WO2002102455A1 - Matrice et systeme de stimulation miniatures implantables conçus pour la stimulation de la paupiere - Google Patents

Matrice et systeme de stimulation miniatures implantables conçus pour la stimulation de la paupiere Download PDF

Info

Publication number
WO2002102455A1
WO2002102455A1 PCT/US2002/017852 US0217852W WO02102455A1 WO 2002102455 A1 WO2002102455 A1 WO 2002102455A1 US 0217852 W US0217852 W US 0217852W WO 02102455 A1 WO02102455 A1 WO 02102455A1
Authority
WO
WIPO (PCT)
Prior art keywords
eyelid
signal
electrode
stimulator
implantable
Prior art date
Application number
PCT/US2002/017852
Other languages
English (en)
Other versions
WO2002102455A8 (fr
Inventor
Charles L. Byers
Kate E. Fey
Ralph M. Weisner
Gary D. Schnittgrund
Original Assignee
Alfred E. Mann Foundation For Scientific Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfred E. Mann Foundation For Scientific Research filed Critical Alfred E. Mann Foundation For Scientific Research
Priority to EP02739717A priority Critical patent/EP1404405B1/fr
Publication of WO2002102455A1 publication Critical patent/WO2002102455A1/fr
Publication of WO2002102455A8 publication Critical patent/WO2002102455A8/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0543—Retinal electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes

