WO2002067945A1 - Utilisation de n-acetyl-d-glucosamine dans la fabrication d'un produit pharmaceutique destine au traitement de l'erosion cervicale - Google Patents
Utilisation de n-acetyl-d-glucosamine dans la fabrication d'un produit pharmaceutique destine au traitement de l'erosion cervicale Download PDFInfo
- Publication number
- WO2002067945A1 WO2002067945A1 PCT/CN2002/000118 CN0200118W WO02067945A1 WO 2002067945 A1 WO2002067945 A1 WO 2002067945A1 CN 0200118 W CN0200118 W CN 0200118W WO 02067945 A1 WO02067945 A1 WO 02067945A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- glucosamine
- acetyl
- cervical erosion
- treating cervical
- manufacture
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Definitions
- the invention relates to the application of N-acetyl-D-glucosamine in the preparation of a medicine for treating cervical erosion.
- Cervical erosion is a common gynecological condition. It is caused by superficial defects formed by squamous epithelial necrosis of the cervix and vagina in the process of chronic cervical inflammation, or caused by exudation and secretion of the cervical mucosa. Increased material, cervical mucosal congestion, edema and ulceration, microbial infection, etc. Not only does this condition persist and hardly affect normal life, it also has the potential to develop into cancer.
- N-acetyl-D-glucosamine is a chemical agent that has been used in the treatment of periodontitis (W09102530A1), microbial infections (W09718790A3), inflammatory bowel disease (W09953929A1), corneal disease ( JP10287570A2), prostate hypertrophy (US05116615), organic gastrointestinal lesions of the lower digestive tract (W093 / 14765), and tissue growth regulators (W0 / 8 702244), beauty (JP59013708A2), shampoo preparations (JP2011505A2), etc. There is currently no application in the preparation of drugs for treating cervical erosion.
- N-acetyl-D-glucosamine can effectively treat cervical erosion, which is very unexpected, because to cure cervical erosion requires controlling microbial infection, resisting local exudation, eliminating tissue inflammatory edema and pain, and To promote cooperation in various aspects such as tissue repair, doctors must prescribe multiple drugs for patients. It is now found that drugs using N-acetyl-D-glucosamine alone as an active ingredient can cure cervical erosion. Although the antimicrobial infection and tissue growth regulating effects of N-acetyl-D-glucosamine have been disclosed in the prior art, this finding is still surprising. Summary of the Invention
- the present invention relates to the use of N-acetyl-D-glucosamine and a pharmaceutically acceptable salt thereof in the preparation of a medicament for treating cervical erosion.
- the invention in another aspect, relates to a method for treating cervical erosion, comprising administering to a patient in need thereof a therapeutically effective amount of N-acetyl-D-glucosamine or a pharmaceutically acceptable salt thereof.
- N-acetamidine-D-glucosamine is a compound having the following structure: N-acetyl-D-amino It is commercially available or can be prepared according to known methods.
- patent application W097 / 31121 discloses a method for preparing N-acetyl-D-glucosamine from a chitinase method.
- Japanese patent application JP63273493 discloses a method for preparing chitin Partial acid hydrolysis to N-acetyl-chitooligosaccharide, and then treated with an enzyme to obtain N-acetyl-D-glucosamine.
- pharmaceutically acceptable salts of N-acetyl-D-glucosamine mention may be made of those formed with pharmaceutically acceptable acids, such as those formed with inorganic acids, such as hydrochloride, hydrobromide, borate Salts, phosphates, sulfates, hydrogen sulfates, and hydrogen phosphates, as well as those formed with organic acids, such as citrate, stearic acid, ascorbate, methyl sulfate, naphthalene-2-sulfonate, Picrate, fumarate, maleate, malonate, oxalate, succinate, acetate, tartrate, mesylate, tosylate, isethionate, Alpha -ketoglutarate, alpha -glycerol phosphate, and glucose-1-phosphate.
- pharmaceutically acceptable acids such as those formed with inorganic acids, such as hydrochloride, hydrobromide, borate Salts, phosphates, sulfates, hydrogen sulf
- the compound of formula (I) or a pharmaceutically acceptable salt thereof is used as a main active ingredient in combination with various pharmaceutically acceptable excipients and / or carriers to prepare external water preparations, emulsions, creams, ointments, and suppositories. Other preparations are used to treat cervical erosion.
- the amount of active substance is 0.2 to 6% of the total formulation.
- the daily dose of the drug is 100-2000 mg of N-acetyl-D-glucosamine per person.
- N-acetyl-D-glucosamine exerts its special effects by regulating cell redistribution at different levels. Macro cell location For the performance of fluctuating growth. N-acetyl-D-glucosamine works normally by regulating the undulating growth of body cells and microbial cells, so that microorganisms cannot colonize locally.
