WO2002067920A1 - Remedes pour hepatite c chronique - Google Patents
Remedes pour hepatite c chronique Download PDFInfo
- Publication number
- WO2002067920A1 WO2002067920A1 PCT/JP2001/007533 JP0107533W WO02067920A1 WO 2002067920 A1 WO2002067920 A1 WO 2002067920A1 JP 0107533 W JP0107533 W JP 0107533W WO 02067920 A1 WO02067920 A1 WO 02067920A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- chronic hepatitis
- hcv
- administration
- bezafibrate
- represented
- Prior art date
Links
- 208000005176 Hepatitis C Diseases 0.000 title claims abstract description 34
- 208000006154 Chronic hepatitis C Diseases 0.000 title claims abstract description 32
- 208000010710 hepatitis C virus infection Diseases 0.000 title claims abstract description 32
- IIBYAHWJQTYFKB-UHFFFAOYSA-N bezafibrate Chemical compound C1=CC(OC(C)(C)C(O)=O)=CC=C1CCNC(=O)C1=CC=C(Cl)C=C1 IIBYAHWJQTYFKB-UHFFFAOYSA-N 0.000 claims abstract description 19
- 150000003839 salts Chemical class 0.000 claims abstract description 14
- 239000004480 active ingredient Substances 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 claims 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- -1 4-chlorobenzoylaminoethyl Chemical group 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 20
- 239000003814 drug Substances 0.000 abstract description 18
- 108010050904 Interferons Proteins 0.000 abstract description 9
- 102000014150 Interferons Human genes 0.000 abstract description 9
- 229940079322 interferon Drugs 0.000 abstract description 9
- 102000004190 Enzymes Human genes 0.000 abstract description 5
- 108090000790 Enzymes Proteins 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 5
- 230000035755 proliferation Effects 0.000 abstract description 5
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- 229960000516 bezafibrate Drugs 0.000 description 17
- 229940124597 therapeutic agent Drugs 0.000 description 13
- 230000003908 liver function Effects 0.000 description 8
- 108010003415 Aspartate Aminotransferases Proteins 0.000 description 6
- 102000004625 Aspartate Aminotransferases Human genes 0.000 description 6
- 230000003247 decreasing effect Effects 0.000 description 6
- 230000007774 longterm Effects 0.000 description 5
- 239000000546 pharmaceutical excipient Substances 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 4
- 108010082126 Alanine transaminase Proteins 0.000 description 4
- 101000856500 Bacillus subtilis subsp. natto Glutathione hydrolase proenzyme Proteins 0.000 description 4
- 208000031226 Hyperlipidaemia Diseases 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 239000000314 lubricant Substances 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000007884 disintegrant Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 description 2
- 229960001661 ursodiol Drugs 0.000 description 2
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 description 1
- 208000019838 Blood disease Diseases 0.000 description 1
- 241000711549 Hepacivirus C Species 0.000 description 1
- 108010078049 Interferon alpha-2 Proteins 0.000 description 1
- 108010047761 Interferon-alpha Proteins 0.000 description 1
- 102000006992 Interferon-alpha Human genes 0.000 description 1
- GSDSWSVVBLHKDQ-JTQLQIEISA-N Levofloxacin Chemical compound C([C@@H](N1C2=C(C(C(C(O)=O)=C1)=O)C=C1F)C)OC2=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-JTQLQIEISA-N 0.000 description 1
- 238000013381 RNA quantification Methods 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000003405 delayed action preparation Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000002662 enteric coated tablet Substances 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 230000009422 growth inhibiting effect Effects 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 230000004730 hepatocarcinogenesis Effects 0.000 description 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229960003376 levofloxacin Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000012317 liver biopsy Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229960001699 ofloxacin Drugs 0.000 description 1
- 238000007427 paired t-test Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 235000015170 shellfish Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
- F16B39/00—Locking of screws, bolts or nuts
- F16B39/02—Locking of screws, bolts or nuts in which the locking takes place after screwing down
- F16B39/12—Locking of screws, bolts or nuts in which the locking takes place after screwing down by means of locknuts
- F16B39/16—Locking of screws, bolts or nuts in which the locking takes place after screwing down by means of locknuts in which the screw-thread of the locknut differs from that of the nut
- F16B39/18—Locking of screws, bolts or nuts in which the locking takes place after screwing down by means of locknuts in which the screw-thread of the locknut differs from that of the nut in which the locknut grips with screw-thread in the nuts as well as on the bolt
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
- F16B39/00—Locking of screws, bolts or nuts
- F16B39/22—Locking of screws, bolts or nuts in which the locking takes place during screwing down or tightening
- F16B39/24—Locking of screws, bolts or nuts in which the locking takes place during screwing down or tightening by means of washers, spring washers, or resilient plates that lock against the object
Definitions
- the present invention relates to a therapeutic agent for chronic hepatitis C
- the present invention provides a formula A- [4- (4-chlorobenzoylaminoethyl) phenoxy] isobutyric acid (generic name bezafibrate, bezafibrate, hereafter referred to as bezafibrate) or a pharmacologically acceptable salt thereof is effective
- the present invention relates to a therapeutic agent for chronic hepatitis C contained as an ingredient.