Definitions

  • This invention relates to a prosthetic medical device and methods, and more particularly to implantable eyelid devices and methods for controlling the opening and closing of an eyelid.
  • the structure of the eyelid 56 is shown in FIG. 1.
  • the muscle fibers of the orbicularis oculi 50 surround the palpebral fissure, which is the slit between the upper and lower lids.
  • the function of the orbicularis oculi 50 is to close the eye.
  • the palpebral part 52 sweeps in curves in the upper and lower eyelids. On contraction, the eyelids are closed gently.
  • the orbital part 54 sweeps in concentric curves in the forehead and cheek as a flat, thin sheet of muscle. Contraction lowers the eyebrow, and when this muscle contracts with the palpebral part 52, the eyes are squeezed tightly shut.
  • the orbicularis oculi 50 can fail to contract in a damaged, partially denervated eyelid, thus there is a loss of eyelid blinking.
  • the levator palpebrae superioris 58 functions to elevate the upper eyelid, thus opposing the orbicularis oculi 50 muscle.
  • the frontalis- occipitalis 60 elevates the eyebrows and is a dilator of the palpebral fissure.
  • U.S. Patent Nos. 4,799,487 and 5,843,147 presents an implantable electrode approach to solving this problem.
  • the electrode for the system must be designed such that it can be easily implanted, is chronically stable once implanted, and provides electrical stimulation without causing pain to the patients. For example, it is important to avoid stimulation of surrounding facial muscles or nearby sensory nerves.
  • Current known electrodes do not provide all of such functionality as applicable to the eyelid, eye, and surrounding area.
  • U.S. Patent No. 6,275,735 describes normal retinal cell function as a photochemical reaction converting light energy to an electrical impulse that travels to the brain and vision occurs.
  • AMD age-related macular degeneration
  • ATP Adenosine triphosphate
  • protein synthesis drops, the electrical resistance goes up, and cell membrane electrical potential goes down.
  • the cells may go dormant for a time before they die.
  • microcurrent stimulation will help rejuvenate the cells in the retina to slow or stop degeneration of the eye due to AMD. With the proper microcurrent stimulation waveform and therapy procedures, AMD may be slowed or stopped in a large number of people suffering from the disease.
  • the apparatus of the instant invention is an implantable miniature stimulator and/or sensor for eyelids.
  • the device is surgically implanted on or near a nerve or muscle that controls the blinking function of an eyelid.
  • Electrical pulses are transmitted from a control device that may be located remotely from the stimulator, and which may be implanted in the body.
  • the stimulating electric pulses travel along an electrically insulated cable that contains a number of very small diameter wires.
  • the wires pass through an electrically insulating silicone body and down a leaflet body where they are attached to an electrode.
  • the electrode rests on the nerve or muscle to be stimulated.
  • an electrical stimulating pulse is transmitted to the electrodes, at intervals on the order of several times per minute, which causes the paralyzed eyelid to open or close for normal blinking.
  • the feedback signal in a closed loop control case may be generated in response to a sensor on a functional eyelid, responsive to a neurostimulator muscular signal, which is then used to trigger stimulation of the paralyzed eyelid.
  • the input stimulation signal may be adjusted to give a satisfactory and consistent response.
  • FIG. 1 illustrates the structure of the human eyelid.
  • FIG. 2 illustrates a top view of the eyelid stimulator.
  • FIG. 3 illustrates a side view of the eyelid stimulator of FIG. 2.
  • FIG. 4 illustrates a cross-sectional view of the stimulating and neutral electrodes of the eyelid stimulator through section 4-4 of FIG. 2.
  • FIG. 5 illustrates simplified top view electrode connection schemes.
  • FIG. 6 illustrates a top view of an alternative eyelid stimulator.
  • FIG. 7 illustrates the implanted eyelid stimulator connected to an implanted miniature electric generator.
  • FIG. 8 illustrates a control scheme for an eyelid stimulator.
  • FIG. 9 illustrates a master control scheme for an eyelid stimulator.
  • FIG. 10 illustrates a closed loop control scheme for an eyelid stimulator.
  • FIG. 1 illustrates relevant facial muscles relating to eyelid stimulation.
  • An eyelid stimulator 2 and a controller 3 are illustrated in a preferred implant orientation to a paralyzed eyelid 9.
  • Implantable eyelid stimulator 2 is generally illustrated in FIG. 2.
  • the overall approximate dimensions of the eyelid stimulator 2, excluding insulated signal cable bundle 14 and insulated neutral cable bundle 16, are less than about 20 mm in length by less than about 10 mm in width, and, as shown in FIG. 3, less than about 0.50 mm in thickness.
  • the eyelid stimulator 2 contains an electrode array.
  • Leaflet bodies 4 hold electrically conductive signal electrodes 6 and neutral electrodes 7 that contact a nerve or a muscle that is to be stimulated.
  • the signal electrodes 6 pass a stimulating electrical signal to the nerve or muscle, with the neutral electrodes 7 also contacting the nerve or muscle, thereby completing the stimulation circuit.
  • neutral electrode and “signal electrode” is arbitrary, because the neutral electrodes 7 and the signal electrodes 6 will preferably be reverse biased on each cycle.
  • the eyelid stimulator 2 may be used as a sensor to detect signals and to transmit these signals to a remotely located signal receiver and processor.
  • the eyelid stimulator 2 is similar to those disclosed in U.S. Patent Nos. 6,315,721 and 6,208,894, which are incorporated in their entirety by reference herein.
  • a feature of this preferred embodiment is the flexibility of leaflet bodies 4, which are free to move with the eyelid and the stimulated muscle.
  • the signal electrodes 6 and the neutral electrodes 7 are located in the leaflet body 4.
  • Apertures 30 are located in one surface of the leaflet body 4 to expose the signal electrodes 6 and the neutral electrodes 7 to the living tissue, thereby allowing electrical contact between the living tissue and the signal electrodes 6 and the neutral electrode 7.
  • Electrode lead body 10, FIG. 2 is joined to the leaflet bodies 4 such that a joint 12 is formed between the leaflet bodies 4, near the attachment of the leaflet bodies 4 and the electrode lead body 10.
  • Anchor holes 20 in the electrode lead body 10 or leaflet bodies 4 preferably provide locations where attachments, such as sutures, may be placed for anchoring the eyelid stimulator 2. Alternately, living tissue may grow into the anchor holes 20, forming an attachment to the living tissue.
