WO2002077017A3 - Medical uses of intercellular communication facilitating compounds - Google Patents

Medical uses of intercellular communication facilitating compounds Download PDF

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Publication number
WO2002077017A3
WO2002077017A3 PCT/US2002/005773 US0205773W WO02077017A3 WO 2002077017 A3 WO2002077017 A3 WO 2002077017A3 US 0205773 W US0205773 W US 0205773W WO 02077017 A3 WO02077017 A3 WO 02077017A3
Authority
WO
WIPO (PCT)
Prior art keywords
medical uses
intercellular communication
facilitating compounds
communication facilitating
peptides
Prior art date
Application number
PCT/US2002/005773
Other languages
French (fr)
Other versions
WO2002077017A2 (en
Inventor
Bjarne Due Larsen
Jorgen Soberg Petersen
Eddie Meier
Anne Louise Kjolbye
Niklas Rye Jorgensen
Morten Schak Nielsen
Niels-Henrik Holstein-Rathlou
James B Martins
Original Assignee
Zealand Pharma As
Bjarne Due Larsen
Jorgen Soberg Petersen
Eddie Meier
Anne Louise Kjolbye
Niklas Rye Jorgensen
Morten Schak Nielsen
Niels-Henrik Holstein-Rathlou
James B Martins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2001/000127 external-priority patent/WO2001062775A2/en
Priority claimed from US09/792,286 external-priority patent/US7250397B2/en
Priority to CA2439101A priority Critical patent/CA2439101C/en
Priority to MXPA03007537A priority patent/MXPA03007537A/en
Priority to JP2002576275A priority patent/JP2005506295A/en
Priority to IL15744702A priority patent/IL157447A0/en
Priority to AU2002254033A priority patent/AU2002254033B2/en
Priority to KR10-2003-7011099A priority patent/KR20040004538A/en
Priority to NZ527571A priority patent/NZ527571A/en
Priority to DK02723240.4T priority patent/DK1370276T3/en
Application filed by Zealand Pharma As, Bjarne Due Larsen, Jorgen Soberg Petersen, Eddie Meier, Anne Louise Kjolbye, Niklas Rye Jorgensen, Morten Schak Nielsen, Niels-Henrik Holstein-Rathlou, James B Martins filed Critical Zealand Pharma As
Priority to AT02723240T priority patent/ATE497967T1/en
Priority to BR0207476-1A priority patent/BR0207476A/en
Priority to EP02723240A priority patent/EP1370276B1/en
Priority to EA200300912A priority patent/EA007792B1/en
Priority to DE60239126T priority patent/DE60239126D1/en
Publication of WO2002077017A2 publication Critical patent/WO2002077017A2/en
Priority to NO20033641A priority patent/NO20033641L/en
Priority to US10/646,294 priority patent/US7585839B2/en
Publication of WO2002077017A3 publication Critical patent/WO2002077017A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Disclosed are novel peptides including antiarrhythmic peptides that have improved stability. Further disclosed are compositions that include such peptides and methods of using the compositions particularly as medicaments.
PCT/US2002/005773 2000-02-23 2002-02-22 Medical uses of intercellular communication facilitating compounds WO2002077017A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
EA200300912A EA007792B1 (en) 2001-02-22 2002-02-22 Medical uses of intercellular communication facilitating compounds
DE60239126T DE60239126D1 (en) 2001-02-22 2002-02-22 INTERCELLULAR COMMUNICATION SIMPLIFIED CONNECTIONS AND THEIR MEDICAL USES
AT02723240T ATE497967T1 (en) 2001-02-22 2002-02-22 INTERCELLULAR COMMUNICATION FACILITATING COMPOUNDS AND THEIR MEDICAL USES
JP2002576275A JP2005506295A (en) 2001-02-22 2002-02-22 Novel medicinal use of intercellular communication promoting compounds
IL15744702A IL157447A0 (en) 2001-02-22 2002-02-22 New medical uses of intercellular communication facilitating compounds
AU2002254033A AU2002254033B2 (en) 2001-02-22 2002-02-22 Medical uses of intercellular communication facilitating compounds
KR10-2003-7011099A KR20040004538A (en) 2001-08-23 2002-02-22 New medical uses of intercellular communication facilitating compounds
NZ527571A NZ527571A (en) 2001-02-22 2002-02-22 peptides including novel antiarrhythmic peptides of linear or cyclic structure having improved stability in vitro and/or in vivo, to compositions comprising said peptides, and to uses of said peptides for the preparation of medicaments.
DK02723240.4T DK1370276T3 (en) 2001-02-22 2002-02-22 Intracellular communication-facilitating compounds and their medical applications
CA2439101A CA2439101C (en) 2001-02-22 2002-02-22 New medical uses of intercellular communication facilitating compounds
MXPA03007537A MXPA03007537A (en) 2001-02-22 2002-02-22 New medical uses of intercellular communication facilitating compounds.
BR0207476-1A BR0207476A (en) 2001-02-22 2002-02-22 Use of a compound and pharmaceutical composition
EP02723240A EP1370276B1 (en) 2001-02-22 2002-02-22 Intercellular communication facilitating compounds and their medical use
NO20033641A NO20033641L (en) 2001-02-22 2003-08-15 New medical applications of intercellular communication facilitating compounds
US10/646,294 US7585839B2 (en) 2000-02-23 2003-08-22 Medical uses of intercellular communication facilitating compounds

