WO2002087468A1 - Areal implant - Google Patents
Areal implant Download PDFInfo
- Publication number
- WO2002087468A1 WO2002087468A1 PCT/EP2002/003459 EP0203459W WO02087468A1 WO 2002087468 A1 WO2002087468 A1 WO 2002087468A1 EP 0203459 W EP0203459 W EP 0203459W WO 02087468 A1 WO02087468 A1 WO 02087468A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- implant
- implant according
- basic structure
- reinforcing structure
- elements
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
- A61F2250/0031—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts
Definitions
- the invention relates to an areal implant, which can be used in particular for the treatment of inguinal hernias.
- a preferred, surgical technique is the Lichtenstein technique, in which the spermatic cord is pushed through a slit in the implant mesh used, so that it comes to rest in the middle area of the mesh.
- a preferred material for implant meshes is polypropylene, as it has a relatively high strength in the body of a patient and displays long-term stability and is largely chemically inert.
- Im- plant meshes made from polypropylene also have disadvantages, however.
- a chronic reaction to foreign bodies is -induced, i.e. a chronic wound forms in the area of the implant.
- the effects on the immune system are still not known.
- a ca. 20% deformation of the implant mesh can lead to hard scar plates, so that an explantation of the mesh can become necessary.
- the long- term effect of such an implant on the organism is unknown, as there are ' no studies extending over 30 to 50 years.
- EP 1 025 821 Al shows a product, which can also be used as implant mesh for the treatment of . hernias, which consists of three layers. A separately embroidered layer serving as a spacer is connected on both sides to another layer. The surface has a plurality of openings which are arranged in at least two hole patterns with significantly different hole sizes.
- An implant developed especially for the Lichtenstein technique is known • from WO 00/67663.
- a commercial implant mesh for hernia surgery is provided in a section with an anti-adhesive layer in order to avoid deformities on the spermatic cord.
- a further implant mesh for the treatment of hernias is shown in WO 99/51163.
- This mesh has two 'resorbable layers, the one layer, being able to be quickly resorbed and the other layer being able to be slowly resorbed.
- a textile surgical implant with a resorbable backing material is described in US 5 990 378 onto which a mesh structure is embroidered in a regular pattern.
- the backing material helps with the positioning of the implant during the surgery.
- Claim 12 relates to a process for preparing such an implant.
- Advantageous designs of the invention emerge from the dependent claims .
- the areal implant according to the invention has a flexible, porous basic structure made from resorbable material and a flexi ⁇ ble, spider's web-like reinforcing structure made from non- resorbable material.
- the reinforcing structure has generally ra- dially-running radial elements and connection elements running transverse to the radial elements. At least part of the connection elements . can be continuous and run as a whole in the form of a spiral. It is also conceivable that at least part of the connection elements forms curves which are closed in themselves and run alongside each other.
- the reinforcing structure looks similar to a spider's web.
- the radial elements need not all converge on one point, but they are more dense in- the central area of the implant (which does not have to lie in the geometric centre) .
- the connection elements can have a greater density in the central area, as is the case for many types of spirals.
- the •reinforcing-., .st-ructure is strong, enough-.-in -.the• ⁇ centr-al--.area of - the implant, i.e. where a particularly high stress occurs in a patient after implantation.
- a sufficient strength is guaranteed in the outer areas of the implant even with a material density that is generally lower (as is typical of a spider's web structure) .
- the spider' s web-like reinforcing structure matched to the stresses which occur in the patient permits a dramatic reduction in the amount of non-resorbable material in the implant.
- commercial monofilament implant meshes for the treatment of inguinal hernias with a unit weight of 90 to 100 g/m 2 and a size of 15 cm x 7 cm (as is normal for the Lichtenstein technique) require a thread length of 50 to 60 m per implant
- the reinforcing structure of the implant according to the invention manages with a thread length of, e.g., 9 m.
- the flexible, porous basic structure consists of resorbable material.
- the handling of the implant during the surgery is much improved by the basic structure.
- connective tissue grows into the basic structure, which is still not resorbed, which leads to an early increase in strength and is necessary for the healing process as a whole.
- connection elements and radial elements of the spider's web-like reinforcing structure are attached to each other at intersections, and preferably knotted.
- Two radial elements running alongside each other can be provided (which are preferably aligned parallel to each other) between which the implant for forming a slit can be incised- when using the surgery technique according to Lichtenstein.
- the implant can preferably be trimmed by cutting, between connection elements running alongside each other.
- Such designs • enable- the implant-.to be. adapted to the anatomical, circumstances of the patient before or during the surgery (fashioning) .