- micro-ecological efficacy In terms of micro-ecological efficacy, it mainly supports the growth of normal flora, and does not adopt the method of supplementing ecological flora, which avoids the adaptability of the colonizing conditions in the supplementary flora. In terms of promoting skin and mucosal tissue repair, it has a controlling effect on inflammation, injury, infection, and exudation, which is a unique feature of this product. It can be widely used to control symptoms and treat the underlying problem. Best Mode of the Invention
- test examples are used to demonstrate the wave-promoting properties, low toxicity, antimicrobial colonization activity, and clinical observations of treating cervical erosion by the compound of formula (I) of the present invention.
- LB medium Improved LB medium (composition: 1% tryptone, 0.5% yeast extract, 1% sodium chloride, 0.1% glucose, 0.002% TTC, PH7. 2_7. 4).
- the liquid culture results show that the compound of formula (I) can promote the growth of lactic acid bacteria.
- This experiment uses a biological wave model to study the wave-promoting effect of compounds of formula (I) As a result, it can be seen that the compound of formula (I) can not only make bacterial cells show normal biological wave characteristics, but also make this fluctuation show a more detailed wave mode, indicating that the compound of formula (I) can promote biological fluctuations. This wave-promoting effect can be involved in the repair and redistribution of skin cells.
- Acute toxicity test including oral, intravenous and maximum dose test
- the test results show that the acute toxicity test dose of the compound of formula (I) exceeds 2 g / kg, which is 300 times the human injection dose, and there is no acute poisoning reaction.
- the highest dose has reached lg / kg. After four weeks of testing It was observed that no poisoning reaction occurred.
- the reproduction test the mice were fed with a regular dose of 7 mg / kg, and after three passages, it was proved that the compound of formula (I) had no effect on the pregnancy, childbirth, breastfeeding, and development of pups in mice. Non-toxic substance.
- N-acetamidine-D-glucosamine spray was used for trials in the population. As of August 1999, a total of 123 patients were observed. From the trial results, compared with the blank control group (without drugs) and the positive drug (AgN03) control group, statistical analysis shows that the treatment group is significantly different from the positive drug control group and the blank control group in terms of recovery rate and effectiveness. N-acetyl -The therapeutic effect of D-glucosamine spray on cervical erosion is significant 63 ⁇ 4. The statistical results of the effect are as follows:
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Communicable Diseases (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/469,268 US6992073B2 (en) | 2001-02-28 | 2002-02-28 | Use of N-acetyl-D-glucosamine in the manufacture of a medicament for treating cervical erosion |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN01104884.O | 2001-02-28 | ||
CNB011048840A CN1173706C (zh) | 2001-02-28 | 2001-02-28 | N-乙酰-d-氨基葡萄糖在制备治疗宫颈糜烂药物中的应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002067945A1 true WO2002067945A1 (fr) | 2002-09-06 |
Family
ID=4654073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2002/000118 WO2002067945A1 (fr) | 2001-02-28 | 2002-02-28 | Utilisation de n-acetyl-d-glucosamine dans la fabrication d'un produit pharmaceutique destine au traitement de l'erosion cervicale |
Country Status (3)
Country | Link |
---|---|
US (1) | US6992073B2 (zh) |
CN (1) | CN1173706C (zh) |
WO (1) | WO2002067945A1 (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1533776A (zh) * | 2003-03-27 | 2004-10-06 | 中国人民解放军第三军医大学 | N-乙酰氨基葡萄糖在制备用于治疗病毒或细菌感染所致的局部损伤和全身症状的药物中的应用 |
CN1232257C (zh) | 2003-03-27 | 2005-12-21 | 中国人民解放军第三军医大学 | N-乙酰氨基葡萄糖在制备治疗和控制物理化学因素致非特异性炎症的药物中的应用 |
AU2003261624A1 (en) * | 2003-09-05 | 2005-03-29 | Shenyang Sunbellcom Bio-Pharmaceutical Co., Ltd. | A red nocardia cell wall skeleton preparation process and its therapeutic use on treating cervical erosion |