  • the insulated signal cable bundle 14 and the insulated neutral cable bundle 16, shown in FIG. 2 are each connected to a remotely located implanted miniature electric generator 66 (see FIG. 7) that produces electrical impulses that in turn stimulate the nerve or muscle that causes the eyelid to blink.
  • the electric generator 66 could be a microstimulator or it could be another type of stimulator.
  • the strands of wire comprising the insulated signal cable bundle 14 or insulated neutral cable bundle 16 are made of a highly conductive metal that is benign in the body, such as MP35N, stainless steel, iridium or an alloy of iridium, platinum or an alloy of platinum, such as platinum-iridium.
  • each strand of the wire has a diameter of approximately 0.001 inches.
  • insulated signal cable bundle 14 and insulated neutral cable bundle 16 are comprised of approximately 19 strands of platinum-20 weight percent iridium wire.
  • the insulated signal cable bundle 14 and the insulated neutral cable bundle 16 are electrically isolated from each other and from the environment in the living tissue by electrical insulation 32, which is preferably an outer covering of Teflon ® , a registered trademark of E.I. du Pont de Nemours and Company, Wilmington, Delaware.
  • electrical insulation 32 which is preferably an outer covering of Teflon ® , a registered trademark of E.I. du Pont de Nemours and Company, Wilmington, Delaware.
  • the signal electrodes 6 and the neutral electrodes 7 are made of a biocompatible material, such as stainless steel, iridium or an alloy of iridium, platinum or an alloy of platinum, such as platinum-iridium, and in a preferred embodiment, they are platinum-10 weight percent iridium.
  • the signal electrodes 6 and the neutral electrodes 7 are essentially identical physically and are approximately 0.50 mm thick and 0.80 mm in diameter. While the signal electrodes 6 and the neutral electrodes 7 are shown in FIGS. 2 and 3 with the preferred round shape, the signal electrodes 6 and the neutral electrodes 7 may be of any shape, for example, rectangular, square, oval, or round, etc.
  • the eyelid stimulator 2 of FIGS. 2 and 3 is preferably oriented in the eyelid such that the leaflet bodies 4 lay across the orbicularis oculi muscle 50 (see FIG. 1). Accordingly, as the muscle contracts due to the applied electrical stimulation, the flexible leaflet bodies 4 of the present invention move freely with the muscle.
  • FIG. 3 illustrates the eyelid stimulator 2 from a side view and illustrates the insulated neutral cable bundle 16 entering the electrode lead body 10 at seal 18.
  • the electrode lead body 10 is comprised of a top layer 24 and a bottom layer 26 that are joined together.
  • the joint 12 is formed where the leaflet bodies 4 join the electrode lead body 10.
  • FIG. 5a illustrates a simplified view of the electrodes connection scheme, where the signal electrodes 6 operate in unison and where the neutral electrodes 7 operate in unison.
  • FIG. 5b illustrates a simplified view of the electrodes connection scheme, where an alternative embodiment preferably has a common insulated signal cable bundle 14 that is connected to all of the signal electrodes 6 in the leaflet bodies 4. At least one ground electrode 8, which may be located remote from the eyelid stimulator 2, is in electrical contact with the living tissue. The ground electrode 8 is utilized to complete the circuit.
  • FIG. 5c illustrates a simplified view of the electrodes connection scheme, where a further alternative embodiment preferably has the individual signal electrodes 6 each connected to the individual signal lead wires 23, such that each signal electrode 6 may be individually powered and controlled.
  • the ground electrode 8 may be either locally mounted in the eyelid stimulator 2 or in contact with the living tissue remote from the eyelid stimulator 2.
  • FIG. 5d illustrates a simplified view of the electrodes connection scheme, where a further alternative embodiment is described as bipolar pairs, which preferably has individual signal electrodes 6 each connected to individual signal lead wires 23, such that each signal electrode 6 may be individually powered.
  • Each signal electrode 6 is paired with a neutral electrode 7, forming a bipolar pair.
  • This bipolar pair is powered by an electric pulse generator, such as the implanted miniature electric generator 66, where generator 66a powers one bipolar pair, generator 66b powers a second bipolar pair, etc. It is obvious that one electric generator 66 may power sequentially or simultaneously one or any combination of bipolar pairs.
  • the preferred manner of arranging the neutral electrodes 7, shown in FIG. 4 is to attach each neutral electrode 7 to a separate neutral lead wire 22, that in turn passes along and through the leaflet body 4, along and through lead body 10, through seal 18 (see FIGS. 2 and 3), and into insulated neutral cable bundle 16. It is obvious that more than one neutral electrode 7 can be attached to the neutral lead wire 22.
  • the signal electrodes 6 are attached to the separate signal lead wire 23 that passes through the leaflet bodies 4 and along the lead body 10, through the seal 18, and into the insulated signal cable bundle 14.
  • the lead body 10 is comprised of the top layer 24 and the bottom layer 26.
  • the leaflet bodies 4 and the electrode lead body 10 are preferably made of a biocompatible material that is electrically insulating.
  • the biocompatible material is silicone having a hardness of about 70 on the Shore A scale as measured with a durometer.
  • the insulated signal cable bundle 14 and insulated neutral cable bundle 16 pass through the seal 18, which is attached to the electrode lead body 10.
  • the seal 18 is preferably made of silicone.
  • the electrode lead body 10 and the leaflet bodies 4 are comprised of a biodegradable material that is resorbed by the body post-implantation. It is obvious that the insulated signal cable bundle 14 and the insulated neutral cable bundle 16 may be combined into one cable bundle.
  • An alternative method (not illustrated) of making the eyelid stimulator 2 is to utilize a flexible substrate on which a circuit is printed on one surface that is conformal-coated using biocompatible materials.
  • the electrical contact points are made by placing holes through the substrate.
  • contact points may be made by masking the conformal coating or photolithographically patterning the conformal coating.
  • the signal electrodes 6 are preferably attached by welding to the signal lead wire 23 at signal bond joint 34.
