WO2002059323A3 - Aminoacyl trna synthetases - Google Patents
Aminoacyl trna synthetases Download PDFInfo
- Publication number
- WO2002059323A3 WO2002059323A3 PCT/US2001/048575 US0148575W WO02059323A3 WO 2002059323 A3 WO2002059323 A3 WO 2002059323A3 US 0148575 W US0148575 W US 0148575W WO 02059323 A3 WO02059323 A3 WO 02059323A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aminoacyl trna
- trna synthetases
- atrs
- provides
- polynucleotides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01994254A EP1349939A2 (en) | 2000-12-15 | 2001-12-13 | Aminoacyl trna synthetases |
JP2002559808A JP2004537270A (en) | 2000-12-15 | 2001-12-13 | Aminoacyl-tRNA synthetase |
US10/450,727 US20040048290A1 (en) | 2001-12-13 | 2001-12-13 | Aminoacyl trna synthetases |
CA002431493A CA2431493A1 (en) | 2000-12-15 | 2001-12-13 | Aminoacyl trna synthetases |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25596300P | 2000-12-15 | 2000-12-15 | |
US60/255,963 | 2000-12-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002059323A2 WO2002059323A2 (en) | 2002-08-01 |
WO2002059323A3 true WO2002059323A3 (en) | 2003-07-24 |
Family
ID=22970573
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/048575 WO2002059323A2 (en) | 2000-12-15 | 2001-12-13 | Aminoacyl trna synthetases |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1349939A2 (en) |
JP (1) | JP2004537270A (en) |
CA (1) | CA2431493A1 (en) |
WO (1) | WO2002059323A2 (en) |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8835387B2 (en) | 2012-02-16 | 2014-09-16 | Atyr Pharma, Inc. | Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases |
US8945541B2 (en) | 2010-05-14 | 2015-02-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases |
US8946157B2 (en) | 2010-05-03 | 2015-02-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-tRNA synthetases |
US8961960B2 (en) | 2010-04-27 | 2015-02-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases |
US8962560B2 (en) | 2010-06-01 | 2015-02-24 | Atyr Pharma Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases |
US8961961B2 (en) | 2010-05-03 | 2015-02-24 | a Tyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases |
US8969301B2 (en) | 2010-07-12 | 2015-03-03 | Atyr Pharma Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-tRNA synthetases |
US8981045B2 (en) | 2010-05-03 | 2015-03-17 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetases |
US8980253B2 (en) | 2010-04-26 | 2015-03-17 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase |
US8986681B2 (en) | 2010-04-27 | 2015-03-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl-tRNA synthetases |
US8986680B2 (en) | 2010-04-29 | 2015-03-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases |
US8993723B2 (en) | 2010-04-28 | 2015-03-31 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases |
US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
US9034320B2 (en) | 2010-04-29 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Valyl-tRNA synthetases |
US9034321B2 (en) | 2010-05-03 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases |
US9034598B2 (en) | 2010-05-17 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
US9127268B2 (en) | 2009-12-11 | 2015-09-08 | Atyr Pharma, Inc. | Aminoacyl tRNA synthetases for modulating inflammation |
US9347053B2 (en) | 2010-05-27 | 2016-05-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases |
US9399770B2 (en) | 2010-10-06 | 2016-07-26 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tryptophanyl-tRNA synthetases |
US9404104B2 (en) | 2010-05-04 | 2016-08-02 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of P38 multi-tRNA synthetase complex |
US9422539B2 (en) | 2010-07-12 | 2016-08-23 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-tRNA synthetases |
US9428743B2 (en) | 2010-08-25 | 2016-08-30 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-trna synthetases |
US9453214B2 (en) | 2009-02-27 | 2016-09-27 | Atyr Pharma, Inc. | Polypeptide structural motifs associated with cell signaling activity |
US9574187B2 (en) | 2010-05-04 | 2017-02-21 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases |
US9587235B2 (en) | 2013-03-15 | 2017-03-07 | Atyr Pharma, Inc. | Histidyl-tRNA synthetase-Fc conjugates |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2727622A1 (en) | 2008-06-11 | 2009-12-17 | Atyr Pharma, Inc. | Thrombopoietic activity of tyrosyl-trna synthetase polypeptides |
WO2009158649A1 (en) | 2008-06-26 | 2009-12-30 | Atyr Pharma, Inc. | Compositions and methods comprising glycyl-trna synthetases having non-canonical biological activities |
DK2408905T3 (en) | 2009-03-16 | 2017-08-28 | Pangu Biopharma Ltd | Compositions and Methods comprising Histidyl-tRNA Synthetase Splicing Variants with Non-Canonical Biological Activities |
EP2414513B1 (en) | 2009-03-31 | 2015-10-28 | Atyr Pharma, Inc. | Compositions and methods comprising aspartyl-trna synthetases having non-canonical biological activities |
WO2011072266A2 (en) * | 2009-12-11 | 2011-06-16 | Atyr Pharma, Inc. | Aminoacyl trna synthetases for modulating hematopoiesis |
US8828395B2 (en) | 2009-12-11 | 2014-09-09 | Atyr Pharma, Inc. | Antibodies that bind tyrosyl-tRNA synthetases |
EP2593125B1 (en) | 2010-07-12 | 2017-11-01 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases |
US9714419B2 (en) | 2011-08-09 | 2017-07-25 | Atyr Pharma, Inc. | PEGylated tyrosyl-tRNA synthetase polypeptides |
WO2013086228A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Pegylated aspartyl-trna synthetase polypeptides |
US9816084B2 (en) | 2011-12-06 | 2017-11-14 | Atyr Pharma, Inc. | Aspartyl-tRNA synthetases |
EP2797959A4 (en) | 2011-12-29 | 2015-08-26 | Atyr Pharma Inc | Aspartyl-trna synthetase-fc conjugates |
EP3612215A4 (en) | 2017-04-20 | 2021-05-26 | aTyr Pharma, Inc. | Compositions and methods for treating lung inflammation |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0909818A1 (en) * | 1997-10-17 | 1999-04-21 | Smithkline Beecham Corporation | Valyl tRNA synthetase (EC 6.1.1.9) from Streptococcus pneumoniae |
WO2001090330A2 (en) * | 2000-05-25 | 2001-11-29 | Incyte Genomics, Inc. | AMINOACYL tRNA SYNTHETASES |
-
2001
- 2001-12-13 EP EP01994254A patent/EP1349939A2/en not_active Withdrawn
- 2001-12-13 JP JP2002559808A patent/JP2004537270A/en active Pending
- 2001-12-13 CA CA002431493A patent/CA2431493A1/en not_active Abandoned
- 2001-12-13 WO PCT/US2001/048575 patent/WO2002059323A2/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0909818A1 (en) * | 1997-10-17 | 1999-04-21 | Smithkline Beecham Corporation | Valyl tRNA synthetase (EC 6.1.1.9) from Streptococcus pneumoniae |
WO2001090330A2 (en) * | 2000-05-25 | 2001-11-29 | Incyte Genomics, Inc. | AMINOACYL tRNA SYNTHETASES |
Non-Patent Citations (5)
Title |
---|
DATABASE EMBL [online] 13 November 1995 (1995-11-13), VILALATA ET AL.: "Human tansfer valyl-tRNA synthetase mRNA 3'end of cds", retrieved from EMBL Database accession no. M98326 * |
DATABASE EMBL [online] 22 February 2000 (2000-02-22), SUGANO ET AL.: "Homo sapiens cDNA, highly similar to SYV_FUGRU Valyl-tRNA synthetase", XP002224910, Database accession no. AK000511 * |
HSIEH S-L ET AL: "EVIDENCE THAT GENE G7A IN THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX ENCODES VALYL-TRANSFER RNA SYNTHETASE", BIOCHEMICAL JOURNAL, vol. 278, no. 3, 1991, pages 809 - 816, XP009002689, ISSN: 0264-6021 * |
SCHIMMEL PAUL ET AL: "Aminoacyl tRNA synthetases as targets for new anti-infectives", FASEB JOURNAL (FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY), BETHESDA, US, vol. 12, no. 15, December 1998 (1998-12-01), pages 1599 - 1609, XP002191843, ISSN: 0892-6638 * |
VILALTA ADRIAN ET AL: "Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase.", GENE (AMSTERDAM), vol. 123, no. 2, 1993, pages 181 - 186, XP001121728, ISSN: 0378-1119 * |
Cited By (39)
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---|---|---|---|---|
US9453214B2 (en) | 2009-02-27 | 2016-09-27 | Atyr Pharma, Inc. | Polypeptide structural motifs associated with cell signaling activity |
US9328340B2 (en) | 2009-12-11 | 2016-05-03 | Atyr Pharma, Inc. | Amino acyl tRNA synthetases for modulating inflammation |
US9127268B2 (en) | 2009-12-11 | 2015-09-08 | Atyr Pharma, Inc. | Aminoacyl tRNA synthetases for modulating inflammation |