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
PCT/DK2001/000127 WO2001062775A2 (en) 2000-02-23 2001-02-22 Novel antiarrhythmic peptides
US09/792,286 US7250397B2 (en) 2000-02-23 2001-02-22 Antiarrhythmic peptides
DKPCT/DK01/00127 2001-02-22
US09/792,286 2001-02-22
US31447001P 2001-08-23 2001-08-23
US60/314,470 2001-08-23

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/646,294 Continuation US7585839B2 (en) 2000-02-23 2003-08-22 Medical uses of intercellular communication facilitating compounds

Publications (2)

Publication Number Publication Date
WO2002077017A2 WO2002077017A2 (en) 2002-10-03
WO2002077017A3 true WO2002077017A3 (en) 2003-10-09

Family

ID=27222186

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/005773 WO2002077017A2 (en) 2000-02-23 2002-02-22 Medical uses of intercellular communication facilitating compounds

Country Status (6)

Country Link
EP (1) EP1370276B1 (en)
JP (1) JP2005506295A (en)
AT (1) ATE497967T1 (en)
IL (1) IL157447A0 (en)
MX (1) MXPA03007537A (en)
WO (1) WO2002077017A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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US7250397B2 (en) 2000-02-23 2007-07-31 Zealand Pharma A/S Antiarrhythmic peptides
CN1939529A (en) * 2002-01-29 2007-04-04 Wyeth公司 Compositions and methods for modulating connexin hemichannels
ZA200503600B (en) * 2002-11-25 2006-08-30 Zealand Pharma As Peptide gap junction modulators
WO2005061437A2 (en) * 2003-12-23 2005-07-07 Wyeth Isopeptide gap junction modulators
DE102005005270A1 (en) * 2005-02-04 2006-08-10 Peter Heger Use of a hydroxystilbene-containing active substance combination containing resveratrol and piceatannol precursors, to prevent and/or treat diseases caused by increased serum interleukin-6 level e.g. depression
GB0514071D0 (en) 2005-07-07 2005-08-17 Zealand Pharma As N- or C- terminally modified small peptides
AU2006332945C1 (en) 2005-12-23 2013-02-28 Wyeth Modified lysine-mimetic compounds
EP2074087A2 (en) 2006-12-21 2009-07-01 Wyeth Synthesis of pyrrolidine compounds
EP2212343A2 (en) * 2007-07-15 2010-08-04 Zealand Pharma A/S Peptide gap junction modulators
WO2010026487A1 (en) * 2008-09-08 2010-03-11 University Of Concepcion Therapeutic methods and compositions
GB201512139D0 (en) * 2015-07-10 2015-08-19 Zealand Pharma As Methods of treatment
ES2870106T3 (en) 2017-05-05 2021-10-26 Zealand Pharma As Modulators of gap junctional communication and their use for the treatment of diabetic eye disease
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