WO2002076529A1 - Dispositif de traitement de sang - Google Patents

Dispositif de traitement de sang Download PDF

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Publication number
WO2002076529A1
WO2002076529A1 PCT/NL2002/000170 NL0200170W WO02076529A1 WO 2002076529 A1 WO2002076529 A1 WO 2002076529A1 NL 0200170 W NL0200170 W NL 0200170W WO 02076529 A1 WO02076529 A1 WO 02076529A1
Authority
WO
WIPO (PCT)
Prior art keywords
plates
channels
blood
foregoing
membranes
Prior art date
Application number
PCT/NL2002/000170
Other languages
English (en)
Inventor
Robert Mathieu Johan Sillen
Etienne Lutger Martijn Swinkels
Frank Klein Sotebier
Original Assignee
Stichting Hogeschool Van Utrecht
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Hogeschool Van Utrecht filed Critical Stichting Hogeschool Van Utrecht
Priority to EP02705615A priority Critical patent/EP1370309A1/fr
Publication of WO2002076529A1 publication Critical patent/WO2002076529A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698—Blood oxygenators with or without heat-exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A61M1/1629—Constructional aspects thereof with integral heat exchanger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A61M1/1631—Constructional aspects thereof having non-tubular membranes, e.g. sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3623—Means for actively controlling temperature of blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/08—Flat membrane modules
    • B01D63/082—Flat membrane modules comprising a stack of flat membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3606—General characteristics of the apparatus related to heating or cooling cooled