US9540628B2 (en) | 2009-12-11 | 2017-01-10 | Atyr Pharma, Inc. | Aminoacyl tRNA synthetases for modulating inflammation |
US9540629B2 (en) | 2010-04-26 | 2017-01-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Cysteinyl-tRNA synthetase |
US8980253B2 (en) | 2010-04-26 | 2015-03-17 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase |
US8961960B2 (en) | 2010-04-27 | 2015-02-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases |
US9528103B2 (en) | 2010-04-27 | 2016-12-27 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases |
US8986681B2 (en) | 2010-04-27 | 2015-03-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl-tRNA synthetases |
US9580706B2 (en) | 2010-04-27 | 2017-02-28 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of threonyl-tRNA synthetases |
US8993723B2 (en) | 2010-04-28 | 2015-03-31 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases |
US9320782B2 (en) | 2010-04-28 | 2016-04-26 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl tRNA synthetases |
US9556425B2 (en) | 2010-04-29 | 2017-01-31 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Valyl-tRNA synthetases |
US8986680B2 (en) | 2010-04-29 | 2015-03-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases |
US9034320B2 (en) | 2010-04-29 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Valyl-tRNA synthetases |
US8981045B2 (en) | 2010-05-03 | 2015-03-17 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetases |
US8961961B2 (en) | 2010-05-03 | 2015-02-24 | a Tyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases |
US9034321B2 (en) | 2010-05-03 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases |
US8946157B2 (en) | 2010-05-03 | 2015-02-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-tRNA synthetases |
US9422538B2 (en) | 2010-05-03 | 2016-08-23 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetasis |
US9593322B2 (en) | 2010-05-03 | 2017-03-14 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases |
US9593323B2 (en) | 2010-05-03 | 2017-03-14 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases |
US9340780B2 (en) | 2010-05-03 | 2016-05-17 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-tRNA synthetases |
US9404104B2 (en) | 2010-05-04 | 2016-08-02 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of P38 multi-tRNA synthetase complex |
US9574187B2 (en) | 2010-05-04 | 2017-02-21 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases |
US8945541B2 (en) | 2010-05-14 | 2015-02-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases |
US9034598B2 (en) | 2010-05-17 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
US9347053B2 (en) | 2010-05-27 | 2016-05-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases |
US9322009B2 (en) | 2010-06-01 | 2016-04-26 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases |
US8962560B2 (en) | 2010-06-01 | 2015-02-24 | Atyr Pharma Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases |
US9315794B2 (en) | 2010-07-12 | 2016-04-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-tRNA synthetases |
US9422539B2 (en) | 2010-07-12 | 2016-08-23 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-tRNA synthetases |
US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
US8969301B2 (en) | 2010-07-12 | 2015-03-03 | Atyr Pharma Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-tRNA synthetases |
US9428743B2 (en) | 2010-08-25 | 2016-08-30 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-trna synthetases |
US9399770B2 (en) | 2010-10-06 | 2016-07-26 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tryptophanyl-tRNA synthetases |
US8835387B2 (en) | 2012-02-16 | 2014-09-16 | Atyr Pharma, Inc. | Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases |
US9273302B2 (en) | 2012-02-16 | 2016-03-01 | Atyr Pharma, Inc. | Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases |
US9587235B2 (en) | 2013-03-15 | 2017-03-07 | Atyr Pharma, Inc. | Histidyl-tRNA synthetase-Fc conjugates |
Also Published As
Publication number | Publication date |
---|---|
CA2431493A1 (en) | 2002-08-01 |
WO2002059323A2 (en) | 2002-08-01 |
JP2004537270A (en) | 2004-12-16 |
EP1349939A2 (en) | 2003-10-08 |
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