDF

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Publication number
WO2003013617A3
WO2003013617A3 PCT/EP2002/008000 EP0208000W WO03013617A3 WO 2003013617 A3 WO2003013617 A3 WO 2003013617A3 EP 0208000 W EP0208000 W EP 0208000W WO 03013617 A3 WO03013617 A3 WO 03013617A3
Authority
WO
WIPO (PCT)
Prior art keywords
conjugates
radiodiagnosis
biomolecules
radiotherapy
metal complexes
Prior art date
Application number
PCT/EP2002/008000
Other languages
English (en)
French (fr)
Other versions
WO2003013617A2 (de
Inventor
Johannes Platzek
Heribert Schmitt-Willich
Guenther Michl
Thomas Frenzel
Detlev Suelzle
Hans Bauer
Bernd Raduechel
Hanns-Joachim Weinmann
Heiko Schirmer
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Priority to EP02794507A priority Critical patent/EP1450864A2/de
Priority to KR10-2004-7000905A priority patent/KR20040030825A/ko
Priority to MXPA04000400A priority patent/MXPA04000400A/es
Priority to CA002453214A priority patent/CA2453214A1/en
Priority to AU2002355333A priority patent/AU2002355333B2/en
Priority to JP2003518619A priority patent/JP2004536889A/ja
Priority to BR0211150-0A priority patent/BR0211150A/pt
Priority to IL15929102A priority patent/IL159291A0/xx
Publication of WO2003013617A2 publication Critical patent/WO2003013617A2/de
Priority to NO20040239A priority patent/NO20040239L/no
Publication of WO2003013617A3 publication Critical patent/WO2003013617A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/143—Peptides, e.g. proteins the protein being an albumin, e.g. HSA, BSA, ovalbumin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Die Erfindung betrifft Konjugate aus makrocyclischen Metallkomplexen mit Biomolekülen und deren Herstellung. Die Konjugate eignen sich als Kontrastmittel in der NMR- und Radiodiagnostik sowie als Mittel für die Radiotherapie. Durch eine spezielle Ligandierung der Makrocyclen wird eine hohe Relaxivität erreicht und ein Feintuning der Relaxivität ermöglicht.
PCT/EP2002/008000 2001-07-20 2002-07-18 Konjugate makrocyclischer metallkomplex mit biomolekülen und deren verwendung zur herstellung von mitteln für die nmr- und radiodiagnostik sowie die radiotherapie WO2003013617A2 (de)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP02794507A EP1450864A2 (de) 2001-07-20 2002-07-18 Konjugate makrocyclischer metallkomplexe mit biomolekülen und deren verwendung zur herstellung von mitteln für nmr- und radiodiagnostik sowie die radiotherapie
KR10-2004-7000905A KR20040030825A (ko) 2001-07-20 2002-07-18 마크로시클릭 금속 착물과 생체분자와의 콘쥬게이트 및ｎｍｒ 진단 및 방사성진단 및 방사성치료에 사용하기위한 약제의 제조를 위한 그의 이용
MXPA04000400A MXPA04000400A (es) 2001-07-20 2002-07-18 Conjugados de complejos metalicos macrociclicos con biomoleculas y su uso para la preparacion de medios de diagnostico por resonancia magnetica nuclear, radiodiagnostico y radioterapia.
CA002453214A CA2453214A1 (en) 2001-07-20 2002-07-18 Conjugates of macrocyclic metal complexes with biomolecules and the utilization thereof for producing agents for use in nmr diagnosis and radiodiagnosis and radiotherapy
AU2002355333A AU2002355333B2 (en) 2001-07-20 2002-07-18 Conjugates of macrocyclic metal complexes with biomolecules and the utilization thereof for producing agents for use in NMR diagnosis and radiodiagnosis and radiotherapy
JP2003518619A JP2004536889A (ja) 2001-07-20 2002-07-18 大環状金属錯体と生体分子との結合体並びにｎｍｒ診断及び放射性診断及び放射線治療における使用のための薬剤を製造するためのその使用
BR0211150-0A BR0211150A (pt) 2001-07-20 2002-07-18 Complexos metálicos macrocìclicos conjugados e uso dos mesmos para produção de agentes para o diagnóstico de rmn e radiodiagnóstico, bem como radioterapia
IL15929102A IL159291A0 (en) 2001-07-20 2002-07-18 Conjugates of macrocyclic metal complexes with biomolecules and the utilization thereof for producing agents for use in nmr diagnosis and radiodiagnosis and radiotherapy
NO20040239A NO20040239L (no) 2001-07-20 2004-01-19 Konjugater av makrosykliske metallkomplekser med biomolekyler og anvendelse derav til fremstilling av midler for anvendelse i NMR- og røntgendiagnose, samt ved strålebehandling