Definitions

  • Oxygenators have been developed for this purpose. These devices are able to absorb carbon dioxide from the blood and to add oxygen to the blood.
  • the already existing oxygenators have a number of drawbacks, however.
  • the priming volume of the blood required to work with an oxygenator is very large in the existing devices. In the case of humans 10% of the blood volume of an adult is required for the priming volume.
  • Another drawback is that the ratio of the priming volume and the effective contact surface that can be used for the transfer of oxygen and carbon dioxide is small.
  • the present invention provides a blood processing device, comprising:
  • An advantage of the present invention is a relatively large ratio of the priming volume and the contact surface. It is further possible to achieve a very low priming volume by keeping the dimensioning of the plates and the channels very small. It hereby even becomes possible to connect small mammals, such as rats or children, to the blood processing device without external blood having to be added for this purpose.
  • Such a device can be applied with the same advantages for performing for instance blood dialysis.
  • a flushing liquid is herein passed through the channels whereby substances are exchanged with the blood in the other channels.
  • This application can also be used in further embodiments which are described hereinbelow, wherein for 'gases' can be read 'liquids'.
  • the membranes are suitable for exchanging contaminating substances occurring in blood.
  • a preferred embodiment further provides a device as specified above wherein channels in one direction debouch at the ends thereof in a supply or discharge chamber which is bounded on one side by the ends of the plates with the channel ends, and to which is connected a supply or discharge of respectively the fluid and the gases, wherein each channel is directly connected to the supply or discharge chambers.
  • the channels are preferably arranged such that the angle between the channels is situated at an angle between 0 and 180°.
  • An embodiment with an angle of 180° i.e. the channels are parallel and the streams of the fluids flowing through the channels flow in opposing directions, has the advantage that the differences in concentration of the substances to be exchanged between the two fluids via the membrane are maximal during the whole progress through the channels.
  • An embodiment with an angle of 90° has the advantage that it is relatively simple to manufacture, since only one chamber need be arranged per side.
  • a further preferred embodiment of the present invention has the feature that the angle between the first and the second direction is an angle in an interval of 30-90 * .
  • An embodiment with an angle of for instance 30° can be applied for a plurality of flow directions, as in the following embodiment.
  • a further embodiment provides third plates with third channels in a third direction for transporting cooling agents or heating means therein.
  • cooling agents By transporting cooling agents it is possible to cool the blood during the treatment.
  • Heating means are applied in similar manner to heat the blood.
  • a further preferred embodiment of the present invention includes the feature that the plates and the membranes are manufactured from a biocompatible material. It is further recommended that the membranes are made of a microporous material to allow passage of the gases, such as oxygen and carbon dioxide.
  • An example of such a microporous material is polypropylene.
  • biocompatible materials are RVS 316 (DIN 1.4401), RVS 316L (DIN 1.4404), ASTM F6795 or ASTM F1314-95, wherein the RVS codes are AISI codes.
  • the plates can be manufactured from these alloys. Plastics have properties which are very advantageous in the manufacture of the plates.
  • Manufacturing techniques which can be used to manufacture small channels such as are suitable for application in a device according to the present invention are roller embossing, UV embossing and injection moulding. By applying such techniques in the manufacture of channel structures according to the present invention it becomes possible to apply such structures economically in a device according to the present invention.
  • Such devices with channel structures are usually suitable for once-only use. Now that these technologies can be applied advantageously to the manufacture of channel structures according to the invention, it is possible to apply such channel structures in economic manner in devices for one-only use.
  • a further embodiment of the present invention comprises one or more third plates comprising third channels in a third direction for cooling or heating the device.
  • a significant advantage hereof is that the temperature of the blood can be varied during the treatment. This cooling or heating can take place by supplying a cooling or heating medium through the third channels. It is possible to add the third plates in the same ratio as first and second plates of the device, or in a higher or lower ratio. It may suffice for instance to add a third plate alternately via ten first and second plates for the purpose of cooling or heating.
  • a further preferred embodiment of the present invention comprises a blood processing device wherein the first plate comprises a first channel on one side and comprises a second channel on the other side. This embodiment has the advantage that, among other things, material and space can be saved by applying in one plate the functions of two separate plates.
  • a further preferred embodiment of the present invention comprises a stacking of the first plates, second plates and membranes for increasing the treatment capacity of the device.
  • This treatment capacity is related inter alia to the size of the contact surface between the blood for treating and the gas for treating. On this contact surface the blood is separated from the gas by the membrane.
  • the contact surface is situated at the intersections of the first channels and the second channels. The larger the contact surface available for passage of the gases, such as oxygen and carbon dioxide, the more gas can be exchanged.