  • the neutral electrodes 7 are attached by welding to the neutral lead wire 22 at neutral bond joint 36.
  • the leaflet bodies 4 are comprised of the top layer 24 and the bottom layer 26, which are bonded together (see FIG. 4). Sandwiched between the top layer 24 and the bottom layer 26 is a separation layer 28.
  • the separation layer 28 is preferably comprised of an electrically insulating material that is soft and biocompatible. In a preferred embodiment, the separation layer 28 is silicone having a hardness of about 70 on the Shore A scale as measured with a durometer.
  • FIG. 6 illustrates an alternative embodiment of an eyelid stimulator 37, wherein flexible leg electrodes 40 are contained within flexible legs 38.
  • the eyelid stimulator 37 has a generally sinusoidal shape with rounded ends.
  • the flexible legs 38 are connected by flexible joints 44, which provide flexibility for the apparatus to conform to the eyelid while maintaining electrical contact with the living tissue as it moves during muscle contraction.
  • the flexible leg electrodes 40 are located with apertures 41 in the flexible legs 38.
  • the flexible leg electrodes 40 make contact with the nerve or muscle tissue that is to be stimulated by contacting it through the apertures 41 in the flexible legs 38.
  • the flexible leg 38 is made of a material, such as silicon, which has a hardness of about 25 on the Shore A scale as measured with a durometer.
  • the eyelid stimulator 37 is very flexible, allowing it to move and flex with the muscle as it responds to the electrical stimulation.
  • An advantage of this embodiment is that the eyelid stimulator 37 is very soft and flexible, easily conforming to the shape of the eyelid.
  • the eyelid stimulator 37 is preferably oriented in the eyelid such that the flexible legs 38 lay across the orbicularis oculi muscle 50 (see FIG. 1). As the orbicularis oculi muscle 50 contracts due to the applied electrical stimulation, the flexible legs 38 move freely with the muscle.
  • the flexible leg electrodes 40 may be positive, negative, or neutral biased, depending upon which wire in cable bundle 42 is attached to the flexible leg electrodes 40.
  • FIG. 7 illustrates an exemplary open loop control system of the present invention wherein an implanted eyelid stimulator 62 is located in an eyelid.
  • the implanted miniature electric generator 66 is located in an implanted position under the skin of the patient near the implanted eyelid stimulator 62 and connected to it by a transmission wire 64.
  • the implanted miniature electric generator 66 is controlled by internal programming to generate an electric pulse on a programmed schedule at regular or irregular intervals.
  • the implanted miniature electric generator 66 may receive an electric signal from a remote controller (not illustrated) to generate an electric pulse. Examples of known pulse generators are disclosed by U.S. Patent Nos. 6,185,452; 6,208,894; and 6,315,721.
  • a further alternative embodiment combines the controller with the implanted eyelid stimulator 62.
  • This embodiment is not illustrated.
  • the controller exemplified by electric generator 66, is mounted on and therefore is a part of eyelid stimulator 62. More than one stimulator 62, having a controller integrally mounted thereon, may be connected with other similar stimulators 62.
  • Known examples of miniature electric pulse generators are disclosed in U.S. Patent No. 5,999,848, incorporated in its entirety by reference herein, which describes an implantable sensor/stimulator connectable to a controller.
  • FIG. 8 illustrates an exemplary open loop control scheme 100 that coordinates stimulation between a functioning eyelid 111 and a paralyzed eyelid 109 via an implanted eyelid stimulator 112, located in the paralyzed eyelid 109.
  • the implanted eyelid stimulator 112 is controlled by an implanted miniature electric pulse generator 104 via a transmission wire 110.
  • the electric pulse generator 104, transmission wire 110, and eyelid stimulator 112 in combination form a stimulating device.
  • Known examples of miniature electric pulse generators are disclosed in U.S. Patent Nos. 6,164,284; 6,185,452; 6,208,894; and 6,315,721, each of which is incorporated in its entirety by reference herein.
  • the implanted eyelid stimulator 112 may be located on the nerves or on the muscles to cause the eyelid to open or to close.
  • the miniature electric pulse generator 104 and control microsensor 102 are typical of the miniature monitoring and/or stimulating devices for implantation in living tissue disclosed by Schulman et al. (U.S. Patent No. 6,164,284), Schulman et al. (U.S. Patent No. 6,185,452), and Schulman et al. (U.S. Patent No. 6,208,894), each of which is incorporated in its entirety by reference.
  • connection 108 between the control microsensor 102 and the implanted miniature electric pulse generator 104 may be sent by wireless means, such as by RF signals, propagated radio signals, or alternating magnetic fields.
  • wireless means such as by RF signals, propagated radio signals, or alternating magnetic fields.
  • FIG. 9 illustrates an embodiment wherein a master control unit 116 may control one or more implanted miniature electric pulse generators 104, to control opening and/or closing of the paralyzed eyelid 109 in a timing sequence determined by the master control unit 116.
  • a master control unit 116 may control one or more implanted miniature electric pulse generators 104, to control opening and/or closing of the paralyzed eyelid 109 in a timing sequence determined by the master control unit 116.
  • FIG. 9 illustrates an embodiment where there is one paralyzed eyelid 109 and one functioning eyelid 111. Closing the functioning eyelid 111 causes an electric signal to be generated that triggers the implanted eyelid pulse generators 104 to close the paralyzed eyelid 109.
  • a further embodiment is a closed loop control scheme 101 that uses a signal from the paralyzed eyelid 109, which is preferably detected by an implanted eyelid sensor electrode 118 to modify the electric signal that closes the paralyzed eyelid 109. For example, if the paralyzed eyelid 109 fails to close properly, then the electric pulse is increased (in amplitude and/or duration) to properly stimulate the eyelid 109 to close. The electric feedback signal is generated when the paralyzed eyelid 109 closes. Eyelid closure is detected by implanted eyelid sensor electrode 118 and is transmitted to an implanted miniature electric pulse sensor 120. A signal is then transmitted to the control microsensor 102 via a connection 122.
  • AMD By virtue of having the eyelid stimulated, the additional benefit of therapeutic electrical stimulation to the eye and/or the retina can be achieved.