- Hepatitis C is a disease caused by infection of the hepatitis C virus (HCV, hereinafter referred to as HCV) from the blood. More than half of the disease becomes chronic. Therefore, drug therapy is indispensable in the treatment of chronic hepatitis C to prevent hepatocarcinogenesis.
- HCV hepatitis C virus
- the treatment goals for chronic hepatitis C are to maintain normal liver function, i.e., to improve liver function, and to prevent HCV-RNA continuous negativity, i.e., to remove HCV.
- Huen has liver function-improving effects and anti-HCV effects, and although it is the most widely used, daily and total doses are prescribed, and precautions must be taken in prescribing. Its effectiveness is limited and many patients are not effective.
- As other therapeutic agents strong minophagen C, dalitinoleritin, ursodeoxycholic acid, etc. are used, but all have only liver function improving effect, and do not affect HCV-RNA continuous negative, liver function Is used only for the purpose of sustained normality, and invalid cases are often reported.
- Ursodeoxycholic acid has also been reported to be effective to some extent, but it has been reported that it is not recommended, and a reliable effect cannot be expected.
- oral antiviral agents such as ofloxacin (of 1 oX acin) and levofloxacin are being studied for the purpose of removing HCV, but oral antiviral agents generally have problems with toxicity and side effects due to long-term continuous administration. In most cases, long-term continuous administration is difficult.
- the bezafiprate of the present invention represented by the above formula (I) or a pharmacologically acceptable salt thereof has a cholesterol-lowering effect, is a compound useful as a therapeutic agent for hyperlipidemia, It is widely used in the treatment of blood disorders.
- bezafibrate is effective in treating chronic hepatitis C.
- the present inventor has a remarkable liver function improving effect and anti-HCV effect, is effective even in cases of interferon ineffective as a first-line drug for treating chronic hepatitis C, and has no problem of side effects even in long-term continuous administration
- the above-mentioned formula of the present invention which has a cholesterol-lowering effect and is already widely used as a therapeutic agent for hyperlipidemia
- the present inventors have found that the bezafibrate represented by (I) reduces hepatobiliary enzymes by long-term oral administration, suppresses HCV proliferation, and has a therapeutic effect on chronic hepatitis C in interferon-ineffective patients. Was reached.
- the present invention also relates to a therapeutic agent for chronic hepatitis C containing as an active ingredient bezafibrate represented by the formula (I) or a pharmaceutically acceptable salt thereof. It is.
- the present invention also relates to a method for treating chronic hepatitis C, which comprises administering an effective amount of bezafibrate represented by the formula (I) or a pharmaceutically acceptable salt thereof.
- the present invention relates to the use of bezafibrate represented by the above formula (I) or a pharmaceutically acceptable salt thereof for producing a preparation for treating chronic hepatitis C.
- the key points in the treatment of chronic hepatitis C are improvement of liver function, ie, reduction of hepatobiliary enzymes, and continuous elimination of HCV-RNA, ie, removal of HCV, as described above.
- the present inventor has proposed that bezafiprate 200 be used for ineffective cases in which no improvement was observed even if interferon therapy using natural interferon ⁇ , natural interferon) 3 or recombinant interferon ⁇ -2b was continued for 6 months.
- ALT and y-GTP hepatobiliary enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT) and ⁇ - Changes in dartameal transferase ( ⁇ -GTP, hereafter referred to as ⁇ -GTP) were measured over time.
- AST aspartate aminotransferase
- ALT alanine aminotransferase
- ⁇ -GTP dartameal transferase
- bezafiprate also had an inhibitory effect on HCV proliferation.
- the bezafibrate of the present invention represented by the above formula (I) has been confirmed to have a blood cholesterol lowering effect as described above, and has already been widely used as a therapeutic agent for hyperlipidemia.
- bezafibrate has never been reported to exhibit a hepatobiliary enzyme lowering effect and an inhibitory effect on HCV proliferation due to chronic hepatitis C.
- bezafibrate has a hepatobiliary enzyme-lowering effect and inhibits HCV proliferation. It has a remarkable therapeutic effect on chronic hepatitis C and is effective even in cases of ineffectiveness of interferve, which is the first-line drug for the treatment of chronic hepatitis C. have.
- the bezafibrate represented by the formula (I) or a pharmacologically acceptable salt thereof of the present invention is a very useful compound as a therapeutic agent for chronic hepatitis C, and therefore, bezafiprate or a pharmacologically acceptable salt thereof.
- a highly useful pharmaceutical composition as a therapeutic agent for chronic hepatitis C can be produced by incorporating a salt of the present invention as an active ingredient and mixing it with a pharmaceutical additive according to a conventional method as appropriate.
- oral administration agents include powders, granules, tablets, capsules, Parenteral preparations such as dry syrups include injections, suppositories, patches and the like.
- compositions can be mixed with appropriate pharmaceutical additives, such as shellfish, disintegrants, binders, lubricants, etc., according to the dosage form, according to the usual pharmacological techniques, and according to the usual method. It can be manufactured by dispensing.
- appropriate pharmaceutical additives such as shellfish, disintegrants, binders, lubricants, etc.
- powders are prepared by adding appropriate excipients, lubricants, and the like to the active ingredient, if necessary, and thoroughly mixing to obtain a powder.
- Tablets are prepared by adding appropriate excipients, disintegrants, binders, lubricants and the like, if necessary, to the active ingredient and compressing the tablets according to the usual method. If necessary, the composition is coated as appropriate to obtain film-coated tablets, sugar-coated tablets, enteric-coated tablets and the like.
- Capsules may be added to the active ingredient, if necessary, by adding appropriate excipients, lubricants, etc., and mixed well, or alternatively, formed into granules or fine granules by a conventional method, and filled in suitable capsules. Into capsules.
- an immediate release or sustained release preparation can be prepared depending on the treatment method.
- the dose of the active ingredient is appropriately determined according to the patient's age, body weight, degree of disease, therapeutic effect, and the like.
- a pharmacologically acceptable salt thereof is administered in an amount of 100 to 100 Omg, preferably 400 to 60 Omg per day for an adult. It may be increased or decreased as appropriate according to the symptoms.
- the content of the present invention will be described in more detail by the following examples.
- Hepatitis C was diagnosed by liver biopsy, and interferon therapy with natural interferon o; natural interferon j3 or transgenic interferon ⁇ - 2b was ineffective for 6 months.
- the effect of bezafibrate on the treatment of chronic hepatitis C was confirmed in patients who underwent chronic hepatitis C.
- the target cases, administration method, measurement items and results are as follows.
- AST, ALT, y-GTP and HCV-RNA were quantified before administration of bezafibrate, and at 1, 3, and 6 months after administration, and compared with the values before administration.
- HCV-RNA quantification was performed using a copass amplifier monitor (Co bas A m 1 icor Monitor) method. Quantitative values are expressed as IU / L for AST, AL ⁇ , ⁇ -GT ⁇ , and KIU / mL for HCV-R ⁇ , and are shown as mean soil standard deviation (mean SD). Was. The significance test was performed by the t test (pairedttest). “NS” in the table means no significant difference.
- the eight-catch amount decreased significantly after the first month of administration.
- the bezafiprate represented by the above formula (I) and a pharmacologically acceptable salt thereof have a hepatobiliary enzyme lowering effect and an HCV growth inhibitory effect, and are markedly inhibited by the present invention against chronic hepatitis C by the present invention. It is possible to provide a therapeutic agent for chronic hepatitis C having an excellent therapeutic effect. Furthermore, the therapeutic agent for chronic hepatitis C of the present invention has an outstanding action effect that it is effective even in cases of intervening ineffectiveness, which is the first-line drug for the treatment of chronic hepatitis C, Suitable for treating chronic hepatitis C.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mechanical Engineering (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention porte sur des remèdes pour traiter l'hépatite C chronique contenant un acide α-[4-(4-chlorobenzoylaminoéthyl)phénoxy]isobutyrique comme principe actif dont les effets sont la suppression des enzymes hépatobiliaires et l'inhibition de la prolifération du virus de l'hépatite C. L'acide en question est représenté par la formule (I) ou ses sels pharmaceutiquement acceptables. Ces remèdes ont un effet remarquable même lorsque l'interféron, réputé être le médicament par excellence dans le traitement de l'hépatite C chronique, s'avère inefficace.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001047942A JP4829411B2 (ja) | 2001-02-23 | 2001-02-23 | C型慢性肝炎治療剤 |
JP2001-47942 | 2001-02-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002067920A1 true WO2002067920A1 (fr) | 2002-09-06 |
Family
ID=18909284
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2001/007533 WO2002067920A1 (fr) | 2001-02-23 | 2001-08-31 | Remedes pour hepatite c chronique |
Country Status (3)
Country | Link |
---|---|
JP (1) | JP4829411B2 (fr) |
KR (1) | KR100753709B1 (fr) |
WO (1) | WO2002067920A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007028424A1 (fr) * | 2005-02-15 | 2007-03-15 | F. Hoffmann-La Roche Ag | Dérivés d'amides en tant qu’activateurs de ppar |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10130142A (ja) * | 1996-10-31 | 1998-05-19 | Zensei Yakuhin Kogyo Kk | 放出持続型圧縮製剤 |
FR2774591B1 (fr) * | 1998-02-12 | 2000-05-05 | Lipha | Composition pharmaceutique comprenant l'association metformine et fibrate et son utilisation pour la preparation de medicaments destines a reduire l'hyperglycemie |
-
2001
- 2001-02-23 JP JP2001047942A patent/JP4829411B2/ja not_active Expired - Fee Related
- 2001-03-22 KR KR1020010014905A patent/KR100753709B1/ko not_active IP Right Cessation
- 2001-08-31 WO PCT/JP2001/007533 patent/WO2002067920A1/fr active Search and Examination
Non-Patent Citations (2)
Title |
---|
Amacher David E. et al. "Hepatitic microsomal enzyme induction, bèta-oxidation, and cell proliferation following administration of clofibrate, gemfibrozil, orbezafibrate in the CD rat," Toxicol.Appl.Pharmacol., Vol.142, No.1 (1997), pp. 143-150 * |
Kurihara T., et al. "Study of effectiveness of bezafibrate in the treatment of chronic hepatitis C," American Journal of Gastroenterology, Vol.96, No. 5, (May 2001), pp.1659-1660 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007028424A1 (fr) * | 2005-02-15 | 2007-03-15 | F. Hoffmann-La Roche Ag | Dérivés d'amides en tant qu’activateurs de ppar |
Also Published As
Publication number | Publication date |
---|---|
JP2002249429A (ja) | 2002-09-06 |
JP4829411B2 (ja) | 2011-12-07 |
KR100753709B1 (ko) | 2007-08-30 |
KR20020069078A (ko) | 2002-08-29 |
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