  • This contact surface can be enlarged by using or adding to the device more stacks of first and second plates with membranes therebetween. Another option for enlarging the contact surface is to increase the width of the plates, whereby more channels become possible per plate.
  • the treatment capacity of the device can be varied by varying the number of plates and the size of the plates.
  • the plates and membranes being contained in a housing.
  • the housing holds the membranes and the plates pressed against each other.
  • the upper side and the underside of the housing can hold a stack of plates and membranes clamped and the side walls of the housing can be clamped against the stack of plates and membranes.
  • Such a method of constructing the device is one possibility of keeping the flows of gas, blood and cooling agents separated other than via the membranes.
  • the membranes are at least permeable to oxygen and carbon dioxide.
  • the advantage hereof is that the treatment can at least have an oxygen- and carbon dioxide-exchanging effect.
  • a thickness of the plates of for instance 100 to 200 ⁇ m and a depth of the channels of 20 to 70 ⁇ m and a width of the channels of 50 to 250 ⁇ m.
  • a further preferred embodiment of the present invention has the feature that the first direction and the second direction or the third direction and the second direction lie in the interval between 10° and 45°.
  • This embodiment can further have the feature that the largest angle between the first direction and the second direction or the third direction and the second direction lies in the interval between 45° and 90°.
  • the present invention provides a method for manufacturing an above described plate for use in the above described device comprising steps for arranging micro-ridges in a plate material.
  • Arranging of the ridges is preferably carried out by means of hot embossing or roller embossing.
  • Roller embossing is a variant of hot embossing wherein a drum with the profile of the ridges presses the ridges into the appropriate plate material at a predetermined temperature by means of the profile.
  • the use of a drum has the advantage that it is possible to work in a continuous process. Under some conditions hot embossing can however likewise have advantages, such as utilizing machine capacity. Tests have shown that very suitable plates could be manufactured using hot embossing.
  • plates are provided with ridges for use in a device according to the invention by means of UV embossing.
  • This technique per se known from optical applications, is suitable for arranging ridges in plate material.
  • Use is herein made of plastics which cure under the influence of UV light.
  • - figure 1 is a perspective view of an assembled embodiment of the present invention
  • - figure 2 is an exploded view in perspective of the embodiment of figure 1;
  • FIG. 3 is a perspective view of an embodiment of the plates according to the present invention.
  • FIG. 4 is a perspective view of another embodiment of the plates according to the present invention.
  • - figure 5 is a perspective view of a third embodiment of the plates according to the present invention
  • - figure 6 is a perspective view of a fourth embodiment of plates according to the present invention
  • - figure 7 is a perspective view of a fifth embodiment of plates according to the present invention
  • - figure 8 is an exploded schematic representation in perspective of a further embodiment according to the present invention
  • FIG. 9 is a view in perspective of the embodiment of figure 8;
  • - figure 10 is an exploded schematic representation in perspective of a further embodiment according to the present invention.
  • FIG 11 is a perspective view of the embodiment of figure 10.
  • An embodiment of the present invention (figure 1, 2) is a blood oxygenator with a very small so-called priming volume or operating volume, wherein the quantity lies in the order of magnitude of several millilitres, around 3 ml for the embodiment described here. Using the present invention this volume can be readily increased by using a plurality of modules according to the embodiment described here or by using larger modules.
  • a housing of oxygenator 1 comprises an upper plate 2 and a lower plate 3 fastened thereto with screw bolts la - Id.
  • the housing furthermore comprises four side walls 4, 5, 6, 7, which are thicker on the inside along the edges than in a middle part for the purpose of allowing passage of blood and gas.
  • Side walls 4 and 6 respectively 5 and 7 are pressed toward each other by means of screw bolts 5a - 5d respectively 6a - 6d.
  • Screw bolts 5a - 5d respectively 6a - 6d.
  • These tubes are intended for feed and discharge of blood respectively gas.
  • Situated inside the housing are stacks of plates 11 and 12 with membranes 13 therebetween.
  • plates 11 are arranged channels for transporting oxygen gases and in plates 12 are arranged channels for transporting blood.
  • the membrane 13 separating the channels is gas- permeable.
  • the *upper and lower plate are manufactured from polypropylene which is inexpensive and simple to process. Both plates are preferably as mutually symmetrical as possible. Using the screw bolts the stack of membranes and plates is fixed and clamped between the plates of the housing so as to enable the realization of a good sealing.
  • the side walls are manufactured from polycarbonate.
  • Polycarbonate is transparent, whereby possible leakages can be easily located visually.
  • Slotted holes are arranged in the side walls to make the housing suitable for various stacking heights of the membranes and plates.
  • a seal (not shown) is further provided between the side walls and the edges of the plates. It is important that this sealing material is not too hard, since a hard sealing material requires a greater biasing force for a good sealing. The biasing force should however be minimal in order to limit or prevent deformation of stacks.
