WO2002074438A8 - Structural units that define fluidic functions - Google Patents

Structural units that define fluidic functions

Info

Publication number
WO2002074438A8
WO2002074438A8 PCT/SE2002/000531 SE0200531W WO02074438A8 WO 2002074438 A8 WO2002074438 A8 WO 2002074438A8 SE 0200531 W SE0200531 W SE 0200531W WO 02074438 A8 WO02074438 A8 WO 02074438A8
Authority
WO
WIPO (PCT)
Prior art keywords
substructure
microchannel
axis
annular zones
microchannel structures
Prior art date
Application number
PCT/SE2002/000531
Other languages
French (fr)
Other versions
WO2002074438A2 (en
WO2002074438A3 (en
Inventor
Per Andersson
Gunnar Ekstrand
Ulrike Selditz
Susanne Wallenborg
Helene Derand
Gunnar Thorsen
Ebru Togan-Tekin
Original Assignee
Gyros Ab
Per Andersson
Gunnar Ekstrand
Ulrike Selditz
Susanne Wallenborg
Helene Derand
Gunnar Thorsen
Ebru Togan-Tekin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0100952A external-priority patent/SE0100952D0/en
Priority claimed from US09/812,123 external-priority patent/US6717136B2/en
Priority claimed from SE0100951A external-priority patent/SE0100951D0/en
Priority claimed from US09/811,741 external-priority patent/US6653625B2/en
Priority claimed from SE0200242A external-priority patent/SE0200242D0/en
Application filed by Gyros Ab, Per Andersson, Gunnar Ekstrand, Ulrike Selditz, Susanne Wallenborg, Helene Derand, Gunnar Thorsen, Ebru Togan-Tekin filed Critical Gyros Ab
Priority to JP2002573143A priority Critical patent/JP2004529333A/en
Priority to AU2002243148A priority patent/AU2002243148A1/en
Priority to EP02708887A priority patent/EP1390144A2/en
Priority to US10/472,255 priority patent/US7429354B2/en
Priority to CA002439627A priority patent/CA2439627A1/en
Priority to PCT/SE2002/001539 priority patent/WO2003018198A1/en
Priority to EP10184038.7A priority patent/EP2283924B1/en
Priority to EP10183978A priority patent/EP2281633A1/en
Priority to EP10184014.8A priority patent/EP2269736B1/en
Priority to CA002456421A priority patent/CA2456421A1/en
Priority to AT02763153T priority patent/ATE492342T1/en
Priority to JP2003522704A priority patent/JP4181497B2/en
Priority to DE60238716T priority patent/DE60238716D1/en
Priority to US10/229,676 priority patent/US6919058B2/en
Priority to EP02763153A priority patent/EP1483052B1/en
Publication of WO2002074438A2 publication Critical patent/WO2002074438A2/en
Publication of WO2002074438A3 publication Critical patent/WO2002074438A3/en
Publication of WO2002074438A8 publication Critical patent/WO2002074438A8/en
Priority to US11/010,870 priority patent/US7275858B2/en
Priority to US11/010,957 priority patent/US8268262B2/en
Priority to US11/010,869 priority patent/US7459129B2/en
Priority to US11/010,977 priority patent/US7300199B2/en

