WO2002066623A3 - Regulation of human phosphatidic acid-preferring phospholipase a1 - Google Patents

Regulation of human phosphatidic acid-preferring phospholipase a1 Download PDF

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Publication number
WO2002066623A3
WO2002066623A3 PCT/EP2002/001684 EP0201684W WO02066623A3 WO 2002066623 A3 WO2002066623 A3 WO 2002066623A3 EP 0201684 W EP0201684 W EP 0201684W WO 02066623 A3 WO02066623 A3 WO 02066623A3
Authority
WO
WIPO (PCT)
Prior art keywords
phosphatidic acid
regulation
disorders
human phosphatidic
preferring phospholipase
Prior art date
Application number
PCT/EP2002/001684
Other languages
French (fr)
Other versions
WO2002066623A2 (en
Inventor
Alex Smolyar
Original Assignee
Bayer Ag
Alex Smolyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Alex Smolyar filed Critical Bayer Ag
Priority to AU2002308285A priority Critical patent/AU2002308285A1/en
Publication of WO2002066623A2 publication Critical patent/WO2002066623A2/en
Publication of WO2002066623A3 publication Critical patent/WO2002066623A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01032—Phospholipase A1 (3.1.1.32)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reagents that regulate human phosphatidic acid-preferring phospholipase A1 and reagents which bind to human phosphatidic acid-preferring phospholipase A1 gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, CNS disorders, genitourinary disorders, cardiovascular disorders, hematological disorders, cancer, asthma or COPD.
PCT/EP2002/001684 2001-02-21 2002-02-18 Regulation of human phosphatidic acid-preferring phospholipase a1 WO2002066623A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002308285A AU2002308285A1 (en) 2001-02-21 2002-02-18 Regulation of human phosphatidic acid-preferring phospholipase a1

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26985601P 2001-02-21 2001-02-21
US60/269,856 2001-02-21
US30148301P 2001-06-29 2001-06-29
US60/301,483 2001-06-29

Publications (2)

Publication Number Publication Date
WO2002066623A2 WO2002066623A2 (en) 2002-08-29
WO2002066623A3 true WO2002066623A3 (en) 2003-01-30

Family

ID=26953944

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/001684 WO2002066623A2 (en) 2001-02-21 2002-02-18 Regulation of human phosphatidic acid-preferring phospholipase a1

Country Status (2)

Country Link
AU (1) AU2002308285A1 (en)
WO (1) WO2002066623A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001042467A2 (en) * 1999-12-08 2001-06-14 Millennium Pharmaceuticals, Inc. Genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
WO2001060860A2 (en) * 2000-02-17 2001-08-23 Millennium Predictive Medicine, Inc. Genes differentially expressed in human prostate cancer and their use
WO2002020738A2 (en) * 2000-09-08 2002-03-14 Millennium Pharmaceuticals, Inc. 27877, a phospholipase and uses therefor
WO2002046418A2 (en) * 2000-12-08 2002-06-13 Incyte Genomics, Inc. Lipid-associated molecules

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001042467A2 (en) * 1999-12-08 2001-06-14 Millennium Pharmaceuticals, Inc. Genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
WO2001060860A2 (en) * 2000-02-17 2001-08-23 Millennium Predictive Medicine, Inc. Genes differentially expressed in human prostate cancer and their use
WO2002020738A2 (en) * 2000-09-08 2002-03-14 Millennium Pharmaceuticals, Inc. 27877, a phospholipase and uses therefor
WO2002046418A2 (en) * 2000-12-08 2002-06-13 Incyte Genomics, Inc. Lipid-associated molecules

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 13 May 2000 (2000-05-13), HEILIG R. ET AL.: "Human chromosome 14 DNA sequence BAC R-547D23 of library RPCI-11 from chromosome 14 of Homo sapiens (Human)", XP002195659, Database accession no. CNS05TDA *
DATABASE EMBL [online] 5 December 2000 (2000-12-05), "uz84c02.y1 NCI_CGAP_Lu29 Mus musculus cDNA clone IMAGE:3675746 5' similar to TR:O46606 O46606 PHOSPHATIDIC ACID-PREFERRING PHOSPHOLIPASE A1. ;, mRNA sequence.", XP002219784, Database accession no. BF452087 *
DATABASE GENESEQ [online] 16 September 2002 (2002-09-16), SCHLEGEL R ET AL.: "Human prostate expression marker cDNA 24195.", XP002219785, Database accession no. ABV24204 *
DATABASE GENESEQ [online] 19 September 2001 (2001-09-19), SCHLEGEL R. ET AL.: "Human cervical cancer marker nucleic acid 4519.", XP002195655, Database accession no. AAH73245 *
HIGGS H N ET AL: "CLONING OF A PHOSPHATIDIC ACID-PREFERRING PHOSPHOLIPASE A1 FROM BOVINE TESTIS", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 10, 6 March 1998 (1998-03-06), pages 5468 - 5477, XP002949599, ISSN: 0021-9258 *
HIGGS HENRY N ET AL: "Purification and properties of a phosphatidic acid-preferring phospholipase A-1 from bovine testis: Examination of the molecular basis of its activation.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 18, 1996, pages 10874 - 10883, XP002219783, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2002066623A2 (en) 2002-08-29
AU2002308285A1 (en) 2002-09-04

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