Abstract

L'invention concerne un dispositif à électrodes (2) miniature implantable pour paupière, lequel dispositif est conçu pour permettre l'ouverture et la fermeture d'une paupière paralysée (9) par application d'un courant d'électrostimulation à un nerf ou à un muscle. Ce dispositif comprend un corps non-conducteur qui est souple sur sa longueur et qui contient des électrodes conçues pour appliquer un signal électrique à un nerf ou à un muscle avoisinant, ce qui permet d'ouvrir ou de fermer la paupière.
PCT/US2002/017852 2001-06-18 2002-06-05 Matrice et systeme de stimulation miniatures implantables conçus pour la stimulation de la paupiere WO2002102455A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP02739717A EP1404405B1 (fr) 2001-06-18 2002-06-05 Matrice et systeme de stimulation miniatures implantables con us pour la stimulation de la paupiere

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29937901P 2001-06-18 2001-06-18
US60/299,379 2001-06-18
US10/160,804 US6792314B2 (en) 2001-06-18 2002-05-31 Miniature implantable array and stimulation system suitable for eyelid stimulation
US10/160,804 2002-05-31

Publications (2)

Publication Number Publication Date
WO2002102455A1 true WO2002102455A1 (fr) 2002-12-27
WO2002102455A8 WO2002102455A8 (fr) 2004-05-21

Family

ID=26857241

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/017852 WO2002102455A1 (fr) 2001-06-18 2002-06-05 Matrice et systeme de stimulation miniatures implantables conçus pour la stimulation de la paupiere

Country Status (3)

Country Link
US (1) US6792314B2 (fr)
EP (1) EP1404405B1 (fr)
WO (1) WO2002102455A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1648554A2 (fr) * 2003-06-26 2006-04-26 Northstar Neuroscience, Inc. Appareils et systemes permettant d'appliquer une stimulation electrique chez un patient
JP2015513980A (ja) * 2012-04-05 2015-05-18 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 脳神経刺激のための皮下電極
WO2021069058A1 (fr) * 2019-10-07 2021-04-15 Abuyousef Nuha Awni Système, dispositif et procédé permettant d'induire un mouvement de paupière