- connection elements and radial elements of the spider' s web-like reinforcing structure are attached to each other at intersections, there is no need to fear that the cuts re-, quired for trimming to the desired shape or for- forming a slit for the spermatic cord according to the Lichtenstein technique damage the reinforcing structure so that it can no longer fulfil its function.
- trimming for example the outer "rings” or "spiral coils" of the spider's web-like reinforcing structure can be cut off. If the reinforcing structure has a different colour from the basic structure, the necessary cuts between the elements of the reinforcing structure are made easier.
- the basic structure is preferably warp-knitted but can also be prepared as another textile structure.
- the reinforcing structure which preferably contains monofilaments and/or multi- filaments, is embroidered onto the basic structure.
- a spider's web-like reinforcing structure in any form can be produced in a simple way, it also being possible to form knot structures at the intersections between connection elements and radial elements.
- the basic -structure serves as backing during the embroidering process. After the basic structure is resorbed in the " patient's body after the implantation, the reinforcing structure is self-supporting and manages without the basic structure.
- Preferred resorbable materials for the basic structure are co- polymers of L-lactide and glycolide, e.g. in the mass ratio 10:90 (e.g. Vicryl ® , Ethicon) or in the mass ratio 95:5 (e.g. Panacryl ® , Ethicon) , poly-p-dioxanone (PDS) , copolymers of glycolide and ⁇ -caprolactone, e.g. in the mass ratio 75:25 (e.g. Monocryl ® , Ethicon) or mixtures of such materials, but other resorbable materials are also conceivable.
- mass ratio 10:90 e.g. Vicryl ® , Ethicon
- 95:5 e.g. Panacryl ® , Ethicon
- PDS poly-p-dioxanone
- copolymers of glycolide and ⁇ -caprolactone e.g. in the mass ratio 75:25 (e.g. Monocryl ®
- the reinforcing structure comprises non-resorbable material, a term which is also taken to include very slowly resorbable materials (e.g. polyesters).
- Polypropylene e.g. Prolene ® , Ethicon
- polyamide e.g. Ethilon ® , Ethicon, from polyamide 6
- PET polyethylene terephthalate
- PVDF polyvinylidene fluoride
- Copolymers of vinylidene fluoride and hexafluoropropene e.g. Pronova ® , Ethicon
- Mixtures also e.g. in the form of multifilaments, of these materials or other non-, or very slowly, resorbable materials are also possible.
- the implant according to the invention is thus characterized by a high long-term compatibility in the body of a patient, as the non-resorbable proportion of foreign bodies is dramatically reduced compared with conventional implant meshes.
- No small-pored mesh with an uncertain long-term effect remains, but simply a spider's web-like reinforcing structure of low mass, which • is matched to the anatomical circumstances and the occurring forces. This is comparable with the "biological" surgery according to Shouldice.
- the resorbable basic structure helps with the positioning of the implant and is a temporary support in the first weeks after the surgery. During this time, a fibrohystiocytic reaction is induced, connective tissue growing into the implant (early phase of the healing process).
- Figure 1 a top view of a version of the implant according to the invention.
- a version of a flexible, areal implant 1 is represented in Figure 1 in top. view.
- the implant 1 has a basic structure 2 which is flexible and porous and is made from resorbable material.
- the basic structure 2 whose edge is numbered by 3, is warp-knitted in the conventional way, with a closed, small-pored warp-knit structure.
- the size of the implant 1 or of the basic structure 2 is approx. 7.5 cm x 15 cm in the embodiment .
- Examples of materials of the basic structure 2 are PDS, Vicryl ® , Monocryl ® and Panacryl ® , as explained in more detail above; for simplicity's sake, the abbreviations are used here.
- the thread material used for the basic structure can contain monofilaments or ultifilaments, mixtures also being conceivable.
- a flexible, spider's web-like reinforcing structure 4 is placed onto the basic structure 2.
- the reinforcing structure 4 is embroidered onto the basic structure.
- the -basic structure 2 has the function of a backing mesh.
- the reinforcing structure 4 consists of a non- resorbable material and becomes self-supporting when the basic structure 2 is resorbed after the implant 1 has been implanted.
- the reinforcing structure preferably consists of monofilaments and/or multifilaments of the referenced materials, mixed forms also being possible, e.g. the use of multifilament yarns with filaments from different materials.
- the reinforcing structure 4 is similar to a spider-web. However, no circular structure is realised in the embodiment, as in the most common spider' s wheel network, but more of an elliptical structure.
- the centre of the reinforcing structure is at 5, i.e. not in the geometric centre of the implant 1.
- the elliptical design of the reinforcing structure 4 is advantageous, as the area to be covered with the implant 1 in the groin of a patient with medial and lateral hernia gaps resembles the shape of an ellipse.
- the reinforcing structure 4 has a structuring with a concentrated quantity of thread in the area in which possible relapses are to be expected, i.e. between internal inguinal ring and mons pubis, i.e. in the area of the medial and lateral hernia gaps.
- the reinforcing structure 4 contains radial elements 10, which generally run radially and more or less (but not necessarily exactly) start from the centre 5.
- Connection elements 12 extend transversely to the radial elements 10.
- the connection elements cohere in the area of the centre 5 and run as a whole in the form of a spiral. Further out are connection elements 14 which do not co- here with the spiral of the connection elements 12. Furthermore, a largely closed connection element 16 runs alongside the edge 3 of the basic structure 2.
- Two radial elements 18 and 19 extend parallel to each other roughly from the centre 5 to the edge 3 of the basic structure 2.
- the implant 1 can be ' incised between the radial elements 18 and 19 in order to form a slit matched to the patient, to accommodate the spermatic cord.
- the thread material is interwoven in the manner of knots at the intersections numbered 20 between the radial ele- mentS' 10, 18, 19 and the connection elements .12, 14,..16, so that the reinforcing structure 4 is self-supporting and stable even after the resorption of the basic structure 2.
- the knot-like intersections 20 ensure in particular that the reinforcing structure 4 also at least largely retains its stability when a cut is made laterally into the implant 1 in the course of the surgery.
- a slit can be formed with the surgery technique according to Lichtenstein, as already mentioned.
- the cuts necessary for this preferably run between and largely parallel to the connection elements 12, 14, 16.
- the intersections 20 should not be damaged when cutting.
- the reinforcing structure 4 is preferably distinguished from the basic structure 2 by its colour.
- a coloured reinforcing structure 4 also allows better recognition of the edge area of the reinforcing structure 4 which should also be included when fixing the implant 1 in the course of the surgery so that the reinforcing structure 4 can reliably fulfil its function.
- Suitable as dyes are, e.g., copper phthalocyanine blue (C.I.: 74160; in particular for colouring polypropylene and Pronova ® ) , D & C Green No. 6 (C.I.: 61565; in particular for colouring polyethylene terephthalate) as well as Pigment Blue 9860/Chromophtal Blue A3R (C.I. Pigment Blue 60; in particular for colouring polyamide 6) .
- copper phthalocyanine blue C.I.: 74160; in particular for colouring polypropylene and Pronova ®
- D & C Green No. 6 C.I.: 61565; in particular for colouring polyethylene terephthalate
- Pigment Blue 9860/Chromophtal Blue A3R C.I. Pigment Blue 60; in particular for colouring polyamide 6 .
- the material of the basic structure 2 the material of the reinforcing structure 4 and the stitch type for the reinforcing structure 4 are given for six embodiments.
- the reinforcing structure 4 was -embroidered- onto the oa- ⁇ sic structure 2 using a 10211-495 MSCI type embroidery machine manufactured by ZSK-Stickmaschinen GmbH.
- the material consumption of commercial non- resorbable implants is compared with that of two versions of the implant according to the invention.
- the commercial implants are designated with their trade names Marlex ® Mesh (made from polypropylene; manufacturer: Bard), Atrium ® Mesh (made from polypropylene; manufacturer: Atrium Medical Corporation) and Prolene ® Mesh (made from polypropylene; manufacturer: Ethicon GmbH) and consist essentially of a largely homogeneous mesh structure without additional reinforcing structure.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2001121193 DE10121193A1 (de) | 2001-04-30 | 2001-04-30 | Flächiges Implantat |
DE10121193.7 | 2001-04-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002087468A1 true WO2002087468A1 (en) | 2002-11-07 |
Family
ID=7683286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2002/003459 WO2002087468A1 (en) | 2001-04-30 | 2002-03-27 | Areal implant |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE10121193A1 (de) |
WO (1) | WO2002087468A1 (de) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004075936A1 (en) * | 2003-02-25 | 2004-09-10 | Ethicon Gmbh | Surgical implant |
EP1520552A1 (de) * | 2003-09-30 | 2005-04-06 | Ethicon, Inc. | Implantierbares chirurgisches Netz |
WO2005051448A1 (en) * | 2003-11-26 | 2005-06-09 | Ethicon Gmbh | Surgical implants for controlled release of medicaments |
WO2006092236A1 (en) * | 2005-03-01 | 2006-09-08 | Ethicon Gmbh | Surgical implant |
CN1895686A (zh) * | 2005-07-13 | 2007-01-17 | GfE医学技术有限公司 | 适于插入体内的可吸收的医学元件,特别是可吸收的植入物 |
WO2007050382A1 (en) * | 2005-10-25 | 2007-05-03 | Ethicon, Inc. | Template for surgical meshes |
US8147478B2 (en) | 2000-09-07 | 2012-04-03 | Ams Research Corporation | Coated sling material |
US8298290B2 (en) | 2004-09-20 | 2012-10-30 | Davol, Inc. | Implantable prosthesis for soft tissue repair |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102008044005A1 (de) | 2008-11-24 | 2010-05-27 | Leibniz-Institut Für Polymerforschung Dresden E.V. | Flächiges Implantat und Verfahren zu seiner Herstellung |
DE102009024648B4 (de) * | 2009-06-03 | 2018-05-09 | Aesculap Ag | Markierte Venen-Ummantelung, insbesondere zur Wiederherstellung der Venenklappenfunktion variköser Venen |
DE102010048710B4 (de) * | 2010-03-30 | 2013-05-23 | 3T Textiltechnologietransfer Gmbh | Implantat mit einer Sandwich-Struktur |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2604085A1 (fr) * | 1986-09-19 | 1988-03-25 | Audion Michel | Plaque d'osteosynthese pour la contention et la reduction d'effondrement des planchers orbitaires |
WO1993017635A1 (en) * | 1992-03-04 | 1993-09-16 | C.R. Bard, Inc. | Composite prosthesis and method for limiting the incidence of postoperative adhesions |
US5954767A (en) * | 1993-09-13 | 1999-09-21 | C.R. Bard Inc. | Curved prosthetic mesh and its method of manufacture |
US5990378A (en) * | 1995-05-25 | 1999-11-23 | Bridport Gundry (Uk) Limited | Textile surgical implants |
WO2001015625A1 (en) * | 1999-08-31 | 2001-03-08 | Ethicon Gmbh | Reinforced areal implant |
-
2001
- 2001-04-30 DE DE2001121193 patent/DE10121193A1/de not_active Withdrawn
-
2002
- 2002-03-27 WO PCT/EP2002/003459 patent/WO2002087468A1/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2604085A1 (fr) * | 1986-09-19 | 1988-03-25 | Audion Michel | Plaque d'osteosynthese pour la contention et la reduction d'effondrement des planchers orbitaires |
WO1993017635A1 (en) * | 1992-03-04 | 1993-09-16 | C.R. Bard, Inc. | Composite prosthesis and method for limiting the incidence of postoperative adhesions |
US5954767A (en) * | 1993-09-13 | 1999-09-21 | C.R. Bard Inc. | Curved prosthetic mesh and its method of manufacture |
US5990378A (en) * | 1995-05-25 | 1999-11-23 | Bridport Gundry (Uk) Limited | Textile surgical implants |
WO2001015625A1 (en) * | 1999-08-31 | 2001-03-08 | Ethicon Gmbh | Reinforced areal implant |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8147478B2 (en) | 2000-09-07 | 2012-04-03 | Ams Research Corporation | Coated sling material |
WO2004075936A1 (en) * | 2003-02-25 | 2004-09-10 | Ethicon Gmbh | Surgical implant |
DE10307946B4 (de) * | 2003-02-25 | 2014-06-18 | Johnson & Johnson Medical Gmbh | Chirurgisches Implantat |
EP1520552A1 (de) * | 2003-09-30 | 2005-04-06 | Ethicon, Inc. | Implantierbares chirurgisches Netz |
WO2005051448A1 (en) * | 2003-11-26 | 2005-06-09 | Ethicon Gmbh | Surgical implants for controlled release of medicaments |
US8298290B2 (en) | 2004-09-20 | 2012-10-30 | Davol, Inc. | Implantable prosthesis for soft tissue repair |
WO2006092236A1 (en) * | 2005-03-01 | 2006-09-08 | Ethicon Gmbh | Surgical implant |
AU2006220037B2 (en) * | 2005-03-01 | 2012-07-12 | Johnson & Johnson Medical Gmbh | Surgical implant |
US8814887B2 (en) | 2005-03-01 | 2014-08-26 | Ethicon, Inc. | Surgical implant |
US8888863B2 (en) | 2005-03-01 | 2014-11-18 | Ethicon, Inc. | Surgical implant |
CN1895686A (zh) * | 2005-07-13 | 2007-01-17 | GfE医学技术有限公司 | 适于插入体内的可吸收的医学元件,特别是可吸收的植入物 |
WO2007050382A1 (en) * | 2005-10-25 | 2007-05-03 | Ethicon, Inc. | Template for surgical meshes |
US8506582B2 (en) | 2005-10-25 | 2013-08-13 | Ethicon, Inc. | Template for surgical meshes |
Also Published As
Publication number | Publication date |
---|---|
DE10121193A1 (de) | 2002-11-28 |
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