  • Used as seal in this embodiment is intertwined teflon tape combined with vaseline. However, many types of seal could be used here, such as for instance sealing rings, gaskets or glueing.
  • channels 14a are formed by plate 11 and channel partitions 14.
  • Channels 15a are formed by plates 12 and elevations 15 thereof. Blood flow B flows through channels 14a and gas flow G flows through channels 15a.
  • Gas is then exchanged between the gas flow and the blood flow through membrane 13. This is an exchange of oxygen from the gas flow to the blood flow and an exchange of carbon dioxide from the blood flow to the gas flow. It is self-evident here that the gas flow comprises at least oxygen and that the blood flow comprises at least carbon dioxide.
  • the channels have very small dimensions and the membranes and the plates are very thin, it is possible to arrange a stack of many plates and membranes in the oxygenator.
  • plates of 0.12 mm and membranes of 0.035 mm are used, wherein the membranes consist of microporous polypropylene.
  • the channels have a width of 100 ⁇ m and a depth of 50 ⁇ m, wherein the ridges have a width of 50 ⁇ m and a height of 50 ⁇ m. This assumes the plates as shown in figure 2a. There are therefore always two plates and one membrane required for a proper operation of a combination hereof. Further prototypes were provided for test purposes with channels having a width of 200 ⁇ m.
  • FIG. 5 Another embodiment, that of figure 4, provides channels on both sides of the plates which lie crosswise of each other.
  • the membranes and the plates can be stacked alternately for the exchange of oxygen and carbon dioxide in the blood.
  • An advantage of this embodiment is that the stacking becomes easier and that space can be saved.
  • a third embodiment (figure 5) provides that the membrane forms part of the plates or that the plates are manufactured from the membrane material.
  • the rear wall 13d of plates lib consists of the gas-permeable material.
  • the whole plate consists of the membrane material.
  • the advantages of this embodiment are that gases can be exchanged along two sides of the channels, which on the one hand makes it possible to reduce the number of channels and on the other makes it possible to exchange more gases with the same quantity of blood.
  • the plates can be manufactured from for instance polypropylene.
  • the plates have a channel/throughflow function as well as a membrane function.
  • a process such as for instance hot embossing these plates 11 and 12 can be produced inexpensively and accurately. Further manufacturing methods which can be made specifically suitable for mass production of plates are described below.
  • a particular embodiment (figure 6) consists of hexagonal plates 31, 32 and 34 with a hexagonal membrane 33.
  • the channels 35a of plate 32 and 36a of plate 31 serve for passage of blood respectively gases in similar manner as in previous embodiments, wherein membrane 33 provides the exchange.
  • a plate 34 is also provided with channels 37a for admitting an additional flow L which can be used for cooling and/or heating.
  • partitions 35, 36 and 37 which, together with the respective plates, form the channels. Because in the case of a rectangular embodiment of figure 6 a higher blood volume is required per contact surface between channels 36a and 34a, another rectangular embodiment (figure 7) is provided having short blood channels 35a and longer gas channels 36a and cooling liquid channels 37a.
  • An advantage hereof is that there is an equally large contact surface between the blood and gas channels as in the embodiments of figure 2. Although more gas and cooling liquid volume is required, this can be supplied in large quantities, while the quantity of blood available in a body of a human or animal is limited. Certainly in the case of small animals or children the quantity of blood available is small.
  • FIG. 89 the flow channels or ridges in the plates are embodied in a different manner.
  • Two plates for the purpose of transporting air and blood are herein provided in channels on the sides facing each other.
  • the view of figure 9 shows the inlet for blood 43 and the inlet for gas 41.
  • Figure 8 shows how these channels are designed by means of bends or angles so as to create a large contact surface between the blood and gas channels. This contact surface is separated by membrane 47.
  • the gas channels run from inlet 41 to gas outlet 42.
  • the blood channels run from blood inlet 43, which is situated substantially at top left in figure 8, to blood outlet 44 at bottom right. Because in this embodiment the ends of the blood and air channels are situated on one side of the plates it becomes possible to also equip a square embodiment with channels with a cooling system.
  • plate 53 is provided with water channels, as can be seen in figure 8, with inlet openings 45 on the left-hand side and outlet openings 46 on the right-hand side.
  • air channels run from the right-hand side of the plate stack, from air inlet 63 to the bottom left-hand and top left-hand side of the plate stack to air outlet 64.
  • These air channels are arranged in plate 54.
  • a membrane 57 is arranged between plate 54 and 55 for the purpose of the oxygen and carbon dioxide exchange.
  • This embodiment is also provided with cooling plates 56 through which run water channels 66.
  • These water channels run from water inlet 65 on the upper side to water outlet 66 on the underside. Owing to this arrangement of water, blood and gas inlet and outlet, it is likewise possible to embody the channel inlet and channel outlet by means of a chamber which in very simple manner provides all channels of one type with sufficient supply and discharge.
  • a chamber is arranged for this purpose round blood inlet 61 and gas inlet 63 of all channels.
  • all chambers can also be provided in this embodiment with a sufficient supply and discharge in very simple manner.
  • An advantage of this embodiment is that all feeds and discharges are arranged on either side of the device, whereby in simple manner the device can for instance be dimensioned in many formats and capacities.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