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4204066B2 (ja) * 2002-12-05 2009-01-07 保雄 田野 人工視覚システム
US7321795B2 (en) * 2003-03-24 2008-01-22 Les Bogdanowicz Compositions for electric stimulation of the eye
US7035692B1 (en) * 2003-04-30 2006-04-25 The Regents Of The University Of California High density polymer-based integrated electrode array
US9278208B1 (en) 2003-10-20 2016-03-08 University Of Central Florida Research Foundation, Inc. Spatial-temporal deep brain stimulation methods and systems
US8024049B1 (en) 2003-10-20 2011-09-20 University Of Central Florida Research Foundation, Inc. Spatial-temporal deep brain stimulation methods and systems
GB0409769D0 (en) * 2004-04-30 2004-06-09 Algotec Ltd Electrical nerve stimulation device
US9168383B2 (en) 2005-10-14 2015-10-27 Pacesetter, Inc. Leadless cardiac pacemaker with conducted communication
EP2471451A1 (fr) 2005-10-14 2012-07-04 Nanostim, Inc. Stimulateur cardiaque sans fil et système
CN100591391C (zh) * 2006-07-28 2010-02-24 中国科学院上海微系统与信息技术研究所 一种集成药剂释放功能的植入式微电极、制作方法及应用
DE102006048819A1 (de) * 2006-10-10 2008-04-17 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Vorrichtung mit einem Grundkörper
US20080103572A1 (en) 2006-10-31 2008-05-01 Medtronic, Inc. Implantable medical lead with threaded fixation
US8019443B2 (en) 2008-04-01 2011-09-13 Boston Scientific Neuromodulation Corporation Anchoring units for leads of implantable electric stimulation systems and methods of making and using
US9320891B2 (en) * 2008-04-02 2016-04-26 Boston Scientific Neuromodulation Corporation Lead anchor for implantable devices and methods of manufacture and use
US8685093B2 (en) 2009-01-23 2014-04-01 Warsaw Orthopedic, Inc. Methods and systems for diagnosing, treating, or tracking spinal disorders
US8126736B2 (en) 2009-01-23 2012-02-28 Warsaw Orthopedic, Inc. Methods and systems for diagnosing, treating, or tracking spinal disorders
US8527068B2 (en) 2009-02-02 2013-09-03 Nanostim, Inc. Leadless cardiac pacemaker with secondary fixation capability
US8718784B2 (en) * 2010-01-14 2014-05-06 Nano-Retina, Inc. Penetrating electrodes for retinal stimulation
US8150526B2 (en) * 2009-02-09 2012-04-03 Nano-Retina, Inc. Retinal prosthesis
US8706243B2 (en) 2009-02-09 2014-04-22 Rainbow Medical Ltd. Retinal prosthesis techniques
US8442641B2 (en) 2010-08-06 2013-05-14 Nano-Retina, Inc. Retinal prosthesis techniques
US8428740B2 (en) 2010-08-06 2013-04-23 Nano-Retina, Inc. Retinal prosthesis techniques
US9352147B2 (en) * 2009-04-27 2016-05-31 Boston Scientific Neuromodulation Corporation Torque lock anchor and methods and devices using the anchor
US9887470B2 (en) 2009-04-27 2018-02-06 Boston Scienific Neuromodulation Corporation Torque lock anchor and methods and devices using the anchor
US9061134B2 (en) * 2009-09-23 2015-06-23 Ripple Llc Systems and methods for flexible electrodes
CN103249452A (zh) 2010-10-12 2013-08-14 内诺斯蒂姆股份有限公司 用于无引线心脏起博器的温度传感器
US9060692B2 (en) 2010-10-12 2015-06-23 Pacesetter, Inc. Temperature sensor for a leadless cardiac pacemaker
US9020611B2 (en) 2010-10-13 2015-04-28 Pacesetter, Inc. Leadless cardiac pacemaker with anti-unscrewing feature
AU2011328900B2 (en) 2010-11-16 2015-03-19 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for treatment of dry eye
US9821159B2 (en) 2010-11-16 2017-11-21 The Board Of Trustees Of The Leland Stanford Junior University Stimulation devices and methods
CN103429296A (zh) 2010-12-13 2013-12-04 内诺斯蒂姆股份有限公司 递送导管系统和方法
JP6023720B2 (ja) 2010-12-13 2016-11-09 ナノスティム・インコーポレイテッドＮａｎｏｓｔｉｍ， Ｉｎｃ． ペースメーカーの取出システム及び取出方法
EP2654889B1 (fr) 2010-12-20 2017-03-01 Pacesetter, Inc. Stimulateur cardiaque sans dérivation présentant un mécanisme de fixation radiale
US8571669B2 (en) 2011-02-24 2013-10-29 Nano-Retina, Inc. Retinal prosthesis with efficient processing circuits
WO2013067496A2 (fr) 2011-11-04 2013-05-10 Nanostim, Inc. Stimulateur cardiaque sans dérivation ayant une batterie intégrale et des soudures redondantes
EP2790774B1 (fr) * 2011-12-14 2017-10-25 MED-EL Elektromedizinische Geräte GmbH Système de stimulation de paupière
CN104284695A (zh) * 2012-03-23 2015-01-14 微阵列有限公司 带有电极和有生理学活性的前体物质的皮肤敷料
EP2879758B1 (fr) 2012-08-01 2018-04-18 Pacesetter, Inc. Circuit de biostimulation avec cellule autonome
US8849408B1 (en) 2013-01-04 2014-09-30 University Of Central Florida Research Foundation, Inc. Methods for electronic directionality of deep-brain stimulation
WO2014110575A1 (fr) 2013-01-14 2014-07-17 Massachusetts Eye & Ear Infirmary Détection et stimulation de mouvements et d'expressions faciaux
WO2014138709A1 (fr) 2013-03-08 2014-09-12 Oculeve, Inc. Dispositifs et procédés pour traiter un œil sec chez des animaux
EP2967817B1 (fr) 2013-03-12 2021-03-10 Oculeve, Inc. Dispositifs et systèmes de pose d'implant
US9370417B2 (en) 2013-03-14 2016-06-21 Nano-Retina, Inc. Foveated retinal prosthesis
CA2883874A1 (fr) 2013-04-19 2014-10-23 Oculeve, Inc. Dispositifs et procedes de stimulation nasale
US9517334B2 (en) 2013-08-19 2016-12-13 Boston Scientific Neuromodulation Corporation Lead anchors and systems and methods employing the lead anchors
US9216563B2 (en) 2013-08-19 2015-12-22 Boston Scientific Neuromodulation Corporation Lead anchor with adhesive and systems and methods using the lead anchor
US9474902B2 (en) 2013-12-31 2016-10-25 Nano Retina Ltd. Wearable apparatus for delivery of power to a retinal prosthesis
US9331791B2 (en) 2014-01-21 2016-05-03 Nano Retina Ltd. Transfer of power and data
ES2812752T3 (es) 2014-02-25 2021-03-18 Oculeve Inc Formulaciones de polímeros para estimulación nasolagrimal
US9415212B2 (en) 2014-02-28 2016-08-16 Boston Scientific Neuromodulation Corporation Side loading lead anchor and methods of making and using thereof
US9987482B2 (en) 2014-05-27 2018-06-05 Boston Scientific Neuromodulation Corporation Systems and methods for making and using reversible mechanical lead anchors for electrical stimulation systems
EP3171928B1 (fr) 2014-07-25 2020-02-26 Oculeve, Inc. Stimulation pulsée pour traiter l'oeil sec
CN106659882A (zh) 2014-08-15 2017-05-10 艾克索尼克斯调制技术股份有限公司 用于进行神经刺激以减轻膀胱功能障碍和其他适应症的可植入引线附着结构
CN107106843A (zh) 2014-10-22 2017-08-29 奥库利维公司 用于治疗干眼症的刺激装置和方法
EP3209370A4 (fr) 2014-10-22 2018-05-30 Oculeve, Inc. Lentille de contact permettant une augmentation de la production de larmes
EP3209371A4 (fr) 2014-10-22 2018-10-24 Oculeve, Inc. Systèmes et procédés de stimulateur nasal implantable
US9636498B2 (en) 2015-08-03 2017-05-02 Boston Scientific Neuromodulation Corporation Lead anchor with a wedge and systems using the lead anchor
EP3349844B1 (fr) 2015-09-15 2021-01-20 i-Lumen Scientific, Inc. Appareil pour thérapie de stimulation oculaire par microcourants
US10426958B2 (en) 2015-12-04 2019-10-01 Oculeve, Inc. Intranasal stimulation for enhanced release of ocular mucins and other tear proteins
US10252048B2 (en) 2016-02-19 2019-04-09 Oculeve, Inc. Nasal stimulation for rhinitis, nasal congestion, and ocular allergies
WO2017151438A1 (fr) 2016-02-29 2017-09-08 Boston Scientific Neuromodulation Corporation Point d'ancrage de conducteur électrique pour système de stimulation électrique
CA3022683A1 (fr) 2016-05-02 2017-11-09 Oculeve, Inc. Stimulation intranasale pour le traitement de la maladie de la glande de meibomius et de la blepharite
WO2017201058A1 (fr) 2016-05-17 2017-11-23 Boston Scientific Neuromodulation Corporation Systèmes et procédés d'ancrage d'un fil pour neurostimulation d'une anatomie cible
JP2020500609A (ja) 2016-12-02 2020-01-16 オキュリーブ， インコーポレイテッド ドライアイ予測及び治療勧告のための装置及び方法
US10709886B2 (en) 2017-02-28 2020-07-14 Boston Scientific Neuromodulation Corporation Electrical stimulation leads and systems with elongate anchoring elements and methods of making and using
US10835739B2 (en) 2017-03-24 2020-11-17 Boston Scientific Neuromodulation Corporation Electrical stimulation leads and systems with elongate anchoring elements and methods of making and using
US10857351B2 (en) 2017-04-28 2020-12-08 Boston Scientific Neuromodulation Corporation Lead anchors for electrical stimulation leads and systems and methods of making and using
US11602630B2 (en) 2017-06-07 2023-03-14 Neuronexus Technologies, Inc. Systems and methods for flexible electrode arrays
WO2019083863A1 (fr) 2017-10-23 2019-05-02 Patent Holding Company 001, Llc Dispositifs, procédés et systèmes de communication
US10729564B2 (en) 2018-01-12 2020-08-04 Ripple Llc Sensor system
AU2019224043A1 (en) 2018-02-22 2020-08-20 Axonics, Inc. Neurostimulation leads for trial nerve stimulation and methods of use
WO2020035852A2 (fr) 2018-08-14 2020-02-20 Neurotrigger Ltd. Procédé et appareil de stimulation transcutanée du nerf facial et applications associées
WO2020072468A1 (fr) 2018-10-01 2020-04-09 Biovisics Medical, Llc Système et procédés de modulation électrique commandée pour une thérapie de la vision
US11305118B2 (en) 2018-11-30 2022-04-19 Biovisics Medical, Inc. Head worn apparatuses for vision therapy
PL3897817T3 (pl) 2018-12-20 2024-03-11 I-Lumen Scientific, Inc. System do stymulacyjnej terapii mikroprądowej
CN109718468A (zh) * 2019-01-13 2019-05-07 常州瑞神安医疗器械有限公司 一种体外供电电极
EP3952979A1 (fr) 2019-04-10 2022-02-16 Biovisics Medical, Inc. Systèmes et interfaces de thérapie oculaire
US11511112B2 (en) 2019-06-14 2022-11-29 Biovisics Medical, Inc. Wearable medical device
WO2022094439A1 (fr) 2020-10-30 2022-05-05 Datafeel Inc. Appareil de communication de données portable, trousses, procédés et systèmes
USD1010832S1 (en) * 2021-12-01 2024-01-09 I-Lumen Scientific, Inc. Medical electrode

