WO2002086097A3 - Methods for identifying the target of a compound which inhibits cellular proliferation - Google Patents

Methods for identifying the target of a compound which inhibits cellular proliferation Download PDF

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Publication number
WO2002086097A3
WO2002086097A3 PCT/US2002/003987 US0203987W WO02086097A3 WO 2002086097 A3 WO2002086097 A3 WO 2002086097A3 US 0203987 W US0203987 W US 0203987W WO 02086097 A3 WO02086097 A3 WO 02086097A3
Authority
WO
WIPO (PCT)
Prior art keywords
identifying
methods
target
compound
cellular proliferation
Prior art date
Application number
PCT/US2002/003987
Other languages
French (fr)
Other versions
WO2002086097A8 (en
WO2002086097A2 (en
Inventor
Grant J Carr
Howard H Xu
Gordon J Foulkes
Carlos Zamudio
Robert Haselbeck
Kari L Ohlsen
Judith W Zyskind
Daniel Wall
John D Trawick
Robert T Yamamoto
Terry Roemer
Bo Jiang
Charles Boone
Howard Bussey
Original Assignee
Elitra Pharmaceuticals Inc
Grant J Carr
Howard H Xu
Gordon J Foulkes
Carlos Zamudio
Robert Haselbeck
Kari L Ohlsen
Judith W Zyskind
Daniel Wall
John D Trawick
Robert T Yamamoto
Terry Roemer
Bo Jiang
Charles Boone
Howard Bussey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elitra Pharmaceuticals Inc, Grant J Carr, Howard H Xu, Gordon J Foulkes, Carlos Zamudio, Robert Haselbeck, Kari L Ohlsen, Judith W Zyskind, Daniel Wall, John D Trawick, Robert T Yamamoto, Terry Roemer, Bo Jiang, Charles Boone, Howard Bussey filed Critical Elitra Pharmaceuticals Inc
Priority to JP2002583612A priority Critical patent/JP2004528846A/en
Priority to EP02728338A priority patent/EP1360335A2/en
Priority to CA002436216A priority patent/CA2436216A1/en
Publication of WO2002086097A2 publication Critical patent/WO2002086097A2/en
Publication of WO2002086097A3 publication Critical patent/WO2002086097A3/en
Publication of WO2002086097A8 publication Critical patent/WO2002086097A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to cultures or collections of strains which overexpress or underexpress gene products required for the proliferation of an organism. The present invention also includes methods for identifying the target on which a compound which inhibits the proliferation of an organims acts and methods for identifying the extent to which a strain is present in a culture or collection of strains.
PCT/US2002/003987 2001-02-09 2002-02-08 Methods for identifying the target of a compound which inhibits cellular proliferation WO2002086097A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2002583612A JP2004528846A (en) 2001-02-09 2002-02-08 Methods for identifying targets for compounds that inhibit cell proliferation
EP02728338A EP1360335A2 (en) 2001-02-09 2002-02-08 Methods for identifying the target of a compound which inhibits cellular proliferation
CA002436216A CA2436216A1 (en) 2001-02-09 2002-02-08 Methods for identifying the target of a compound which inhibits cellular proliferation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26763601P 2001-02-09 2001-02-09
US60/267,636 2001-02-09

Publications (3)

Publication Number Publication Date
WO2002086097A2 WO2002086097A2 (en) 2002-10-31
WO2002086097A3 true WO2002086097A3 (en) 2003-03-06
WO2002086097A8 WO2002086097A8 (en) 2004-11-25

Family

ID=23019593

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/003987 WO2002086097A2 (en) 2001-02-09 2002-02-08 Methods for identifying the target of a compound which inhibits cellular proliferation

Country Status (4)

Country Link
EP (1) EP1360335A2 (en)
JP (1) JP2004528846A (en)
CA (1) CA2436216A1 (en)
WO (1) WO2002086097A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003091418A2 (en) 2002-04-26 2003-11-06 Bristol-Myers Squibb Company Novel essential fungal polynucleotides, polypeptides, and methods of use
US7960312B2 (en) 2005-11-10 2011-06-14 National University Of Corporation Hiroshima University Method and agent for immobilizing protein via protein bound to silicon oxide-containing substance
EP2358908B1 (en) 2008-11-14 2014-01-08 Gen-Probe Incorporated Compositions and methods for detection of campylobacter nucleic acid

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BRAKHAGE A.A. ET AL.: "Use of reporter genes to identify recessive trans-acting mutations specifally involved in the regulation of aspergillus nidulans pencillin biosynthesis genes", JOURNAL OF BACTERIOLOGY, vol. 177, no. 10, May 1995 (1995-05-01), pages 2781 - 2788, XP002956425 *
DAVIS B.D. ET AL.: "Microbiology", 1968, HOEBER MEDICAL DIVISION, HARPER & ROW, NEW YORK, USA, XP002956426 *

Also Published As

Publication number Publication date
WO2002086097A8 (en) 2004-11-25
JP2004528846A (en) 2004-09-24
CA2436216A1 (en) 2002-10-31
EP1360335A2 (en) 2003-11-12
WO2002086097A2 (en) 2002-10-31

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