La présente invention concerne un dispositif comprenant une première plaque pourvue d'un certain nombre de premiers canaux agencés dans une première direction pour le transport d'un liquide tel que du sang, une seconde plaque proche de la première plaque et pourvue d'un certain nombre de seconds canaux, agencés dans une seconde direction pour le transport d'un ou de plusieurs gaz ou bien d'un mélange de milieux gazeux, ainsi qu'une membrane perméable aux gaz disposée entre les premiers et seconds canaux.
PCT/NL2002/000170 2001-03-12 2002-03-12 Dispositif de traitement de sang WO2002076529A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP02705615A EP1370309A1 (fr) 2001-03-12 2002-03-12 Dispositif de traitement de sang

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1017570 2001-03-12
NL1017570A NL1017570C2 (nl) 2001-03-12 2001-03-12 Bloedbehandelingsinrichting.

Publications (1)

Publication Number Publication Date
WO2002076529A1 true WO2002076529A1 (fr) 2002-10-03

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ID=19773047

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PCT/NL2002/000170 WO2002076529A1 (fr) 2001-03-12 2002-03-12 Dispositif de traitement de sang

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EP (1) EP1370309A1 (fr)
NL (1) NL1017570C2 (fr)
WO (1) WO2002076529A1 (fr)

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FR2855071A1 (fr) * 2003-05-21 2004-11-26 Orelis Dispositif de separation par une pluralite de membranes de filtration d'un fluide en au moins deux fractions et son utilisation
WO2006042079A1 (fr) 2004-10-06 2006-04-20 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Dialyseur mecs
WO2007131748A1 (fr) * 2006-05-12 2007-11-22 Jvk Filtration Systems Gmbh Plaque de filtre à chambre
US7670797B2 (en) 2003-01-16 2010-03-02 The General Hospital Corporation Method of determining toxicity with three dimensional structures
WO2010025926A1 (fr) * 2008-09-03 2010-03-11 Novalung Gmbh Dispositif de transfert de gaz et utilisation d'une membrane structurée
US7759113B2 (en) 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
US7776021B2 (en) 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
WO2010151419A1 (fr) * 2009-06-24 2010-12-29 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Dispositifs microfluidiques pour dialyse
US7960166B2 (en) 2003-05-21 2011-06-14 The General Hospital Corporation Microfabricated compositions and processes for engineering tissues containing multiple cell types
WO2011082323A1 (fr) * 2009-12-31 2011-07-07 The Charles Stark Draper Laboratory, Inc. Dispositif microfluidique facilitant les échanges gazeux, ses procédés d'utilisation et de fabrication
WO2011150216A1 (fr) * 2010-05-26 2011-12-01 The Charles Stark Draper Laboratory, Inc. Dispositif respiratoire de poumon artificiel microfabriqué et procédés d'utilisation et de fabrication de celui-ci
US8097456B2 (en) 2003-08-18 2012-01-17 The Charles Stark Draper Laboratory Nanotopographic compositions and methods for cellular organization in tissue engineered structures
US8147562B2 (en) 2002-09-23 2012-04-03 The General Hospital Corporation Three dimensional construct for the design and fabrication of physiological fluidic networks
EP2493597A1 (fr) * 2009-10-29 2012-09-05 The Charles Stark Draper Laboratory, Inc. Dispositif microfluidique pour la dialyse du sang
AU2011218729B2 (en) * 2004-10-06 2012-09-06 Home Dialysis Plus, Ltd. Mecs dialyzer
US8266791B2 (en) 2007-09-19 2012-09-18 The Charles Stark Draper Laboratory, Inc. Method of fabricating microfluidic structures for biomedical applications
WO2013022945A3 (fr) * 2011-08-10 2013-06-13 Oasys Water, Inc. Modules membranaires
WO2013086011A1 (fr) * 2011-12-05 2013-06-13 The Charles Stark Draper Laboratory, Inc. Procédé de réduction de la zone de surface membranaire et du volume d'amorçage en sang dans des dispositifs d'assistance pulmonaire microfluidique
US8591597B2 (en) 2007-04-12 2013-11-26 The General Hospital Corporation Biomimetic vascular network and devices using the same
WO2014135295A1 (fr) * 2013-03-04 2014-09-12 Robert Bosch Gmbh Élément de construction pour dispositif d'enrichissement en oxygène, empilage d'éléments de construction, dispositif de production d'un fluide enrichi en oxygène, batterie métal-oxygène et véhicule automobile
US9095817B2 (en) 2009-02-12 2015-08-04 Novalung Gmbh Device for the treatment of biological fluid
US9138687B2 (en) 2010-06-07 2015-09-22 Oregon State University Fluid purification system
US9328969B2 (en) 2011-10-07 2016-05-03 Outset Medical, Inc. Heat exchange fluid purification for dialysis system
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US9545469B2 (en) 2009-12-05 2017-01-17 Outset Medical, Inc. Dialysis system with ultrafiltration control
US9595206B2 (en) 2008-02-11 2017-03-14 The General Hospital System and method for in vitro blood vessel modeling
US9657261B2 (en) 2011-06-15 2017-05-23 The Charles Stark Draper Laboratory, Inc. Systems, methods, and devices relating to a biomimetic cellularized nephron unit
JP2017513625A (ja) * 2014-04-23 2017-06-01 ザ チャールズ スターク ドレイパー ラボラトリー インク 血液酸素供給器
US9895480B2 (en) 2010-06-07 2018-02-20 Oregon State University Dialysis system
CN111201048A (zh) * 2017-06-08 2020-05-26 凯斯西储大学 对血液进行亚硝化的设备和方法
US11534537B2 (en) 2016-08-19 2022-12-27 Outset Medical, Inc. Peritoneal dialysis system and methods

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