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843147A (en) * 1996-04-30 1998-12-01 Medtronic, Inc. Implantable eyelid electrode and method of implanting same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271841A (en) 1980-01-31 1981-06-09 Medtronic, Inc. Electro-ocular stimulation system
US4799487A (en) * 1987-05-11 1989-01-24 Bleicher Joel N Reanimation device and method for treating the paralyzed face
US5324322A (en) 1992-04-20 1994-06-28 Case Western Reserve University Thin film implantable electrode and method of manufacture
US5255692A (en) 1992-09-04 1993-10-26 Siemens Aktiengesellschaft Subcostal patch electrode
DE4433111A1 (de) * 1994-09-16 1996-03-21 Fraunhofer Ges Forschung Cuff-Elektrode
US6164284A (en) * 1997-02-26 2000-12-26 Schulman; Joseph H. System of implantable devices for monitoring and/or affecting body parameters
US6208894B1 (en) * 1997-02-26 2001-03-27 Alfred E. Mann Foundation For Scientific Research And Advanced Bionics System of implantable devices for monitoring and/or affecting body parameters
US6185452B1 (en) * 1997-02-26 2001-02-06 Joseph H. Schulman Battery-powered patient implantable device
US5999848A (en) * 1997-09-12 1999-12-07 Alfred E. Mann Foundation Daisy chainable sensors and stimulators for implantation in living tissue
US5999849A (en) * 1997-09-12 1999-12-07 Alfred E. Mann Foundation Low power rectifier circuit for implantable medical device
US6259937B1 (en) * 1997-09-12 2001-07-10 Alfred E. Mann Foundation Implantable substrate sensor
US5917346A (en) * 1997-09-12 1999-06-29 Alfred E. Mann Foundation Low power current to frequency converter circuit for use in implantable sensors
US6088608A (en) * 1997-10-20 2000-07-11 Alfred E. Mann Foundation Electrochemical sensor and integrity tests therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843147A (en) * 1996-04-30 1998-12-01 Medtronic, Inc. Implantable eyelid electrode and method of implanting same