WO2005025580A1 (fr) * | 2003-09-17 | 2005-03-24 | Third Military Medical University, Chinese People's Liberation Army, P.R. Of China | Utilisation de n-acetyl-d-aminoglycosamine pour la preparation de medicaments servant a moduler des micro-organismes sur la membrane muqueuse |
AU2003271016A1 (en) * | 2003-09-17 | 2005-04-06 | Bio-Wave Institute Of Suzhou Hi-Tech New District Corporation, Ltd. | Use of n-acetyl-d-aminoglycosamine in preparation of drugs for the treatment of cacer and metastasis |
WO2005025582A1 (fr) * | 2003-09-18 | 2005-03-24 | Third Military Medical University, Chinese People's Liberation Army, P.R. Of China | Compositions antibacteriennes a base de n-acetyl-d-aminoglycosamine et d'antibiotiques |
US20100152304A1 (en) * | 2008-12-17 | 2010-06-17 | Geng Funeng | Pharmaceutical composition comprising periplaneta americana or its ethanol extract and a method of using the same for treating inflammations |
CN107334782A (zh) * | 2017-07-26 | 2017-11-10 | 吉林省始祖生物波医学研究院有限公司 | 一种抑菌消炎剂及其制备方法和应用 |
CN113912656A (zh) * | 2021-09-30 | 2022-01-11 | 上海玉曜生物医药科技有限公司 | N-乙酰基-d-氨基葡萄糖的晶型及其制备方法、应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993014765A1 (en) * | 1992-01-28 | 1993-08-05 | The University Of British Columbia | Use of n-acetyl glucosamine for treating lower gastrointestinal tract disorders |
WO1993018775A1 (en) * | 1992-03-19 | 1993-09-30 | The University Of British Columbia | Method and composition for suppression of side effects of anti-inflammatory drugs |
CN1156027A (zh) * | 1996-12-27 | 1997-08-06 | 中国人民解放军第三军医大学 | N-乙酰-d-氨基葡萄糖在治疗肠道疾病药物制剂中的应用 |
CN1156028A (zh) * | 1996-12-27 | 1997-08-06 | 中国人民解放军第三军医大学 | N-乙酰-d-氨基葡萄糖在制备皮肤卫生用品制剂的应用 |
CN1156026A (zh) * | 1996-12-27 | 1997-08-06 | 中国人民解放军第三军医大学 | N-乙酰-d-氨基葡萄糖在治疗呼吸道疾病药物制剂中的应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5913708A (ja) | 1982-07-14 | 1984-01-24 | Shiseido Co Ltd | 化粧料 |
GB8524807D0 (en) | 1985-10-08 | 1985-11-13 | Hendry N G C | Tissue growth regulation |
JPS63273493A (ja) | 1987-04-30 | 1988-11-10 | Kyogyo Kumiai N F I | N−アセチル−d−グルコサミンの製造法 |
JP2552536B2 (ja) | 1988-06-29 | 1996-11-13 | 川研ファインケミカル株式会社 | ヘアリンス剤 |
US5116615A (en) | 1989-01-27 | 1992-05-26 | Immunolytics, Inc. | Method for treating benign prostatic hypertrophy |
JPH0383927A (ja) | 1989-08-25 | 1991-04-09 | Sunstar Inc | 歯周組織再生促進剤 |
WO1997018790A2 (en) | 1995-11-22 | 1997-05-29 | The Research And Development Institute, Inc. | Therapeutic and diagnostic agents for the treatment of microbial infections |
US5998173A (en) | 1996-02-20 | 1999-12-07 | The University Of Bristish Columbia | Process for producing N-acetyl-D-glucosamine |
JP4290231B2 (ja) | 1997-04-09 | 2009-07-01 | 生化学工業株式会社 | 角膜障害症治癒促進剤 |
US6046179A (en) | 1998-04-17 | 2000-04-04 | Murch; Simon | Composition for and treatment of inflammatory bowel disease by colon administration of N-acetylglucosamine |
WO2002010138A2 (en) * | 2000-08-01 | 2002-02-07 | Schering Corporation | Uses of mammalian genes and related reagents |
-
2001
- 2001-02-28 CN CNB011048840A patent/CN1173706C/zh not_active Expired - Fee Related
-
2002
- 2002-02-28 WO PCT/CN2002/000118 patent/WO2002067945A1/zh not_active Application Discontinuation
- 2002-02-28 US US10/469,268 patent/US6992073B2/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993014765A1 (en) * | 1992-01-28 | 1993-08-05 | The University Of British Columbia | Use of n-acetyl glucosamine for treating lower gastrointestinal tract disorders |
WO1993018775A1 (en) * | 1992-03-19 | 1993-09-30 | The University Of British Columbia | Method and composition for suppression of side effects of anti-inflammatory drugs |
CN1156027A (zh) * | 1996-12-27 | 1997-08-06 | 中国人民解放军第三军医大学 | N-乙酰-d-氨基葡萄糖在治疗肠道疾病药物制剂中的应用 |
CN1156028A (zh) * | 1996-12-27 | 1997-08-06 | 中国人民解放军第三军医大学 | N-乙酰-d-氨基葡萄糖在制备皮肤卫生用品制剂的应用 |
CN1156026A (zh) * | 1996-12-27 | 1997-08-06 | 中国人民解放军第三军医大学 | N-乙酰-d-氨基葡萄糖在治疗呼吸道疾病药物制剂中的应用 |
Also Published As
Publication number | Publication date |
---|---|
US6992073B2 (en) | 2006-01-31 |
US20040138174A1 (en) | 2004-07-15 |
CN1173706C (zh) | 2004-11-03 |
CN1372931A (zh) | 2002-10-09 |
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