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10135355A DE10135355C1 (de) 2001-07-20 2001-07-20 Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie
DE10135355.3 2001-07-20

Publications (2)

Publication Number Publication Date
WO2003013617A2 WO2003013617A2 (de) 2003-02-20
WO2003013617A3 true WO2003013617A3 (de) 2004-06-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/008000 WO2003013617A2 (de) 2001-07-20 2002-07-18 Konjugate makrocyclischer metallkomplex mit biomolekülen und deren verwendung zur herstellung von mitteln für die nmr- und radiodiagnostik sowie die radiotherapie

Country Status (19)

Country Link
US (2) US20030206865A1 (de)
EP (1) EP1450864A2 (de)
JP (1) JP2004536889A (de)
KR (1) KR20040030825A (de)
CN (1) CN1301750C (de)
AR (1) AR036182A1 (de)
AU (1) AU2002355333B2 (de)
BR (1) BR0211150A (de)
CA (1) CA2453214A1 (de)
DE (1) DE10135355C1 (de)
IL (1) IL159291A0 (de)
MX (1) MXPA04000400A (de)
NO (1) NO20040239L (de)
PE (1) PE20030190A1 (de)
PL (1) PL366421A1 (de)
RU (1) RU2004105262A (de)
TW (1) TWI238722B (de)
UY (1) UY27389A1 (de)
WO (1) WO2003013617A2 (de)

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EP1286704B1 (de) 2000-06-02 2014-07-23 Board of Regents, The University of Texas System ETHYLENEDICYSTEINE (EC)-Glucose Analoge KONJUGATE
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JP2007511503A (ja) * 2003-11-17 2007-05-10 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 医療画像化技術用の造影剤及びその使用
US9050378B2 (en) * 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
FR2868320B1 (fr) * 2004-03-31 2007-11-02 Centre Nat Rech Scient Cnrse Agent de contraste pour l'imagerie par resonance magnetique
CA2581639C (en) 2004-09-30 2016-07-26 Molecular Devices Corporation Luminescent lanthanide complexes
EP1881852B1 (de) * 2005-04-26 2009-08-19 Koninklijke Philips Electronics N.V. Kontrastmittel für die magnetresonanzbildgebung mit cest-aktivem paramagnetischem komplex
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US8758723B2 (en) * 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
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US9120837B2 (en) 2012-01-06 2015-09-01 Molecular Insight Pharmaceuticals Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase IX
EP3545978B1 (de) 2013-01-14 2021-09-08 Molecular Insight Pharmaceuticals, Inc. Radiopharmazeutika auf triazinbasis und strahlungsbildgebungsmittel
US20170050988A1 (en) * 2013-11-25 2017-02-23 Sanofi Dotam derivatives for therapeutic use
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Also Published As

Publication number Publication date
PE20030190A1 (es) 2003-03-22
TWI238722B (en) 2005-09-01
CA2453214A1 (en) 2003-02-20
CN1301750C (zh) 2007-02-28
PL366421A1 (en) 2005-01-24
US20070014725A1 (en) 2007-01-18
DE10135355C1 (de) 2003-04-17
AU2002355333B2 (en) 2007-01-04
JP2004536889A (ja) 2004-12-09
NO20040239L (no) 2004-01-19
US20030206865A1 (en) 2003-11-06
IL159291A0 (en) 2004-06-01
CN1541114A (zh) 2004-10-27
MXPA04000400A (es) 2004-03-18
AR036182A1 (es) 2004-08-18
EP1450864A2 (de) 2004-09-01
BR0211150A (pt) 2004-06-29
UY27389A1 (es) 2003-02-28
WO2003013617A2 (de) 2003-02-20
KR20040030825A (ko) 2004-04-09
RU2004105262A (ru) 2005-07-10

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