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1648554A2 (fr) * 2003-06-26 2006-04-26 Northstar Neuroscience, Inc. Appareils et systemes permettant d'appliquer une stimulation electrique chez un patient
EP1648554A4 (fr) * 2003-06-26 2009-06-24 Northstar Neuroscience Inc Appareils et systemes permettant d'appliquer une stimulation electrique chez un patient
JP2015513980A (ja) * 2012-04-05 2015-05-18 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 脳神経刺激のための皮下電極
WO2021069058A1 (fr) * 2019-10-07 2021-04-15 Abuyousef Nuha Awni Système, dispositif et procédé permettant d'induire un mouvement de paupière

Also Published As

Publication number Publication date
EP1404405B1 (fr) 2012-04-11
EP1404405A4 (fr) 2007-01-03
US6792314B2 (en) 2004-09-14
EP1404405A1 (fr) 2004-04-07
WO2002102455A8 (fr) 2004-05-21
US20030023297A1 (en) 2003-01-30

Similar Documents

Publication Publication Date Title
EP1404405B1 (fr) Matrice et systeme de stimulation miniatures implantables con us pour la stimulation de la paupiere
US7628750B2 (en) Actuation and control of limbs through motor nerve stimulation
Szeto et al. Sensory feedback using electrical stimulation of the tactile sense
EP1706178B1 (fr) Système d'acheminement de courant électrique à des tissus corporels via des conducteurs passifs implantés
US7236831B2 (en) Methods and apparatus for effectuating a lasting change in a neural-function of a patient
JP2017185252A (ja) ドライアイを治療するためのシステムおよび方法
JP5188494B2 (ja) 埋め込み刺激装置のセットアップ間における電極調節のために複数のタイミングチャネルを用いるシステムと方法
US6530954B1 (en) Adaptive senso-motor encoder for neuroprostheses
US20070049988A1 (en) Optimal electrode contact polarity configurations for implantable stimulation systems
Mokwa et al. Intraocular epiretinal prosthesis to restore vision in blind humans
Kelly et al. Realization of a 15-channel, hermetically-encased wireless subretinal prosthesis for the blind
Uhlir et al. Performance of epimysial stimulating electrodes in the lower extremities of individuals with spinal cord injury
Prodanov et al. Functional electric stimulation for sensory and motor functions: progress and problems
Prochazka Motor neuroprostheses
Popovic et al. Recruitment and comfort of BION implanted electrical stimulation: implications for FES applications
Stieglitz et al. Neural Implants in Clinical Practice: Interfacing neurons for neuro-modulatin, limb control, and to restore vision–Part I
US20210038896A1 (en) Devices and methods for improving headache disorders
Stieglitz Neural prostheses in clinical practice: biomedical microsystems in neurological rehabilitation
Heetderks et al. Applied neural control in the 1990s
Niu et al. Vision implants: An electrical device will bring light to the blind
Azman et al. The design of non-invasive functional electrical stimulation (FES) for restoration of muscle function
Meadows Portable electrical stimulation systems
Sherwood et al. Biomedical engineering specifications for epidural spinal cord stimulation to augment motor performance
Soulier et al. Advances in implanted functional electrical stimulation
US20220288400A1 (en) Cable-Less Lead Adapter For Implantable Neurostimulator System

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2002739717

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002739717

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: IN PCT GAZETTE 52/2002 UNDER (71) REPLACE "ALFRED E. MANN FOUNDATION RESEARCH" BY "ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH"; REPLACE "(71) APPLICANTS AND (72) INVENTORS" BY "(72) INVENTORS"

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP