WO2002078674A1 - A process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use - Google Patents

A process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use Download PDF

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Publication number
WO2002078674A1
WO2002078674A1 PCT/US2002/010715 US0210715W WO02078674A1 WO 2002078674 A1 WO2002078674 A1 WO 2002078674A1 US 0210715 W US0210715 W US 0210715W WO 02078674 A1 WO02078674 A1 WO 02078674A1
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WO
WIPO (PCT)
Prior art keywords
solvent
amphiphilic copolymer
mixing
nanoparticles
mixing vessel
Prior art date
Application number
PCT/US2002/010715
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English (en)
French (fr)
Inventor
Brian K. Johnson
Robert K. Prud'homme
Original Assignee
Trustees Of Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trustees Of Princeton University filed Critical Trustees Of Princeton University
Priority to US10/472,071 priority Critical patent/US8137699B2/en
Publication of WO2002078674A1 publication Critical patent/WO2002078674A1/en
Priority to US13/368,888 priority patent/US9956179B2/en
Priority to US15/913,294 priority patent/US20180193280A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/66—1,3,5-Triazines, not hydrogenated and not substituted at the ring nitrogen atoms
    • A01N43/68—1,3,5-Triazines, not hydrogenated and not substituted at the ring nitrogen atoms with two or three nitrogen atoms directly attached to ring carbon atoms
    • A01N43/70—Diamino—1,3,5—triazines with only one oxygen, sulfur or halogen atom or only one cyano, thiocyano (—SCN), cyanato (—OCN) or azido (—N3) group directly attached to a ring carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/91—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with propellers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
    • B01F35/2211—Amount of delivered fluid during a period
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
    • B01F35/2213—Pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
    • B01F35/2214—Speed during the operation
    • B01F35/22142—Speed of the mixing device during the operation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
    • B01F35/2215—Temperature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004—Preparation of sols
    • B01J13/0021—Preparation of sols containing a solid organic phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F21/00—Dissolving
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst

Definitions

  • PAA polyacrylic acid
  • PAA polyacrylic acid
  • Mucoadhesive properties in a drug coating can be used to target a highly potent or water insoluble drugs to a targeted area in the patient. By targeting the drug to a mucosal lining, a lower dose may be administered with the same therapeutic effect. In addition, an altered water solubility of a drug should increase its bioavailability.
  • Additional polymers that are mucoadherents and are potential components in pharmaceutical formulations include poly(d-glucosamine), poly(d-glucaronic acid-N-acetylglucosamine), poly(N- isopropylacrylamide), poly(vinyl amine), and poly(methacrylic acid).
  • “Mucoadhesion of polystyrene nanoparticles having surface hydrophilic polymeric chains in the gastrointestinal tract” International Journal of Pharmaceutics 177 (1999) 161-172.
  • Bioadhesion Technologies for the delivery of Peptide and Protein Drugs to the Gastrointestinal Tract Critical Reviews in Thereapeutic Drug Carrier Systems 11(2&3):119 - 160 (1994).
  • the amphiphilic character of the copolymer becomes apparent and either the hydrophobic portion or the hydrophilic portion of the copolymer can no longer exist in the soluble state, and thus precipitates.
  • the soluble portion of the amphiphilic copolymer affords steric or steric and electrostatic stabilization of the nanoparticles sufficient for post processing or harvesting.
  • Figure 9 is a graphic depiction of nanoparticle size in relation to the mixing velocity for nanoparticles formed from PBA(7500)-b-PAA(7500) at varying weight percentage (wt%) concentration of copolymer before mixing in MeOH and water in a continuous flash mixer; threshold mixing times and aggregation times are also presented in relation to nanoparticle size; and
  • the mixing velocity is considered the highest average velocity of any of the fluid streams entering the mixing chamber.
  • the angle of incidence of the two streams can be varied.
  • the angling of the inlet streams can affect the mixing velocity.
  • the streams are directed towards each other causing them to collide and essentially increasing the mixing velocity while decreasing the mixing time.
  • the velocity of the fluid exiting the inlet tube is between about 0.02 m/s and 12.0 m/s.
  • macrogol ethers such as cetomacrogol 1000
  • polyoxyethylene sorbitan fatty acid esters eg. the commercially available Tweens® of ICI specialty chemicals
  • polyoxyethylene castor oil derivatives e.g. the commercially available Tweens® of ICI specialty chemicals
  • polyoxyethylene castor oil derivatives eg. the commercially available Tweens® of ICI specialty chemicals
  • polyoxyethylene castor oil derivatives eg. the commercially available Tweens® of ICI specialty chemicals
  • polyoxyethylene castor oil derivatives eg. the commercially available Tweens® of ICI specialty chemicals
  • polyoxyethylene castor oil derivatives eg. the commercially available Tweens® of ICI specialty chemicals
  • polyoxyethylene castor oil derivatives e. the commercially available Tweens® of ICI specialty chemicals
  • polyoxyethylene castor oil derivatives e. the commercially available Tweens® of ICI specialty chemicals
  • polyoxyethylene castor oil derivatives eg
  • nanoparticles are formed in the absence of a target molecule.
  • the hydrophobic additive target molecule and optionally supplemental additives are added and the nanoparticles are loaded with a target molecule using differential partitioning where the solvent quality for the target molecule is slowly changed using dialysis or distillation.
  • the resulting loaded particles are then isolated and used in a pharmaceutical formulation.
  • the stream of nanoparticles produced via the flash precipitation is distilled to remove any toxic solvents and sterile filtered using a 0.22 ⁇ m nominal pore size filter to yield a sterile solution.
  • the process solvent streams are sterilized prior to use and are flash precipitated in a sterile environment to produce a sterile formulation.
  • the fluid jet velocity of the process solvent exiting the inlet tube was varied between 0.26 m/s and 4.1 m/s and the mechanical agitator tip speed was varied between 0.26 m/s and 4.1 m/s.
  • Each combination of jet velocity and tip speed is presented in Figure 6 with the greatest volume percent of particles having a diameter of ⁇ 1060 nm when the jet velocity and agitator tip speed were high.
  • the organic stream was charged to 180 grams of RO water at 35 °C to a volume ratio with the exception of Example ID 62 in which the charge was 128 grams.
  • the data in Figure 7 was collected by further dilution of the batch product stream to that appropriate for analysis by the Mastersizer S.
PCT/US2002/010715 2001-03-30 2002-03-29 A process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use WO2002078674A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/472,071 US8137699B2 (en) 2002-03-29 2002-03-29 Process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use
US13/368,888 US9956179B2 (en) 2001-03-30 2012-02-08 Process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use
US15/913,294 US20180193280A1 (en) 2001-03-30 2018-03-06 Process and Apparatuses For Preparing Nanoparticle Compositions with Amphiphilic Copolymers and Their Use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28043301P 2001-03-30 2001-03-30
US60/280,433 2001-03-30

Related Child Applications (3)

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US10472071 A-371-Of-International 2002-03-29
US10/472,071 A-371-Of-International US8137699B2 (en) 2001-03-30 2002-03-29 Process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use
US13/368,888 Continuation US9956179B2 (en) 2001-03-30 2012-02-08 Process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use

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PCT/US2002/009732 WO2002082900A1 (en) 2001-03-30 2002-03-29 Aqeuous suspension of nanoparticles comprising an agrochemical active ingredient

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US11731099B2 (en) 2018-07-20 2023-08-22 The Trustees Of Princeton University Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation
US11737981B2 (en) 2017-09-12 2023-08-29 The Trustees Of Princeton University Cellulosic polymer nanoparticles and methods of forming them

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