Links

Classifications

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    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
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    • B01F35/717Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7172Feed mechanisms characterised by the means for feeding the components to the mixer using capillary forces
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01F25/42Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
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    • B01F25/43Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
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    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
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    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01L2200/10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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    • B01L2300/069Absorbents; Gels to retain a fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01L2300/0803Disc shape
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
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    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
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    • B01L2400/04Moving fluids with specific forces or mechanical means
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    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0418Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
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  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
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  • Food Science & Technology (AREA)
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  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and therebetween a substructure comprising a fluidic function. The device has an axis of symmetry around which the microchannel structures are arranged as two or more concentric annular zones. for an inlet port and an outlet port of the same microchannel structure the inlet port is typically closer to the axis of symmetry than the outlet port. Each microchannel structure comprises a substructure that can retain liquid while the disc is spun around the axis and/or the inlet ports are positioned separate from the paths waste liquid leaving open waste outlet ports will follow across the surface of the disc when it is spun. For the microchannel structures of an annular zones the corresponding substructures are at essentially at the same radial distance while corresponding substructures in microchannel structures of different annular zones are at different radial distances. The invention also refers to several other substructures. The substructure are primarily adapted for transporting liquid aliquots that have a surface tnsion > 5 mN/m with centrifugal force.
PCT/SE2002/000531 2001-03-19 2002-03-19 Structural units that define fluidic functions WO2002074438A2 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
JP2002573143A JP2004529333A (en) 2001-03-19 2002-03-19 Structural unit that defines fluid function
AU2002243148A AU2002243148A1 (en) 2001-03-19 2002-03-19 Structural units that define fluidic functions
EP02708887A EP1390144A2 (en) 2001-03-19 2002-03-19 Structural units that define fluidic functions
US10/472,255 US7429354B2 (en) 2001-03-19 2002-03-19 Structural units that define fluidic functions
CA002439627A CA2439627A1 (en) 2001-03-19 2002-03-19 Structural units that define fluidic functions
AT02763153T ATE492342T1 (en) 2001-08-28 2002-08-28 MICROCHAMBERS AND MICROFLUIDIC STRUCTURES FOR HANDLING SMALL QUANTITIES OF LIQUID
JP2003522704A JP4181497B2 (en) 2001-08-28 2002-08-28 Microfluidic microcavity and other microfluidic structures for holding
DE60238716T DE60238716D1 (en) 2001-08-28 2002-08-28 MICRO-CHAMBERS AND MICROFLUIDIC STRUCTURES FOR HANDLING SMALL FLUID QUANTITIES
US10/229,676 US6919058B2 (en) 2001-08-28 2002-08-28 Retaining microfluidic microcavity and other microfluidic structures
EP10184038.7A EP2283924B1 (en) 2001-08-28 2002-08-28 Inlet unit with means supporting liquid entrance into a microchannel structure
EP10184014.8A EP2269736B1 (en) 2001-08-28 2002-08-28 Retaining microfluidic microcavity and other microfluidic structures
EP02763153A EP1483052B1 (en) 2001-08-28 2002-08-28 Retaining microfluidic microcavity and other microfluidic structures
EP10183978A EP2281633A1 (en) 2001-08-28 2002-08-28 Retaining microfluidic microcavity and other microfluidic structures
PCT/SE2002/001539 WO2003018198A1 (en) 2001-08-28 2002-08-28 Retaining microfluidic microcavity and other microfluidic structures
CA002456421A CA2456421A1 (en) 2001-08-28 2002-08-28 Retaining microfluidic microcavity and other microfluidic structures
US11/010,977 US7300199B2 (en) 2001-08-28 2004-12-13 Retaining microfluidic microcavity and other microfluidic structures
US11/010,869 US7459129B2 (en) 2001-08-28 2004-12-13 Retaining microfluidic microcavity and other microfluidic structures
US11/010,957 US8268262B2 (en) 2001-08-28 2004-12-13 Retaining microfluidic microcavity and other microfluidic structures
US11/010,870 US7275858B2 (en) 2001-08-28 2004-12-13 Retaining microfluidic microcavity and other microfluidic structures

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US09/811,741 US6653625B2 (en) 2001-03-19 2001-03-19 Microfluidic system (MS)
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US09/811,741 2001-03-19
SE0100951A SE0100951D0 (en) 2001-03-19 2001-03-19 A microfluidic system (EDI)
US09/812,123 US6717136B2 (en) 2001-03-19 2001-03-19 Microfludic system (EDI)
SE0100952-1 2001-03-19
SE0100952A SE0100952D0 (en) 2001-03-19 2001-03-19 A microfluidic system (MS)
US09/812,123 2001-03-19
US31547101P 2001-08-28 2001-08-28
US60/315,471 2001-08-28
SE0200242A SE0200242D0 (en) 2002-01-28 2002-01-28 A Microfluidic System (EDI)
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